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Conserved domains on  [gi|15596737|ref|NP_250231|]
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multidrug efflux system protein MdtI [Pseudomonas aeruginosa PAO1]

Protein Classification

multidrug/spermidine efflux SMR transporter subunit MdtI( domain architecture ID 10013592)

multidrug/spermidine efflux SMR transporter subunit MdtI catalyzes the excretion of spermidine, and can also confer resistance to deoxycholate and SDS

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10650 PRK10650
multidrug/spermidine efflux SMR transporter subunit MdtI;
1-91 6.78e-41

multidrug/spermidine efflux SMR transporter subunit MdtI;


:

Pssm-ID: 182618  Cd Length: 109  Bit Score: 130.93  E-value: 6.78e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596737    1 MLTLNWIPFAWLGLAIALEVVANLLLKYSDGFRRRGLGIASILCVMAAFTALAQAVKDIELSLAYAIWGGFGILATVAMG 80
Cdd:PRK10650   1 MQQFEWIHAAWLALAIVLEIVANIFLKFSDGFRRKIYGILSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAG 80

                         90
                 ....*....|.
gi 15596737   81 WALFGQRLAWR 91
Cdd:PRK10650  81 WILFGQRLNRK 91
 
Name Accession Description Interval E-value
PRK10650 PRK10650
multidrug/spermidine efflux SMR transporter subunit MdtI;
1-91 6.78e-41

multidrug/spermidine efflux SMR transporter subunit MdtI;


Pssm-ID: 182618  Cd Length: 109  Bit Score: 130.93  E-value: 6.78e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596737    1 MLTLNWIPFAWLGLAIALEVVANLLLKYSDGFRRRGLGIASILCVMAAFTALAQAVKDIELSLAYAIWGGFGILATVAMG 80
Cdd:PRK10650   1 MQQFEWIHAAWLALAIVLEIVANIFLKFSDGFRRKIYGILSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAG 80

                         90
                 ....*....|.
gi 15596737   81 WALFGQRLAWR 91
Cdd:PRK10650  81 WILFGQRLNRK 91
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
8-91 5.58e-18

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 72.44  E-value: 5.58e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596737   8 PFAWLGLAIALEVVANLLLKYSDGFRRRGLGIASILCVMAAFTALAQAVKDIELSLAYAIWGGFGILATVAMGWALFGQR 87
Cdd:COG2076   1 AWLYLLLAGLLEVVWTLALKLSDGFTRLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEP 80


                ....
gi 15596737  88 LAWR 91
Cdd:COG2076  81 LSLA 84
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 11-90 2.39e-16

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 68.08  E-value: 2.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596737    11 WLGLAIALEVVANLLLKYSDGFRRRGLGIASILCVMAAFTALAQAVKDIELSLAYAIWGGFGILATVAMGWALFGQRLAW 90
Cdd:pfam00893   5 LLVLAIVLEVVGTSLLKYSEGFTRLWPSILVIVGYGLSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGILLFGESLSL 84
 
Name Accession Description Interval E-value
PRK10650 PRK10650
multidrug/spermidine efflux SMR transporter subunit MdtI;
1-91 6.78e-41

multidrug/spermidine efflux SMR transporter subunit MdtI;


Pssm-ID: 182618  Cd Length: 109  Bit Score: 130.93  E-value: 6.78e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596737    1 MLTLNWIPFAWLGLAIALEVVANLLLKYSDGFRRRGLGIASILCVMAAFTALAQAVKDIELSLAYAIWGGFGILATVAMG 80
Cdd:PRK10650   1 MQQFEWIHAAWLALAIVLEIVANIFLKFSDGFRRKIYGILSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAG 80

                         90
                 ....*....|.
gi 15596737   81 WALFGQRLAWR 91
Cdd:PRK10650  81 WILFGQRLNRK 91
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
8-91 5.58e-18

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 72.44  E-value: 5.58e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596737   8 PFAWLGLAIALEVVANLLLKYSDGFRRRGLGIASILCVMAAFTALAQAVKDIELSLAYAIWGGFGILATVAMGWALFGQR 87
Cdd:COG2076   1 AWLYLLLAGLLEVVWTLALKLSDGFTRLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEP 80


                ....
gi 15596737  88 LAWR 91
Cdd:COG2076  81 LSLA 84
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 11-90 2.39e-16

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 68.08  E-value: 2.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596737    11 WLGLAIALEVVANLLLKYSDGFRRRGLGIASILCVMAAFTALAQAVKDIELSLAYAIWGGFGILATVAMGWALFGQRLAW 90
Cdd:pfam00893   5 LLVLAIVLEVVGTSLLKYSEGFTRLWPSILVIVGYGLSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGILLFGESLSL 84
emrE PRK09541
EmrE family multidrug efflux SMR transporter;
8-88 1.55e-15

EmrE family multidrug efflux SMR transporter;


Pssm-ID: 137367  Cd Length: 110  Bit Score: 66.53  E-value: 1.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596737    8 PFAWLGLAIALEVVANLLLKYSDGFRRRGLGIASILCVMAAFTALAQAVKDIELSLAYAIWGGFGILATVAMGWALFGQR 87
Cdd:PRK09541   3 PYIYLGGAILAEVIGTTLMKFSEGFTRLWPSVGTIICYCASFWLLAQTLAYIPTGIAYAIWSGVGIVLISLLSWGFFGQR 82


                 .
gi 15596737   88 L 88
Cdd:PRK09541  83 L 83
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
10-86 2.47e-04

quaternary ammonium compound efflux SMR transporter SugE;


Pssm-ID: 171110  Cd Length: 105  Bit Score: 37.15  E-value: 2.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596737   10 AWLGLAIA--LEVVANLLLKYSDGFRRRGLGIASILCVMAAFTALAQAVKDIELSLAYAIWGGFGILATVAMGWALFGQ 86
Cdd:PRK11431   2 SWIILVIAglLEVVWAVGLKYTHGFSRLTPSIITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGE 80
PRK10452 PRK10452
multidrug/spermidine efflux SMR transporter subunit MdtJ;
12-89 8.90e-04

multidrug/spermidine efflux SMR transporter subunit MdtJ;


Pssm-ID: 182471  Cd Length: 120  Bit Score: 35.90  E-value: 8.90e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596737   12 LGLAIALEVVANLLLKYSDGFRRRGLGIASILCVMAAFTALAQAVKDIELSLAYAIWGGFGILATVAMGWALFGQRLA 89
Cdd:PRK10452   7 LALAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLFDESLS 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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