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Conserved domains on  [gi|15596586|ref|NP_250080|]
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glycosyl transferase family protein [Pseudomonas aeruginosa PAO1]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 289-471 1.72e-25

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 107.62  E-value: 1.72e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 289 YFPASDHAEAIPTAGSTILWASRISPQKRPDLLYEIALALPEYLFEVH----GEVDPACRGETQRKLRRLPNVRLHGRYD 364
Cdd:cd03801 178 FSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRlvivGGDGPLRAELEELELGLGDRVRFLGFVP 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 365 sFQALARQGRYA-MLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNTETGYLVGADADAGEFARAIRSALGNPGE 443
Cdd:cd03801 258 -DEELPALYAAAdVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPEL 336

                       170       180
                ....*....|....*....|....*...
gi 15596586 444 TARRVKRARELLTRRHGWAAFRDAARNI 471
Cdd:cd03801 337 RARLGRAARERVAERFSWERVAERLLDL 364
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 289-471 1.72e-25

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 107.62  E-value: 1.72e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 289 YFPASDHAEAIPTAGSTILWASRISPQKRPDLLYEIALALPEYLFEVH----GEVDPACRGETQRKLRRLPNVRLHGRYD 364
Cdd:cd03801 178 FSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRlvivGGDGPLRAELEELELGLGDRVRFLGFVP 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 365 sFQALARQGRYA-MLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNTETGYLVGADADAGEFARAIRSALGNPGE 443
Cdd:cd03801 258 -DEELPALYAAAdVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPEL 336

                       170       180
                ....*....|....*....|....*...
gi 15596586 444 TARRVKRARELLTRRHGWAAFRDAARNI 471
Cdd:cd03801 337 RARLGRAARERVAERFSWERVAERLLDL 364
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 378-471 3.01e-17

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 77.72  E-value: 3.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 378 LLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFL-NTETGYLVGADaDAGEFARAIRSALGNPGETARRVKRARELLT 456
Cdd:COG0438  24 FVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIeDGETGLLVPPG-DPEALAEAILRLLEDPELRRRLGEAARERAE 102

                        90
                ....*....|....*
gi 15596586 457 RRHGWAAFRDAARNI 471
Cdd:COG0438 103 ERFSWEAIAERLLAL 117
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
305-440 1.50e-16

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 76.40  E-value: 1.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586   305 TILWASRISP-QKRPDLLYEIALALPEYLFEVH----GEVDPAcrgETQRKLRRLP-NVRLHGRYDSFQALARQGRyaML 378
Cdd:pfam13692   3 VILFVGRLHPnVKGVDYLLEAVPLLRKRDNDVRlvivGDGPEE---ELEELAAGLEdRVIFTGFVEDLAELLAAAD--VF 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596586   379 LYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNTETGYLVgADADAGEFARAIRSALGN 440
Cdd:pfam13692  78 VLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELVDGENGLLV-PPGDPEALAEAILRLLED 138
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 382-467 1.35e-08

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 56.66  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586   382 SRYDGLPNILLEATAAGLPIVAPDVGGIAEFL-NTETGYLVGADaDAGEFARAIRSALGNPGETARRVKRARELLTRRHG 460
Cdd:TIGR03088 280 SLAEGISNTILEAMASGLPVIATAVGGNPELVqHGVTGALVPPG-DAVALARALQPYVSDPAARRAHGAAGRARAEQQFS 358


                  ....*..
gi 15596586   461 WAAFRDA 467
Cdd:TIGR03088 359 INAMVAA 365
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
 296-456 8.35e-06

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 48.49  E-value: 8.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586  296 AEAIPTAGSTIlwasRISPQKRPDLLYEIAlalpeylfevhgevdpacrgetQRKLRRLPNVRL----HGR-YDSFQALA 370
Cdd:PRK15179 514 SDARFTVGTVM----RVDDNKRPFLWVEAA----------------------QRFAASHPKVRFimvgGGPlLESVREFA 567

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586  371 RQGRYA-MLLYT-------------------SRYDGLPNILLEATAAGLPIVAPDVGGIAE-FLNTETGYLVGADA---- 425
Cdd:PRK15179 568 QRLGMGeRILFTglsrrvgywltqfnaflllSRFEGLPNVLIEAQFSGVPVVTTLAGGAGEaVQEGVTGLTLPADTvtap 647

                        170       180       190
                 ....*....|....*....|....*....|..
gi 15596586  426 DAGE-FARAIRSALGNPGETARRVKRARELLT 456
Cdd:PRK15179 648 DVAEaLARIHDMCAADPGIARKAADWASARFS 679
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 377-466 4.10e-03

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 39.53  E-value: 4.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586  377 MLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNTET---------GYLVG-ADADAgeFARAIRSALGNPG--ET 444
Cdd:NF038011 386 LMVLSSISEALPLVVLEAFAAGVPVVTTDVGSCRQLIEGLDeedralgaaGEVVAiADPQA--LARAALDLLRDPQrwQA 463

                         90       100
                 ....*....|....*....|....
gi 15596586  445 ARR--VKRARELLTRRHGWAAFRD 466
Cdd:NF038011 464 AQAagLARVERYYTEELMFDRYRE 487
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 289-471 1.72e-25

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 107.62  E-value: 1.72e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 289 YFPASDHAEAIPTAGSTILWASRISPQKRPDLLYEIALALPEYLFEVH----GEVDPACRGETQRKLRRLPNVRLHGRYD 364
Cdd:cd03801 178 FSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRlvivGGDGPLRAELEELELGLGDRVRFLGFVP 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 365 sFQALARQGRYA-MLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNTETGYLVGADADAGEFARAIRSALGNPGE 443
Cdd:cd03801 258 -DEELPALYAAAdVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPEL 336

                       170       180
                ....*....|....*....|....*...
gi 15596586 444 TARRVKRARELLTRRHGWAAFRDAARNI 471
Cdd:cd03801 337 RARLGRAARERVAERFSWERVAERLLDL 364
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 272-447 1.66e-18

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 86.64  E-value: 1.66e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 272 QQIHERDGIPPELMHGLY---------FPASDHAEAIPTAGSTILWASRISPQKRPDLL----YEIALALPEYLFEVHGE 338
Cdd:cd03811 148 EDLIRLGPSPPEKIEVIYnpididrirALAKEPILNEPEDGPVILAVGRLDPQKGHDLLieafAKLRKKYPDVKLVILGD 227

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 339 VDpaCRGETQRKLRRL---PNVRLHGRYD---SFQALARqgryaMLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEF 412
Cdd:cd03811 228 GP--LREELEKLAKELglaERVIFLGFQSnpyPYLKKAD-----LFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREI 300

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 15596586 413 L-NTETGYLVGADADAGEFARAIRSALGNPGETARR 447
Cdd:cd03811 301 LdDGENGLLVPDGDAAALAGILAALLQKKLDAALRE 336
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 378-471 3.01e-17

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 77.72  E-value: 3.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 378 LLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFL-NTETGYLVGADaDAGEFARAIRSALGNPGETARRVKRARELLT 456
Cdd:COG0438  24 FVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIeDGETGLLVPPG-DPEALAEAILRLLEDPELRRRLGEAARERAE 102

                        90
                ....*....|....*
gi 15596586 457 RRHGWAAFRDAARNI 471
Cdd:COG0438 103 ERFSWEAIAERLLAL 117
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
305-440 1.50e-16

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 76.40  E-value: 1.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586   305 TILWASRISP-QKRPDLLYEIALALPEYLFEVH----GEVDPAcrgETQRKLRRLP-NVRLHGRYDSFQALARQGRyaML 378
Cdd:pfam13692   3 VILFVGRLHPnVKGVDYLLEAVPLLRKRDNDVRlvivGDGPEE---ELEELAAGLEdRVIFTGFVEDLAELLAAAD--VF 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596586   379 LYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNTETGYLVgADADAGEFARAIRSALGN 440
Cdd:pfam13692  78 VLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELVDGENGLLV-PPGDPEALAEAILRLLED 138
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 311-463 3.63e-16

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 80.05  E-value: 3.63e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 311 RISPQKRPDLLYEIALAL----PEYLFEVHGevdpacRGETQRKLRRL-------PNVRLHG-RYDSFQALARQGRYAMl 378
Cdd:cd03807 198 RLHPVKDHSDLLRAAALLvethPDLRLLLVG------RGPERPNLERLllelgleDRVHLLGeRSDVPALLPAMDIFVL- 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 379 lyTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNTETGYLVGAdADAGEFARAIRSALGNPGETARRVKRARELLTRR 458
Cdd:cd03807 271 --SSRTEGFPNALLEAMACGLPVVATDVGGAAELVDDGTGFLVPA-GDPQALADAIRALLEDPEKRARLGRAARERIANE 347


                ....*
gi 15596586 459 HGWAA 463
Cdd:cd03807 348 FSIDA 352
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 306-453 1.13e-15

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 74.23  E-value: 1.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586   306 ILWASRISPQKRPDLLYE----IALALPEYLFEVHGEvdpacrGETQRKLRRL-------PNVRLHGrYDSFQALARQGR 374
Cdd:pfam00534   5 ILFVGRLEPEKGLDLLIKafalLKEKNPNLKLVIAGD------GEEEKRLKKLaeklglgDNVIFLG-FVSDEDLPELLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586   375 YA-MLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFL-NTETGYLVgADADAGEFARAIRSALGNPGETARRVKRAR 452
Cdd:pfam00534  78 IAdVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVkDGETGFLV-KPNNAEALAEAIDKLLEDEELRERLGENAR 156


                  .
gi 15596586   453 E 453
Cdd:pfam00534 157 K 157
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 289-469 1.42e-15

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 78.19  E-value: 1.42e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 289 YFPASDHAEAIPTAGSTILWASRISPQKRPDLLYEIALALPEYLFEVH------GEVDPACRGETQRkLRRLPNVRLHGR 362
Cdd:cd03798 186 RFQPEDRGLGLPLDAFVILFVGRLIPRKGIDLLLEAFARLAKARPDVVllivgdGPLREALRALAED-LGLGDRVTFTGR 264

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 363 YDSFQALARQGRYAMLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNT-ETGYLVgADADAGEFARAIRSALgNP 441
Cdd:cd03798 265 LPHEQVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDpETGLLV-PPGDADALAAALRRAL-AE 342

                       170       180
                ....*....|....*....|....*...
gi 15596586 442 GETARRVKRARELLTRRHGWAAFRDAAR 469
Cdd:cd03798 343 PYLRELGEAARARVAERFSWVKAADRIA 370
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 266-459 4.16e-15

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 76.48  E-value: 4.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 266 DNRTFLQQIHERDGIPPELMHG-----LYFPASDhaEAIPTAGSTILWASRISPQKRPDLLYEIA--LALPEYLFEVH-- 336
Cdd:cd03808 149 DDRDLAIKKGIIKKKKTVLIPGsgvdlDRFQYSP--ESLPSEKVVFLFVARLLKDKGIDELIEAAkiLKKKGPNVRFLlv 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 337 GEVDPacRGETQRKLRRL---PNVRLHGRYDSFQALARQgrYAMLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAE-F 412
Cdd:cd03808 227 GDGEL--ENPSEILIEKLgleGRIEFLGFRSDVPELLAE--SDVFVLPSYREGLPRSLLEAMAAGRPVITTDVPGCRElV 302

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15596586 413 LNTETGYLVGADaDAGEFARAIRSALGNPGETARRVKRARELLTRRH 459
Cdd:cd03808 303 IDGVNGFLVPPG-DVEALADAIEKLIEDPELRKEMGEAARKRVEEKF 348
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 306-473 9.73e-14

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 72.33  E-value: 9.73e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 306 ILWASRISPQKRPDLLYEIALALPEYL---FEVHGevDPACRGETQRklrRLPNVRLHGRYDSfQALARQgrYA---MLL 379
Cdd:cd03814 201 LLYVGRLAPEKNLEALLDADLPLAASPpvrLVVVG--DGPARAELEA---RGPDVIFTGFLTG-EELARA--YAsadVFV 272

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 380 YTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFL-NTETGYLVgADADAGEFARAIRSALGNPGETARRVKRARElLTRR 458
Cdd:cd03814 273 FPSRTETFGLVVLEAMASGLPVVAADAGGPRDIVrPGGTGALV-EPGDAAAFAAALRALLEDPELRRRMAARARA-EAER 350

                       170
                ....*....|....*
gi 15596586 459 HGWAAFRDAARNIPG 473
Cdd:cd03814 351 YSWEAFLDNLLDYYA 365
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 277-454 1.62e-13

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 71.62  E-value: 1.62e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 277 RDGIPPELMHGLYFPASDHAEAIPTAGSTILWASRISPQKRPDLLYEIALALPEYL---FEVHGevDPACRGETQRKLRR 353
Cdd:cd03819 156 PNGVDTDRFPPEAEAEERAQLGLPEGKPVVGYVGRLSPEKGWLLLVDAAAELKDEPdfrLLVAG--DGPERDEIRRLVER 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 354 L---PNVRLHGRYDSFQALARQGryAMLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFL-NTETGYLVgADADAGE 429
Cdd:cd03819 234 LglrDRVTFTGFREDVPAALAAS--DVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVvHGRTGLLV-PPGDAEA 310

                       170       180
                ....*....|....*....|....*
gi 15596586 430 FARAIRSALGNPGETARRVKRAREL 454
Cdd:cd03819 311 LADAIRAAKLLPEAREKLQAAAALT 335
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 307-421 7.47e-12

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 65.12  E-value: 7.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 307 LWASRISPQKRPDLLYEIALALPEYLFEVH------GEVDPAcRGETQRKLRRLPNVRLHGRYDSFQALARQGRYAMLLY 380
Cdd:cd01635 114 VSVGRLVPEKGIDLLLEALALLKARLPDLVlvlvggGGEREE-EEALAAALGLLERVVIIGGLVDDEVLELLLAAADVFV 192

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15596586 381 T-SRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNTE-TGYLV 421
Cdd:cd01635 193 LpSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGeNGLLV 235
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 305-457 7.93e-12

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 66.49  E-value: 7.93e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 305 TILWASRISPQKRPDLLYE----IALALPEYLFEVHGEvdpacrGETQRKLRRLPN-------VRLHGRY-DSFQALARQ 372
Cdd:cd03820 183 RILAVGRLTYQKGFDLLIEawalIAKKHPDWKLRIYGD------GPEREELEKLIDklgledrVKLLGPTkNIAEEYANS 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 373 GRYAMllyTSRYDGLPNILLEATAAGLPIVAPD-VGGIAEFL-NTETGYLVGaDADAGEFARAIRSALGNPGETARRVKR 450
Cdd:cd03820 257 SIFVL---SSRYEGFPMVLLEAMAYGLPIISFDcPTGPSEIIeDGENGLLVP-NGDVDALAEALLRLMEDEELRKKMGKN 332


                ....*..
gi 15596586 451 ARELLTR 457
Cdd:cd03820 333 ARKNAER 339
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 382-458 2.09e-10

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 62.35  E-value: 2.09e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596586 382 SRYDGLPNILLEATAAGLPIVAPDVGGIAEFL-NTETGYLVGAdADAGEFARAIRSALGNPGETARRVKRARELLTRR 458
Cdd:cd03825 271 SLADNLPNTLLEAMACGTPVVAFDTGGSPEIVqHGVTGYLVPP-GDVQALAEAIEWLLANPKERESLGERARALAENH 347
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 280-463 8.83e-10

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 60.33  E-value: 8.83e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 280 IPPELMHGLYFPASDHAE-----AIPTAGSTILWASRISPQKRPDLLYEIALALPEYLFE-----VHGEVDPACRGETQR 349
Cdd:cd03800 192 VPPGVDLERFFPVDRAEArrarlLLPPDKPVVLALGRLDPRKGIDTLVRAFAQLPELRELanlvlVGGPSDDPLSMDREE 271

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 350 KLRRLPNVRLHGRYDSFQALARQgRYAMLLY-------TSRYD--GLpnILLEATAAGLPIVAPDVGGIAEFL-NTETGY 419
Cdd:cd03800 272 LAELAEELGLIDRVRFPGRVSRD-DLPELYRaadvfvvPSLYEpfGL--TAIEAMACGTPVVATAVGGLQDIVrDGRTGL 348

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 15596586 420 LVgADADAGEFARAIRSALGNPGETARRVKRARELLTRRHGWAA 463
Cdd:cd03800 349 LV-DPHDPEALAAALRRLLDDPALWQRLSRAGLERARAHYTWES 391
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 291-471 1.38e-09

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 59.62  E-value: 1.38e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 291 PASDHAEAIPTAGSTILWASRISPQKRPDLLYE-IALA---LPEYLFEVHGEvdpacrGETQRKLRRL-------PNVRL 359
Cdd:cd04949 148 QLDTAESNHERKSNKIITISRLAPEKQLDHLIEaVAKAvkkVPEITLDIYGY------GEEREKLKKLieelhleDNVFL 221

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 360 HGRYDSFQALARQgrYAMLLYTSRYDGLPNILLEATAAGLPIVAPDVG-GIAEFL-NTETGYLVGADaDAGEFARAIrsa 437
Cdd:cd04949 222 KGYHSNLDQEYQD--AYLSLLTSQMEGFGLTLMEAIGHGLPVVSYDVKyGPSELIeDGENGYLIEKN-NIDALADKI--- 295

                       170       180       190
                ....*....|....*....|....*....|....
gi 15596586 438 lgnpgetarrvkraRELLTRRHGWAAFRDAARNI 471
Cdd:cd04949 296 --------------IELLNDPEKLQQFSEESYKI 315
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 279-459 1.10e-08

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 57.08  E-value: 1.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 279 GIPPELMHGLYF---PASDHAEAIPTAGSTILWASRISPQKRPDLLYE----IALALPEYLFEVHGevDPACRGETQRKL 351
Cdd:cd05844 162 GLPAERIHVHYIgidPAKFAPRDPAERAPTILFVGRLVEKKGCDVLIEafrrLAARHPTARLVIAG--DGPLRPALQALA 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 352 RRLPNVRLHGRYDSFQALARQGRYAMLLYTSRY------DGLPNILLEATAAGLPIVAPDVGGIAE-FLNTETGYLVgAD 424
Cdd:cd05844 240 AALGRVRFLGALPHAEVQDWMRRAEIFCLPSVTaasgdsEGLGIVLLEAAACGVPVVSSRHGGIPEaILDGETGFLV-PE 318

                       170       180       190
                ....*....|....*....|....*....|....*
gi 15596586 425 ADAGEFARAIRSALGNPGETARRVKRARELLTRRH 459
Cdd:cd05844 319 GDVDALADALQALLADRALADRMGGAARAFVCEQF 353
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 382-467 1.35e-08

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 56.66  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586   382 SRYDGLPNILLEATAAGLPIVAPDVGGIAEFL-NTETGYLVGADaDAGEFARAIRSALGNPGETARRVKRARELLTRRHG 460
Cdd:TIGR03088 280 SLAEGISNTILEAMASGLPVIATAVGGNPELVqHGVTGALVPPG-DAVALARALQPYVSDPAARRAHGAAGRARAEQQFS 358


                  ....*..
gi 15596586   461 WAAFRDA 467
Cdd:TIGR03088 359 INAMVAA 365
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
381-463 3.24e-08

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 51.07  E-value: 3.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586   381 TSRYDGLPNI-LLEATAAGLPIVAPDVGGIAEFLNTETGYLVGADADagEFARAIRSALGNPGETARRVKRARELLTRRH 459
Cdd:pfam13524   5 PSRRPDSPNMrVFEAAACGAPLLTDRTPGLEELFEPGEEILLYRDPE--ELAEKIRYLLEHPEERRAIAAAGRERVLAEH 82


                  ....
gi 15596586   460 GWAA 463
Cdd:pfam13524  83 TYAH 86
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 270-466 3.94e-08

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 55.03  E-value: 3.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 270 FLQQIHERDGIPPELMHGLYF---PASDHAEAIPTAGSTI--LWASRISPQKRPDLLYEIALALPEYLFEVH--GEvdpa 342
Cdd:cd03823 153 FTANLHEANGLFSARISVIPNavePDLAPPPRRRPGTERLrfGYIGRLTEEKGIDLLVEAFKRLPREDIELViaGH---- 228

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 343 CRGETQRKLRRLPNVRLHGRYDSFQALARQGRYAMLLYTSR-YDGLPNILLEATAAGLPIVAPDVGGIAEFLNT-ETGYL 420
Cdd:cd03823 229 GPLSDERQIEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFGLVVREAIAAGLPVIASDLGGIAELIQPgVNGLL 308

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 15596586 421 VGADADAgEFARAIRSALGNPGETARRVKRARELLTRRHGWAAFRD 466
Cdd:cd03823 309 FAPGDAE-DLAAAMRRLLTDPALLERLRAGAEPPRSTESQAEEYLK 353
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 306-453 1.74e-07

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 53.14  E-value: 1.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 306 ILWASRISPQKRPDLLYEIALALPEYLFEVH----GEVDPACRGETQRKLRRL--PNVRLHGR-YDsfqaLARQGRYA-- 376
Cdd:cd03821 207 ILFLGRIHPKKGLDLLIRAARKLAEQGRDWHlviaGPDDGAYPAFLQLQSSLGlgDRVTFTGPlYG----EAKWALYAsa 282

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596586 377 -MLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNTETGYLVgaDADAGEFARAIRSALGNPGETARRVKRARE 453
Cdd:cd03821 283 dLFVLPSYSENFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVV--DPNVSSLAEALAEALRDPADRKRLGEMARR 358
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 368-453 2.93e-07

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 52.46  E-value: 2.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 368 ALARQGRYAMLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNTET-GYLVGADADAGEFARAIRSALGNPGETAR 446
Cdd:cd04946 298 QLYKENDVDVFVNVSESEGIPVSIMEAISFGIPVIATNVGGTREIVENETnGLLLDKDPTPNEIVSSIMKFYLDGGDYKT 377


                ....*..
gi 15596586 447 RVKRARE 453
Cdd:cd04946 378 MKISARE 384
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 272-467 4.74e-06

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 48.87  E-value: 4.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 272 QQIHERDGIPPELMHGLY--FPASDHAEAI----PTAGSTILWASRISPQKrpDL---LYEIALAL---PEYLFEVHG-- 337
Cdd:cd03813 256 RRRQIRLGADPDKTRVIPngIDIQRFAPAReerpEKEPPVVGLVGRVVPIK--DVktfIRAFKLVRramPDAEGWLIGpe 333

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 338 EVDPA----CRGETQRkLRRLPNVRLHGRYDSFQALARQGryaMLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFL 413
Cdd:cd03813 334 DEDPEyaqeCKRLVAS-LGLENKVKFLGFQNIKEYYPKLG---LLVLTSISEGQPLVILEAMASGVPVVATDVGSCRELI 409

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596586 414 ------NTETGyLVGADADAGEFARAIRSALGNP------GETARrvKRARELLTRRHGWAAFRDA 467
Cdd:cd03813 410 ygaddaLGQAG-LVVPPADPEALAEALIKLLRDPelrqafGEAGR--KRVEKYYTLEGMIDSYRKL 472
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
 296-456 8.35e-06

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 48.49  E-value: 8.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586  296 AEAIPTAGSTIlwasRISPQKRPDLLYEIAlalpeylfevhgevdpacrgetQRKLRRLPNVRL----HGR-YDSFQALA 370
Cdd:PRK15179 514 SDARFTVGTVM----RVDDNKRPFLWVEAA----------------------QRFAASHPKVRFimvgGGPlLESVREFA 567

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586  371 RQGRYA-MLLYT-------------------SRYDGLPNILLEATAAGLPIVAPDVGGIAE-FLNTETGYLVGADA---- 425
Cdd:PRK15179 568 QRLGMGeRILFTglsrrvgywltqfnaflllSRFEGLPNVLIEAQFSGVPVVTTLAGGAGEaVQEGVTGLTLPADTvtap 647

                        170       180       190
                 ....*....|....*....|....*....|..
gi 15596586  426 DAGE-FARAIRSALGNPGETARRVKRARELLT 456
Cdd:PRK15179 648 DVAEaLARIHDMCAADPGIARKAADWASARFS 679
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 346-466 1.06e-05

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 47.72  E-value: 1.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 346 ETQRKLRRLPNVRLHGR-----YDSFQALARqgryaMLLYT-----SRYDGLPNILLEATAAGLPIVAPDVGGIAEF-LN 414
Cdd:cd03794 263 KELAKARGLDNVTFLGRvpkeeVPELLSAAD-----VGLVPlkdnpANRGSSPSKLFEYMAAGKPILASDDGGSDLAvEI 337

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15596586 415 TETGYLVGADaDAGEFARAIRSALGNPGETARRVKRARELLTRRHGWAAFRD 466
Cdd:cd03794 338 NGCGLVVEPG-DPEALADAILELLDDPELRRAMGENGRELAEEKFSREKLAD 388
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 307-475 2.73e-05

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 46.13  E-value: 2.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 307 LWASRISPQKRPDLLYEIALALPEYLFeVHGEVDPACRGETQRKLRRLPNVRLHGRYDSFQALARQGRYAMLLYTSRYD- 385
Cdd:cd03802 173 AFLGRIAPEKGLEDAIRVARRAGLPLK-IAGKVRDEDYFYYLQEPLPGPRIEFIGEVGHDEKQELLGGARALLFPINWDe 251

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 386 --GLpnILLEATAAGLPIVAPDVGGIAEFLN-TETGYLVGadaDAGEFARAIRSalgnpgetARRVKRARellTRRHGWA 462
Cdd:cd03802 252 pfGL--VMIEAMACGTPVIAYRRGGLPEVIQhGETGFLVD---SVEEMAEAIAN--------IDRIDRAA---CRRYAED 315

                       170
                ....*....|...
gi 15596586 463 AFrDAARNIPGYL 475
Cdd:cd03802 316 RF-SAARMADRYE 327
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 303-470 2.86e-05

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 46.63  E-value: 2.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586  303 GSTILWASRISPQKRPDLLYEIALALPEYLFEVHGevDPACRGETQRKLRRLPNV---RLHGRYDSfQALARQGRYAMll 379
Cdd:PLN02871 263 KPLIVYVGRLGAEKNLDFLKRVMERLPGARLAFVG--DGPYREELEKMFAGTPTVftgMLQGDELS-QAYASGDVFVM-- 337

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586  380 yTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLN----TETGYLVgADADAGEFARAIRSALGNPGETARRVKRARElL 455
Cdd:PLN02871 338 -PSESETLGFVVLEAMASGVPVVAARAGGIPDIIPpdqeGKTGFLY-TPGDVDDCVEKLETLLADPELRERMGAAARE-E 414

                        170
                 ....*....|....*
gi 15596586  456 TRRHGWAAFRDAARN 470
Cdd:PLN02871 415 VEKWDWRAATRKLRN 429
GT4_TuaH-like cd04950
teichuronic acid biosynthesis glycosyltransferase TuaH and similar proteins; Members of this ...
 319-461 7.60e-05

teichuronic acid biosynthesis glycosyltransferase TuaH and similar proteins; Members of this family may function in teichuronic acid biosynthesis/cell wall biogenesis. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340856 [Multi-domain]  Cd Length: 373  Bit Score: 45.05  E-value: 7.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 319 DLLYEIALALPEYLFEVHGEV---DPACrgetqrkLRRLPNVRLHGrydsfqalarQGRYAML-LYTSRYDG--LPNILL 392
Cdd:cd04950 221 DLIEELAKARPQWNFVFIGPVvkiDPSS-------LPRAPNIHWLG----------PKPYKELpAYLAGFDValLPFALN 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 393 EAT------------AAGLPIVAPdvgGIAEFLNTEtGYLVGADADAGEFARAIRSALGNPGeTARRVKRARELLtRRHG 460
Cdd:cd04950 284 EYTrfisplklfeylAAGKPVVAT---SIPSVVRFY-GEAVLCGDDPDEFSAAIEKALALKG-DARDKRLARALA-RQES 357


                .
gi 15596586 461 W 461
Cdd:cd04950 358 W 358
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 306-453 8.44e-05

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 44.58  E-value: 8.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 306 ILWASRISPQKRPDLL---YEIALALPEYLFEVHGEvdpacrGETQRKLRRLP-------NVRLHGRYDSFQALARqgrY 375
Cdd:cd03817 204 LLYVGRLAKEKNIDFLlraFAELKKEPNIKLVIVGD------GPEREELKELArelgladKVIFTGFVPREELPEY---Y 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 376 AM---LLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAE-FLNTETGYLVgaDADAGEFARAIRSALGNPGETARRVKRA 451
Cdd:cd03817 275 KAadlFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASElVEDGENGFLF--EPNDETLAEKLLHLRENLELLRKLSKNA 352


                ..
gi 15596586 452 RE 453
Cdd:cd03817 353 EI 354
GlgA COG0297
Glycogen synthase [Carbohydrate transport and metabolism];
310-461 1.37e-04

Glycogen synthase [Carbohydrate transport and metabolism];


Pssm-ID: 440066 [Multi-domain]  Cd Length: 476  Bit Score: 44.31  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 310 SRISPQKRPDLLYEialALPEYLFE-----VHGEVDPacrgETQRKLRRL-----PNVRLHGRYDsfQALARQGrYA--- 376
Cdd:COG0297 302 SRLTEQKGLDLLLE---ALDELLEEdvqlvVLGSGDP----EYEEAFRELaarypGRVAVYIGYD--EALAHRI-YAgad 371

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 377 MLLYTSRYD--GLpNILLeATAAG-LPIVApDVGGIA-------EFLNTETGYLVgADADAGEFARAIRSALG---NPGE 443
Cdd:COG0297 372 FFLMPSRFEpcGL-NQMY-ALRYGtVPIVR-RTGGLAdtvidynEATGEGTGFVF-DEYTAEALLAAIRRALAlyrDPEA 447

                       170
                ....*....|....*...
gi 15596586 444 TARRVKRArelLTRRHGW 461
Cdd:COG0297 448 WRKLQRNA---MKQDFSW 462
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
382-437 1.37e-04

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 44.31  E-value: 1.37e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15596586  382 SRYDGLPNILLEATAAGLPIVAPDVGGIAE-FLNTETGYLVGaDADAGEFARAIRSA 437
Cdd:PRK15490 480 SRYEGLPNVLIEAQMVGVPVISTPAGGSAEcFIEGVSGFILD-DAQTVNLDQACRYA 535
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
 310-462 1.49e-04

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 44.09  E-value: 1.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 310 SRISPQKRPDLLYEialALPEYLFE-----VHGEVDPACRGETQRKLRRLP-NVRLHGRYDsfQALARQgRYA---MLLY 380
Cdd:cd03791 301 GRLTEQKGVDLILD---ALPELLEEggqlvVLGSGDPEYEQAFRELAERYPgKVAVVIGFD--EALAHR-IYAgadFFLM 374

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 381 TSRYD--GLpnILLEATAAG-LPIVAPdVGGIA-------EFLNTETGYLVGaDADAGEFARAIRSAL---GNPGETARR 447
Cdd:cd03791 375 PSRFEpcGL--VQMYAMRYGtLPIVRR-TGGLAdtvfdydPETGEGTGFVFE-DYDAEALLAALRRALalyRNPELWRKL 450

                       170
                ....*....|....*
gi 15596586 448 VKRArelLTRRHGWA 462
Cdd:cd03791 451 QKNA---MKQDFSWD 462
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 391-475 3.46e-04

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 42.72  E-value: 3.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 391 LLEATAAGLPIVAPDVGGIAEFL-NTETGYLVGADaDAGEFARAIRSALGNPGETARRVKRARElltrrhgWAAFR-DAA 468
Cdd:cd04962 286 ALEAMACGVPVVSSNAGGIPEVVkHGETGFLSDVG-DVDAMAKSALSILEDDELYNRMGRAARK-------RAAERfDPE 357


                ....*..
gi 15596586 469 RNIPGYL 475
Cdd:cd04962 358 RIVPQYE 364
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
272-405 5.29e-04

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 42.39  E-value: 5.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586  272 QQIHERdGIPPELMHGLYFPASDHAEAIP----TAGSTILWASRI--SPQKR-PDLLYEIALALPEYLFEVHG--EVDPA 342
Cdd:PRK09922 146 EQMMAR-GISAQRISVIYNPVEIKTIIIPpperDKPAVFLYVGRLkfEGQKNvKELFDGLSQTTGEWQLHIIGdgSDFEK 224

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596586  343 CRgETQRKLRRLPNVRLHGRYDSFQALARQGRY--AMLLYTSRYDGLPNILLEATAAGLPIVAPD 405
Cdd:PRK09922 225 CK-AYSRELGIEQRIIWHGWQSQPWEVVQQKIKnvSALLLTSKFEGFPMTLLEAMSYGIPCISSD 288
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 377-446 5.51e-04

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 42.19  E-value: 5.51e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596586 377 MLLYTSRYD--GL-PnilLEATAAGLPIVAPDVGGIAE-FLNTETGYLVgaDADAGEFARAIRSALGNPGETAR 446
Cdd:cd03805 302 ALLYTPSNEhfGIvP---LEAMYAGKPVIACNSGGPLEtVVEGVTGFLC--EPTPEAFAEAMLKLANDPDLADR 370
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 391-475 5.92e-04

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 41.96  E-value: 5.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 391 LLEATAAGLPIVAPDVGGIAEFL-NTETGYLVGADaDAGEFARAIRSALGNPGEtARRVKRArellTRRHGWAAFrDAAR 469
Cdd:cd03818 317 LLEAMACGCPVIGSDTAPVREVIrDGRNGLLVDFF-DPDALAAAVLELLEDPDR-AAALRRA----ARRTVERSD-SLDV 389


                ....*.
gi 15596586 470 NIPGYL 475
Cdd:cd03818 390 CLARYL 395
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 379-458 1.98e-03

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 40.38  E-value: 1.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 379 LYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFL-NTETGYLV-GADADAGEFARAIRsalgNPGETARRVKRARELLT 456
Cdd:cd03792 284 LQLSTREGFGLTVSEALWKGKPVIATPAGGIPLQViDGETGFLVnSVEGAAVRILRLLT----DPELRRKMGLAAREHVR 359


                ..
gi 15596586 457 RR 458
Cdd:cd03792 360 DN 361
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 391-457 2.09e-03

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 40.34  E-value: 2.09e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596586 391 LLEATAAGLPIVAPDVGGIAEF--LNTETGyLVGADADAGEFARAIRSALGNP------GETARrvKRARELLTR 457
Cdd:cd03795 280 LLEAMMCGKPVISTNIGTGVPYvnNNGETG-LVVPPKDPDALAEAIDKLLSDEelresyGENAK--KRFEELFTA 351
COG4641 COG4641
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
330-462 3.48e-03

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 39.53  E-value: 3.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586 330 EYLFEVHGEVDPACRGETQRKLRRLPNVRLHGR--YDSFQALARQGRYAM-LLYTSRYDGLPNI-LLEATAAGLPIVAPD 405
Cdd:COG4641 155 EELLLAPAGLRLKIYGPGWPKLALPANVRRGGHlpGEEHPAAYASSKITLnVNRMAASPDSPTRrTFEAAACGAFLLSDP 234

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15596586 406 VGGIAEFLNTETGYLVGADADagEFARAIRSALGNPGETARRVKRARELLTRRHGWA 462
Cdd:COG4641 235 WEGLEELFEPGEEVLVFRDGE--ELAEKLRYLLADPEERRAIAEAGRRRVLAEHTYA 289
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 377-466 4.10e-03

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 39.53  E-value: 4.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596586  377 MLLYTSRYDGLPNILLEATAAGLPIVAPDVGGIAEFLNTET---------GYLVG-ADADAgeFARAIRSALGNPG--ET 444
Cdd:NF038011 386 LMVLSSISEALPLVVLEAFAAGVPVVTTDVGSCRQLIEGLDeedralgaaGEVVAiADPQA--LARAALDLLRDPQrwQA 463

                         90       100
                 ....*....|....*....|....
gi 15596586  445 ARR--VKRARELLTRRHGWAAFRD 466
Cdd:NF038011 464 AQAagLARVERYYTEELMFDRYRE 487
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 385-427 7.19e-03

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 38.59  E-value: 7.19e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15596586 385 DGLPNILLEATAAGLPIVAPDVGGIAEFL-NTETGYLVGA-DADA 427
Cdd:cd03799 267 DGPPNTLKEAMAMGLPVISTEHGGIPELVeDGVSGFLVPErDAEA 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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