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Conserved domains on  [gi|15596460|ref|NP_249954|]
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hypothetical protein PA1263 [Pseudomonas aeruginosa PAO1]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 16009404)

helix-turn-helix (HTH) transcriptional regulator containing a XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator; also contains a MmyB-like transcription regulator ligand binding domain

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  2644244|8831795|15808743
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MLTR_LBD pfam17765
MmyB-like transcription regulator ligand binding domain; This domain is found in a family of ...
 149-314 2.43e-35

MmyB-like transcription regulator ligand binding domain; This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.


:

Pssm-ID: 465492  Cd Length: 168  Bit Score: 125.76  E-value: 2.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596460   149 SAATQAILDALDPLPAMVQNARFDIRGYNRAYCRLVGiDLAEIPEEDRNCIYLALTHERWRYCMANREEALPRMVGFFRA 228
Cdd:pfam17765   2 RPALRRLLDALEPTPAFVLDRRWDVLAWNRLARALFG-DFAALPPPERNLLRLLFLDPGARELYVDWEEVARDLVARLRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596460   229 AMVERMGDPLWERQLQRCLEASAEFREIWRRNEVMGIENQLKRFRHARCGEFELQQTNWWSAPKNGDRLLVFV--PLDDH 306
Cdd:pfam17765  81 AAGRHPDDPRLAALVGELSARSPEFRRLWARHDVRARTSGTKRFRHPVVGELTLDYETLGLPDDPGLELVVYTaePGDPS 160


                  ....*...
gi 15596460   307 ARDCLEQL 314
Cdd:pfam17765 161 AAAALRLL 168
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 49-128 1.43e-09

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


:

Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 53.30  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596460    49 QLGAFLRRRRESiepqrvgisrlgrrrtPGLRREEVAQLAGVGVTWYTWLEQGRAVRASEQVIGAIARALLCNETETHHL 128
Cdd:pfam13560   1 ELGARLRRLRER----------------AGLSQEALARRLGVSRSTLSRLETGRRGRPSPAVVERLARALGVDGAERAEL 64
 
Name Accession Description Interval E-value
MLTR_LBD pfam17765
MmyB-like transcription regulator ligand binding domain; This domain is found in a family of ...
 149-314 2.43e-35

MmyB-like transcription regulator ligand binding domain; This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.


Pssm-ID: 465492  Cd Length: 168  Bit Score: 125.76  E-value: 2.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596460   149 SAATQAILDALDPLPAMVQNARFDIRGYNRAYCRLVGiDLAEIPEEDRNCIYLALTHERWRYCMANREEALPRMVGFFRA 228
Cdd:pfam17765   2 RPALRRLLDALEPTPAFVLDRRWDVLAWNRLARALFG-DFAALPPPERNLLRLLFLDPGARELYVDWEEVARDLVARLRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596460   229 AMVERMGDPLWERQLQRCLEASAEFREIWRRNEVMGIENQLKRFRHARCGEFELQQTNWWSAPKNGDRLLVFV--PLDDH 306
Cdd:pfam17765  81 AAGRHPDDPRLAALVGELSARSPEFRRLWARHDVRARTSGTKRFRHPVVGELTLDYETLGLPDDPGLELVVYTaePGDPS 160


                  ....*...
gi 15596460   307 ARDCLEQL 314
Cdd:pfam17765 161 AAAALRLL 168
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 49-128 1.43e-09

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 53.30  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596460    49 QLGAFLRRRRESiepqrvgisrlgrrrtPGLRREEVAQLAGVGVTWYTWLEQGRAVRASEQVIGAIARALLCNETETHHL 128
Cdd:pfam13560   1 ELGARLRRLRER----------------AGLSQEALARRLGVSRSTLSRLETGRRGRPSPAVVERLARALGVDGAERAEL 64
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
73-118 2.94e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 41.91  E-value: 2.94e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15596460  73 RRRTPGLRREEVAQLAGVGVTWYTWLEQGRAvRASEQVIGAIARAL 118
Cdd:COG1396  15 LRKARGLTQEELAERLGVSRSTISRIERGRR-NPSLETLLKLAKAL 59
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
73-124 1.37e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 39.04  E-value: 1.37e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 15596460     73 RRRTPGLRREEVAQLAGVGVTWYTWLEQGRAvRASEQVIGAIARALLCNETE 124
Cdd:smart00530   5 LREEKGLTQEELAEKLGVSRSTLSRIENGKR-KPSLETLKKLAKALGVSLDE 55
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 73-124 1.94e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.99  E-value: 1.94e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 15596460  73 RRRTPGLRREEVAQLAGVGVTWYTWLEQGRAvRASEQVIGAIARALLCNETE 124
Cdd:cd00093   7 LRKEKGLTQEELAEKLGVSRSTISRIENGKR-NPSLETLEKLAKALGVSLDE 57
 
Name Accession Description Interval E-value
MLTR_LBD pfam17765
MmyB-like transcription regulator ligand binding domain; This domain is found in a family of ...
 149-314 2.43e-35

MmyB-like transcription regulator ligand binding domain; This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.


Pssm-ID: 465492  Cd Length: 168  Bit Score: 125.76  E-value: 2.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596460   149 SAATQAILDALDPLPAMVQNARFDIRGYNRAYCRLVGiDLAEIPEEDRNCIYLALTHERWRYCMANREEALPRMVGFFRA 228
Cdd:pfam17765   2 RPALRRLLDALEPTPAFVLDRRWDVLAWNRLARALFG-DFAALPPPERNLLRLLFLDPGARELYVDWEEVARDLVARLRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596460   229 AMVERMGDPLWERQLQRCLEASAEFREIWRRNEVMGIENQLKRFRHARCGEFELQQTNWWSAPKNGDRLLVFV--PLDDH 306
Cdd:pfam17765  81 AAGRHPDDPRLAALVGELSARSPEFRRLWARHDVRARTSGTKRFRHPVVGELTLDYETLGLPDDPGLELVVYTaePGDPS 160


                  ....*...
gi 15596460   307 ARDCLEQL 314
Cdd:pfam17765 161 AAAALRLL 168
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 49-128 1.43e-09

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 53.30  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596460    49 QLGAFLRRRRESiepqrvgisrlgrrrtPGLRREEVAQLAGVGVTWYTWLEQGRAVRASEQVIGAIARALLCNETETHHL 128
Cdd:pfam13560   1 ELGARLRRLRER----------------AGLSQEALARRLGVSRSTLSRLETGRRGRPSPAVVERLARALGVDGAERAEL 64
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
73-118 2.94e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 41.91  E-value: 2.94e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15596460  73 RRRTPGLRREEVAQLAGVGVTWYTWLEQGRAvRASEQVIGAIARAL 118
Cdd:COG1396  15 LRKARGLTQEELAERLGVSRSTISRIERGRR-NPSLETLLKLAKAL 59
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
73-124 1.37e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 39.04  E-value: 1.37e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 15596460     73 RRRTPGLRREEVAQLAGVGVTWYTWLEQGRAvRASEQVIGAIARALLCNETE 124
Cdd:smart00530   5 LREEKGLTQEELAEKLGVSRSTLSRIENGKR-KPSLETLKKLAKALGVSLDE 55
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 73-124 1.94e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.99  E-value: 1.94e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 15596460  73 RRRTPGLRREEVAQLAGVGVTWYTWLEQGRAvRASEQVIGAIARALLCNETE 124
Cdd:cd00093   7 LRKEKGLTQEELAEKLGVSRSTISRIENGKR-NPSLETLEKLAKALGVSLDE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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