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Conserved domains on  [gi|15595926|ref|NP_249420|]
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hypothetical protein PA0729 [Pseudomonas aeruginosa PAO1]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10007814)

type II toxin-antitoxin (TA) system RelE/ParE family toxin is the RelE/ParE-like toxin component of a type II toxin-antitoxin system, its activity is attenuated by interaction with its cognate antitoxin

Gene Ontology:  GO:0110001|GO:0090729
PubMed:  20143871|20487277|28279904|15718296

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
6-105 9.16e-11

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


:

Pssm-ID: 442885  Cd Length: 96  Bit Score: 54.13  E-value: 9.16e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595926   6 IRFTDTAEQSIEDQVHHLAPFQGEQAALQsvlsLLDEIEEKI-SLA--PKGYPVSQQaslLGVLSYRELNTGPYRVFYEF 82
Cdd:COG3668   3 VRWTPEAEADLEEIYDYIAEDWGPEAAER----YLDEIEEAIeLLAefPELGRPRPE---LRVPGLRELVVGPYVIFYRV 75

                        90       100
                ....*....|....*....|...
gi 15595926  83 HEEqgEVAVILVLRQKQSVEQQL 105
Cdd:COG3668  76 DDD--TVEILRVLHGRRDLPALL 96
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
6-105 9.16e-11

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 54.13  E-value: 9.16e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595926   6 IRFTDTAEQSIEDQVHHLAPFQGEQAALQsvlsLLDEIEEKI-SLA--PKGYPVSQQaslLGVLSYRELNTGPYRVFYEF 82
Cdd:COG3668   3 VRWTPEAEADLEEIYDYIAEDWGPEAAER----YLDEIEEAIeLLAefPELGRPRPE---LRVPGLRELVVGPYVIFYRV 75

                        90       100
                ....*....|....*....|...
gi 15595926  83 HEEqgEVAVILVLRQKQSVEQQL 105
Cdd:COG3668  76 DDD--TVEILRVLHGRRDLPALL 96
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 6-99 1.59e-10

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595926     6 IRFTDTAEQSIEDQVHHLAPFQGEQAAlqsvlSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFYEFHEE 85
Cdd:pfam05016   1 VILTPKALKDLKKIADYIAQDNPDAAE-----RFLKALEEALELLAENPALGRPLPEGGLKGLRRIRIGDYRIIYRIDDD 75

                          90
                  ....*....|....
gi 15595926    86 QGEVAVILVLRQKQ 99
Cdd:pfam05016  76 DLVILILRVGHRRR 89
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
6-105 9.16e-11

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 54.13  E-value: 9.16e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595926   6 IRFTDTAEQSIEDQVHHLAPFQGEQAALQsvlsLLDEIEEKI-SLA--PKGYPVSQQaslLGVLSYRELNTGPYRVFYEF 82
Cdd:COG3668   3 VRWTPEAEADLEEIYDYIAEDWGPEAAER----YLDEIEEAIeLLAefPELGRPRPE---LRVPGLRELVVGPYVIFYRV 75

                        90       100
                ....*....|....*....|...
gi 15595926  83 HEEqgEVAVILVLRQKQSVEQQL 105
Cdd:COG3668  76 DDD--TVEILRVLHGRRDLPALL 96
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 6-99 1.59e-10

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595926     6 IRFTDTAEQSIEDQVHHLAPFQGEQAAlqsvlSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFYEFHEE 85
Cdd:pfam05016   1 VILTPKALKDLKKIADYIAQDNPDAAE-----RFLKALEEALELLAENPALGRPLPEGGLKGLRRIRIGDYRIIYRIDDD 75

                          90
                  ....*....|....
gi 15595926    86 QGEVAVILVLRQKQ 99
Cdd:pfam05016  76 DLVILILRVGHRRR 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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