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Conserved domains on  [gi|15595603|ref|NP_249097|]
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transporter TonB [Pseudomonas aeruginosa PAO1]

Protein Classification

energy transducer TonB( domain architecture ID 11435256)

energy transducer TonB interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.)

PubMed:  8188372

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TonB_C pfam03544
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
233-311 9.10e-17

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


:

Pssm-ID: 427361 [Multi-domain]  Cd Length: 79  Bit Score: 73.86  E-value: 9.10e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15595603   233 NLNYPDEARRQKLYGSLRLLVSINRDGTIYEVQVLESSGEPILDQAAQRIVRLaAPYAPFSGDLADIDRlEIIRTWRFE 311
Cdd:pfam03544   2 EPVYPEEARRRGIEGTVVVEFLIDPDGNVTNVRVVKSSGYSILDEAALEAVKK-WRFKPAPKNGQPVTV-EITVPIRFK 78
PRK11901 super family cl36081
hypothetical protein; Reviewed
92-220 3.27e-03

hypothetical protein; Reviewed


The actual alignment was detected with superfamily member PRK11901:

Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 38.90  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595603   92 DYLAQMNQQGSGTLEHKAA--PKTTEVAPFQDNQVKKVAPPATPKQARSEEAPKVAVTTTRQRQQKAPSKTQAQKAEQVA 169
Cdd:PRK11901 161 NAASQNAQGNTSTLPTAPAtvAPSKGAKVPATAETHPTPPQKPATKKPAVNHHKTATVAVPPATSGKPKSGAASARALSS 240
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15595603  170 KPAPHFdSTQLSAeiASLEADLakeqQAYAKRpriHRLSAA---STMRDKGAWY 220
Cdd:PRK11901 241 APASHY-TLQLSS--ASRSDTL----NAYAKK---QNLSHYhvyETKRDGKPWY 284
 
Name Accession Description Interval E-value
TonB_C pfam03544
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
233-311 9.10e-17

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


Pssm-ID: 427361 [Multi-domain]  Cd Length: 79  Bit Score: 73.86  E-value: 9.10e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15595603   233 NLNYPDEARRQKLYGSLRLLVSINRDGTIYEVQVLESSGEPILDQAAQRIVRLaAPYAPFSGDLADIDRlEIIRTWRFE 311
Cdd:pfam03544   2 EPVYPEEARRRGIEGTVVVEFLIDPDGNVTNVRVVKSSGYSILDEAALEAVKK-WRFKPAPKNGQPVTV-EITVPIRFK 78
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
237-291 1.90e-14

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 67.22  E-value: 1.90e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15595603 237 PDEARRQKLYGSLRLLVSINRDGTIYEVQVLESSGEPILDQAAQRIVRLAAPYAP 291
Cdd:COG0810   1 PEEARRRGIEGTVTVRFTIDADGRVTDVEVVKSSGHPLLDEAALRAVRRWRFKPA 55
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
238-313 6.26e-11

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 57.70  E-value: 6.26e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15595603   238 DEARRQKLYGSLRLLVSINRDGTIYEVQVLESSGEPILDQAAQRIVRLAAPYAPFSGDlaDIDRLEIIRTWRFERG 313
Cdd:TIGR01352   1 ARARRRGIEGTVVVRFTVDPSGRVTSVSVLKSSGDRALDRAALEAVRKARFEPPPPPG--GVVAASVTIPVRFKLP 74
PRK11901 PRK11901
hypothetical protein; Reviewed
92-220 3.27e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 38.90  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595603   92 DYLAQMNQQGSGTLEHKAA--PKTTEVAPFQDNQVKKVAPPATPKQARSEEAPKVAVTTTRQRQQKAPSKTQAQKAEQVA 169
Cdd:PRK11901 161 NAASQNAQGNTSTLPTAPAtvAPSKGAKVPATAETHPTPPQKPATKKPAVNHHKTATVAVPPATSGKPKSGAASARALSS 240
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15595603  170 KPAPHFdSTQLSAeiASLEADLakeqQAYAKRpriHRLSAA---STMRDKGAWY 220
Cdd:PRK11901 241 APASHY-TLQLSS--ASRSDTL----NAYAKK---QNLSHYhvyETKRDGKPWY 284
 
Name Accession Description Interval E-value
TonB_C pfam03544
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
233-311 9.10e-17

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


Pssm-ID: 427361 [Multi-domain]  Cd Length: 79  Bit Score: 73.86  E-value: 9.10e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15595603   233 NLNYPDEARRQKLYGSLRLLVSINRDGTIYEVQVLESSGEPILDQAAQRIVRLaAPYAPFSGDLADIDRlEIIRTWRFE 311
Cdd:pfam03544   2 EPVYPEEARRRGIEGTVVVEFLIDPDGNVTNVRVVKSSGYSILDEAALEAVKK-WRFKPAPKNGQPVTV-EITVPIRFK 78
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
237-291 1.90e-14

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 67.22  E-value: 1.90e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15595603 237 PDEARRQKLYGSLRLLVSINRDGTIYEVQVLESSGEPILDQAAQRIVRLAAPYAP 291
Cdd:COG0810   1 PEEARRRGIEGTVTVRFTIDADGRVTDVEVVKSSGHPLLDEAALRAVRRWRFKPA 55
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
238-313 6.26e-11

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 57.70  E-value: 6.26e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15595603   238 DEARRQKLYGSLRLLVSINRDGTIYEVQVLESSGEPILDQAAQRIVRLAAPYAPFSGDlaDIDRLEIIRTWRFERG 313
Cdd:TIGR01352   1 ARARRRGIEGTVVVRFTVDPSGRVTSVSVLKSSGDRALDRAALEAVRKARFEPPPPPG--GVVAASVTIPVRFKLP 74
PRK11901 PRK11901
hypothetical protein; Reviewed
92-220 3.27e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 38.90  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595603   92 DYLAQMNQQGSGTLEHKAA--PKTTEVAPFQDNQVKKVAPPATPKQARSEEAPKVAVTTTRQRQQKAPSKTQAQKAEQVA 169
Cdd:PRK11901 161 NAASQNAQGNTSTLPTAPAtvAPSKGAKVPATAETHPTPPQKPATKKPAVNHHKTATVAVPPATSGKPKSGAASARALSS 240
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15595603  170 KPAPHFdSTQLSAeiASLEADLakeqQAYAKRpriHRLSAA---STMRDKGAWY 220
Cdd:PRK11901 241 APASHY-TLQLSS--ASRSDTL----NAYAKK---QNLSHYhvyETKRDGKPWY 284
TonB_2 pfam13103
TonB C terminal; This family contains TonB members that are not captured by pfam03544.
246-295 3.92e-03

TonB C terminal; This family contains TonB members that are not captured by pfam03544.


Pssm-ID: 463788 [Multi-domain]  Cd Length: 85  Bit Score: 35.77  E-value: 3.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15595603   246 YGSLRLLVSI--NRDGTIYEVQVLESSGEPILDQAAQRIVRLAAPYAPFSGD 295
Cdd:pfam13103  23 SGNLEAVVEItiDPDGTIVSVRLVKSSGNEAFDKAVLRALEKSSPLPPPPEY 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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