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Conserved domains on  [gi|15595555|ref|NP_249049|]
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hypothetical protein PA0358 [Pseudomonas aeruginosa PAO1]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10168429)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 16-178 5.84e-81

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


:

Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 237.50  E-value: 5.84e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  16 GHAMLKLSGWKIEGQLPALDKFVVIGAHHTSNWDFVAFLAAKFVLRLNARWFGKHTLFNGPLGGLMRRWGGIPIQRHLKL 95
Cdd:cd07988   1 ARLLLRLSGWRIEGEPPNKPKFVVIGAPHTSNWDFVLGLLAAFALGLKISFLGKHSLFKPPLGPFMRWLGGIPVDRSRAG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  96 NTVDQAIQAFREHREFMLIIAPEGTRKKVDRWRMGFYHIARGAGVPVVPAALDYENRRIVIGEPFWPTGNEDADLCSLIG 175
Cdd:cd07988  81 GLVEQVVEEFRRREEFVLAIAPEGTRSKVDKWKTGFYHIARGAGVPILLVYLDYKRKTVGIGPLFEPSGDIEADLAAIRA 160


                ...
gi 15595555 176 FYR 178
Cdd:cd07988 161 FYR 163
 
Name Accession Description Interval E-value
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 16-178 5.84e-81

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 237.50  E-value: 5.84e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  16 GHAMLKLSGWKIEGQLPALDKFVVIGAHHTSNWDFVAFLAAKFVLRLNARWFGKHTLFNGPLGGLMRRWGGIPIQRHLKL 95
Cdd:cd07988   1 ARLLLRLSGWRIEGEPPNKPKFVVIGAPHTSNWDFVLGLLAAFALGLKISFLGKHSLFKPPLGPFMRWLGGIPVDRSRAG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  96 NTVDQAIQAFREHREFMLIIAPEGTRKKVDRWRMGFYHIARGAGVPVVPAALDYENRRIVIGEPFWPTGNEDADLCSLIG 175
Cdd:cd07988  81 GLVEQVVEEFRRREEFVLAIAPEGTRSKVDKWKTGFYHIARGAGVPILLVYLDYKRKTVGIGPLFEPSGDIEADLAAIRA 160


                ...
gi 15595555 176 FYR 178
Cdd:cd07988 161 FYR 163
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 8-170 1.40e-33

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 118.57  E-value: 1.40e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555   8 RNTLVESLGHAMLKLSGWKIE----GQLPAlDKFVVIGAHHTSNWDFVAFLAAkfvLRLNARWFGKHTLFNGP-LGGLMR 82
Cdd:COG0204  12 RYRLVRLWARLLLRLLGVRVRveglENLPA-DGPVLIVANHQSWLDILLLLAA---LPRPVRFVAKKELFKIPlLGWLLR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  83 RWGGIPIQR---HLKLNTVDQAIQAFREHRefMLIIAPEGTRK---KVDRWRMGFYHIARGAGVPVVPAALDYENR---- 152
Cdd:COG0204  88 ALGAIPVDRskrRAALRALRQAVEALKAGE--SLVIFPEGTRSpdgRLLPFKTGAARLALEAGVPIVPVAIDGTERalpk 165

                       170       180
                ....*....|....*....|....*..
gi 15595555 153 ---------RIVIGEPFWPTGNEDADL 170
Cdd:COG0204 166 gflprpgkvTVRIGPPIDPSDLEGEDR 192
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 38-149 1.16e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 80.09  E-value: 1.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555     38 VVIGAHHTSNWDFVAFLAAKFVLRLNARWFGKHTLFNGPL-GGLMRRWGGIPIQRHLKlntvDQAIQAFREHREFM---- 112
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLlGWLLRLLGAIFIDRSNG----RKARAALREAVELLkege 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 15595555    113 -LIIAPEGTR---KKVDRWRMGFYHIARGAGVPVVPAALDY 149
Cdd:smart00563  77 wLLIFPEGTRsrpGKLLPFKKGAARLALEAGVPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 31-147 1.85e-13

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 64.22  E-value: 1.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555    31 LPALDKFVVIgAHHTSNWDFVaFLAAKFVLRLNARWF-GKHTLFNGPL-GGLMRRWGGIPIQRHLKL---NTVDQAIQAF 105
Cdd:pfam01553  10 LPRGGPAIVV-ANHQSYLDVL-LLSLALYKRGRPLVFvAKKELFDIPLvGWLMRLLGCIFIDRKNRKdaaGTLEYLVELL 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 15595555   106 REHRefMLIIAPEGTRKKVDRWRM---GFYHIARGAGVPVVPAAL 147
Cdd:pfam01553  88 REGK--LVVIFPEGTRSREGELLPfkkGAFRLAIEAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 35-147 1.83e-07

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 48.11  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555    35 DKFVVIGAHHTSNWDFVAFLAAkfvLRLNARWFGKHTLFNGP-LGGLMRRWGGIPIQRHLKL---NTVDQAIQAFREHRe 110
Cdd:TIGR00530  15 KSPVLVVANHQSNLDPLTLSAA---FPPPIVFIAKKELKWIPfFGIMLWLTGAIFIDRENIRaiaTALKAAIEVLKQGR- 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 15595555   111 fMLIIAPEGTRKKVDR---WRMGFYHIARGAGVPVVPAAL 147
Cdd:TIGR00530  91 -SIGVFPEGTRSRGRDilpFKKGAFHIAIKAGVPILPVVL 129
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 5-154 2.02e-03

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 37.69  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555    5 YLPRN-TLVESLGHAMLKLS---GWKIEGQLPALDKF---VVIGAHHTSNWDFVAflaAKFVLRLNARWFGKHTLFNGPL 77
Cdd:PRK15018  27 FSPRNpKHVATFGHMFGRLAplfGLKVECRKPADAESygnAIYIANHQNNYDMVT---ASNIVQPPTVTVGKKSLLWIPF 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555   78 -GGLMRRWGGIPIQRHLKL---NTVDQAIQAFREhREFMLIIAPEGTRKK---VDRWRMGFYHIARGAGVPVVPAALDYE 150
Cdd:PRK15018 104 fGQLYWLTGNLLIDRNNRTkahGTIAEVVNHFKK-RRISIWMFPEGTRSRgrgLLPFKTGAFHAAIAAGVPIIPVCVSTT 182


                 ....
gi 15595555  151 NRRI 154
Cdd:PRK15018 183 SNKI 186
 
Name Accession Description Interval E-value
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 16-178 5.84e-81

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 237.50  E-value: 5.84e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  16 GHAMLKLSGWKIEGQLPALDKFVVIGAHHTSNWDFVAFLAAKFVLRLNARWFGKHTLFNGPLGGLMRRWGGIPIQRHLKL 95
Cdd:cd07988   1 ARLLLRLSGWRIEGEPPNKPKFVVIGAPHTSNWDFVLGLLAAFALGLKISFLGKHSLFKPPLGPFMRWLGGIPVDRSRAG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  96 NTVDQAIQAFREHREFMLIIAPEGTRKKVDRWRMGFYHIARGAGVPVVPAALDYENRRIVIGEPFWPTGNEDADLCSLIG 175
Cdd:cd07988  81 GLVEQVVEEFRRREEFVLAIAPEGTRSKVDKWKTGFYHIARGAGVPILLVYLDYKRKTVGIGPLFEPSGDIEADLAAIRA 160


                ...
gi 15595555 176 FYR 178
Cdd:cd07988 161 FYR 163
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 8-170 1.40e-33

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 118.57  E-value: 1.40e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555   8 RNTLVESLGHAMLKLSGWKIE----GQLPAlDKFVVIGAHHTSNWDFVAFLAAkfvLRLNARWFGKHTLFNGP-LGGLMR 82
Cdd:COG0204  12 RYRLVRLWARLLLRLLGVRVRveglENLPA-DGPVLIVANHQSWLDILLLLAA---LPRPVRFVAKKELFKIPlLGWLLR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  83 RWGGIPIQR---HLKLNTVDQAIQAFREHRefMLIIAPEGTRK---KVDRWRMGFYHIARGAGVPVVPAALDYENR---- 152
Cdd:COG0204  88 ALGAIPVDRskrRAALRALRQAVEALKAGE--SLVIFPEGTRSpdgRLLPFKTGAARLALEAGVPIVPVAIDGTERalpk 165

                       170       180
                ....*....|....*....|....*..
gi 15595555 153 ---------RIVIGEPFWPTGNEDADL 170
Cdd:COG0204 166 gflprpgkvTVRIGPPIDPSDLEGEDR 192
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 38-149 1.16e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 80.09  E-value: 1.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555     38 VVIGAHHTSNWDFVAFLAAKFVLRLNARWFGKHTLFNGPL-GGLMRRWGGIPIQRHLKlntvDQAIQAFREHREFM---- 112
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLlGWLLRLLGAIFIDRSNG----RKARAALREAVELLkege 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 15595555    113 -LIIAPEGTR---KKVDRWRMGFYHIARGAGVPVVPAALDY 149
Cdd:smart00563  77 wLLIFPEGTRsrpGKLLPFKKGAARLALEAGVPIVPVAIRG 117
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 17-169 2.55e-19

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 80.78  E-value: 2.55e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  17 HAMLKLSGWK--IEGQLPALDK--FVVIgAHHTSNWDFVAFLAAkfvLRLNARWFGKHTLFNGPLGG-LMRRWGGIPIQR 91
Cdd:cd07989   2 RLLLRLLGVRvrVEGLENLPPKgpVIIV-ANHQSYLDPLVLGAA---LPRPIRFVAKKELFKIPFLGwLLRLLGAIPIDR 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  92 H---LKLNTVDQAIQAFREHRefMLIIAPEGTRKKVD---RWRMGFYHIARGAGVPVVPAALDYENR------------- 152
Cdd:cd07989  78 GngrSAREALREAIEALKEGE--SVVIFPEGTRSRDGellPFKSGAFRLAKEAGVPIVPVAISGTWGslpkgkklprpgr 155

                       170
                ....*....|....*...
gi 15595555 153 -RIVIGEPFWPTGNEDAD 169
Cdd:cd07989 156 vTVRIGEPIPPEGLELAE 173
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 31-147 1.85e-13

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 64.22  E-value: 1.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555    31 LPALDKFVVIgAHHTSNWDFVaFLAAKFVLRLNARWF-GKHTLFNGPL-GGLMRRWGGIPIQRHLKL---NTVDQAIQAF 105
Cdd:pfam01553  10 LPRGGPAIVV-ANHQSYLDVL-LLSLALYKRGRPLVFvAKKELFDIPLvGWLMRLLGCIFIDRKNRKdaaGTLEYLVELL 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 15595555   106 REHRefMLIIAPEGTRKKVDRWRM---GFYHIARGAGVPVVPAAL 147
Cdd:pfam01553  88 REGK--LVVIFPEGTRSREGELLPfkkGAFRLAIEAGVPIVPVAI 130
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 24-159 4.28e-11

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 58.96  E-value: 4.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  24 GWKIEG---QLPALDKFVVIGAHHTSNWDFVA-FLAAKFVLRLNARWFGKHtlFNGPLGGLMRRWGGIPIQRHLKLN--- 96
Cdd:cd06551  11 FVRLEVkgpPPPPGGGPVLFVSNHSSWWDGLIlFLLLERGLRRDVYGLMDE--ELLERYPFFTRLGAFSVDRDSPRSaak 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15595555  97 TVDQAIQAFREHREfMLIIAPEGTRKKVD----RWRMGFYHIARGAGVPVVPAALDYENR--------RIVIGEP 159
Cdd:cd06551  89 SLKYVARLLSKPGS-VVWIFPEGTRTRRDkrplQFKPGVAHLAEKAGVPIVPVALRYTFElfeqfpeiFVRIGPP 162
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 35-147 1.83e-07

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 48.11  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555    35 DKFVVIGAHHTSNWDFVAFLAAkfvLRLNARWFGKHTLFNGP-LGGLMRRWGGIPIQRHLKL---NTVDQAIQAFREHRe 110
Cdd:TIGR00530  15 KSPVLVVANHQSNLDPLTLSAA---FPPPIVFIAKKELKWIPfFGIMLWLTGAIFIDRENIRaiaTALKAAIEVLKQGR- 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 15595555   111 fMLIIAPEGTRKKVDR---WRMGFYHIARGAGVPVVPAAL 147
Cdd:TIGR00530  91 -SIGVFPEGTRSRGRDilpFKKGAFHIAIKAGVPILPVVL 129
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 26-163 2.96e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 39.90  E-value: 2.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555  26 KIEGQLPALDKFVVIGAHHTSNWDFVAFLAAKF---VLRlnarwfgKHTLFNGPLGGLMRRWGGIPIQRhLKLNTVDQAI 102
Cdd:cd07991  14 KVHGKPDPPEAPRIIVANHTSFIDPLILFSDLFpsiVAK-------KELGKLPFIGTILRALGCIFVDR-SEPKDRKKVV 85

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15595555 103 QAFREH----REFMLIIAPEGT---RKKVDRWRMGfyhiARGAGVPVVPAALDYENRRiviGEPFWPT 163
Cdd:cd07991  86 EEIKERatdpNWPPILIFPEGTttnGKALIMFKKG----AFEPGVPVQPVAIRYPNKF---VDAFWNS 146
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 5-154 2.02e-03

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 37.69  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555    5 YLPRN-TLVESLGHAMLKLS---GWKIEGQLPALDKF---VVIGAHHTSNWDFVAflaAKFVLRLNARWFGKHTLFNGPL 77
Cdd:PRK15018  27 FSPRNpKHVATFGHMFGRLAplfGLKVECRKPADAESygnAIYIANHQNNYDMVT---ASNIVQPPTVTVGKKSLLWIPF 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595555   78 -GGLMRRWGGIPIQRHLKL---NTVDQAIQAFREhREFMLIIAPEGTRKK---VDRWRMGFYHIARGAGVPVVPAALDYE 150
Cdd:PRK15018 104 fGQLYWLTGNLLIDRNNRTkahGTIAEVVNHFKK-RRISIWMFPEGTRSRgrgLLPFKTGAFHAAIAAGVPIIPVCVSTT 182


                 ....
gi 15595555  151 NRRI 154
Cdd:PRK15018 183 SNKI 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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