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Conserved domains on  [gi|15610806|ref|NP_218187|]
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epoxide hydrolase EphE [Mycobacterium tuberculosis H37Rv]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 20-323 3.45e-37

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 132.43  E-value: 3.45e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  20 VHANGIRFHVVEAVPSGQPegpdaatppmqpalarplVILLHGFGSFWWSWRHQLCGL-TGARVVAVDLRGYGGSDKPPR 98
Cdd:COG0596   7 VTVDGVRLHYREAGPDGPP------------------VVLLHGLPGSSYEWRPLIPALaAGYRVIAPDLRGHGRSDKPAG 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  99 GYDGWTLAGDTAGLIRALGHPSATLVGHADGGLACWTTALLHSRLVRAIALIssphpaalrrstltrrdqrhallptllr 178
Cdd:COG0596  69 GYTLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLV---------------------------- 120

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806 179 yqlpiwperlltrnnaaeierlvrargcakwlasedfSQAIDHLRQAIQIPAAAhcaleyqRWAVRSQLRSEGRRFIRAM 258
Cdd:COG0596 121 -------------------------------------DEVLAALAEPLRRPGLA-------PEALAALLRALARTDLRER 156

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15610806 259 TQQLGMPLLHLRGDADPYVLADPVERTQRYAPHGRYISIAGAGHFSHEEAPEEVNRHLMRFLEQV 323
Cdd:COG0596 157 LARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 20-323 3.45e-37

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 132.43  E-value: 3.45e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  20 VHANGIRFHVVEAVPSGQPegpdaatppmqpalarplVILLHGFGSFWWSWRHQLCGL-TGARVVAVDLRGYGGSDKPPR 98
Cdd:COG0596   7 VTVDGVRLHYREAGPDGPP------------------VVLLHGLPGSSYEWRPLIPALaAGYRVIAPDLRGHGRSDKPAG 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  99 GYDGWTLAGDTAGLIRALGHPSATLVGHADGGLACWTTALLHSRLVRAIALIssphpaalrrstltrrdqrhallptllr 178
Cdd:COG0596  69 GYTLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLV---------------------------- 120

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806 179 yqlpiwperlltrnnaaeierlvrargcakwlasedfSQAIDHLRQAIQIPAAAhcaleyqRWAVRSQLRSEGRRFIRAM 258
Cdd:COG0596 121 -------------------------------------DEVLAALAEPLRRPGLA-------PEALAALLRALARTDLRER 156

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15610806 259 TQQLGMPLLHLRGDADPYVLADPVERTQRYAPHGRYISIAGAGHFSHEEAPEEVNRHLMRFLEQV 323
Cdd:COG0596 157 LARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 55-309 4.41e-24

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 98.35  E-value: 4.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806    55 PLVILLHGFGSFWWSWRHQLCGL--TGARVVAVDLRGYGGSDKPPRGYDG--WTLAGDTAGLIRALGHPSATLVGHADGG 130
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALarDGFRVIALDLRGFGKSSRPKAQDDYrtDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   131 LACWTTALLHSRLVRAIALISSPHPaalrrstltrrdqrHALLPTLLRYQLPIWPERLltRNNAAEIERLVRARGCAKWL 210
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDP--------------PHELDEADRFILALFPGFF--DGFVADFAPNPLGRLVAKLL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   211 ASEDFSQAIDHLRQAIQIPAAAHCAL---EYQRWAVRSQLRSEGRRFiRAMTQQLGMPLLHLRGDADPYVLADPVERTQR 287
Cdd:pfam00561 145 ALLLLRLRLLKALPLLNKRFPSGDYAlakSLVTGALLFIETWSTELR-AKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQ 223

                         250       260
                  ....*....|....*....|..
gi 15610806   288 YAPHGRYISIAGAGHFSHEEAP 309
Cdd:pfam00561 224 LFPNARLVVIPDAGHFAFLEGP 245
PLN02578 PLN02578
hydrolase
 57-320 1.69e-18

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 84.89  E-value: 1.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   57 VILLHGFGSFWWSWRHQLCGLTGA-RVVAVDLRGYGGSDKPPRGYDGWTLAGDTAGLIRALGHPSATLVGHADGGLACWT 135
Cdd:PLN02578  89 IVLIHGFGASAFHWRYNIPELAKKyKVYALDLLGFGWSDKALIEYDAMVWRDQVADFVKEVVKEPAVLVGNSLGGFTALS 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  136 TALLHSRLVRAIALISSphpAALRRSTLTRRDQRHALLPTLLRYQL--PI--WPERLL------TRNNAAEIERLVRArg 205
Cdd:PLN02578 169 TAVGYPELVAGVALLNS---AGQFGSESREKEEAIVVEETVLTRFVvkPLkeWFQRVVlgflfwQAKQPSRIESVLKS-- 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  206 cakwlASEDFSQAIDHLRQAIQIPAAAHCALE-YQRWAVRSQLRsEGRRFIRAMTQQLGMPLLHLRGDADPYVLADPVER 284
Cdd:PLN02578 244 -----VYKDKSNVDDYLVESITEPAADPNAGEvYYRLMSRFLFN-QSRYTLDSLLSKLSCPLLLLWGDLDPWVGPAKAEK 317

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 15610806  285 TQRYAPHGRYISIAgAGHFSHEEAPEEVNRHLMRFL 320
Cdd:PLN02578 318 IKAFYPDTTLVNLQ-AGHCPHDEVPEQVNKALLEWL 352
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 20-323 3.45e-37

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 132.43  E-value: 3.45e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  20 VHANGIRFHVVEAVPSGQPegpdaatppmqpalarplVILLHGFGSFWWSWRHQLCGL-TGARVVAVDLRGYGGSDKPPR 98
Cdd:COG0596   7 VTVDGVRLHYREAGPDGPP------------------VVLLHGLPGSSYEWRPLIPALaAGYRVIAPDLRGHGRSDKPAG 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  99 GYDGWTLAGDTAGLIRALGHPSATLVGHADGGLACWTTALLHSRLVRAIALIssphpaalrrstltrrdqrhallptllr 178
Cdd:COG0596  69 GYTLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLV---------------------------- 120

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806 179 yqlpiwperlltrnnaaeierlvrargcakwlasedfSQAIDHLRQAIQIPAAAhcaleyqRWAVRSQLRSEGRRFIRAM 258
Cdd:COG0596 121 -------------------------------------DEVLAALAEPLRRPGLA-------PEALAALLRALARTDLRER 156

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15610806 259 TQQLGMPLLHLRGDADPYVLADPVERTQRYAPHGRYISIAGAGHFSHEEAPEEVNRHLMRFLEQV 323
Cdd:COG0596 157 LARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 55-309 4.41e-24

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 98.35  E-value: 4.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806    55 PLVILLHGFGSFWWSWRHQLCGL--TGARVVAVDLRGYGGSDKPPRGYDG--WTLAGDTAGLIRALGHPSATLVGHADGG 130
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALarDGFRVIALDLRGFGKSSRPKAQDDYrtDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   131 LACWTTALLHSRLVRAIALISSPHPaalrrstltrrdqrHALLPTLLRYQLPIWPERLltRNNAAEIERLVRARGCAKWL 210
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDP--------------PHELDEADRFILALFPGFF--DGFVADFAPNPLGRLVAKLL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   211 ASEDFSQAIDHLRQAIQIPAAAHCAL---EYQRWAVRSQLRSEGRRFiRAMTQQLGMPLLHLRGDADPYVLADPVERTQR 287
Cdd:pfam00561 145 ALLLLRLRLLKALPLLNKRFPSGDYAlakSLVTGALLFIETWSTELR-AKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQ 223

                         250       260
                  ....*....|....*....|..
gi 15610806   288 YAPHGRYISIAGAGHFSHEEAP 309
Cdd:pfam00561 224 LFPNARLVVIPDAGHFAFLEGP 245
PLN02578 PLN02578
hydrolase
 57-320 1.69e-18

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 84.89  E-value: 1.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   57 VILLHGFGSFWWSWRHQLCGLTGA-RVVAVDLRGYGGSDKPPRGYDGWTLAGDTAGLIRALGHPSATLVGHADGGLACWT 135
Cdd:PLN02578  89 IVLIHGFGASAFHWRYNIPELAKKyKVYALDLLGFGWSDKALIEYDAMVWRDQVADFVKEVVKEPAVLVGNSLGGFTALS 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  136 TALLHSRLVRAIALISSphpAALRRSTLTRRDQRHALLPTLLRYQL--PI--WPERLL------TRNNAAEIERLVRArg 205
Cdd:PLN02578 169 TAVGYPELVAGVALLNS---AGQFGSESREKEEAIVVEETVLTRFVvkPLkeWFQRVVlgflfwQAKQPSRIESVLKS-- 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  206 cakwlASEDFSQAIDHLRQAIQIPAAAHCALE-YQRWAVRSQLRsEGRRFIRAMTQQLGMPLLHLRGDADPYVLADPVER 284
Cdd:PLN02578 244 -----VYKDKSNVDDYLVESITEPAADPNAGEvYYRLMSRFLFN-QSRYTLDSLLSKLSCPLLLLWGDLDPWVGPAKAEK 317

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 15610806  285 TQRYAPHGRYISIAgAGHFSHEEAPEEVNRHLMRFL 320
Cdd:PLN02578 318 IKAFYPDTTLVNLQ-AGHCPHDEVPEQVNKALLEWL 352
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 40-323 2.25e-17

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 81.91  E-value: 2.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   40 GPDAATPpmqpalarplVILLHGFGSFWWSWRHQLCGLT-GARVVAVDLRGYGGSDKPPRGYDGWTLAGDTAGLIRALGH 118
Cdd:PRK14875 127 GEGDGTP----------VVLIHGFGGDLNNWLFNHAALAaGRPVIALDLPGHGASSKAVGAGSLDELAAAVLAFLDALGI 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  119 PSATLVGHADGGLACWTTALLHSRLVRAIALISsphPAALRR-------STLTRRDQRHALLPTLLryQLPIWPErLLTR 191
Cdd:PRK14875 197 ERAHLVGHSMGGAVALRLAARAPQRVASLTLIA---PAGLGPeingdyiDGFVAAESRRELKPVLE--LLFADPA-LVTR 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  192 nnaAEIERLVRARgcakwlasedfsqAIDHLRQAIQIPAAAHCALEYQRWAVRSQLRSegrrfiramtqqLGMPLLHLRG 271
Cdd:PRK14875 271 ---QMVEDLLKYK-------------RLDGVDDALRALADALFAGGRQRVDLRDRLAS------------LAIPVLVIWG 322

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15610806  272 DADPYVladPVERTQRYAPHGRYISIAGAGHFSHEEAPEEVNRHLMRFLEQV 323
Cdd:PRK14875 323 EQDRII---PAAHAQGLPDGVAVHVLPGAGHMPQMEAAADVNRLLAEFLGKA 371
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 55-321 4.66e-13

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 68.61  E-value: 4.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   55 PLVILLHGFGSFWWSWRHQLCGLTGA-RVVAVDLRGYGGSDKP-PRG------YDGWTLAGDTAGLIRALGHPSATLVGH 126
Cdd:PLN02824  30 PALVLVHGFGGNADHWRKNTPVLAKShRVYAIDLLGYGYSDKPnPRSappnsfYTFETWGEQLNDFCSDVVGDPAFVICN 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  127 ADGGLACWTTALLHSRLVRAIALISsphpAALRRSTLTRRD--QRH--ALLPTLLRyQLPIwpERLLTRNNAAEieRLVR 202
Cdd:PLN02824 110 SVGGVVGLQAAVDAPELVRGVMLIN----ISLRGLHIKKQPwlGRPfiKAFQNLLR-ETAV--GKAFFKSVATP--ETVK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  203 ARGCAkwlASEDFSQAIDHLRQAIQIPA----AAHCALEYQRWAvrsqlrseGRRFIRAMTQQLGMPLLHLRGDADPYvl 278
Cdd:PLN02824 181 NILCQ---CYHDDSAVTDELVEAILRPGlepgAVDVFLDFISYS--------GGPLPEELLPAVKCPVLIAWGEKDPW-- 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 15610806  279 aDPVERTQRYAPHG---RYISIAGAGHFSHEEAPEEVNRHLMRFLE 321
Cdd:PLN02824 248 -EPVELGRAYANFDaveDFIVLPGVGHCPQDEAPELVNPLIESFVA 292
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
53-177 1.65e-11

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 62.71  E-value: 1.65e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  53 ARPLVILLHGFGSFWWSWRHQLCGLT--GARVVAVDLRGYGGSDKPPRGYDGW-TLAGDTAGLIRALGHPSAT---LVGH 126
Cdd:COG2267  27 PRGTVVLVHGLGEHSGRYAELAEALAaaGYAVLAFDLRGHGRSDGPRGHVDSFdDYVDDLRAALDALRARPGLpvvLLGH 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15610806 127 ADGGLACWTTALLHSRLVRAIALISS--------PHPAALRRSTLTRRDQRHALLPTLL 177
Cdd:COG2267 107 SMGGLIALLYAARYPDRVAGLVLLAPayradpllGPSARWLRALRLAEALARIDVPVLV 165
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 40-323 3.49e-08

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 54.46  E-value: 3.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   40 GPDAATPPMQPalarplVILLHGFGSFWWSWRHQLCGLTGARVV-AVDLRGYGGSDKPPR-GYDGWTLAGDTAGLIRALG 117
Cdd:PLN02679  80 GSPEVTSSGPP------VLLVHGFGASIPHWRRNIGVLAKNYTVyAIDLLGFGASDKPPGfSYTMETWAELILDFLEEVV 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  118 HPSATLVGHADGGLACWTTALLHSR-LVRAIALISSphpAALRRSTLTRRDQR-HALLPTLLRYQLpiwpeRLLTRNNAA 195
Cdd:PLN02679 154 QKPTVLIGNSVGSLACVIAASESTRdLVRGLVLLNC---AGGMNNKAVVDDWRiKLLLPLLWLIDF-----LLKQRGIAS 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  196 EIERLVRARGCAKWLASEDFS--QAIDH-LRQAIQIPAAAHCALEyqrwAVRSQLRSEGRRFIRAMTQQLGMPLLHLRGD 272
Cdd:PLN02679 226 ALFNRVKQRDNLKNILLSVYGnkEAVDDeLVEIIRGPADDEGALD----AFVSIVTGPPGPNPIKLIPRISLPILVLWGD 301

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15610806  273 ADPYVLAD-PVERTQRYAPHGR----YISIAGAGHFSHEEAPEEVNRHLMRFLEQV 323
Cdd:PLN02679 302 QDPFTPLDgPVGKYFSSLPSQLpnvtLYVLEGVGHCPHDDRPDLVHEKLLPWLAQL 357
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 57-320 1.04e-07

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 52.30  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   57 VILLHGFGSFWWSWRHQLCGLTG-ARVVAVDLRGYGGSDKPPRGY---------DGWtlagdtaglIRALGHPSATLVGH 126
Cdd:PRK03592  30 IVFLHGNPTSSYLWRNIIPHLAGlGRCLAPDLIGMGASDKPDIDYtfadharylDAW---------FDALGLDDVVLVGH 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  127 ADGGLACWTTALLHSRLVRAIAL---ISSP------HPAALRRSTLTRRDQRHallptllryqlpiwpERLLTRNNAAeI 197
Cdd:PRK03592 101 DWGSALGFDWAARHPDRVRGIAFmeaIVRPmtwddfPPAVRELFQALRSPGEG---------------EEMVLEENVF-I 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  198 ERLVRArGCAKWLASEDfsqaIDHLR----------------QAIQI---PAAAHCALE-YQRWAVRSQlrsegrrfira 257
Cdd:PRK03592 165 ERVLPG-SILRPLSDEE----MAVYRrpfptpesrrptlswpRELPIdgePADVVALVEeYAQWLATSD----------- 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15610806  258 mtqqlgMPLLHLRGDADPYVLADPVERTQRYAPHGRYISIAGAG-HFSHEEAPEEVNRHLMRFL 320
Cdd:PRK03592 229 ------VPKLLINAEPGAILTTGAIRDWCRSWPNQLEITVFGAGlHFAQEDSPEEIGAAIAAWL 286
PRK10673 PRK10673
esterase;
47-321 4.25e-07

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 50.50  E-value: 4.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   47 PMQPALARPlVILLHG-FGSFwwswrHQLCGLtgAR-------VVAVDLRGYGGSDKPPRgYDGWTLAGDTAGLIRALGH 118
Cdd:PRK10673  10 AQNPHNNSP-IVLVHGlFGSL-----DNLGVL--ARdlvndhdIIQVDMRNHGLSPRDPV-MNYPAMAQDLLDTLDALQI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  119 PSATLVGHADGGLACWT-TALLHSRLVRAIALISSPHPAALRRstltrrdqrHALLPTLLRyqlPIWPERLLTRNNAAEI 197
Cdd:PRK10673  81 EKATFIGHSMGGKAVMAlTALAPDRIDKLVAIDIAPVDYHVRR---------HDEIFAAIN---AVSEAGATTRQQAAAI 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  198 ER-LVRARGCAKWLAsEDFSQA------------IDHLRQAIQIPAAAHcaleyqrwavrsqlrsegrrfiramtqqlgm 264
Cdd:PRK10673 149 MRqHLNEEGVIQFLL-KSFVDGewrfnvpvlwdqYPHIVGWEKIPAWPH------------------------------- 196

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15610806  265 PLLHLRGDADPYVLADPVERTQRYAPHGRYISIAGAGHFSHEEAPEEVNRHLMRFLE 321
Cdd:PRK10673 197 PALFIRGGNSPYVTEAYRDDLLAQFPQARAHVIAGAGHWVHAEKPDAVLRAIRRYLN 253
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 57-314 1.05e-05

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 45.93  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806    57 VILLHGFGSFWWSWRHQLcgLTGARVVAVDLRGYGGSDKPPrgyDGWTLAGDTAGLIRALG-HPSATLVGHADGGLACWT 135
Cdd:pfam12697   1 VVLVHGAGLSAAPLAALL--AAGVAVLAPDLPGHGSSSPPP---LDLADLADLAALLDELGaARPVVLVGHSLGGAVALA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   136 TALLHSRLVRAIALISSPHPAALRRSTLTRRDQRHALLPTLLRYQLPIwperlltrnnaaeierlvrargcAKWLASEDF 215
Cdd:pfam12697  76 AAAAALVVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLA-----------------------RGFLDDLPA 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   216 SQAIDHLRQAIQIPAAAHCALEYQRWAVRsqlrsegrrfiramtqqlgMPLLHLRGDADPYVlADPVERTQRYAPHGRYI 295
Cdd:pfam12697 133 DAEWAAALARLAALLAALALLPLAAWRDL-------------------PVPVLVLAEEDRLV-PELAQRLLAALAGARLV 192

                         250
                  ....*....|....*....
gi 15610806   296 SIAGAGHFSHEEaPEEVNR 314
Cdd:pfam12697 193 VLPGAGHLPLDD-PEEVAE 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
54-174 1.15e-05

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 45.78  E-value: 1.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  54 RPLVILLHGF-GSFWWSWRHQLCGLT--GARVVAVDLRGYGGSDKPPRGYDGWtlagDTAGLIRAL-GHPSAT-----LV 124
Cdd:COG1506  23 YPVVVYVHGGpGSRDDSFLPLAQALAsrGYAVLAPDYRGYGESAGDWGGDEVD----DVLAAIDYLaARPYVDpdrigIY 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15610806 125 GHADGGLACWTTALLHSRLVRAIALISSPHPAALRRSTLTRRDQRHALLP 174
Cdd:COG1506  99 GHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTTREYTERLMGGP 148
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 55-100 1.80e-05

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 46.03  E-value: 1.80e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 15610806   55 PLVILLHGFGSFWWSWRHQLCGLT-GARVVAVDLRGYGGSDKPPRGY 100
Cdd:PLN03084 128 PPVLLIHGFPSQAYSYRKVLPVLSkNYHAIAFDWLGFGFSDKPQPGY 174
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 50-154 6.24e-05

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 41.35  E-value: 6.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  50 PALARPLVILLHGFGSFWWSWRHQLCGLT--GARVVAVDLrgyggsdkPPRGYDGWTLAGDTAGLIRAL----GHPSATL 123
Cdd:COG1075   1 YAATRYPVVLVHGLGGSAASWAPLAPRLRaaGYPVYALNY--------PSTNGSIEDSAEQLAAFVDAVlaatGAEKVDL 72

                        90       100       110
                ....*....|....*....|....*....|...
gi 15610806 124 VGHADGGLAC--WTTALLHSRLVRAIALISSPH 154
Cdd:COG1075  73 VGHSMGGLVAryYLKRLGGAAKVARVVTLGTPH 105
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 53-302 1.01e-04

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 42.97  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806    53 ARPLVILLHGFGSFwwSWR-HQLC---GLTGARVVAVDLRGYGGSDkPPRGY-DGW-TLAGDTAGLIRALG--HPSA--T 122
Cdd:pfam12146   3 PRAVVVLVHGLGEH--SGRyAHLAdalAAQGFAVYAYDHRGHGRSD-GKRGHvPSFdDYVDDLDTFVDKIReeHPGLplF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   123 LVGHADGGLACWTTALLHSRLVRAIALISsphPAALRRSTLTRRDQRHAL-LPTLLRYQLPIWPERL---LTRnNAAEIE 198
Cdd:pfam12146  80 LLGHSMGGLIAALYALRYPDKVDGLILSA---PALKIKPYLAPPILKLLAkLLGKLFPRLRVPNNLLpdsLSR-DPEVVA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   199 RLVRargcakwlasedfsqaiDHLRQAIQIPAAAHCALEYQRWAVRSqlrsegrrfiramTQQLGMPLLHLRGDADPYVL 278
Cdd:pfam12146 156 AYAA-----------------DPLVHGGISARTLYELLDAGERLLRR-------------AAAITVPLLLLHGGADRVVD 205

                         250       260
                  ....*....|....*....|....*.
gi 15610806   279 ADPVERTQRYAP--HGRYISIAGAGH 302
Cdd:pfam12146 206 PAGSREFYERAGstDKTLKLYPGLYH 231
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 18-131 1.57e-04

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 42.65  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   18 LDVHANGIRFHVVEavpsgqpEGPDAATPpmqpalarplVILLHGFGSfwWS--WRHQLCGLTGA--RVVAVDLRGYGGS 93
Cdd:PRK00870  27 DDGDGGPLRMHYVD-------EGPADGPP----------VLLLHGEPS--WSylYRKMIPILAAAghRVIAPDLIGFGRS 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 15610806   94 DKPPRGYD-------GWTLAgdtagLIRALGHPSATLVGHADGGL 131
Cdd:PRK00870  88 DKPTRREDytyarhvEWMRS-----WFEQLDLTDVTLVCQDWGGL 127
PRK05855 PRK05855
SDR family oxidoreductase;
53-203 3.05e-04

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 42.28  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806   53 ARPLVILLHGFGSFWWSWRHqLCGLTGAR--VVAVDLRGYGGSDKpPRGYDGWT---LAGDTAGLIRALGHPSAT-LVGH 126
Cdd:PRK05855  24 DRPTVVLVHGYPDNHEVWDG-VAPLLADRfrVVAYDVRGAGRSSA-PKRTAAYTlarLADDFAAVIDAVSPDRPVhLLAH 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  127 ADGGLACWtTALLHSRLVRAIA---LISSP---HPAALRRSTLTRRDQRH--ALLPTLLR------YQLPIWPERLLTRN 192
Cdd:PRK05855 102 DWGSIQGW-EAVTRPRAAGRIAsftSVSGPsldHVGFWLRSGLRRPTPRRlaRALGQLLRswyiylFHLPVLPELLWRLG 180

                        170
                 ....*....|.
gi 15610806  193 NAAEIERLVRA 203
Cdd:PRK05855 181 LGRAWPRLLRR 191
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
48-323 3.30e-03

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 38.38  E-value: 3.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806  48 MQPALARPL--------VILLHGFGSFWWSWR---HQLCGlTGARVVAVDLRGYGGS--DKPPRGYDGWTLAGDTAGLIR 114
Cdd:COG1647   1 MKILGAEPFfleggrkgVLLLHGFTGSPAEMRplaEALAK-AGYTVYAPRLPGHGTSpeDLLKTTWEDWLEDVEEAYEIL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806 115 ALGHPSATLVGHADGG-LACWttALLHSRLVRAIALISSPhpaalrrstLTRRDQRHALLPtLLRYqlpiwperlltrnn 193
Cdd:COG1647  80 KAGYDKVIVIGLSMGGlLALL--LAARYPDVAGLVLLSPA---------LKIDDPSAPLLP-LLKY-------------- 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610806 194 aaeierlvrargcakwlasedFSQAIDHLRQAIQIPAAAHCALEYQRWAVRSQLrsegRRFIRAMTQQLGM---PLLHLR 270
Cdd:COG1647 134 ---------------------LARSLRGIGSDIEDPEVAEYAYDRTPLRALAEL----QRLIREVRRDLPKitaPTLIIQ 188

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15610806 271 GDADPYVladPVERTQRYA-----PHGRYISIAGAGH-FSHEEAPEEVNRHLMRFLEQV 323
Cdd:COG1647 189 SRKDEVV---PPESARYIYerlgsPDKELVWLEDSGHvITLDKDREEVAEEILDFLERL 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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