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Conserved domains on  [gi|15610683|ref|NP_218064|]
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deazaflavin-dependent nitroreductase [Mycobacterium tuberculosis H37Rv]

Protein Classification

nitroreductase family deazaflavin-dependent oxidoreductase( domain architecture ID 10513519)

nitroreductase family deazaflavin-dependent oxidoreductase similar to Mycobacterium tuberculosis deazaflavin-dependent nitroreductase and F420H(2)-dependent quinone reductase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F420H2_quin_red pfam04075
F420H(2)-dependent quinone reductase; This family of proteins is found in the genera ...
 22-150 3.52e-69

F420H(2)-dependent quinone reductase; This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.


:

Pssm-ID: 281995  Cd Length: 129  Bit Score: 204.99  E-value: 3.52e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610683    22 SRINTWMYRRNDGEgLGGTFQKIPVALLTTTGRKTGQPRVNPLYFLRDGGRVIVAASKGGAEKNPMWYLNLKANPKVQVQ 101
Cdd:pfam04075   2 YREHVARYRRTGGT-VGRRLPGVPVLLLTTTGRKTGQPRTTPLGGVRDGDSYLVVASKGGAPRHPGWYYNLKANPRVRVQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 15610683   102 IKKEVLDLTARDATDEERAEYWPQLVTMYPSYQDYQSWTDRTIPIVVCE 150
Cdd:pfam04075  81 IGGRWLDGTARLAPDDERARLWQLPVLNSPGYAVYQSGTDRPIPVVVLT 129
 
Name Accession Description Interval E-value
F420H2_quin_red pfam04075
F420H(2)-dependent quinone reductase; This family of proteins is found in the genera ...
 22-150 3.52e-69

F420H(2)-dependent quinone reductase; This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.


Pssm-ID: 281995  Cd Length: 129  Bit Score: 204.99  E-value: 3.52e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610683    22 SRINTWMYRRNDGEgLGGTFQKIPVALLTTTGRKTGQPRVNPLYFLRDGGRVIVAASKGGAEKNPMWYLNLKANPKVQVQ 101
Cdd:pfam04075   2 YREHVARYRRTGGT-VGRRLPGVPVLLLTTTGRKTGQPRTTPLGGVRDGDSYLVVASKGGAPRHPGWYYNLKANPRVRVQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 15610683   102 IKKEVLDLTARDATDEERAEYWPQLVTMYPSYQDYQSWTDRTIPIVVCE 150
Cdd:pfam04075  81 IGGRWLDGTARLAPDDERARLWQLPVLNSPGYAVYQSGTDRPIPVVVLT 129
hi_GC_TIGR00026 TIGR00026
deazaflavin-dependent oxidoreductase, nitroreductase family; This model represents a family of ...
 38-150 3.58e-53

deazaflavin-dependent oxidoreductase, nitroreductase family; This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 211538  Cd Length: 113  Bit Score: 163.73  E-value: 3.58e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610683    38 GGTFQKIPVALLTTTGRKTGQPRVNPLYFLRDGGRVIVAASKGGAEKNPMWYLNLKANPKVQVQIKKEVLDLTARDATDE 117
Cdd:TIGR00026   1 GGIARGLPVLLLTTTGRKTGKPRTTPVYYVRHDPGVLVVASNGGAPRHPDWYKNLKANPRVRVRVGGKVFVATARLVSGD 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 15610683   118 ERAEYWPQLVTMYPSYQDYQSWTDRTIPIVVCE 150
Cdd:TIGR00026  81 ERAQLWAGVVRLYPRYQRYQSRTDRPIPVVVLT 113
NimA COG3467
Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5 ...
 57-98 7.04e-03

Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5'-phosphate oxidase superfamily [Defense mechanisms];


Pssm-ID: 442690 [Multi-domain]  Cd Length: 144  Bit Score: 34.90  E-value: 7.04e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15610683  57 GQPRVNPLYFLRDGGRVIVAASKGGaeknpMWYLNLKANPKV 98
Cdd:COG3467  31 GRPYVVPVNYVYDGDTIYFHTAKEG-----RKLDNLRRNPRV 67
 
Name Accession Description Interval E-value
F420H2_quin_red pfam04075
F420H(2)-dependent quinone reductase; This family of proteins is found in the genera ...
 22-150 3.52e-69

F420H(2)-dependent quinone reductase; This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.


Pssm-ID: 281995  Cd Length: 129  Bit Score: 204.99  E-value: 3.52e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610683    22 SRINTWMYRRNDGEgLGGTFQKIPVALLTTTGRKTGQPRVNPLYFLRDGGRVIVAASKGGAEKNPMWYLNLKANPKVQVQ 101
Cdd:pfam04075   2 YREHVARYRRTGGT-VGRRLPGVPVLLLTTTGRKTGQPRTTPLGGVRDGDSYLVVASKGGAPRHPGWYYNLKANPRVRVQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 15610683   102 IKKEVLDLTARDATDEERAEYWPQLVTMYPSYQDYQSWTDRTIPIVVCE 150
Cdd:pfam04075  81 IGGRWLDGTARLAPDDERARLWQLPVLNSPGYAVYQSGTDRPIPVVVLT 129
hi_GC_TIGR00026 TIGR00026
deazaflavin-dependent oxidoreductase, nitroreductase family; This model represents a family of ...
 38-150 3.58e-53

deazaflavin-dependent oxidoreductase, nitroreductase family; This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 211538  Cd Length: 113  Bit Score: 163.73  E-value: 3.58e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610683    38 GGTFQKIPVALLTTTGRKTGQPRVNPLYFLRDGGRVIVAASKGGAEKNPMWYLNLKANPKVQVQIKKEVLDLTARDATDE 117
Cdd:TIGR00026   1 GGIARGLPVLLLTTTGRKTGKPRTTPVYYVRHDPGVLVVASNGGAPRHPDWYKNLKANPRVRVRVGGKVFVATARLVSGD 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 15610683   118 ERAEYWPQLVTMYPSYQDYQSWTDRTIPIVVCE 150
Cdd:TIGR00026  81 ERAQLWAGVVRLYPRYQRYQSRTDRPIPVVVLT 113
Putative_PNPOx pfam01243
Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family ...
 41-98 6.98e-03

Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as Swiss:Q06199 and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.


Pssm-ID: 426149 [Multi-domain]  Cd Length: 88  Bit Score: 33.76  E-value: 6.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15610683    41 FQKIPVALLTTTgRKTGQPRVNPLYFLRDGGRV-IVAASKGGAEKnpmwYLNLKANPKV 98
Cdd:pfam01243   9 LAEPNAVVLATV-DKDGRPNVRPVGLKYGFDTVgILFATNTDSRK----ARNLEENPRV 62
NimA COG3467
Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5 ...
 57-98 7.04e-03

Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5'-phosphate oxidase superfamily [Defense mechanisms];


Pssm-ID: 442690 [Multi-domain]  Cd Length: 144  Bit Score: 34.90  E-value: 7.04e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15610683  57 GQPRVNPLYFLRDGGRVIVAASKGGaeknpMWYLNLKANPKV 98
Cdd:COG3467  31 GRPYVVPVNYVYDGDTIYFHTAKEG-----RKLDNLRRNPRV 67
COG5015 COG5015
Pyridoxamine 5'-phosphate oxidase (PNPOx-like) family protein [General function prediction ...
 41-132 9.70e-03

Pyridoxamine 5'-phosphate oxidase (PNPOx-like) family protein [General function prediction only];


Pssm-ID: 444039 [Multi-domain]  Cd Length: 130  Bit Score: 34.04  E-value: 9.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610683  41 FQKIPVALLTTTGRktGQPRVNPLYFLR-DGGRVIVAASKGgaeKNpmWYLNLKANPKV----------QVQIKKEVLDL 109
Cdd:COG5015   7 LKENPVFYLATVDG--GQPRVRPFGFVFeDEGKLYFCTSNQ---KD--VYKQLKANPKVeicamkkdgeWIRLSGKAVFV 79

                        90       100
                ....*....|....*....|...
gi 15610683 110 TARDATDEERAEYwPQLVTMYPS 132
Cdd:COG5015  80 DDRELKEKILEEN-PFLKEIYPS 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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