|
Name |
Accession |
Description |
Interval |
E-value |
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
1-336 |
0e+00 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 619.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 1 MKLAIIAGDGIGPEVTAEAVKVLDAVV---PGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSVPSGV 77
Cdd:PRK03437 5 MKLAVIPGDGIGPEVVAEALKVLDAVAaggPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDPSVPSGV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 78 LERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRR 157
Cdd:PRK03437 85 LERGLLLKLRFALDHYVNLRPSKLYPGVTSPLAGPGDIDFVVVREGTEGPYTGNGGALRVGTPHEVATEVSVNTAFGVER 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 158 VVADAFERARRR-RKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDI 236
Cdd:PRK03437 165 VVRDAFERAQKRpRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTDNLFGDI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 237 ITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLA 316
Cdd:PRK03437 245 ITDLAAAVTGGIGLAASGNINPTGTNPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARIEAAVEADLA 324
|
330 340
....*....|....*....|
gi 15610132 317 TRGSERLATSDVGERIAAAL 336
Cdd:PRK03437 325 ERGKMGRSTAEVGDRIAARL 344
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
1-336 |
5.60e-156 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 440.60 E-value: 5.60e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 1 MKLAIIAGDGIGPEVTAEAVKVLDAV----VPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSVPSG 76
Cdd:COG0473 2 YKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDDG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 77 VLERGLLLRLRFELDHHINLRPARLYPGVASPLSGN--PGIDFVVVREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFG 154
Cdd:COG0473 82 VRPESGLLALRKELDLYANLRPAKLYPGLPSPLKPEivEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDTRVYTRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 155 VRRVVADAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFG 234
Cdd:COG0473 162 IERIARYAFELARKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTENLFG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 235 DIITDLAAAVCGGIGLAASGNIDATRanPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAH 314
Cdd:COG0473 242 DILSDLAAGLTGSLGLAPSANIGDEG--KALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKV 319
|
330 340
....*....|....*....|....*...
gi 15610132 315 LA----TR--GSErLATSDVGERIAAAL 336
Cdd:COG0473 320 LAegvrTPdlGGK-AGTSEMGDAIIAAL 346
|
|
| TTC |
TIGR02089 |
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ... |
2-329 |
2.89e-106 |
|
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]
Pssm-ID: 273963 Cd Length: 352 Bit Score: 314.85 E-value: 2.89e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 2 KLAIIAGDGIGPEVTAEAVKVLDAVVP-----GVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPS-VPS 75
Cdd:TIGR02089 5 RIAAIPGDGIGKEVVAAALQVLEAAAKrhggfSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPAlVPD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 76 GVLERGLLLRLRFELDHHINLRPARLYPGVASPL-SGNPG-IDFVVVREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAF 153
Cdd:TIGR02089 85 HISLWGLLLKIRREFDQYANVRPAKLLPGVTSPLrNCGPGdFDFVVVRENSEGEYSGVGGRIHRGTDEEVATQNAIFTRK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 154 GVRRVVADAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLF 233
Cdd:TIGR02089 165 GVERIMRFAFELAQKRRKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVIVASNLF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 234 GDIITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEA 313
Cdd:TIGR02089 245 GDILSDLGAALMGSLGVAPSANINPEGKFPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKIMDAIER 324
|
330
....*....|....*.
gi 15610132 314 HLAtrgsERLATSDVG 329
Cdd:TIGR02089 325 VTA----AGILTPDVG 336
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
2-332 |
3.70e-92 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 278.41 E-value: 3.70e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 2 KLAIIAGDGIGPEVTAEAVKVLDAVVP----GVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPS-VPSG 76
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEkaplEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKwDPAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 77 VLERGLLLRLRFELDHHINLRPARLYP--GVASPLSGNP-GIDFVVVREGTEGPYTGNGGAIrVGTPNEVATEVSVNTAF 153
Cdd:pfam00180 81 VRPENGLLALRKELGLFANLRPAKVFPplGDASPLKNEVeGVDIVIVRELTGGIYFGIEKGI-KGSGNEVAVDTKLYSRD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 154 GVRRVVADAFERAR-RRRKHLTLVHKTNVLTFAGgLWLRTVDEVGEC-YPDVEVAYQHVDAATIHMITDPGRFDVIVTDN 231
Cdd:pfam00180 160 EIERIARVAFELARkRGRKKVTSVDKANVLKSSD-LWRKIVTEVAKAeYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 232 LFGDIITDLAAAVCGGIGLAASGNIDATRanPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSH-LGEHDAAARVDRA 310
Cdd:pfam00180 239 LFGDILSDEASMLTGSLGLLPSASLGANG--FGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAA 316
|
330 340 350
....*....|....*....|....*....|
gi 15610132 311 VEAHLAT--------RGSERLATSDVGERI 332
Cdd:pfam00180 317 VLKVLESgirtgdlaGSATYVSTSEFGEAV 346
|
|
| AksF2_Meth |
NF040626 |
homoisocitrate dehydrogenase; |
2-329 |
4.97e-82 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468598 Cd Length: 332 Bit Score: 251.96 E-value: 4.97e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 2 KLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGD-PSVPSGVLER 80
Cdd:NF040626 3 KITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTStPGQKSPIITL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 81 GLLLrlrfelDHHINLRPARLYPGVASPlsgNPGIDFVVVREGTEGPYTGNggaIRVGTPnEVATEVSVNTAFGVRRVVA 160
Cdd:NF040626 83 RKEL------DLYANLRPIKSYEGINCL---FKDLDFLIVRENTEGLYSGL---EEEYTE-EKAIAERVITRKASERICK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 161 DAFERARRR-RKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITD 239
Cdd:NF040626 150 FAFEYAIKLgRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDILSD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 240 LAAAVCGGIGLAASGNIDAtraNPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLATRg 319
Cdd:NF040626 230 EAAGLVGGLGLAPSANIGD---KNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREG- 305
|
330
....*....|
gi 15610132 320 seRLATSDVG 329
Cdd:NF040626 306 --KVVTPDLG 313
|
|
| AksF_Meth |
NF040619 |
homoisocitrate dehydrogenase; |
1-332 |
1.06e-67 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468591 Cd Length: 332 Bit Score: 215.39 E-value: 1.06e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 1 MKLAIIAGDGIGPEVTAEAVKVLDAVvPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSvPSGVLER 80
Cdd:NF040619 2 PKICVIEGDGIGKEVIPETVRVLKEL-GDFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPK-PTELKNK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 81 GLLL---RLRFELDHHINLRPARLYpgvaSPLSGNPGIDFVVVREGTEGPYTGNGgaiRVGTPNEVATEVSVNTAFGVRR 157
Cdd:NF040619 80 NYKSpilTLRKELDLYANVRPINNF----GDGQDVKNIDFVIIRENTEGLYVGRE---YYDEENEIAIAERIISKKGSER 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 158 VVADAFERARR-RRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQH--VDAATIHMITDPGRFDVIVTDNLFG 234
Cdd:NF040619 153 IIKFAFEYAKKnNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYKNFNIEADDylVDATAMYLIKNPEMFDVIVTTNLFG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 235 DIITDLAAAVCGGIGLAASGNIDATRAnpsMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAH 314
Cdd:NF040619 233 DILSDEASGLIGGLGLAPSANIGDKKG---LFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVKKC 309
|
330 340
....*....|....*....|....*
gi 15610132 315 LATR-------GSerLATSDVGERI 332
Cdd:NF040619 310 LENGkvtpdlgGN--LKTKEVTDKI 332
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
1-336 |
0e+00 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 619.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 1 MKLAIIAGDGIGPEVTAEAVKVLDAVV---PGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSVPSGV 77
Cdd:PRK03437 5 MKLAVIPGDGIGPEVVAEALKVLDAVAaggPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDPSVPSGV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 78 LERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRR 157
Cdd:PRK03437 85 LERGLLLKLRFALDHYVNLRPSKLYPGVTSPLAGPGDIDFVVVREGTEGPYTGNGGALRVGTPHEVATEVSVNTAFGVER 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 158 VVADAFERARRR-RKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDI 236
Cdd:PRK03437 165 VVRDAFERAQKRpRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTDNLFGDI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 237 ITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLA 316
Cdd:PRK03437 245 ITDLAAAVTGGIGLAASGNINPTGTNPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARIEAAVEADLA 324
|
330 340
....*....|....*....|
gi 15610132 317 TRGSERLATSDVGERIAAAL 336
Cdd:PRK03437 325 ERGKMGRSTAEVGDRIAARL 344
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
1-336 |
5.60e-156 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 440.60 E-value: 5.60e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 1 MKLAIIAGDGIGPEVTAEAVKVLDAV----VPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSVPSG 76
Cdd:COG0473 2 YKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDDG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 77 VLERGLLLRLRFELDHHINLRPARLYPGVASPLSGN--PGIDFVVVREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFG 154
Cdd:COG0473 82 VRPESGLLALRKELDLYANLRPAKLYPGLPSPLKPEivEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDTRVYTRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 155 VRRVVADAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFG 234
Cdd:COG0473 162 IERIARYAFELARKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTENLFG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 235 DIITDLAAAVCGGIGLAASGNIDATRanPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAH 314
Cdd:COG0473 242 DILSDLAAGLTGSLGLAPSANIGDEG--KALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKV 319
|
330 340
....*....|....*....|....*...
gi 15610132 315 LA----TR--GSErLATSDVGERIAAAL 336
Cdd:COG0473 320 LAegvrTPdlGGK-AGTSEMGDAIIAAL 346
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
1-336 |
5.58e-119 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 347.09 E-value: 5.58e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 1 MKLAIIAGDGIGPEVTAEAVKVLDAVV----PGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSVPSg 76
Cdd:PRK00772 3 YKIAVLPGDGIGPEVMAEAVKVLDAVAekfgFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 77 vlerglllrlrfeLDHHI-----------------NLRPARLYPGV--ASPLSGN--PGIDFVVVREGTEGPYTGNGGAI 135
Cdd:PRK00772 82 -------------LPPDVrpergllalrkelglfaNLRPAKLYPGLadASPLKPEivAGLDILIVRELTGGIYFGEPRGR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 136 RVGTPNEVATEVSVNTAFGVRRVVADAFERARRRRKHLTLVHKTNVLTfAGGLWLRTVDEVGECYPDVEVAYQHVDAATI 215
Cdd:PRK00772 149 EGLGGEERAFDTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAAM 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 216 HMITDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLAASGNIDAtrANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLL 295
Cdd:PRK00772 228 QLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGE--SGPGLYEPIHGSAPDIAGKGIANPIATILSAAMML 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 15610132 296 SH-LGEHDAAARVDRAVEAHLA--------TRGSERLATSDVGERIAAAL 336
Cdd:PRK00772 306 RYsLGLEEAADAIEAAVEKVLAqgyrtadiAEGGGKVSTSEMGDAILAAL 355
|
|
| TTC |
TIGR02089 |
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ... |
2-329 |
2.89e-106 |
|
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]
Pssm-ID: 273963 Cd Length: 352 Bit Score: 314.85 E-value: 2.89e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 2 KLAIIAGDGIGPEVTAEAVKVLDAVVP-----GVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPS-VPS 75
Cdd:TIGR02089 5 RIAAIPGDGIGKEVVAAALQVLEAAAKrhggfSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPAlVPD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 76 GVLERGLLLRLRFELDHHINLRPARLYPGVASPL-SGNPG-IDFVVVREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAF 153
Cdd:TIGR02089 85 HISLWGLLLKIRREFDQYANVRPAKLLPGVTSPLrNCGPGdFDFVVVRENSEGEYSGVGGRIHRGTDEEVATQNAIFTRK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 154 GVRRVVADAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLF 233
Cdd:TIGR02089 165 GVERIMRFAFELAQKRRKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVIVASNLF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 234 GDIITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEA 313
Cdd:TIGR02089 245 GDILSDLGAALMGSLGVAPSANINPEGKFPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKIMDAIER 324
|
330
....*....|....*.
gi 15610132 314 HLAtrgsERLATSDVG 329
Cdd:TIGR02089 325 VTA----AGILTPDVG 336
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
2-331 |
2.17e-98 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 294.71 E-value: 2.17e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 2 KLAIIAGDGIGPEVTAEAVKVLDAV--VPG---VQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPS-VPS 75
Cdd:PRK08194 5 KIAVIPGDGVGKEVVPAAVRVLKAVaeVHGglkFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKlVPD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 76 GVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVREGTEGPYTGNGGAIRVGtPNEVATEVSVNTAFGV 155
Cdd:PRK08194 85 HISLWGLLIKIRREFEQVINIRPAKQLRGIKSPLANPKDFDLLVVRENSEGEYSEVGGRIHRG-EDEIAIQNAVFTRKGT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 156 RRVVADAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGD 235
Cdd:PRK08194 164 ERAMRYAFELAAKRRKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEFDVIVASNLFGD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 236 IITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHL 315
Cdd:PRK08194 244 ILTDIGAAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLLDVIEDVT 323
|
330
....*....|....*.
gi 15610132 316 AtrgsERLATSDVGER 331
Cdd:PRK08194 324 E----DGIKTPDIGGR 335
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
2-332 |
3.70e-92 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 278.41 E-value: 3.70e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 2 KLAIIAGDGIGPEVTAEAVKVLDAVVP----GVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPS-VPSG 76
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEkaplEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKwDPAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 77 VLERGLLLRLRFELDHHINLRPARLYP--GVASPLSGNP-GIDFVVVREGTEGPYTGNGGAIrVGTPNEVATEVSVNTAF 153
Cdd:pfam00180 81 VRPENGLLALRKELGLFANLRPAKVFPplGDASPLKNEVeGVDIVIVRELTGGIYFGIEKGI-KGSGNEVAVDTKLYSRD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 154 GVRRVVADAFERAR-RRRKHLTLVHKTNVLTFAGgLWLRTVDEVGEC-YPDVEVAYQHVDAATIHMITDPGRFDVIVTDN 231
Cdd:pfam00180 160 EIERIARVAFELARkRGRKKVTSVDKANVLKSSD-LWRKIVTEVAKAeYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 232 LFGDIITDLAAAVCGGIGLAASGNIDATRanPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSH-LGEHDAAARVDRA 310
Cdd:pfam00180 239 LFGDILSDEASMLTGSLGLLPSASLGANG--FGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAA 316
|
330 340 350
....*....|....*....|....*....|
gi 15610132 311 VEAHLAT--------RGSERLATSDVGERI 332
Cdd:pfam00180 317 VLKVLESgirtgdlaGSATYVSTSEFGEAV 346
|
|
| LEU3_arch |
TIGR02088 |
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ... |
3-329 |
2.24e-85 |
|
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.
Pssm-ID: 273962 Cd Length: 322 Bit Score: 260.47 E-value: 2.24e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 3 LAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSVPSgvlERGL 82
Cdd:TIGR02088 1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPANPG---YKSV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 83 LLRLRFELDHHINLRPARLYPGVASpLSGNpGIDFVVVREGTEGPYTGNGgaiRVGtpNEVATEVSVNTAFGVRRVVADA 162
Cdd:TIGR02088 78 IVTLRKELDLYANVRPAKSLPGIPD-LYPN-GKDIVIVRENTEGLYAGFE---FGF--SDRAIAIRVITREGSERIARFA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 163 FERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYpDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLAA 242
Cdd:TIGR02088 151 FNLAKERNRKVTCVHKANVLKGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMFGDILSDLAS 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 243 AVCGGIGLAASGNIDATRAnpsMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLatrgSER 322
Cdd:TIGR02088 230 ALAGSLGLAPSANIGDRKA---LFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEYYI----IEG 302
|
....*..
gi 15610132 323 LATSDVG 329
Cdd:TIGR02088 303 KKTPDLG 309
|
|
| leuB |
TIGR00169 |
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ... |
2-316 |
3.04e-85 |
|
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272939 Cd Length: 346 Bit Score: 260.80 E-value: 3.04e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 2 KLAIIAGDGIGPEVTAEAVKVLDAV--VPGVQKT--SYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDP---SVP 74
Cdd:TIGR00169 1 KIAVLPGDGIGPEVMAQALKVLKAVaeRFGLKFEfeEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPkwdNLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 75 SGVLERGLLLRLRFELDHHINLRPARLYPGV--ASPLSGN--PGIDFVVVREGTEGPYTGNGGAIRVgtpNEVATEVSVN 150
Cdd:TIGR00169 81 RDQRPEQGLLKLRKSLDLFANLRPAKVFPGLedLSPLKEEiaKGVDFVVVRELTGGIYFGEPKGREG---EGEAWDTEVY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 151 TAFGVRRVVADAFERARRRRKHLTLVHKTNVLTfAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTD 230
Cdd:TIGR00169 158 TVPEIERIARVAFEMARKRRKKVTSVDKANVLE-SSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 231 NLFGDIITDLAAAVCGGIGLAASGNIDATRanPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSH-LGEHDAAARVDR 309
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDG--FGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYsFNLEEAADAIEA 314
|
....*..
gi 15610132 310 AVEAHLA 316
Cdd:TIGR00169 315 AVKKVLA 321
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
1-329 |
9.92e-83 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 253.90 E-value: 9.92e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 1 MKLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDpsVPSGVLER 80
Cdd:PRK14025 2 HKICVIEGDGIGKEVVPAALHVLEATGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGE--TAADVIVK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 81 GLLLRlrfelDHHINLRPARLYPGVASPlsgNPGIDFVVVREGTEGPYTGnggaIRVGTPNEVATEVSVNTAFGVRRVVA 160
Cdd:PRK14025 80 LRRIL-----DTYANVRPVKSYKGVKCL---YPDIDYVIVRENTEGLYKG----IEAEIADGVTVATRVITRKASERIFR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 161 DAFERARRR-----RKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGD 235
Cdd:PRK14025 148 FAFEMAKRRkkmgkEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 236 IITDLAAAVCGGIGLAASGNIDATRAnpsMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHL 315
Cdd:PRK14025 228 ILSDGAAGLVGGLGLAPSANIGDKYG---LFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVL 304
|
330
....*....|....
gi 15610132 316 AtrgsERLATSDVG 329
Cdd:PRK14025 305 A----LGLTTPDLG 314
|
|
| AksF2_Meth |
NF040626 |
homoisocitrate dehydrogenase; |
2-329 |
4.97e-82 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468598 Cd Length: 332 Bit Score: 251.96 E-value: 4.97e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 2 KLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGD-PSVPSGVLER 80
Cdd:NF040626 3 KITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTStPGQKSPIITL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 81 GLLLrlrfelDHHINLRPARLYPGVASPlsgNPGIDFVVVREGTEGPYTGNggaIRVGTPnEVATEVSVNTAFGVRRVVA 160
Cdd:NF040626 83 RKEL------DLYANLRPIKSYEGINCL---FKDLDFLIVRENTEGLYSGL---EEEYTE-EKAIAERVITRKASERICK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 161 DAFERARRR-RKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITD 239
Cdd:NF040626 150 FAFEYAIKLgRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDILSD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 240 LAAAVCGGIGLAASGNIDAtraNPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLATRg 319
Cdd:NF040626 230 EAAGLVGGLGLAPSANIGD---KNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREG- 305
|
330
....*....|
gi 15610132 320 seRLATSDVG 329
Cdd:NF040626 306 --KVVTPDLG 313
|
|
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
2-329 |
2.79e-69 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 219.59 E-value: 2.79e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 2 KLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIgdpSVPSGVLERG 81
Cdd:PRK08997 4 TITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPL---TTPVGEGFTS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 82 LLLRLRFELDHHINLRPARLYPGVASPLSGnpgIDFVVVREGTEGPYTGNGGAirVGTPNEVATEVSVNTAFGVRRVVAD 161
Cdd:PRK08997 81 INVTLRKKFDLYANVRPVLSFPGTKARYDN---IDIITVRENTEGMYSGEGQT--VSEDGETAEATSIITRKGAERIVRF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 162 AFERARRR-RKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDL 240
Cdd:PRK08997 156 AYELARKEgRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 241 AAAVCGGIGLAASGNIDATRAnpsMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLATrgS 320
Cdd:PRK08997 236 CAGLVGGLGMAPGANIGRDAA---IFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEA--G 310
|
....*....
gi 15610132 321 ERLaTSDVG 329
Cdd:PRK08997 311 DRT-TRDLG 318
|
|
| AksF_Meth |
NF040619 |
homoisocitrate dehydrogenase; |
1-332 |
1.06e-67 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468591 Cd Length: 332 Bit Score: 215.39 E-value: 1.06e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 1 MKLAIIAGDGIGPEVTAEAVKVLDAVvPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSvPSGVLER 80
Cdd:NF040619 2 PKICVIEGDGIGKEVIPETVRVLKEL-GDFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPK-PTELKNK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 81 GLLL---RLRFELDHHINLRPARLYpgvaSPLSGNPGIDFVVVREGTEGPYTGNGgaiRVGTPNEVATEVSVNTAFGVRR 157
Cdd:NF040619 80 NYKSpilTLRKELDLYANVRPINNF----GDGQDVKNIDFVIIRENTEGLYVGRE---YYDEENEIAIAERIISKKGSER 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 158 VVADAFERARR-RRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQH--VDAATIHMITDPGRFDVIVTDNLFG 234
Cdd:NF040619 153 IIKFAFEYAKKnNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYKNFNIEADDylVDATAMYLIKNPEMFDVIVTTNLFG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 235 DIITDLAAAVCGGIGLAASGNIDATRAnpsMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAH 314
Cdd:NF040619 233 DILSDEASGLIGGLGLAPSANIGDKKG---LFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVKKC 309
|
330 340
....*....|....*....|....*
gi 15610132 315 LATR-------GSerLATSDVGERI 332
Cdd:NF040619 310 LENGkvtpdlgGN--LKTKEVTDKI 332
|
|
| PRK09222 |
PRK09222 |
NADP-dependent isocitrate dehydrogenase; |
2-310 |
1.85e-57 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236416 [Multi-domain] Cd Length: 482 Bit Score: 193.18 E-value: 1.85e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 2 KLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGA---RRFHATGevLPDSVVAELRNHDAILLGAIgdpSVPSGVL 78
Cdd:PRK09222 6 PITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIGEkvyKKGWTSG--ISPSAWESIRRTKVLLKAPI---TTPQGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 79 ERGLLLRLRFELDHHINLRPAR-LYPGVASPlsgNPGIDFVVVREGTEGPYTGnggaIRVGTPNEVATEVSVNTAFGVRR 157
Cdd:PRK09222 81 YKSLNVTLRKTLGLYANVRPCVsYHPFVETK---HPNLDVVIIRENEEDLYAG----IEHRQTPDVYQCLKLISRPGSEK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 158 VVADAFERARRR-RKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDI 236
Cdd:PRK09222 154 IIRYAFEYARANgRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDI 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15610132 237 ITDLAAAVCGGIGLAASGNIDATRAnpsMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRA 310
Cdd:PRK09222 234 LSDIAAEISGSVGLAGSANIGEEYA---MFEAVHGSAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENA 304
|
|
| PLN02329 |
PLN02329 |
3-isopropylmalate dehydrogenase |
3-311 |
5.17e-52 |
|
3-isopropylmalate dehydrogenase
Pssm-ID: 215188 Cd Length: 409 Bit Score: 177.19 E-value: 5.17e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 3 LAIIAGDGIGPEVTAEAVKVLDAVvPGVQKTSYD-----LGARRFHATGEVLPDSVVAELRNHDAILLGAIGD---PSVP 74
Cdd:PLN02329 49 IALLPGDGIGPEVISVAKNVLQKA-GSLEGLEFDfqempVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGykwDKNE 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 75 SGVLERGLLLRLRFELDHHINLRPARLYPGV--ASPLSGN--PGIDFVVVREGTEGPYTGNGGAIRVgtpNEVATEVSVN 150
Cdd:PLN02329 128 KHLRPEMALFYLRRDLKVFANLRPATVLPQLvdASTLKKEvaEGVDMMIVRELTGGIYFGEPRGITI---NENGEEVGVS 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 151 T----AFGVRRVVADAFERARRRRKHLTLVHKTNVLTfAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDV 226
Cdd:PLN02329 205 TeiyaAHEIDRIARVAFETARKRRGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDT 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 227 IVTDNLFGDIITDLAAAVCGGIGLAASGNIDATraNPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSH-LGEHDAAA 305
Cdd:PLN02329 284 IVTNNIFGDILSDEASMITGSIGMLPSASLGES--GPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAK 361
|
....*.
gi 15610132 306 RVDRAV 311
Cdd:PLN02329 362 RIEDAV 367
|
|
| ICDH_alpha |
TIGR02924 |
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ... |
2-310 |
5.15e-46 |
|
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]
Pssm-ID: 274353 [Multi-domain] Cd Length: 473 Bit Score: 162.62 E-value: 5.15e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 2 KLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFH---ATGevLPDSVVAELRNHDAILLGAIgdpSVPSGVL 78
Cdd:TIGR02924 2 PITVAYGDGIGPEIMEAVLLILKEAEAPIDIETIEIGEKVYKkgwPSG--ISPSSWESIRRTKVLLKAPI---TTPQGGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 79 ERGLLLRLRFELDHHINLRPARLYPGVASPLSgnPGIDFVVVREGTEGPYTGnggaIRVGTPNEVATEVSVNTAFGVRRV 158
Cdd:TIGR02924 77 HKSLNVTLRKTLGLYANIRPCVSYHPFIETKS--PNLNIVIVRENEEDLYTG----IEYRQTPDTYECTKLITRSGSEKI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 159 VADAFERARRR-RKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDII 237
Cdd:TIGR02924 151 CRYAFEYARKHnRKKVTCLTKDNIMKMTDGIFHKIFDKIAAEYPDIESEHYIVDIGMARLATNPENFDVIVTPNLYGDIL 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15610132 238 TDLAAAVCGGIGLAASGNIDATRAnpsMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRA 310
Cdd:TIGR02924 231 SDVAAEISGSVGLAGSANIGEEYA---MFEAVHGSAPDIAGQNIANPSGLLNAAIQMLVHIGQSDIAQLIYNA 300
|
|
| PLN00118 |
PLN00118 |
isocitrate dehydrogenase (NAD+) |
8-329 |
1.58e-44 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062 Cd Length: 372 Bit Score: 156.19 E-value: 1.58e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 8 GDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLP-DSVVAELRNHdailLGAIGDPSVPSGVLERGLLLRL 86
Cdd:PLN00118 49 GDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTTVDPRTGSFLTwESLESVRRNK----VGLKGPMATPIGKGHRSLNLTL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 87 RFELDHHINLRPARLYPGVASPLSGnpgIDFVVVREGTEGPYTGNGGAIRVGtpneVATEVSVNTAFGVRRVVADAFERA 166
Cdd:PLN00118 125 RKELGLYANVRPCYSLPGYKTRYDD---VDLVTIRENTEGEYSGLEHQVVRG----VVESLKIITRQASLRVAEYAFHYA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 167 RRR-RKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLAAAVC 245
Cdd:PLN00118 198 KTHgRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 246 GGIGLAASGNIDatRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVeahLATRGSERLAT 325
Cdd:PLN00118 278 GGLGLTPSCNIG--ENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAI---LNTIAEGKYRT 352
|
....
gi 15610132 326 SDVG 329
Cdd:PLN00118 353 ADLG 356
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
6-336 |
8.20e-42 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 149.88 E-value: 8.20e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 6 IAGDGIGPEVTAEAVKVLDAvvpGVQKT----------SYDLGARRFHATGEVLPDSVVAELRNHD-AI----------- 63
Cdd:COG0538 24 IEGDGIGPEITRAIWKVIDA---AVEKAyggkrdiewkEVDAGEKARDETGDWLPDETAEAIKEYGvGIkgplttpvggg 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 64 ---LLGAIgdpsvpsgvlerglllrlRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVREGTEGPYTGnggaI--RVG 138
Cdd:COG0538 101 wrsLNVTI------------------RQILDLYVCRRPVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAG----IewKAG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 139 TPnEVAT---------EVSVN-------------TAFGVRRVVADAFERA-RRRRKHLTLVHKTNVL------------- 182
Cdd:COG0538 159 SP-EALKliffledemGVTVIrfpedsgigikpvSDEGTERLVRAAIQYAlDNKRKSVTLVHKGNIMkftegafkdwgye 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 183 ---------TFAGGLWLRTVDEVgecyPDVEVAYQHV--DAATIHMITDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLA 251
Cdd:COG0538 238 vaeeefgdkFITEGPWEKYKGPK----PAGKIVYKDRiaDDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 252 ASGNI-DATRAnpsMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEA-----------HLATRG 319
Cdd:COG0538 314 PGANIgDDGGA---EFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKtiesgkvtydlARLMEG 390
|
410
....*....|....*..
gi 15610132 320 SERLATSDVGERIAAAL 336
Cdd:COG0538 391 ATELSTSEFGDAIIENL 407
|
|
| PRK06451 |
PRK06451 |
NADP-dependent isocitrate dehydrogenase; |
6-328 |
1.47e-39 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803 Cd Length: 412 Bit Score: 144.20 E-value: 1.47e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 6 IAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDL-------GARRFHATGEVLPDSVVAELRNHDAILLGAIgdpSVPSGVL 78
Cdd:PRK06451 29 VEGDGIGPEITHAAMKVINKAVEKAYGSDREIkwvevlaGDKAEKLTGNRFPKESEELIEKYRVLLKGPL---ETPIGKG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 79 ERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVREGTEGPYTG--------NGGAIRVGTPNEVATEVSVN 150
Cdd:PRK06451 106 WKSINVAIRLMLDLYANIRPVKYIPGIESPLKNPEKIDLIIFRENTDDLYRGieypydseEAKKIRDFLRKELGVEVEDD 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 151 TAFGVRRVVADAFERARR---------RRKHLTLVHKTNVLTFAGGL---W------------LRTVDEVGECYPDVEVA 206
Cdd:PRK06451 186 TGIGIKLISKFKTQRIARmaikyaidhKRKKVTIMHKGNVMKYTEGAfreWayevalkefrdyVVTEEEVTKNYNGVPPS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 207 YQHV------DAATIHMITDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLAASGNIDATRAnpsMFEPVHGSAPDIAGQG 280
Cdd:PRK06451 266 GKVIindriaDNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGG---MFEAIHGTAPKYAGKN 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15610132 281 IADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLatrgSERLATSDV 328
Cdd:PRK06451 343 VANPTGIIKGGELMLRFMGWDKAADLIDKAIMESI----KQKKVTQDL 386
|
|
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
5-329 |
1.50e-37 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 137.69 E-value: 1.50e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 5 IIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDlgarrFHATGEVLPDSVVAELRNHDAILLGAIgdpSVPSGVLERGLLL 84
Cdd:PLN00123 35 LIPGDGIGPLVTGAVEQVMEAMHAPVYFERYE-----VHGDMKKVPEEVLESIRRNKVCLKGGL---ATPVGGGVSSLNV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 85 RLRFELDHHINLRPARLYPGVASPLSGnpgIDFVVVREGTEGPYTGNGGAIRVGtpneVATEVSVNTAFGVRRVVADAFE 164
Cdd:PLN00123 107 QLRKELDLFASLVNCFNLPGLPTRHEN---VDIVVIRENTEGEYSGLEHEVVPG----VVESLKVITKFCSERIAKYAFE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 165 RAR-RRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLAAA 243
Cdd:PLN00123 180 YAYlNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAG 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 244 VCGGIGLAASGNIDATRAnpsMFEPVHGSA----PDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLAtRG 319
Cdd:PLN00123 260 IAGGTGVMPGGNVGADHA---VFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIA-EG 335
|
330
....*....|
gi 15610132 320 SERlaTSDVG 329
Cdd:PLN00123 336 KYR--TKDLG 343
|
|
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
6-318 |
1.53e-35 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 133.26 E-value: 1.53e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 6 IAGDGIGPEVTAEAVKVLDAVVP----GVQKTSYD---LGARRFHATGEV--LPDSVVAELRNHdailLGAIGDP-SVPS 75
Cdd:PRK07006 25 IEGDGIGPDITPAMLKVVDAAVEkaykGERKISWMeiyAGEKATKVYGEDvwLPEETLDLIREY----RVAIKGPlTTPV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 76 GVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVREGTEGPYTG-------------------NGGAIR 136
Cdd:PRK07006 101 GGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGiewkagsaeakkvikflqeEMGVKK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 137 VGTPNEVATEVSVNTAFGVRRVVADAFERA-RRRRKHLTLVHKTNVLTFA----------------------GGLWLRTV 193
Cdd:PRK07006 181 IRFPETSGIGIKPVSEEGTERLVRAAIEYAiDNDRKSVTLVHKGNIMKFTegafkdwgyqlaeeefgdelidGGPWDKIK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 194 DEvgECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLAASGNIDATRAnpsMFEPVHGSA 273
Cdd:PRK07006 261 NP--ETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHA---IFEATHGTA 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15610132 274 PDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLATR 318
Cdd:PRK07006 336 PKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASK 380
|
|
| PRK07362 |
PRK07362 |
NADP-dependent isocitrate dehydrogenase; |
6-318 |
4.07e-16 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 180944 Cd Length: 474 Bit Score: 78.99 E-value: 4.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 6 IAGDGIGPEVTAEAVKVLDAVVpgvqKTSYDlGARRFH--------------ATGEVLPDSVVAELRNHDAillgAIGDP 71
Cdd:PRK07362 34 IRGDGTGVDIWPATQKVLDAAV----AKAYG-GERKINwfkvyagdeacdlyGTYQYLPEDTLEAIREYGV----AIKGP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 72 -SVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVREGTEGPYTG------NGGAIRV------- 137
Cdd:PRK07362 105 lTTPIGGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIYMGieweagDEIGDKLikhlnee 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 138 ---GTPNEVATEVSVNTAFGVR--------RVVADAFERARR---RRKHLTLVHKTNVLTFAGGL---W---LRTVDEVG 197
Cdd:PRK07362 185 vipASPELGKRQIPLGSGIGIKpvsktgsqRHIRRAIEHALRlpgDKRHVTLVHKGNIMKYTEGAfrdWgyeLATTEFRD 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 198 ECY--------------PD---------VEVAY------------QHVDA--ATIH------------MITD-------- 220
Cdd:PRK07362 265 ECVtereswilsnkeknPNisiednarmIEPGYdsltpekkaaicAEVKEvlDSIWsshgngkwkekvLVDDriadsifq 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610132 221 -----PGRFDVIVTDNLFGDIITDLAAAVCGGIGLAASGNIDATRAnpsMFEPVHGSAPDIAGQGIADPTAAIMSVALLL 295
Cdd:PRK07362 345 qiqtrPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAA---IFEATHGTAPKHAGLDRINPGSVILSGVMML 421
|
410 420
....*....|....*....|...
gi 15610132 296 SHLGEHDAAARVDRAVEAHLATR 318
Cdd:PRK07362 422 EYLGWQEAADLITKGLSAAIANK 444
|
|
| pdxA |
PRK02746 |
4-hydroxythreonine-4-phosphate dehydrogenase PdxA; |
268-297 |
3.21e-03 |
|
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
Pssm-ID: 235066 Cd Length: 345 Bit Score: 38.73 E-value: 3.21e-03
10 20 30
....*....|....*....|....*....|...
gi 15610132 268 PVHGSAPDIAGQGIADPT---AAImSVALLLSH 297
Cdd:PRK02746 310 PDHGTAFDIAGKGIARPQsmkAAI-KLAWELSK 341
|
|
| |
