NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15609081|ref|NP_216460|]
View 

hypothetical protein Rv1944c [Mycobacterium tuberculosis H37Rv]

Protein Classification

SEC-C domain-containing protein( domain architecture ID 10500433)

SEC-C domain-containing protein may bind zinc

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SEC-C pfam02810
SEC-C motif; The SEC-C motif found in the C-terminus of the SecA protein, in the middle of ...
 168-185 6.72e-08

SEC-C motif; The SEC-C motif found in the C-terminus of the SecA protein, in the middle of some SWI2 ATPases and also solo in several proteins. The motif is predicted to chelate zinc with the CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain.


:

Pssm-ID: 460704 [Multi-domain]  Cd Length: 19  Bit Score: 46.70  E-value: 6.72e-08
                          10
                  ....*....|....*...
gi 15609081   168 RNQQCWCGSGHKYKKCCA 185
Cdd:pfam02810   1 RNDPCPCGSGKKYKKCCG 18
SecA super family cl43225
Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking, ...
 135-188 6.13e-07

Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG0653:

Pssm-ID: 440418 [Multi-domain]  Cd Length: 876  Bit Score: 48.87  E-value: 6.13e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609081 135 EQGQEPDSPEARAEYAAYLTAHGDHDVMAWP------PGRNQQCWCGSGHKYKKCCAAAS 188
Cdd:COG0653 817 SEEEREEVEEERRENHADPAGEEEEEAPKQPvrkgpkVGRNDPCPCGSGKKYKHCHGKLA 876
 
Name Accession Description Interval E-value
SEC-C pfam02810
SEC-C motif; The SEC-C motif found in the C-terminus of the SecA protein, in the middle of ...
 168-185 6.72e-08

SEC-C motif; The SEC-C motif found in the C-terminus of the SecA protein, in the middle of some SWI2 ATPases and also solo in several proteins. The motif is predicted to chelate zinc with the CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain.


Pssm-ID: 460704 [Multi-domain]  Cd Length: 19  Bit Score: 46.70  E-value: 6.72e-08
                          10
                  ....*....|....*...
gi 15609081   168 RNQQCWCGSGHKYKKCCA 185
Cdd:pfam02810   1 RNDPCPCGSGKKYKKCCG 18
SWIM_PBPRA1643 TIGR04102
SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Members of this protein family have ...
 166-185 1.68e-07

SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Members of this protein family have a SWIM, or SEC-C, domain (see pfam02810), a 21-amino acid putative Zn-binding domain that is shared with SecA, plant MuDR transposases, etc. This small protein family of unknown function occurs primarily in marine bacteria.


Pssm-ID: 200353 [Multi-domain]  Cd Length: 108  Bit Score: 47.69  E-value: 1.68e-07
                          10        20
                  ....*....|....*....|
gi 15609081   166 PGRNQQCWCGSGHKYKKCCA 185
Cdd:TIGR04102  89 PNRNDPCPCGSGKKYKKCCG 108
SecA COG0653
Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking, ...
 135-188 6.13e-07

Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440418 [Multi-domain]  Cd Length: 876  Bit Score: 48.87  E-value: 6.13e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609081 135 EQGQEPDSPEARAEYAAYLTAHGDHDVMAWP------PGRNQQCWCGSGHKYKKCCAAAS 188
Cdd:COG0653 817 SEEEREEVEEERRENHADPAGEEEEEAPKQPvrkgpkVGRNDPCPCGSGKKYKHCHGKLA 876
PRK05590 PRK05590
hypothetical protein; Provisional
 167-184 3.38e-06

hypothetical protein; Provisional


Pssm-ID: 235521  Cd Length: 166  Bit Score: 45.35  E-value: 3.38e-06
                         10
                 ....*....|....*...
gi 15609081  167 GRNQQCWCGSGHKYKKCC 184
Cdd:PRK05590 146 GRNDPCPCGSGKKYKKCC 163
PRK01617 PRK01617
hypothetical protein; Provisional
 134-184 1.22e-05

hypothetical protein; Provisional


Pssm-ID: 234966  Cd Length: 154  Bit Score: 43.48  E-value: 1.22e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15609081  134 AEQGQEPDspEARAEYAAYLTAHGDHDVMA-------------W--------PPGRNQQCWCGSGHKYKKCC 184
Cdd:PRK01617  83 HTWGDADN--EGFVEFVARFTEGGKTGRTAiiersrflkengqWyyidgtrpQFGRNDPCPCGSGKKFKKCC 152
YecA COG3318
Uncharacterized conserved protein YecA, UPF0149 family, contains C-terminal Zn-binding SEC-C ...
 166-186 1.32e-05

Uncharacterized conserved protein YecA, UPF0149 family, contains C-terminal Zn-binding SEC-C motif [Function unknown];


Pssm-ID: 442547 [Multi-domain]  Cd Length: 45  Bit Score: 41.04  E-value: 1.32e-05
                        10        20
                ....*....|....*....|.
gi 15609081 166 PGRNQQCWCGSGHKYKKCCAA 186
Cdd:COG3318  24 VGRNDPCPCGSGKKYKKCCGA 44
 
Name Accession Description Interval E-value
SEC-C pfam02810
SEC-C motif; The SEC-C motif found in the C-terminus of the SecA protein, in the middle of ...
 168-185 6.72e-08

SEC-C motif; The SEC-C motif found in the C-terminus of the SecA protein, in the middle of some SWI2 ATPases and also solo in several proteins. The motif is predicted to chelate zinc with the CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain.


Pssm-ID: 460704 [Multi-domain]  Cd Length: 19  Bit Score: 46.70  E-value: 6.72e-08
                          10
                  ....*....|....*...
gi 15609081   168 RNQQCWCGSGHKYKKCCA 185
Cdd:pfam02810   1 RNDPCPCGSGKKYKKCCG 18
SWIM_PBPRA1643 TIGR04102
SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Members of this protein family have ...
 166-185 1.68e-07

SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Members of this protein family have a SWIM, or SEC-C, domain (see pfam02810), a 21-amino acid putative Zn-binding domain that is shared with SecA, plant MuDR transposases, etc. This small protein family of unknown function occurs primarily in marine bacteria.


Pssm-ID: 200353 [Multi-domain]  Cd Length: 108  Bit Score: 47.69  E-value: 1.68e-07
                          10        20
                  ....*....|....*....|
gi 15609081   166 PGRNQQCWCGSGHKYKKCCA 185
Cdd:TIGR04102  89 PNRNDPCPCGSGKKYKKCCG 108
SecA COG0653
Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking, ...
 135-188 6.13e-07

Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440418 [Multi-domain]  Cd Length: 876  Bit Score: 48.87  E-value: 6.13e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609081 135 EQGQEPDSPEARAEYAAYLTAHGDHDVMAWP------PGRNQQCWCGSGHKYKKCCAAAS 188
Cdd:COG0653 817 SEEEREEVEEERRENHADPAGEEEEEAPKQPvrkgpkVGRNDPCPCGSGKKYKHCHGKLA 876
PRK05590 PRK05590
hypothetical protein; Provisional
 167-184 3.38e-06

hypothetical protein; Provisional


Pssm-ID: 235521  Cd Length: 166  Bit Score: 45.35  E-value: 3.38e-06
                         10
                 ....*....|....*...
gi 15609081  167 GRNQQCWCGSGHKYKKCC 184
Cdd:PRK05590 146 GRNDPCPCGSGKKYKKCC 163
PRK01617 PRK01617
hypothetical protein; Provisional
 134-184 1.22e-05

hypothetical protein; Provisional


Pssm-ID: 234966  Cd Length: 154  Bit Score: 43.48  E-value: 1.22e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15609081  134 AEQGQEPDspEARAEYAAYLTAHGDHDVMA-------------W--------PPGRNQQCWCGSGHKYKKCC 184
Cdd:PRK01617  83 HTWGDADN--EGFVEFVARFTEGGKTGRTAiiersrflkengqWyyidgtrpQFGRNDPCPCGSGKKFKKCC 152
YecA COG3318
Uncharacterized conserved protein YecA, UPF0149 family, contains C-terminal Zn-binding SEC-C ...
 166-186 1.32e-05

Uncharacterized conserved protein YecA, UPF0149 family, contains C-terminal Zn-binding SEC-C motif [Function unknown];


Pssm-ID: 442547 [Multi-domain]  Cd Length: 45  Bit Score: 41.04  E-value: 1.32e-05
                        10        20
                ....*....|....*....|.
gi 15609081 166 PGRNQQCWCGSGHKYKKCCAA 186
Cdd:COG3318  24 VGRNDPCPCGSGKKYKKCCGA 44
PRK02250 PRK02250
hypothetical protein; Provisional
 167-184 2.95e-04

hypothetical protein; Provisional


Pssm-ID: 179393 [Multi-domain]  Cd Length: 166  Bit Score: 39.86  E-value: 2.95e-04
                         10
                 ....*....|....*...
gi 15609081  167 GRNQQCWCGSGHKYKKCC 184
Cdd:PRK02250 148 GRNDPCICGSGKKFKKCC 165
PRK10396 PRK10396
hypothetical protein; Provisional
 143-184 5.29e-04

hypothetical protein; Provisional


Pssm-ID: 236680 [Multi-domain]  Cd Length: 221  Bit Score: 39.34  E-value: 5.29e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 15609081  143 PEARAEYAaYLTAHGDHDVMAWP------PGRNQQCWCGSGHKYKKCC 184
Cdd:PRK10396 173 PAALALHA-YWMAHPQEKAVQQPikaeekVGRNDPCPCGSGKKFKQCC 219
PRK00183 PRK00183
hypothetical protein; Provisional
 167-187 9.14e-04

hypothetical protein; Provisional


Pssm-ID: 166842  Cd Length: 157  Bit Score: 38.24  E-value: 9.14e-04
                         10        20
                 ....*....|....*....|.
gi 15609081  167 GRNQQCWCGSGHKYKKCCAAA 187
Cdd:PRK00183 135 GRNDPCPCGSGQKFKKCCAPY 155
PRK12318 PRK12318
methionyl aminopeptidase;
167-183 2.30e-03

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 37.88  E-value: 2.30e-03
                         10
                 ....*....|....*..
gi 15609081  167 GRNQQCWCGSGHKYKKC 183
Cdd:PRK12318   2 KRNDPCWCGSGKKWKHC 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH