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Conserved domains on  [gi|15608873|ref|NP_216251|]
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membrane protein [Mycobacterium tuberculosis H37Rv]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TDT super family cl04176
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 1-116 5.69e-35

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).


The actual alignment was detected with superfamily member cd09319:

Pssm-ID: 470964  Cd Length: 317  Bit Score: 123.96  E-value: 5.69e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608873   1 MGATAITVLAGAHIVEMADAPMAIV-TSGLVAGASVVFWAFGPWLIPPLVAASIWKHVVHRVPLRYEATLWSVVFPLGMY 79
Cdd:cd09319 201 MGALAISTLAGAKLILAASASPFLAdLRPFLKGTTLLLWAAATWWIPLLVALGIWRHVVHRIPLRYDPLRWSTVFPLGMY 280

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15608873  80 GVGAYRLGLAAHLPIVESIGEFEGWVALAVWTITFVA 116
Cdd:cd09319 281 AAATLALARALGLPWLMAIGRVFLWVALAAWLLVFVG 317
 
Name Accession Description Interval E-value
TDT_like_1 cd09319
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 1-116 5.69e-35

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).


Pssm-ID: 187759  Cd Length: 317  Bit Score: 123.96  E-value: 5.69e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608873   1 MGATAITVLAGAHIVEMADAPMAIV-TSGLVAGASVVFWAFGPWLIPPLVAASIWKHVVHRVPLRYEATLWSVVFPLGMY 79
Cdd:cd09319 201 MGALAISTLAGAKLILAASASPFLAdLRPFLKGTTLLLWAAATWWIPLLVALGIWRHVVHRIPLRYDPLRWSTVFPLGMY 280

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15608873  80 GVGAYRLGLAAHLPIVESIGEFEGWVALAVWTITFVA 116
Cdd:cd09319 281 AAATLALARALGLPWLMAIGRVFLWVALAAWLLVFVG 317
TehA COG1275
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
1-122 2.27e-11

Tellurite resistance protein TehA and related permeases [Defense mechanisms];


Pssm-ID: 440886  Cd Length: 323  Bit Score: 60.64  E-value: 2.27e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608873   1 MGATAITVLAGAhivemadapmaIVTSGLVAGASVVFWAFGPWLIPpLVAASIWKHVvhrvPLRYEATLWSVVFPLGMYG 80
Cdd:COG1275 209 LAPPAVGLLAYL-----------ALGGGPLDGFALILWGFGLWWLL-LLLLLTPRLL----RLPFSPSWWAFTFPLAAYA 272

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15608873  81 VGAYRLGLAAHLPIVESIGEFEGWVALAVWTITFVAMLHHLA 122
Cdd:COG1275 273 TATLRLAEATGLPFLAVLALALLVLATLVWLYVLVRTLRALA 314
SLAC1 pfam03595
Voltage-dependent anion channel; This family of transporters has ten alpha helical ...
 1-109 3.51e-06

Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.


Pssm-ID: 460983  Cd Length: 321  Bit Score: 45.69  E-value: 3.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608873     1 MGATAITVLAGA--HIVEMADAPMAIVTSGLVAGASVVFWAFGPWLIppLVAASIWKHVVHRVPLRYEATLWSVVFPLGM 78
Cdd:pfam03595 213 QGALALLLLGGAapTILPALTALAGEILYVVALLLALFLWGFGLWWF--FIAALSVLSALRRGGLPFNLGWWAFTFPLGA 290

                          90       100       110
                  ....*....|....*....|....*....|.
gi 15608873    79 YGVGAYRLGLAAHLPIVESIGEFEGWVALAV 109
Cdd:pfam03595 291 FALATIELGKALDSPFFRVLGTILSVLLVLV 321
 
Name Accession Description Interval E-value
TDT_like_1 cd09319
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 1-116 5.69e-35

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).


Pssm-ID: 187759  Cd Length: 317  Bit Score: 123.96  E-value: 5.69e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608873   1 MGATAITVLAGAHIVEMADAPMAIV-TSGLVAGASVVFWAFGPWLIPPLVAASIWKHVVHRVPLRYEATLWSVVFPLGMY 79
Cdd:cd09319 201 MGALAISTLAGAKLILAASASPFLAdLRPFLKGTTLLLWAAATWWIPLLVALGIWRHVVHRIPLRYDPLRWSTVFPLGMY 280

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15608873  80 GVGAYRLGLAAHLPIVESIGEFEGWVALAVWTITFVA 116
Cdd:cd09319 281 AAATLALARALGLPWLMAIGRVFLWVALAAWLLVFVG 317
TehA COG1275
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
1-122 2.27e-11

Tellurite resistance protein TehA and related permeases [Defense mechanisms];


Pssm-ID: 440886  Cd Length: 323  Bit Score: 60.64  E-value: 2.27e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608873   1 MGATAITVLAGAhivemadapmaIVTSGLVAGASVVFWAFGPWLIPpLVAASIWKHVvhrvPLRYEATLWSVVFPLGMYG 80
Cdd:COG1275 209 LAPPAVGLLAYL-----------ALGGGPLDGFALILWGFGLWWLL-LLLLLTPRLL----RLPFSPSWWAFTFPLAAYA 272

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15608873  81 VGAYRLGLAAHLPIVESIGEFEGWVALAVWTITFVAMLHHLA 122
Cdd:COG1275 273 TATLRLAEATGLPFLAVLALALLVLATLVWLYVLVRTLRALA 314
TDT_like_3 cd09321
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 1-115 5.63e-07

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).


Pssm-ID: 187761  Cd Length: 327  Bit Score: 47.68  E-value: 5.63e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608873   1 MGATAITVLAGAHIVEMADAPMAIVTSGLVAGASVVFWAFGPWLIppLVAASIWKHVVHRVPLRYEATLWSVVFPLGMYG 80
Cdd:cd09321 212 LAPIGAGVVALINLVKALPFAGLENLVDLANIFALILWGFGLWWL--ILAVLLTLYYLKRGNLPFSLGWWAFIFPLGAYT 289

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15608873  81 VGAYRLGLAAHLPIVESIGEFEGWVALAVWTITFV 115
Cdd:cd09321 290 IATYLVAKVLNFSFLSGLGIFLYWLLLILWAITLF 324
SLAC1 pfam03595
Voltage-dependent anion channel; This family of transporters has ten alpha helical ...
 1-109 3.51e-06

Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.


Pssm-ID: 460983  Cd Length: 321  Bit Score: 45.69  E-value: 3.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608873     1 MGATAITVLAGA--HIVEMADAPMAIVTSGLVAGASVVFWAFGPWLIppLVAASIWKHVVHRVPLRYEATLWSVVFPLGM 78
Cdd:pfam03595 213 QGALALLLLGGAapTILPALTALAGEILYVVALLLALFLWGFGLWWF--FIAALSVLSALRRGGLPFNLGWWAFTFPLGA 290

                          90       100       110
                  ....*....|....*....|....*....|.
gi 15608873    79 YGVGAYRLGLAAHLPIVESIGEFEGWVALAV 109
Cdd:pfam03595 291 FALATIELGKALDSPFFRVLGTILSVLLVLV 321
TDT cd09299
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 1-110 3.14e-05

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).


Pssm-ID: 187756  Cd Length: 326  Bit Score: 42.70  E-value: 3.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608873   1 MGATAITVLAGAhiVEMADAPMAIVTSGLVAGASVVFWAFGPWLIPPLVAASIWKHVVHrvpLRYEATLWSVVFPLGMYG 80
Cdd:cd09299 218 QSIFALLLLGKN--ARLIFFLYASFLQALAVFASIILWGFGLWWLLLALVSILRTLRKK---LPFSLGWWSYVFPLGVYT 292

                        90       100       110
                ....*....|....*....|....*....|
gi 15608873  81 VGAYRLGLAAHLPIVESIGEFEGWVALAVW 110
Cdd:cd09299 293 NGTYALYKLMDLPAFSIFATILLIILVALW 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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