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Conserved domains on  [gi|15608653|ref|NP_216031|]
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hypothetical protein Rv1515c [Mycobacterium tuberculosis H37Rv]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11454890)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 44-169 6.09e-16

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 72.74  E-value: 6.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653  44 SRTLDESSWFISARGILETVFPGDKSHLrlaDVGCLEGGYAVGFARMGFQVLGIEVRElnmAACNYIKSKTNLPNLRFVH 123
Cdd:COG2227   2 SDPDARDFWDRRLAALLARLLPAGGRVL---DVGCGTGRLALALARRGADVTGVDISP---EALEIARERAAELNVDFVQ 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15608653 124 DNALNIA-NHGLFDTVFCCGLFYHLENPKQYLETLSSVTNK--LLILQT 169
Cdd:COG2227  76 GDLEDLPlEDGSFDLVICSEVLEHLPDPAALLRELARLLKPggLLLLST 124
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 44-169 6.09e-16

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 72.74  E-value: 6.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653  44 SRTLDESSWFISARGILETVFPGDKSHLrlaDVGCLEGGYAVGFARMGFQVLGIEVRElnmAACNYIKSKTNLPNLRFVH 123
Cdd:COG2227   2 SDPDARDFWDRRLAALLARLLPAGGRVL---DVGCGTGRLALALARRGADVTGVDISP---EALEIARERAAELNVDFVQ 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15608653 124 DNALNIA-NHGLFDTVFCCGLFYHLENPKQYLETLSSVTNK--LLILQT 169
Cdd:COG2227  76 GDLEDLPlEDGSFDLVICSEVLEHLPDPAALLRELARLLKPggLLLLST 124
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 75-155 3.58e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 50.36  E-value: 3.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653    75 DVGCLEGGYAVGFARMGFQVLGIEVRELNMAACnyiKSKTNLPNLRFVHDNALNIA-NHGLFDTVFCCGLFYHLENPKQY 153
Cdd:pfam08241   2 DVGCGTGLLTELLARLGARVTGVDISPEMLELA---REKAPREGLTFVVGDAEDLPfPDNSFDLVLSSEVLHHVEDPERA 78


                  ..
gi 15608653   154 LE 155
Cdd:pfam08241  79 LR 80
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 72-163 8.01e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.18  E-value: 8.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653  72 RLADVGCLEGGYAVGFAR-MGFQVLGIEVRELNMAACNYIKSKTNLPNLRFVHDNALNI--ANHGLFDTVFCCGLFYHL- 147
Cdd:cd02440   1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELppEADESFDVIISDPPLHHLv 80

                        90
                ....*....|....*.
gi 15608653 148 ENPKQYLETLSSVTNK 163
Cdd:cd02440  81 EDLARFLEEARRLLKP 96
trmB PRK00121
tRNA (guanine-N(7)-)-methyltransferase; Reviewed
 53-132 2.53e-03

tRNA (guanine-N(7)-)-methyltransferase; Reviewed


Pssm-ID: 234649  Cd Length: 202  Bit Score: 38.22  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653   53 FISARGILETVFPGDKS-HLrlaDVGCLEGGYAVGFARM----GFqvLGIEVRELNMAACNYIKSKTNLPNLRFVHDNAL 127
Cdd:PRK00121  26 LSPAPLDWAELFGNDAPiHL---EIGFGKGEFLVEMAKAnpdiNF--IGIEVHEPGVGKALKKIEEEGLTNLRLLCGDAV 100


                 ....*
gi 15608653  128 NIANH 132
Cdd:PRK00121 101 EVLLD 105
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 44-169 6.09e-16

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 72.74  E-value: 6.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653  44 SRTLDESSWFISARGILETVFPGDKSHLrlaDVGCLEGGYAVGFARMGFQVLGIEVRElnmAACNYIKSKTNLPNLRFVH 123
Cdd:COG2227   2 SDPDARDFWDRRLAALLARLLPAGGRVL---DVGCGTGRLALALARRGADVTGVDISP---EALEIARERAAELNVDFVQ 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15608653 124 DNALNIA-NHGLFDTVFCCGLFYHLENPKQYLETLSSVTNK--LLILQT 169
Cdd:COG2227  76 GDLEDLPlEDGSFDLVICSEVLEHLPDPAALLRELARLLKPggLLLLST 124
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 75-155 3.58e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 50.36  E-value: 3.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653    75 DVGCLEGGYAVGFARMGFQVLGIEVRELNMAACnyiKSKTNLPNLRFVHDNALNIA-NHGLFDTVFCCGLFYHLENPKQY 153
Cdd:pfam08241   2 DVGCGTGLLTELLARLGARVTGVDISPEMLELA---REKAPREGLTFVVGDAEDLPfPDNSFDLVLSSEVLHHVEDPERA 78


                  ..
gi 15608653   154 LE 155
Cdd:pfam08241  79 LR 80
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 66-160 4.86e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 48.45  E-value: 4.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653  66 GDKSHLRLADVGCLEGGYAVGFARMGFQVLGIEVRELNMAACNyIKSKTNLPNLRFVHDNA--LNIANHGlFDTVFCCGL 143
Cdd:COG2226  19 GLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELAR-ERAAEAGLNVEFVVGDAedLPFPDGS-FDLVISSFV 96

                        90
                ....*....|....*..
gi 15608653 144 FYHLENPKQYLETLSSV 160
Cdd:COG2226  97 LHHLPDPERALAEIARV 113
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
72-157 1.53e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 45.97  E-value: 1.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653  72 RLADVGCLEGGYAVGFARM--GFQVLGIEVRElNMAAcnyiKSKTNLPNLRFVHDNALNIANHGLFDTVFCCGLFYHLEN 149
Cdd:COG4106   4 RVLDLGCGTGRLTALLAERfpGARVTGVDLSP-EMLA----RARARLPNVRFVVADLRDLDPPEPFDLVVSNAALHWLPD 78


                ....*...
gi 15608653 150 PKQYLETL 157
Cdd:COG4106  79 HAALLARL 86
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 60-164 2.12e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 47.60  E-value: 2.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653  60 LETVFPGDKSHLRLADVGCLEGGYAVGFA-RMGFQVLGIEVRELNMAACNYIKSKTNLPNLRFVHDNALNI--ANHGLFD 136
Cdd:COG0500  17 LLALLERLPKGGRVLDLGCGTGRNLLALAaRFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELdpLPAESFD 96

                        90       100
                ....*....|....*....|....*...
gi 15608653 137 TVFCCGLFYHLeNPKQYLETLSSVTNKL 164
Cdd:COG0500  97 LVVAFGVLHHL-PPEEREALLRELARAL 123
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 75-150 3.56e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 44.48  E-value: 3.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653    75 DVGCLEGGYAVGFARM-GFQVLGIEVRE--LNMAACNYIKSKtnlPNLRFVHDNALNIA-NHGLFDTVFCCGLFYHLENP 150
Cdd:pfam13649   3 DLGCGTGRLTLALARRgGARVTGVDLSPemLERARERAAEAG---LNVEFVQGDAEDLPfPDGSFDLVVSSGVLHHLPDP 79
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 65-169 1.06e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 44.54  E-value: 1.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653  65 PGDkshlRLADVGCLEGGYAVGFARM-GFQVLGIEvreLNMAACNYIKSK---TNLPN-LRFVHDNALNIANHGLFDTVF 139
Cdd:COG2230  51 PGM----RVLDIGCGWGGLALYLARRyGVRVTGVT---LSPEQLEYARERaaeAGLADrVEVRLADYRDLPADGQFDAIV 123

                        90       100       110
                ....*....|....*....|....*....|....
gi 15608653 140 CCGLFYHL--ENPKQYLETLSSVTNK--LLILQT 169
Cdd:COG2230 124 SIGMFEHVgpENYPAYFAKVARLLKPggRLLLHT 157
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 56-183 1.09e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 44.73  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653    56 ARGILETVFPGDKSHLRLADVGCLEGGYAVGFARMGFQVLGIEvrelnmaACNYIKSKTNLPNLRFVHDNALNIANHGLF 135
Cdd:pfam13489   9 LADLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVD-------PSPIAIERALLNVRFDQFDEQEAAVPAGKF 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 15608653   136 DTVFCCGLFYHLENPKQYLETLSSVTNK--LLILQTHfsiiNRSDKWLRL 183
Cdd:pfam13489  82 DVIVAREVLEHVPDPPALLRQIAALLKPggLLLLSTP----LASDEADRL 127
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
45-162 6.49e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 39.98  E-value: 6.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653  45 RTLDESSWFISARGILETVFPGdkSHLRLADVGCLEGGYAVGFARMGFQVLGIEVRElNMAAcnyiKSKTNLPNLRFVHD 124
Cdd:COG4976  24 EDLGYEAPALLAEELLARLPPG--PFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSE-EMLA----KAREKGVYDRLLVA 96

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15608653 125 NALNIANH-GLFDTVFCCGLFYHLENPKQYLETLSSVTN 162
Cdd:COG4976  97 DLADLAEPdGRFDLIVAADVLTYLGDLAAVFAGVARALK 135
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 67-185 7.88e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 39.32  E-value: 7.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653    67 DKSHLRLADVGCLEGGYAVGFA-RMGFQ--VLGIEVRELNMAACNYIKSKTNLPNLRFVHDNALNIANH---GLFDTVFC 140
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAeELGPNaeVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELledDKFDVVIS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 15608653   141 CGLFYHLENPKQYLETLSSVTNK--LLILQTHFSIINRSDKWLRLPT 185
Cdd:pfam13847  81 NCVLNHIPDPDKVLQEILRVLKPggRLIISDPDSLAELPAHVKEDST 127
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 72-163 8.01e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.18  E-value: 8.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653  72 RLADVGCLEGGYAVGFAR-MGFQVLGIEVRELNMAACNYIKSKTNLPNLRFVHDNALNI--ANHGLFDTVFCCGLFYHL- 147
Cdd:cd02440   1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELppEADESFDVIISDPPLHHLv 80

                        90
                ....*....|....*.
gi 15608653 148 ENPKQYLETLSSVTNK 163
Cdd:cd02440  81 EDLARFLEEARRLLKP 96
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 72-169 1.10e-03

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 40.08  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653    72 RLADVGCLEGGYAVGFARMGFQ-VLGIEVRELNMaaCNYIKSKTNLPNLRFVHDNALNIANHGL---FDTVFCCGLFYHL 147
Cdd:pfam08003 118 TILDVGCGNGYHMWRMLGEGAAmVVGIDPSELFL--CQFEAVRKLLGNDQRAHLLPLGIEQLPAlaaFDTVFSMGVLYHR 195

                          90       100
                  ....*....|....*....|....*..
gi 15608653   148 ENPkqyLETLSSVTNKL-----LILQT 169
Cdd:pfam08003 196 RSP---LDHLLQLKDQLvkggeLVLET 219
trmB PRK00121
tRNA (guanine-N(7)-)-methyltransferase; Reviewed
 53-132 2.53e-03

tRNA (guanine-N(7)-)-methyltransferase; Reviewed


Pssm-ID: 234649  Cd Length: 202  Bit Score: 38.22  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653   53 FISARGILETVFPGDKS-HLrlaDVGCLEGGYAVGFARM----GFqvLGIEVRELNMAACNYIKSKTNLPNLRFVHDNAL 127
Cdd:PRK00121  26 LSPAPLDWAELFGNDAPiHL---EIGFGKGEFLVEMAKAnpdiNF--IGIEVHEPGVGKALKKIEEEGLTNLRLLCGDAV 100


                 ....*
gi 15608653  128 NIANH 132
Cdd:PRK00121 101 EVLLD 105
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 75-160 6.74e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 35.42  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608653    75 DVGCLEGGYAVGFARM--GFQVLGIEVRELNMAACNYIKSKTNLPNLRFVHDNALNIANHGL--FDTVFCCGLFYHLENP 150
Cdd:pfam08242   2 EIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPgsFDVVVASNVLHHLADP 81

                          90
                  ....*....|
gi 15608653   151 KQYLETLSSV 160
Cdd:pfam08242  82 RAVLRNIRRL 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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