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Conserved domains on  [gi|15607510|ref|NP_214883|]
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membrane oxidoreductase [Mycobacterium tuberculosis H37Rv]

Protein Classification

SRPBCC family protein( domain architecture ID 10167525)

SRPBCC (START/RHOalphaC/PITP/Bet v1/CoxG/CalC) family protein may have a deep hydrophobic ligand-binding pocket

CATH:  3.30.530.20
Gene Ontology:  GO:0005488
PubMed:  18922149
SCOP:  3000738

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRPBCC_5 cd07823
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized ...
 1-118 6.42e-50

Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.


:

Pssm-ID: 176865  Cd Length: 146  Bit Score: 157.40  E-value: 6.42e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607510   1 MPGAQLIGHEG-DEYLGKVKVKVGPVTSEFSGKVHFVEQDRNQHRAVFDAKGKEARGTGNAAATVAAQLHEVGERTRVTV 79
Cdd:cd07823  28 LPGASLTEVEGdDEYKGTVKVKLGPISASFKGTARLLEDDEAARRAVLEATGKDARGQGTAEATVTLRLSPAGGGTRVTV 107

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15607510  80 DTDLKIVGKLAQFGSGMLQQVSEKLLGQFVDSLEAELAA 118
Cdd:cd07823 108 DTDLALTGKLAQFGRGGIGDVAGRLLAQFAANLEARLAA 146
 
Name Accession Description Interval E-value
SRPBCC_5 cd07823
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized ...
 1-118 6.42e-50

Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.


Pssm-ID: 176865  Cd Length: 146  Bit Score: 157.40  E-value: 6.42e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607510   1 MPGAQLIGHEG-DEYLGKVKVKVGPVTSEFSGKVHFVEQDRNQHRAVFDAKGKEARGTGNAAATVAAQLHEVGERTRVTV 79
Cdd:cd07823  28 LPGASLTEVEGdDEYKGTVKVKLGPISASFKGTARLLEDDEAARRAVLEATGKDARGQGTAEATVTLRLSPAGGGTRVTV 107

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15607510  80 DTDLKIVGKLAQFGSGMLQQVSEKLLGQFVDSLEAELAA 118
Cdd:cd07823 108 DTDLALTGKLAQFGRGGIGDVAGRLLAQFAANLEARLAA 146
CoxG COG3427
Carbon monoxide dehydrogenase subunit CoxG [Energy production and conversion];
1-117 8.57e-38

Carbon monoxide dehydrogenase subunit CoxG [Energy production and conversion];


Pssm-ID: 442653  Cd Length: 145  Bit Score: 126.51  E-value: 8.57e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607510   1 MPGAQLIGHEGD-EYLGKVKVKVGPVTSEFSGKVHFVEQDRNqHRAVFDAKGKEARGtGNAAATVAAQLHEVGERTRVTV 79
Cdd:COG3427  30 IPGCESLEVVGDtEYEATVKVKVGPVKATFKGEVTLSELDPP-ESYTLTGEGKGGRA-GFAKGTATVTLEPDGGGTRLTY 107

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15607510  80 DTDLKIVGKLAQFGSGMLQQVSEKLLGQFVDSLEAELA 117
Cdd:COG3427 108 DADADVGGKLAQLGRRLIDGVAKKLADQFFENLAAKLE 145
COXG pfam06240
Carbon monoxide dehydrogenase subunit G (CoxG); The CO dehydrogenase structural genes coxMSL ...
 2-117 1.24e-12

Carbon monoxide dehydrogenase subunit G (CoxG); The CO dehydrogenase structural genes coxMSL are flanked by nine accessory genes arranged as the cox gene cluster. The cox genes are specifically and coordinately transcribed under chemolithoautotrophic conditions in the presence of CO as carbon and energy source.


Pssm-ID: 399326  Cd Length: 140  Bit Score: 61.61  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607510     2 PGAQLIGHEGDEYLGKVKVKVGPVTSEFSGKVHFVeQDRNQHRAVFDAKGKeARGTGNAAATVAAQLHEVGERTRVTVDT 81
Cdd:pfam06240  27 PGVKSVEKEGDEYKAVLKLQVGPLKGSYKARVELV-DIEKPGSTTLEIKGN-GRGAGVAIDFAIVVLVKPGGGTRLSWSA 104

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15607510    82 DLKIVGKLAQFGSGMLQQVSEKLLGQFVDSLEAELA 117
Cdd:pfam06240 105 DGNVGGLLASLGGRLIDSAARKMINRFFQCISSKLG 140
 
Name Accession Description Interval E-value
SRPBCC_5 cd07823
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized ...
 1-118 6.42e-50

Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.


Pssm-ID: 176865  Cd Length: 146  Bit Score: 157.40  E-value: 6.42e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607510   1 MPGAQLIGHEG-DEYLGKVKVKVGPVTSEFSGKVHFVEQDRNQHRAVFDAKGKEARGTGNAAATVAAQLHEVGERTRVTV 79
Cdd:cd07823  28 LPGASLTEVEGdDEYKGTVKVKLGPISASFKGTARLLEDDEAARRAVLEATGKDARGQGTAEATVTLRLSPAGGGTRVTV 107

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15607510  80 DTDLKIVGKLAQFGSGMLQQVSEKLLGQFVDSLEAELAA 118
Cdd:cd07823 108 DTDLALTGKLAQFGRGGIGDVAGRLLAQFAANLEARLAA 146
CoxG COG3427
Carbon monoxide dehydrogenase subunit CoxG [Energy production and conversion];
1-117 8.57e-38

Carbon monoxide dehydrogenase subunit CoxG [Energy production and conversion];


Pssm-ID: 442653  Cd Length: 145  Bit Score: 126.51  E-value: 8.57e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607510   1 MPGAQLIGHEGD-EYLGKVKVKVGPVTSEFSGKVHFVEQDRNqHRAVFDAKGKEARGtGNAAATVAAQLHEVGERTRVTV 79
Cdd:COG3427  30 IPGCESLEVVGDtEYEATVKVKVGPVKATFKGEVTLSELDPP-ESYTLTGEGKGGRA-GFAKGTATVTLEPDGGGTRLTY 107

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15607510  80 DTDLKIVGKLAQFGSGMLQQVSEKLLGQFVDSLEAELA 117
Cdd:COG3427 108 DADADVGGKLAQLGRRLIDGVAKKLADQFFENLAAKLE 145
CoxG cd05018
Carbon monoxide dehydrogenase subunit G (CoxG); CoxG has been shown, in Oligotropha ...
 1-117 8.50e-18

Carbon monoxide dehydrogenase subunit G (CoxG); CoxG has been shown, in Oligotropha carboxidovorans, to anchor the carbon monoxide (CO) dehydrogenase to the cytoplasmic membrane. The gene encoding CoxG is part of the Cox cluster (coxBCMSLDEFGHIK) located on a low-copy-number, circular, megaplasmid pHCG3. This cluster includes genes encoding subunits of CO dehydrogenase and several accessory components involved in the utilization of CO. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.


Pssm-ID: 176853  Cd Length: 144  Bit Score: 75.31  E-value: 8.50e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607510   1 MPGAQ-LIGHEGDEYLGKVKVKVGPVTSEFSGKVHFVEQDRNqHRAVFDAKGKEARGTGNAAATVaaQLHEVGERTRVTV 79
Cdd:cd05018  30 IPGCEsLEKIGPNEYEATVKLKVGPVKGTFKGKVELSDLDPP-ESYTITGEGKGGAGFVKGTARV--TLEPDGGGTRLTY 106

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15607510  80 DTDLKIVGKLAQFGSGMLQQVSEKLLGQFVDSLEAELA 117
Cdd:cd05018 107 TADAQVGGKLAQLGSRLIDGAARKLINQFFENLASKIG 144
COXG pfam06240
Carbon monoxide dehydrogenase subunit G (CoxG); The CO dehydrogenase structural genes coxMSL ...
 2-117 1.24e-12

Carbon monoxide dehydrogenase subunit G (CoxG); The CO dehydrogenase structural genes coxMSL are flanked by nine accessory genes arranged as the cox gene cluster. The cox genes are specifically and coordinately transcribed under chemolithoautotrophic conditions in the presence of CO as carbon and energy source.


Pssm-ID: 399326  Cd Length: 140  Bit Score: 61.61  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607510     2 PGAQLIGHEGDEYLGKVKVKVGPVTSEFSGKVHFVeQDRNQHRAVFDAKGKeARGTGNAAATVAAQLHEVGERTRVTVDT 81
Cdd:pfam06240  27 PGVKSVEKEGDEYKAVLKLQVGPLKGSYKARVELV-DIEKPGSTTLEIKGN-GRGAGVAIDFAIVVLVKPGGGTRLSWSA 104

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15607510    82 DLKIVGKLAQFGSGMLQQVSEKLLGQFVDSLEAELA 117
Cdd:pfam06240 105 DGNVGGLLASLGGRLIDSAARKMINRFFQCISSKLG 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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