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Conserved domains on  [gi|15240741|ref|NP_201545|]
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Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

Protein Classification

phototropic-responsive NPH3 family protein( domain architecture ID 13033814)

phototropic-responsive NPH3 family protein is a BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and NPH3 domain-containing protein that may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
205-452 1.63e-94

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


:

Pssm-ID: 460777  Cd Length: 218  Bit Score: 288.23  E-value: 1.63e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741   205 DWWVEDLAELSIDLFKRVVSTIRRKGgVLPEVIGEALEVYAAKRIPGFMIQNDDNDDEED--VMEQRSLLETLVSMLPSE 282
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKG-MKPEVIGEALMHYAKKWLPGLSRSSSSSASRSEddNSKQRELLETIVSLLPSE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741   283 KQSVSCGFLIKLLKSSVSFECGEEERKELSRRIGEKLEEANVGDLLIRAPEGGETVYDIDIvetlidefvtqtekrdeld 362
Cdd:pfam03000  80 KGSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEETLYDVDL------------------- 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741   363 csddindsskaNVAKLIDGYLAEISRiETNLSTTKFITIAEKVSTFPRQSHDGVYRAIDMFLKQHPGITKSEKKSSSKLM 442
Cdd:pfam03000 141 -----------KVAKLVDGYLAEIAS-DPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLM 208
                         250
                  ....*....|
gi 15240741   443 DCRKLSPEAC 452
Cdd:pfam03000 209 DCQKLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
20-127 2.22e-50

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 169.05  E-value: 2.22e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  20 VRYVATELATDVVVIVGDVKFHLHKFPLLSKSARLQKLIATTttdEQSDDDEIRIPDIPGGPPAFEICAKFCYGMAVTLN 99
Cdd:cd18312   1 SWFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSS---SESDPSEIELNDFPGGAEAFELVAKFCYGMPINLT 77
                        90       100
                ....*....|....*....|....*...
gi 15240741 100 AYNVVAVRCAAEYLEMYESIENGNLVYK 127
Cdd:cd18312  78 ATNVVGLRCAAEYLEMTESGNLGNLIDK 105
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
205-452 1.63e-94

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 288.23  E-value: 1.63e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741   205 DWWVEDLAELSIDLFKRVVSTIRRKGgVLPEVIGEALEVYAAKRIPGFMIQNDDNDDEED--VMEQRSLLETLVSMLPSE 282
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKG-MKPEVIGEALMHYAKKWLPGLSRSSSSSASRSEddNSKQRELLETIVSLLPSE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741   283 KQSVSCGFLIKLLKSSVSFECGEEERKELSRRIGEKLEEANVGDLLIRAPEGGETVYDIDIvetlidefvtqtekrdeld 362
Cdd:pfam03000  80 KGSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEETLYDVDL------------------- 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741   363 csddindsskaNVAKLIDGYLAEISRiETNLSTTKFITIAEKVSTFPRQSHDGVYRAIDMFLKQHPGITKSEKKSSSKLM 442
Cdd:pfam03000 141 -----------KVAKLVDGYLAEIAS-DPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLM 208
                         250
                  ....*....|
gi 15240741   443 DCRKLSPEAC 452
Cdd:pfam03000 209 DCQKLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
20-127 2.22e-50

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 169.05  E-value: 2.22e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  20 VRYVATELATDVVVIVGDVKFHLHKFPLLSKSARLQKLIATTttdEQSDDDEIRIPDIPGGPPAFEICAKFCYGMAVTLN 99
Cdd:cd18312   1 SWFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSS---SESDPSEIELNDFPGGAEAFELVAKFCYGMPINLT 77
                        90       100
                ....*....|....*....|....*...
gi 15240741 100 AYNVVAVRCAAEYLEMYESIENGNLVYK 127
Cdd:cd18312  78 ATNVVGLRCAAEYLEMTESGNLGNLIDK 105
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
29-135 5.09e-08

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 51.10  E-value: 5.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741    29 TDVVVIVGDVKFHLHKFPLLSKSARLQKLIatTTTDEQSDDDEIRIPDIPggPPAFEICAKFCYGmAVTLNAYNVVAVRC 108
Cdd:pfam00651  11 CDVTLVVGDKEFRAHKAVLAACSPYFKALF--SGQESESSVSEITLDDVS--PEDFEALLEFMYT-GKLISEENVDDLLA 85
                          90       100
                  ....*....|....*....|....*..
gi 15240741   109 AAEYLEMYESIEngnlvyKMEVFLNSS 135
Cdd:pfam00651  86 AADKLQIPSLVD------KCEEFLIKS 106
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
30-120 2.18e-07

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 49.23  E-value: 2.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741     30 DVVVIVGDVKFHLHKFpLLSKSARLQKLIATTTTDEqSDDDEIRIPDIPggPPAFEICAKFCYGMAVTLNAYNVVAVRCA 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKA-VLAAHSPYFKALFSSDFKE-SDKSEIYLDDVS--PEDFRALLNFLYTGKLDLPEENVEELLEL 76
                           90
                   ....*....|.
gi 15240741    110 AEYLEMYESIE 120
Cdd:smart00225  77 ADYLQIPGLVE 87
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
205-452 1.63e-94

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 288.23  E-value: 1.63e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741   205 DWWVEDLAELSIDLFKRVVSTIRRKGgVLPEVIGEALEVYAAKRIPGFMIQNDDNDDEED--VMEQRSLLETLVSMLPSE 282
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKG-MKPEVIGEALMHYAKKWLPGLSRSSSSSASRSEddNSKQRELLETIVSLLPSE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741   283 KQSVSCGFLIKLLKSSVSFECGEEERKELSRRIGEKLEEANVGDLLIRAPEGGETVYDIDIvetlidefvtqtekrdeld 362
Cdd:pfam03000  80 KGSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEETLYDVDL------------------- 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741   363 csddindsskaNVAKLIDGYLAEISRiETNLSTTKFITIAEKVSTFPRQSHDGVYRAIDMFLKQHPGITKSEKKSSSKLM 442
Cdd:pfam03000 141 -----------KVAKLVDGYLAEIAS-DPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLM 208
                         250
                  ....*....|
gi 15240741   443 DCRKLSPEAC 452
Cdd:pfam03000 209 DCQKLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
20-127 2.22e-50

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 169.05  E-value: 2.22e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  20 VRYVATELATDVVVIVGDVKFHLHKFPLLSKSARLQKLIATTttdEQSDDDEIRIPDIPGGPPAFEICAKFCYGMAVTLN 99
Cdd:cd18312   1 SWFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSS---SESDPSEIELNDFPGGAEAFELVAKFCYGMPINLT 77
                        90       100
                ....*....|....*....|....*...
gi 15240741 100 AYNVVAVRCAAEYLEMYESIENGNLVYK 127
Cdd:cd18312  78 ATNVVGLRCAAEYLEMTESGNLGNLIDK 105
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
31-113 2.22e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 76.94  E-value: 2.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  31 VVVIVGDVKFHLHKFPLLSKSARLQKLIATTttDEQSDDDEIRIPDIpgGPPAFEICAKFCYGMAVTLNAYNVVAVRCAA 110
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGG--FRESGQAEINLRDI--SPEDFRALLEFLYGGKRDLDASNLLELLEAA 76

                ...
gi 15240741 111 EYL 113
Cdd:cd01165  77 NFL 79
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
29-113 1.72e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 54.48  E-value: 1.72e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  29 TDVVVIVGDVKFHLHKFPLLSKSARLQKLIatTTTDEQSDDDEIRIPDIPggPPAFEICAKFCYGMAVTLNAYNVVAVRC 108
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRAMF--SSGMKESSSSEIELDDVS--PEAFEALLDYIYTGELELSEENVEELLA 77

                ....*
gi 15240741 109 AAEYL 113
Cdd:cd18186  78 AADKL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
29-135 5.09e-08

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 51.10  E-value: 5.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741    29 TDVVVIVGDVKFHLHKFPLLSKSARLQKLIatTTTDEQSDDDEIRIPDIPggPPAFEICAKFCYGmAVTLNAYNVVAVRC 108
Cdd:pfam00651  11 CDVTLVVGDKEFRAHKAVLAACSPYFKALF--SGQESESSVSEITLDDVS--PEDFEALLEFMYT-GKLISEENVDDLLA 85
                          90       100
                  ....*....|....*....|....*..
gi 15240741   109 AAEYLEMYESIEngnlvyKMEVFLNSS 135
Cdd:pfam00651  86 AADKLQIPSLVD------KCEEFLIKS 106
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
30-120 2.18e-07

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 49.23  E-value: 2.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741     30 DVVVIVGDVKFHLHKFpLLSKSARLQKLIATTTTDEqSDDDEIRIPDIPggPPAFEICAKFCYGMAVTLNAYNVVAVRCA 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKA-VLAAHSPYFKALFSSDFKE-SDKSEIYLDDVS--PEDFRALLNFLYTGKLDLPEENVEELLEL 76
                           90
                   ....*....|.
gi 15240741    110 AEYLEMYESIE 120
Cdd:smart00225  77 ADYLQIPGLVE 87
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
29-121 1.13e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 44.26  E-value: 1.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  29 TDVVVIVGDVKFHLHKFPLLSKSARLQKLIatTTTDEQSDDDEIRIPDIPggPPAFEICAKFCYGMAVTLNAYNVVAVRC 108
Cdd:cd18314   7 SDVVLCVGDRKFFAHRIVLCARSPVFRSML--TGSMIESNLKEVTLEDVE--PEIFETVLKYMYTGQVTLSEENVLDLLM 82
                        90
                ....*....|...
gi 15240741 109 AAEYLeMYESIEN 121
Cdd:cd18314  83 LASKY-QVPDLEK 94
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
30-117 2.34e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 43.81  E-value: 2.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  30 DVVVIVGDVKFHLHKFPLlskSARLQKLIATTTTD-EQSDDDEIRIPDIPggPPAFEICAKFCYGMAVTLNAYNVVAVRC 108
Cdd:cd18247  21 DVTLKVGDQKFSAHRIVL---AATIPYFHAMFTHDmVESKQDEITMQGIE--PSALEALINFAYSGRIAIDTSNVQSLLV 95

                ....*....
gi 15240741 109 AAEYLEMYE 117
Cdd:cd18247  96 GASFLQLQS 104
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
30-92 1.44e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 38.42  E-value: 1.44e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15240741  30 DVVVIVGDVKFHLHKFPLLSKSARLQKLIAT--TTTDEQSDDDEIRIPDIPggPPAFEICAKFCY 92
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSslLTSEDAVGCDVVHIEKVP--PEIFEQLLQFIY 82
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
29-115 1.71e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 38.60  E-value: 1.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  29 TDVVVIVGDVKFHLHKFPLLSKSARLQKLIATTTTDEQSDddEIRIPDIPGgpPAFEICAKFCYGMAVTLNAYNVVAVRC 108
Cdd:cd18265  24 TDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQA--VVEIQKVSA--AAMEVLLDYMYGGGLRIQEDNVESVLE 99

                ....*..
gi 15240741 109 AAEYLEM 115
Cdd:cd18265 100 ASDLLQV 106
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
17-110 3.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 37.65  E-value: 3.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  17 EDCVRYVATELATDVVVIVGDVKFHLHKFpLLSKSARLQKLIATTTTDEQSDDDEIRIPDIPGGPPAFEICAKFCYGMAV 96
Cdd:cd18292   6 QDIAQLYNNEELSDIVLRVGGKVFHAHRL-ILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVFEKFLRYLYTGQI 84
                        90
                ....*....|....
gi 15240741  97 TLNAYNVVAVRCAA 110
Cdd:cd18292  85 SVNLETALPLLMLA 98
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
30-117 5.28e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 37.49  E-value: 5.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  30 DVVVIVGDVKFHLHKFPLLSKSARLQKLIatttTDEQSDDDEIRIPDIPGGPPAFEICAKFCYGMAVTLNAYNVVAVRCA 109
Cdd:cd18194  25 DCTVLVGSAQFPAHRAVLASCSMYFHLFY----RDRLDKRDLVRLNSDIVTAPAFGLLLDFMYEGRLALRDLPVEDVLAA 100

                ....*...
gi 15240741 110 AEYLEMYE 117
Cdd:cd18194 101 ASYLHMYD 108
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
30-120 8.25e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 36.61  E-value: 8.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  30 DVVVIVGDVKFHLHKFPLLSKSARLQKLIATTTTdeQSDDDEIRIPDIPGGppAFEICAKFCYGMAVTLNAYNVVAVRCA 109
Cdd:cd18256  22 DVQLQVGMELFSVHRLVLAASSPYFAALFAGGMS--ESSKDVVQIHGVEPD--IFHILLDFIYTGVVEVTVSNVQELLVA 97
                        90
                ....*....|.
gi 15240741 110 AEYLEMYESIE 120
Cdd:cd18256  98 ADMLQLTEVVE 108
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
26-119 8.44e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 36.34  E-value: 8.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240741  26 ELATDVVVIVGDVKFHLHKFPLLSKSARLQKLI---ATTTTDEQSDDDEIRIPDIpggppaFEICAKFCYGMAVTLNAYN 102
Cdd:cd18329  19 ELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLsqnAKETGQPTVATFDVFSPDT------FTIILDFVYSGKLSLTSQN 92
                        90
                ....*....|....*..
gi 15240741 103 VVAVRCAAEYLEMYESI 119
Cdd:cd18329  93 VIEVMSAASYLQMTDVI 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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