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Conserved domains on  [gi|42568712|ref|NP_201066|]
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ARM repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

exportin/importin beta family protein( domain architecture ID 10658450)

exportin/importin beta family protein such as human exportin-T, which mediates the nuclear export of aminoacylated tRNAs or transportin-3 (importin), which transports target proteins into the nucleus

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
98-243 7.16e-25

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


:

Pssm-ID: 462459  Cd Length: 147  Bit Score: 101.15  E-value: 7.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712    98 PPKVRTQISIAVAALAVHVPAADWGDggIISWLRDEMHMHPEYVPGFLELLTVLPEETFNY-KIAARPDRRRQFEKELTS 176
Cdd:pfam08389   1 PKFIRNKLALALAELAKQEYPNNWPT--FFPDLISLLSSNPTGCELFLRILKVLPEEIFDFsRTSLTQDRNNRLKDLLRS 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42568712   177 QMEAALSILSACLKI-----SELKEQVLEAFASWLRLrhgIPGTVLACHPLVHAALSSLNCDPLSEASVNVI 243
Cdd:pfam08389  79 NMEQILELLLQILEAsqnanSELVEAVLKCLGSWLSW---IPIGLIVNNPLLNLLFSLLNDPDLREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
26-91 1.74e-06

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


:

Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 46.08  E-value: 1.74e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42568712     26 ADRWLQNFQGTLDAWQVADNLLhDSSSNLETLIFCSQTLRSKVQRDFEELPPGAFQKLRQSLTTLL 91
Cdd:smart00913   1 AEKQLEQFQKSPGFWLLLLEIL-ANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELL 65
 
Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
98-243 7.16e-25

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 101.15  E-value: 7.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712    98 PPKVRTQISIAVAALAVHVPAADWGDggIISWLRDEMHMHPEYVPGFLELLTVLPEETFNY-KIAARPDRRRQFEKELTS 176
Cdd:pfam08389   1 PKFIRNKLALALAELAKQEYPNNWPT--FFPDLISLLSSNPTGCELFLRILKVLPEEIFDFsRTSLTQDRNNRLKDLLRS 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42568712   177 QMEAALSILSACLKI-----SELKEQVLEAFASWLRLrhgIPGTVLACHPLVHAALSSLNCDPLSEASVNVI 243
Cdd:pfam08389  79 NMEQILELLLQILEAsqnanSELVEAVLKCLGSWLSW---IPIGLIVNNPLLNLLFSLLNDPDLREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
26-91 1.74e-06

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 46.08  E-value: 1.74e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42568712     26 ADRWLQNFQGTLDAWQVADNLLhDSSSNLETLIFCSQTLRSKVQRDFEELPPGAFQKLRQSLTTLL 91
Cdd:smart00913   1 AEKQLEQFQKSPGFWLLLLEIL-ANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELL 65
IBN_N pfam03810
Importin-beta N-terminal domain;
26-91 3.00e-03

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 37.22  E-value: 3.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712    26 ADRWLQNFQGTLDAWQVADNLLHDSSSNLETLIFCSQTLRSKVQRDFEE----LPPGAFQKLRQSLTTLL 91
Cdd:pfam03810   1 AEKQLEQFEKSPGFWSKLLQILSNSENPLEVRQLAALYLKNLITRHWEEeknsLPPEEKEQIKNNLLNLL 70
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
15-343 4.36e-03

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 41.08  E-value: 4.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712   15 YHHPDDTVRVHADRWLQNFQGTLDAWQVADNLLhDSSSNLETLIFCSQTLRSKVQRDFEELPPGAFQKLRQSLTTLLKKf 94
Cdd:COG5101   23 FYQGDGRKQEQAQRILTKFQELPDAWTKADYIL-NNSKLPQSKYIALSLLDKLITTKWKLLPEGMRQGIRNYVVQLVIE- 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712   95 HKGPPKVRTQISIAVAAL---AVHVPAADWGdggiiswlrdemHMHPEYVPGF--------------LELLTVLPEETFN 157
Cdd:COG5101  101 KSQDDKVRDKQKYVLNKLdltLVQILKQEWP------------RNWPTFIPELinvsqismevcennMIVLKLLSEEVFD 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712  158 YKIAARPDRRRqfeKELTSQMEAALS-ILSACLKISEL--KEQVLEA-FASWLRLRHGIPGTVLACHPLVHAALSSLNCD 233
Cdd:COG5101  169 FSAEQMTQVKK---RLLKNQMKIEFPqIFGLCKQILEYsrDESLIEAtLESLLRFLEWIPLDYIFETNIIELVLEHFNSM 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712  234 P-LSEASVNVISELIHHTASPSSGGISAQTPLI------QVIVPQILSLQAHLRD----SSKDEED-VKAIGRLFADVGD 301
Cdd:COG5101  246 PdTRVATLSCLTEIVDLGRHPQENAEKERILVIhfqcieFLKMYSNKPQEEDIYEvyggMDKNEQIfVQKLAQFLSSLYE 325
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 42568712  302 SYVELI-ATGSDEPMVIVHA-LLEVTAHPEFDIASMTFNFWHSL 343
Cdd:COG5101  326 VYISLLeAREMAENLLNAHGyLIQISRINEREIFKTALEYWNKL 369
 
Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
98-243 7.16e-25

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 101.15  E-value: 7.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712    98 PPKVRTQISIAVAALAVHVPAADWGDggIISWLRDEMHMHPEYVPGFLELLTVLPEETFNY-KIAARPDRRRQFEKELTS 176
Cdd:pfam08389   1 PKFIRNKLALALAELAKQEYPNNWPT--FFPDLISLLSSNPTGCELFLRILKVLPEEIFDFsRTSLTQDRNNRLKDLLRS 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42568712   177 QMEAALSILSACLKI-----SELKEQVLEAFASWLRLrhgIPGTVLACHPLVHAALSSLNCDPLSEASVNVI 243
Cdd:pfam08389  79 NMEQILELLLQILEAsqnanSELVEAVLKCLGSWLSW---IPIGLIVNNPLLNLLFSLLNDPDLREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
26-91 1.74e-06

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 46.08  E-value: 1.74e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42568712     26 ADRWLQNFQGTLDAWQVADNLLhDSSSNLETLIFCSQTLRSKVQRDFEELPPGAFQKLRQSLTTLL 91
Cdd:smart00913   1 AEKQLEQFQKSPGFWLLLLEIL-ANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELL 65
IBN_N pfam03810
Importin-beta N-terminal domain;
26-91 3.00e-03

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 37.22  E-value: 3.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712    26 ADRWLQNFQGTLDAWQVADNLLHDSSSNLETLIFCSQTLRSKVQRDFEE----LPPGAFQKLRQSLTTLL 91
Cdd:pfam03810   1 AEKQLEQFEKSPGFWSKLLQILSNSENPLEVRQLAALYLKNLITRHWEEeknsLPPEEKEQIKNNLLNLL 70
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
15-343 4.36e-03

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 41.08  E-value: 4.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712   15 YHHPDDTVRVHADRWLQNFQGTLDAWQVADNLLhDSSSNLETLIFCSQTLRSKVQRDFEELPPGAFQKLRQSLTTLLKKf 94
Cdd:COG5101   23 FYQGDGRKQEQAQRILTKFQELPDAWTKADYIL-NNSKLPQSKYIALSLLDKLITTKWKLLPEGMRQGIRNYVVQLVIE- 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712   95 HKGPPKVRTQISIAVAAL---AVHVPAADWGdggiiswlrdemHMHPEYVPGF--------------LELLTVLPEETFN 157
Cdd:COG5101  101 KSQDDKVRDKQKYVLNKLdltLVQILKQEWP------------RNWPTFIPELinvsqismevcennMIVLKLLSEEVFD 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712  158 YKIAARPDRRRqfeKELTSQMEAALS-ILSACLKISEL--KEQVLEA-FASWLRLRHGIPGTVLACHPLVHAALSSLNCD 233
Cdd:COG5101  169 FSAEQMTQVKK---RLLKNQMKIEFPqIFGLCKQILEYsrDESLIEAtLESLLRFLEWIPLDYIFETNIIELVLEHFNSM 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568712  234 P-LSEASVNVISELIHHTASPSSGGISAQTPLI------QVIVPQILSLQAHLRD----SSKDEED-VKAIGRLFADVGD 301
Cdd:COG5101  246 PdTRVATLSCLTEIVDLGRHPQENAEKERILVIhfqcieFLKMYSNKPQEEDIYEvyggMDKNEQIfVQKLAQFLSSLYE 325
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 42568712  302 SYVELI-ATGSDEPMVIVHA-LLEVTAHPEFDIASMTFNFWHSL 343
Cdd:COG5101  326 VYISLLeAREMAENLLNAHGyLIQISRINEREIFKTALEYWNKL 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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