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Conserved domains on  [gi|22327990|ref|NP_200888|]
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Heavy metal transport/detoxification superfamily protein [Arabidopsis thaliana]

Protein Classification

heavy-metal-associated domain-containing protein( domain architecture ID 10449815)

heavy-metal-associated domain-containing protein may function as a heavy metal transporter and/or detoxification protein; such as heavy metal-associated isoprenylated plant proteins

Gene Ontology:  GO:0046872
PubMed:  12443926|8905098

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HMA pfam00403
Heavy-metal-associated domain;
28-77 3.48e-06

Heavy-metal-associated domain;


:

Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 43.38  E-value: 3.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 22327990    28 VVLKVDMHCEGCASRIVKCVRSFQGVETVKSESATGKLTVTGALDPVKLR 77
Cdd:pfam00403   1 TFRVSGMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLE 50
HMA pfam00403
Heavy-metal-associated domain;
142-187 8.81e-05

Heavy-metal-associated domain;


:

Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 39.52  E-value: 8.81e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 22327990   142 HCQGCIGKIQKTVTKTKGVNGLTMDKEKNLLTVKGTMDVKKLVEIL 187
Cdd:pfam00403   8 HCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLEKLV 53
 
Name Accession Description Interval E-value
HMA pfam00403
Heavy-metal-associated domain;
28-77 3.48e-06

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 43.38  E-value: 3.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 22327990    28 VVLKVDMHCEGCASRIVKCVRSFQGVETVKSESATGKLTVTGALDPVKLR 77
Cdd:pfam00403   1 TFRVSGMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLE 50
HMA pfam00403
Heavy-metal-associated domain;
142-187 8.81e-05

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 39.52  E-value: 8.81e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 22327990   142 HCQGCIGKIQKTVTKTKGVNGLTMDKEKNLLTVKGTMDVKKLVEIL 187
Cdd:pfam00403   8 HCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLEKLV 53
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 29-69 1.23e-04

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 39.13  E-value: 1.23e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 22327990  29 VLKVD-MHCEGCASRIVKCVRSFQGVETVKSESATGKLTVTG 69
Cdd:cd00371   1 ELSVEgMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEY 42
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
27-74 1.68e-04

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 39.12  E-value: 1.68e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 22327990  27 TVVLKVD-MHCEGCASRIVKCVRSFQGVETVKSESATGKLTVTGALDPV 74
Cdd:COG2608   3 TVTLKVEgMTCGHCVARVEKALKALDGVASVEVDLATGTATVTYDPEKV 51
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 142-194 6.63e-03

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 34.50  E-value: 6.63e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22327990 142 HCQGCIGKIQKTVTKTKGVNGLTMDKEKNLLTVKG--TMDVKKLVEILSEKLKRA 194
Cdd:cd00371   8 TCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYdpEVSPEELLEAIEDAGYKA 62
 
Name Accession Description Interval E-value
HMA pfam00403
Heavy-metal-associated domain;
28-77 3.48e-06

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 43.38  E-value: 3.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 22327990    28 VVLKVDMHCEGCASRIVKCVRSFQGVETVKSESATGKLTVTGALDPVKLR 77
Cdd:pfam00403   1 TFRVSGMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLE 50
HMA pfam00403
Heavy-metal-associated domain;
142-187 8.81e-05

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 39.52  E-value: 8.81e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 22327990   142 HCQGCIGKIQKTVTKTKGVNGLTMDKEKNLLTVKGTMDVKKLVEIL 187
Cdd:pfam00403   8 HCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLEKLV 53
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 29-69 1.23e-04

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 39.13  E-value: 1.23e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 22327990  29 VLKVD-MHCEGCASRIVKCVRSFQGVETVKSESATGKLTVTG 69
Cdd:cd00371   1 ELSVEgMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEY 42
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
27-74 1.68e-04

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 39.12  E-value: 1.68e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 22327990  27 TVVLKVD-MHCEGCASRIVKCVRSFQGVETVKSESATGKLTVTGALDPV 74
Cdd:COG2608   3 TVTLKVEgMTCGHCVARVEKALKALDGVASVEVDLATGTATVTYDPEKV 51
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
27-77 3.39e-03

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 38.59  E-value: 3.39e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 22327990  27 TVVLKVD-MHCEGCASRIVKCVRSFQGVETVKSESATGKLTVTGALDPVKLR 77
Cdd:COG2217   2 RVRLRIEgMTCAACAWLIEKALRKLPGVLSARVNLATERARVEYDPGKVSLE 53
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 142-194 6.63e-03

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 34.50  E-value: 6.63e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22327990 142 HCQGCIGKIQKTVTKTKGVNGLTMDKEKNLLTVKG--TMDVKKLVEILSEKLKRA 194
Cdd:cd00371   8 TCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYdpEVSPEELLEAIEDAGYKA 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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