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Conserved domains on  [gi|15240475|ref|NP_200331|]
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Co-chaperone GrpE family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 139-287 4.31e-55

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


:

Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 175.00  E-value: 4.31e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475 139 EMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVVKESfskidtskdlagatPLLKNLLEGV 218
Cdd:cd00446   2 ELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKE--------------EELKNLLEGV 67

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240475 219 EMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:cd00446  68 EMTLKQLLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 139-287 4.31e-55

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 175.00  E-value: 4.31e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475 139 EMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVVKESfskidtskdlagatPLLKNLLEGV 218
Cdd:cd00446   2 ELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKE--------------EELKNLLEGV 67

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240475 219 EMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:cd00446  68 EMTLKQLLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 134-287 3.38e-50

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 163.01  E-value: 3.38e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475 134 QKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVVKESfskidtskdlagatPLLKN 213
Cdd:COG0576   5 EAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEED--------------EDVKS 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15240475 214 LLEGVEMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:COG0576  71 LLEGVEMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVV 144
GrpE pfam01025
GrpE;
127-287 2.18e-47

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 156.23  E-value: 2.18e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   127 EDLLKVQQKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVVKESfskidtskdlag 206
Cdd:pfam01025  17 EEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPEN------------ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   207 atPLLKNLLEGVEMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVG 286
Cdd:pfam01025  85 --EDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMVV 162


                  .
gi 15240475   287 V 287
Cdd:pfam01025 163 V 163
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 92-287 3.00e-43

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 147.12  E-value: 3.00e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   92 TGETSENVEVGKATDAEIDFDDLSRDDLVKLVSEKEDLLKVQQKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQ 171
Cdd:PRK14141   2 TDEKNKNGNPADAARDANNPVDREAKPYEMEDDPEPDPLEALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  172 NFATSLLDVADNLERASSVVKEsfskidtsKDLAGATPLLKNLLEGVEMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNA 251
Cdd:PRK14141  82 GFARDMLSVSDNLRRALDAIPA--------EARAAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQA 153

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 15240475  252 VFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14141 154 MFEVPNPDVPNNTVVQVVQAGYTIGERVLRPAMVGV 189
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 139-287 4.31e-55

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 175.00  E-value: 4.31e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475 139 EMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVVKESfskidtskdlagatPLLKNLLEGV 218
Cdd:cd00446   2 ELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKE--------------EELKNLLEGV 67

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240475 219 EMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:cd00446  68 EMTLKQLLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 134-287 3.38e-50

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 163.01  E-value: 3.38e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475 134 QKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVVKESfskidtskdlagatPLLKN 213
Cdd:COG0576   5 EAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEED--------------EDVKS 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15240475 214 LLEGVEMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:COG0576  71 LLEGVEMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVV 144
GrpE pfam01025
GrpE;
127-287 2.18e-47

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 156.23  E-value: 2.18e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   127 EDLLKVQQKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVVKESfskidtskdlag 206
Cdd:pfam01025  17 EEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPEN------------ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   207 atPLLKNLLEGVEMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVG 286
Cdd:pfam01025  85 --EDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMVV 162


                  .
gi 15240475   287 V 287
Cdd:pfam01025 163 V 163
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 92-287 3.00e-43

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 147.12  E-value: 3.00e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   92 TGETSENVEVGKATDAEIDFDDLSRDDLVKLVSEKEDLLKVQQKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQ 171
Cdd:PRK14141   2 TDEKNKNGNPADAARDANNPVDREAKPYEMEDDPEPDPLEALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  172 NFATSLLDVADNLERASSVVKEsfskidtsKDLAGATPLLKNLLEGVEMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNA 251
Cdd:PRK14141  82 GFARDMLSVSDNLRRALDAIPA--------EARAAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQA 153

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 15240475  252 VFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14141 154 MFEVPNPDVPNNTVVQVVQAGYTIGERVLRPAMVGV 189
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 84-287 9.05e-35

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 124.73  E-value: 9.05e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   84 ESNTEVPKTGETSENVEVGKATDAEIDFDDLSRDDLVKLVSEKEDLLkvqQKDIMEMKDKFLRTYAEQQNLMDRTNRNAE 163
Cdd:PRK14140   3 EKNEQVEEEVEETEVEEAVEDEVEEETVEEESEAELLDEEQAKIAEL---EAKLDELEERYLRLQADFENYKRRIQKENE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  164 SAKKFAVQNFATSLLDVADNLERASSVVKESFSkidtskdlagatplLKNLLEGVEMTEKQLAEVFRKAGLVKEDPLNEP 243
Cdd:PRK14140  80 AAEKYRAQSLASDLLPALDNFERALQIEADDEQ--------------TKSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQ 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 15240475  244 FNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14140 146 FDPNLHQAVMQDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKV 189
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 136-287 7.25e-33

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 120.07  E-value: 7.25e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  136 DIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVvkesfskidTSKDlaGATPLLKNLL 215
Cdd:PRK14155  28 EVAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRATAA---------SPKD--SADPAVKNFI 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15240475  216 EGVEMTEKQLAEVFRKAGLVKEDP-LNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14155  97 IGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGYELMGRLVRPAMVAV 169
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 79-288 1.76e-32

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 118.54  E-value: 1.76e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   79 EPKGNESNTEVPKTGETSENVEVGKATDAEIDFDDLsrddlvklvsekEDLLKVQQKDIMEMKDKFLRTYAEQQNLMDRT 158
Cdd:PRK14139   2 ENTQQNPSEQEAEEAGAAAQAAAAAAAAAEDAAPAL------------EAELAEAEAKAAELQDSFLRAKAETENVRRRA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  159 NRNAESAKKFAVQNFATSLLDVADNLERAssvvkesfskidtskdLAGATPLLKNLLEGVEMTEKQLAEVFRKAGLVKED 238
Cdd:PRK14139  70 QEDVAKAHKFAIESFAESLLPVKDSLEAA----------------LADESGDLEKLREGVELTLKQLTSAFEKGRVVEIN 133

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 15240475  239 PLNEPFNPNRHNAVFQVPdASKPKGTIAHVLKSGYSLYDRVIRPAEVGVT 288
Cdd:PRK14139 134 PVGEKFDPHQHQAISMVP-AEQEPNTVVAVLQKGYTIADRVLRPALVTVA 182
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 76-287 3.84e-29

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 110.01  E-value: 3.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   76 SSAEPKGNESNTEVPKTGETSENVEVGKA-TDAEIDFDDLSrddlvklVSEKEDLLKVQQKdimEMKDKFLRTYAEQQNL 154
Cdd:PRK14150   2 SNEEQKTPQEQVSEEIEAEVEQQEEADEAeLEDELDEADAR-------IAELEAQLAEAQA---EERDSVLRARAEVENI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  155 MDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVvkesfskIDTSKDLagatplLKNLLEGVEMTEKQLAEVFRKAGL 234
Cdd:PRK14150  72 RRRAEQDVEKAHKFALEKFANELLPVIDNLERALQA-------ADKENEA------LKALIEGVELTLKSLLDTVAKFGV 138

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 15240475  235 VKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14150 139 EVVGPVGEPFNPEVHQAISMQESEDHEPNTVMMVMQKGYTLNGRLLRPAMVMV 191
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 117-290 2.40e-24

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 96.77  E-value: 2.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  117 DDLVKLVSEKEDLLKvqqkdimEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERAssvvkesfs 196
Cdd:PRK14151  23 DDLTARVQELEEQLA-------AAKDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERG--------- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  197 kidtskdLAGATP---LLKNLLEGVEMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGY 273
Cdd:PRK14151  87 -------LELSSAddeAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQKGY 159

                        170
                 ....*....|....*..
gi 15240475  274 SLYDRVIRPAEVGVTCA 290
Cdd:PRK14151 160 LLNGRLLRPAMVVVSKA 176
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 76-287 3.44e-23

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 94.14  E-value: 3.44e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   76 SSAEPKGNESNTEVPKTGETSENVEVGKAtDAEIDFDDLSRDdlvKLVSEKEDLlkvqqkdimemKDKFLRTYAEQQNLM 155
Cdd:PRK14153   3 SKEVGKDKAENSEARNSGSSAEEAEELKE-EPEDSTADSETE---KCREEIESL-----------KEQLFRLAAEFDNFR 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  156 DRTNRNAESAKKFAVQNFATSLLDVADNLERAssvVKESFSKIDTSkdlagatpllkNLLEGVEMTEKQLAEVFRKAGLV 235
Cdd:PRK14153  68 KRTAREMEENRKFVLEQVLLDLLEVTDNFERA---LESARTAEDMN-----------SIVEGIEMVSKQFFSILEKYGLE 133

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15240475  236 KEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14153 134 RIECEGEEFDPHRHEAMMHVETSEVPDNTIVDVCKPGYALNSKVIRPAMVSV 185
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 105-288 2.42e-22

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 91.57  E-value: 2.42e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  105 TDAEIDFDDLSRDDLVKLVSEKED----LLKVQqkdIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDV 180
Cdd:PRK14161   2 IDDNIENNEQTINDIAEEIVETANpeitALKAE---IEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  181 ADNLERASSvVKESFSKIDTSkdlagatpllkNLLEGVEMTEKQLAEVFRKAGLVKEDP-LNEPFNPNRHNAVFQVPDAS 259
Cdd:PRK14161  79 SDNLSRALA-HKPANSDVEVT-----------NIIAGVQMTKDELDKVFHKHHIEEIKPeIGSMFDYNLHNAISQIEHPD 146

                        170       180
                 ....*....|....*....|....*....
gi 15240475  260 KPKGTIAHVLKSGYSLYDRVIRPAEVGVT 288
Cdd:PRK14161 147 HAPNSIITLMQSGYKIRDRLLRPATVQVV 175
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 112-287 2.54e-22

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 91.86  E-value: 2.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  112 DDLSRDDLVKLVSEKEDLlkvQQKdIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVV 191
Cdd:PRK14149  31 GEEKQEASEKEGEIKEDF---ELK-YKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGALKSA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  192 KEsfskidTSKDLAgatpllknLLEGVEMTEKQLAEVFRKAGlVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKS 271
Cdd:PRK14149 107 AE------VDKESA--------LTKGLELTMEKLHEVLARHG-IEGIECLEEFDPNFHNAIMQVKSEEKENGKIVQVLQQ 171

                        170
                 ....*....|....*.
gi 15240475  272 GYSLYDRVIRPAEVGV 287
Cdd:PRK14149 172 GYKYKGRVLRPAMVSI 187
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 76-290 3.25e-22

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 91.66  E-value: 3.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   76 SSAEPKGNESNTEVPKTGETSENVEVGKATDAEIDFDdlSRDDlvKLVSEKEDLLKVQQKDimemKDKFLRTYAEQQNLM 155
Cdd:PRK10325   2 SSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVD--PRDE--KIANLEAQLAEAQTRE----RDGILRVKAEMENLR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  156 DRTNRNAESAKKFAVQNFATSLLDVADNLERASSVVKEsfskidtskdlagATPLLKNLLEGVEMTEKQLAEVFRKAGLV 235
Cdd:PRK10325  74 RRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADK-------------ANPDMSAMVEGIELTLKSMLDVVRKFGVE 140

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15240475  236 KEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGVTCA 290
Cdd:PRK10325 141 VIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKA 195
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 108-287 3.04e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 88.47  E-value: 3.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  108 EIDFDDLSRDdlvklvSEKEDLLKVQ----QKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADN 183
Cdd:PRK14147   7 EFDSEDLAQN------PPETDPLKAEveslRSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  184 LerassvvkesfskiDTSKDLAGATPllKNLLEGVEMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKG 263
Cdd:PRK14147  81 L--------------DAGLTAAGTEP--SPLRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPG 144

                        170       180
                 ....*....|....*....|....
gi 15240475  264 TIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14147 145 HVVQVFQKGYLLNERLLRPALVVV 168
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 94-287 1.63e-20

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 86.67  E-value: 1.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   94 ETSENVEVGKATDAEIDFDDLSRDDlvklvsEKEDLLKVQqKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNF 173
Cdd:PRK14159   3 EQKQEFENENAENSEHLQDENLQNI------EDVEQNKLQ-KDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  174 ATSLLDVADNLERASSVvkESFSKIDtskdlagatplLKnLLEGVEMTEKQLAEVFRKAG--LVKEDplnEPFNPNRHNA 251
Cdd:PRK14159  76 AKDLLDVLDALEAAVNV--ECHDEIS-----------LK-IKEGVQNTLDLFLKKLEKHGvaLIKEE---KEFDPNLHEA 138

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 15240475  252 VFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14159 139 MFHVDSENHQSGEVVQVLQKGYKIADRVIRPTKVSV 174
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 84-287 1.63e-20

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 87.20  E-value: 1.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   84 ESNTEVPKTGETSEnvevgkATDAEIDFDDLSRDDLVKLVSEkedlLKVQQKDimeMKDKFLRTYAEQQNLMDRTNRNAE 163
Cdd:PRK14162  15 EETTDEAPKKEAKE------APKEEDQEKQNPVEDLEKEIAD----LKAKNKD---LEDKYLRSQAEIQNMQNRYAKERA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  164 SAKKFAVQNFATSLLDVADNLERASSVvkesfskidTSKDLAGatpllKNLLEGVEMTEKQLAEVFRKAGLVKEDPLNEP 243
Cdd:PRK14162  82 QLIKYESQSLAKDVLPAMDNLERALAV---------KADDEAA-----KQLKKGVQMTLDHLVKALKDHGVTEIKADGEK 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 15240475  244 FNPNRHNAVFQVP-DASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14162 148 FDPTLHQAVQTVAaENDDQKDHVVQVLQKGYQYKDRTLRPAMVVV 192
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 97-285 3.04e-20

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 86.35  E-value: 3.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   97 ENVEVGKATDAEIDFDDLSRDDLVKLVSEKE------DLLKVQQKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAV 170
Cdd:PRK14148  10 EDKSLDIETAAQVETAQESASGALEELSVEEqlerakDTIKELEDSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  171 QNFATSLLDVADNLERASSvvkesfSKIDTSKDLAgatpllknLLEGVEMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHN 250
Cdd:PRK14148  90 EKFAKELLPVIDSIEQALK------HEVKLEEAIA--------MKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHE 155

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 15240475  251 AVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEV 285
Cdd:PRK14148 156 AMAMIPNPEFEDNTIFDVFQKGYMLNGRIVRAAKV 190
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 124-288 6.00e-20

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 85.55  E-value: 6.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  124 SEKEDLLKVQQKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVVkesfskiDTSKD 203
Cdd:PRK14144  48 TALEEQLTLAEQKAHENWEKSVRALAELENVRRRMEREVANAHKYGVEKLISALLPVVDSLEQALQLA-------DKNSD 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  204 lagatpllKNLLEGVEMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPA 283
Cdd:PRK14144 121 --------PSMHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPPNSVITVFQKGYKLSDRVIRPA 192


                 ....*
gi 15240475  284 EVGVT 288
Cdd:PRK14144 193 RVIVS 197
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 74-287 4.98e-19

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 83.63  E-value: 4.98e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   74 SSSSAEPKGNESNTEVPKTGETS-ENVEVGKA---TDAEIDFDDLSRDDLVKLVSEkedlLKVQQKDIMEMKDKFLRTYA 149
Cdd:PRK14146   7 NKTSEEAKANEKKSQSQTLEESKlENMNSEESqtiTEETQEQAVEGAETETSLQKE----LDNAKKEIESLKDSWARERA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  150 EQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVVKESfskidtskdlagatPLLKNLLEGVEMTEKQLAEVF 229
Cdd:PRK14146  83 EFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGATQNQS--------------EELKPFVEGVKMILKEFYSVL 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15240475  230 RKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYD----RVIRPAEVGV 287
Cdd:PRK14146 149 EKSNVIRFDPKGEPFDPMSMEALSSEEGDQYSEETVIDVYQAGYYYKEnedkFTLRPARVRI 210
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 81-288 5.57e-19

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 83.27  E-value: 5.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   81 KGNESNTEVPKTgETSENVEVGKATDAEIDFDDLSRD---DLVKLVSEKEDLLKVQQKDIMEMKDKFLRTYAEQQNLMDR 157
Cdd:PRK14160  19 KENENKEEDKGK-EEDLEFEEIEKEEIIEDSEESNEVkieELKDENNKLKEENKKLENELEALKDRLLRTVAEYDNYRKR 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  158 TNRNAESAKKFAVQNFATSLLDVADNLERASSVvkesfskiDTSkdlagatplLKNLLEGVEMTEKQLAEVFRKAGlVKE 237
Cdd:PRK14160  98 TAKEKEGIYSDACEDVLKELLPVLDNLERAAAV--------EGS---------VEDLKKGIEMTVKQFKTSLEKLG-VEE 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15240475  238 DPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGVT 288
Cdd:PRK14160 160 ISTEGEFDPNLHNAVMHVEDENYGENEIVEVFQKGYKRGDKVIRYSMVKVA 210
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 117-287 1.28e-18

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 81.42  E-value: 1.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  117 DDLVKLVSEKEDLLKVQQKdIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSVvkesfs 196
Cdd:PRK14156  24 EEVVEETPEKSELELANER-ADEFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNLERALAV------ 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  197 kidtskdlAGATPLLKnllEGVEMTEKQLAEVFRKAGlVKEDPLnEPFNPNRHNAVFQVP-DASKPKGTIAHVLKSGYSL 275
Cdd:PRK14156  97 --------EGLTDDVK---KGLEMVQESLIQALKEEG-VEEVAV-DSFDHNLHMAVQTLPaDDEHPADSIAQVFQKGYKL 163

                        170
                 ....*....|..
gi 15240475  276 YDRVIRPAEVGV 287
Cdd:PRK14156 164 HERLLRPAMVVV 175
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 74-302 4.93e-18

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 81.31  E-value: 4.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   74 SSSSAEPKGNESNTEV--PKTGETSENVEVGKATDAEIDFDDLSRD--DLVKLVSEKEDLLKVQQKDIMEMKDKFLRTYA 149
Cdd:PRK14143  16 SESEAEDNSPESSEEVteQEAELTNPEGDAAEAESSPDSGSAASETaaDNAARLAQLEQELESLKQELEELNSQYMRIAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  150 EQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERASSvvkesfsKIDTSKDLAGAtplLKNLLEGVEmteKQLAEVF 229
Cdd:PRK14143  96 DFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQ-------QLKPEGEEAQA---LHRSYQGLY---KQLVDVL 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15240475  230 RKAGLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGVTCAVENQEGGKESAA 302
Cdd:PRK14143 163 KRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKVSMGPGPSSPAEEDQA 235
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 99-287 3.92e-16

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 74.97  E-value: 3.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   99 VEVGKATDAEIDFDDLSRDDLVKlvsEKEDLLKVQQKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLL 178
Cdd:PRK14158  21 KEAEAAQGKPEAAQPVAAADRIK---ELEEALAAKEAEAAANWDKYLRERADLENYRKRVQKEKEELLKYGNESLILEIL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  179 DVADNLERA-SSVVKESFSKIdtskdlagatpllknlLEGVEMTEKQLAEVFRKAGLVK-EDPLNEPFNPNRHNAVFQVP 256
Cdd:PRK14158  98 PAVDNMERAlDHADEESMSAI----------------IEGIRMTLSMLLSTLKKFGVTPvEAEKGTPFDPAYHQAMCQVE 161

                        170       180       190
                 ....*....|....*....|....*....|.
gi 15240475  257 DASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14158 162 SAEQEPNTVVAVFQKGYLLNERLLRPAMVSV 192
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 77-302 3.96e-14

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 70.15  E-value: 3.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   77 SAEPKGNESNTEVPkTGETSENVEvGKATDAEIDFDDLSRDDLVKLVSEkedlLKVQQKDIMEMKDKFLRTYAEQQNLMD 156
Cdd:PRK14163   2 TEETPGFEEKPDVP-SGATPDDAE-PKAASEEGAAPAGDAAATAGLTAQ----LDQVRTALGERTADLQRLQAEYQNYRR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  157 RTNRNAESAKKFAVQNFATSLLDVADNLERASSvvkesfskidtSKDLAGAtplLKNLLEGVEMTEKQLA-EVFRKAGlv 235
Cdd:PRK14163  76 RVERDRVTVKEIAVANLLSELLPVLDDVGRARE-----------HGELVGG---FKSVAESLETTVAKLGlQQFGKEG-- 139

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240475  236 kedplnEPFNPNRHNAVFQ--VPDASKPkgTIAHVLKSGYSLYDRVIRPAEVGVTcavENQEGGKESAA 302
Cdd:PRK14163 140 ------EPFDPTIHEALMHsyAPDVTET--TCVAILQPGYRIGERTIRPARVAVA---EPQPGAQTAKA 197
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 71-287 2.85e-13

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 67.53  E-value: 2.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   71 GFFSSSSAEPKGNESNTEVPKTGETSENVEVGKAtDAEIDFDDlSRDDLVKLVSEK-EDLLKVQQKDIMEMKDKFLRTYA 149
Cdd:PRK14154   3 GCMSSKNNPESETKAKNKWEKVMEAEEEQEEGGG-DGSQEMEP-HREGLEFPSREKlEGQLTRMERKVDEYKTQYLRAQA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  150 EQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLerassvvkesfskIDTSKDLAGATPLLKNLLEGVEMTEKQLAEVF 229
Cdd:PRK14154  81 EMDNLRKRIEREKADIIKFGSKQLITDLLPVADSL-------------IHGLESPASEDPQVKSMRDGMSLTLDLLHNTL 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15240475  230 RKAGLVKEDP-LNEPFNPNRHNA--VFQVPDAsKPKgTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14154 148 AKHGVQVINPnPGDPFDPALHEAmsVQAVPDA-KPD-TIIQVLQKGYQLNGRVLRAARVIV 206
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 75-287 3.04e-11

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 61.90  E-value: 3.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   75 SSSAEPKGNESNTEVpktGETSENVEVGKATDAEIDFDDLSRDDLVKLVSEKedllkvqqKDIMEMKDKFLRTYAEQQNL 154
Cdd:PRK14157  42 QDSAAQADANAGADA---APAAAEGEAKAAAEKTGEAQSDSDDTLTPLGQAK--------KEAAEYLEALQRERAEFINY 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  155 MDRTNRNAESAKKFAVQNFATSLLDVADNLER--ASSVVKESFSKIDTSKDLAgatpllknllegvemtekqlaevFRKA 232
Cdd:PRK14157 111 RNRTQKEQDRFRQHGIIDVLTALLPALDDIDRirEHSEMDDSFKAVAAKIDKA-----------------------FEKF 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15240475  233 GLVKEDPLNEPFNPNRHNAVFQVPDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14157 168 GVEKFGEKGEDFDPTKHDAILHKPDPDAEKETVDTVVEAGYRIGDRVIRAARVVV 222
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 96-287 7.39e-11

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 60.32  E-value: 7.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   96 SENVEVGKATDAEIDFDDLSRDDLVKLVSEKEDLLKVQQKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFAT 175
Cdd:PRK14145  20 SSNEQMEGPPEDEQAQQNQPQQQTVDEIEELKQKLQQKEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVIL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  176 SLLDVADNLERAssvvkesfskIDTSKDLAgatpllkNLLEGVEMTEKQLAEVFRKAGLVKEDPLNEPFNPNRHNAVFQV 255
Cdd:PRK14145 100 ELLPVMDNFERA----------LASSGDYN-------SLKEGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQE 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 15240475  256 PDASKPKGTIAHVLKSGYSLYDRVIRPAEVGV 287
Cdd:PRK14145 163 EVEGKQPNEIIEVFQKGYYLKDKVIRPSLVKV 194
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 99-285 5.14e-07

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 49.41  E-value: 5.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475   99 VEVGKATDAEIDFDDLSRDDLVKLVSEKEdlLKVQQKDIMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLL 178
Cdd:PRK14164  50 VEGEIDPDLEADLEDLLDDVDPELADDGE--ASTVEAQLAERTEDLQRVTAEYANYRRRTERERQAIIETAKAGVATDLL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  179 DVADNLERAssvvkesfskiDTSKDLAGAtPL------LKNLLEGVEMtekqlaEVFRKAGlvkedplnEPFNPNRHNAV 252
Cdd:PRK14164 128 PILDDLDLA-----------EQHGDLNEG-PLkafsdkLTNVLAGLKV------EKFGEEG--------DAFDPEIHEAV 181

                        170       180       190
                 ....*....|....*....|....*....|...
gi 15240475  253 FQVpdASKPKGTIAHVLKSGYSLYDRVIRPAEV 285
Cdd:PRK14164 182 QDL--SSGDEKVLGTVLRKGYRMGDRVLRTAMV 212
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 137-302 3.00e-06

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 47.30  E-value: 3.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  137 IMEMKDKFLRTYAEQQNLMDRTNRNAESAKKFAVQNFATSLLDVADNLERAssvvkESFSKIDtSKDLAGATPLLKNLLE 216
Cdd:PRK14142  49 VAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERA-----RKHGDLE-SGPLKSVADKLDSALT 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240475  217 GVemtekqlaevfrkaGLVKEDPLNEPFNPNRHNAVFQVPDA---SKPkgTIAHVLKSGYSLYDRVIRPAEVGVTCAVEN 293
Cdd:PRK14142 123 GL--------------GLVAFGAEGEDFDPVLHEAVQHEGDGgqgSKP--VIGTVMRQGYQLGEQVLRHALVGVVDTVVV 186


                 ....*....
gi 15240475  294 QEGGKESAA 302
Cdd:PRK14142 187 DAAELESVD 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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