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Conserved domains on  [gi|79537386|ref|NP_200186|]
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CBS domain-containing protein [Arabidopsis thaliana]

Protein Classification

CBS domain-containing protein( domain architecture ID 10456749)

CBS (cystathione beta synthase) domain-containing protein may bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet; similar to Arabidopsis thaliana CBS domain-containing protein CBSX5

CATH:  3.10.580.10
PubMed:  16275737|24161944|21958115
SCOP:  4000247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CBS pfam00571
CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...
 355-402 1.15e-04

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.


:

Pssm-ID: 425756 [Multi-domain]  Cd Length: 57  Bit Score: 39.50  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 79537386   355 IVCNRKSSLMAVMIQAIAHRVSYVWVIDEDGCLIGMVTFVDILKLFRE 402
Cdd:pfam00571  10 VTVSPDTTLEEALELMREHGISRLPVVDEDGKLVGIVTLKDLLRALLG 57
 
Name Accession Description Interval E-value
CBS pfam00571
CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...
 355-402 1.15e-04

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.


Pssm-ID: 425756 [Multi-domain]  Cd Length: 57  Bit Score: 39.50  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 79537386   355 IVCNRKSSLMAVMIQAIAHRVSYVWVIDEDGCLIGMVTFVDILKLFRE 402
Cdd:pfam00571  10 VTVSPDTTLEEALELMREHGISRLPVVDEDGKLVGIVTLKDLLRALLG 57
CBS COG0517
CBS domain [Signal transduction mechanisms];
355-402 4.12e-04

CBS domain [Signal transduction mechanisms];


Pssm-ID: 440283 [Multi-domain]  Cd Length: 128  Bit Score: 39.85  E-value: 4.12e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 79537386 355 IVCNRKSSLMAVMIQAIAHRVSYVWVIDEDGCLIGMVTFVDILKLFRE 402
Cdd:COG0517  78 VTVSPDTSLEEAAELMEEHKIRRLPVVDDDGRLVGIITIKDLLKALLE 125
 
Name Accession Description Interval E-value
CBS pfam00571
CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...
 355-402 1.15e-04

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.


Pssm-ID: 425756 [Multi-domain]  Cd Length: 57  Bit Score: 39.50  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 79537386   355 IVCNRKSSLMAVMIQAIAHRVSYVWVIDEDGCLIGMVTFVDILKLFRE 402
Cdd:pfam00571  10 VTVSPDTTLEEALELMREHGISRLPVVDEDGKLVGIVTLKDLLRALLG 57
CBS COG0517
CBS domain [Signal transduction mechanisms];
355-402 4.12e-04

CBS domain [Signal transduction mechanisms];


Pssm-ID: 440283 [Multi-domain]  Cd Length: 128  Bit Score: 39.85  E-value: 4.12e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 79537386 355 IVCNRKSSLMAVMIQAIAHRVSYVWVIDEDGCLIGMVTFVDILKLFRE 402
Cdd:COG0517  78 VTVSPDTSLEEAAELMEEHKIRRLPVVDDDGRLVGIITIKDLLKALLE 125
COG3448 COG3448
CBS-domain-containing membrane protein [Signal transduction mechanisms];
362-407 8.14e-04

CBS-domain-containing membrane protein [Signal transduction mechanisms];


Pssm-ID: 442671 [Multi-domain]  Cd Length: 136  Bit Score: 39.46  E-value: 8.14e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 79537386 362 SLMAVMIQAIAHRVSYVWVIDEDGCLIGMVTFVDILKLFREFLDDE 407
Cdd:COG3448  91 PLEEAAELMLEHGIHRLPVVDDDGRLVGIVTRTDLLRALARLLEEE 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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