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Conserved domains on  [gi|15238774|ref|NP_200166|]
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P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
88-253 4.83e-105

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 307.04  E-value: 4.83e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  88 SIGGLESIKQALYELVILPLKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQ 167
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 168 KLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFTTDQNARVMVLAATNRPSELDEAILRRF 247
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160

                ....*.
gi 15238774 248 PQSFEI 253
Cdd:cd19520 161 PKRFHI 166
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
277-313 2.86e-08

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


:

Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 49.46  E-value: 2.86e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15238774   277 DINYDRIARLCEDYTGSDIFELCKKAAYFPIREILEA 313
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEA 37
 
Name Accession Description Interval E-value
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
88-253 4.83e-105

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 307.04  E-value: 4.83e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  88 SIGGLESIKQALYELVILPLKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQ 167
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 168 KLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFTTDQNARVMVLAATNRPSELDEAILRRF 247
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160

                ....*.
gi 15238774 248 PQSFEI 253
Cdd:cd19520 161 PKRFHI 166
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
83-309 1.48e-79

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 248.00  E-value: 1.48e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  83 DVEFGSIGGLESIKQALYELVILPLKRPELFA-YGklLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSK 161
Cdd:COG1222  74 DVTFDDIGGLDEQIEEIREAVELPLKNPELFRkYG--IEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSK 151
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 162 WFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSfLGQRRSTDNE--AMSNMKTEFMALWDGFTTDQNarVMVLAATNRPSEL 239
Cdd:COG1222 152 YIGEGARNVREVFELAREKAPSIIFIDEIDA-IAARRTDDGTsgEVQRTVNQLLAELDGFESRGD--VLIIAATNRPDLL 228
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238774 240 DEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPIRE 309
Cdd:COG1222 229 DPALLRpgRFDRVIEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIRE 300
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
83-309 9.41e-66

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 214.31  E-value: 9.41e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   83 DVEFGSIGGLESIKQALYELVILPLKRPELFAYgklLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMS 160
Cdd:PRK03992 127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEE---VGiePPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQ 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  161 KWFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSfLGQRR-----STDNEAMSNMkTEFMALWDGFTTDQNARVMvlAATNR 235
Cdd:PRK03992 204 KFIGEGARLVRELFELAREKAPSIIFIDEIDA-IAAKRtdsgtSGDREVQRTL-MQLLAEMDGFDPRGNVKII--AATNR 279
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238774  236 PSELDEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPIRE 309
Cdd:PRK03992 280 IDILDPAILRpgRFDRIIEVPLPDEEGRLEILKIHTRKMNLADDVDLEELAELTEGASGADLKAICTEAGMFAIRD 355
cell_div_CdvC NF041006
cell division protein CdvC;
45-339 4.01e-65

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 212.29  E-value: 4.01e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   45 KKSLEHKREIAKRL-GRPLIQTNQYEDVIACDviNPlhiDVEFGSIGGLESIKQALYELVILPLKRPELFAygklLGPQK 123
Cdd:NF041006  65 KKRIEVLEELVPAEpAGPDVEKESDEELVVKE--KP---KVTFSDIVGLEDVKEALKEAIVYPSKRPDLFP----LGWPR 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  124 GVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVSAVFSLAYKL-----QPAIIFIDEVDSFLGQrR 198
Cdd:NF041006 136 GILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAREKskeegKPAIIFIDEIDALLGV-Y 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  199 STDNEAMSNMKTEFMALWDGFT-TDQNARVMVLAATNRPSELDEAILRRFPQSFEIGMPDCQERAQILKVVLKGESVESD 277
Cdd:NF041006 215 SSEVGGEVRVRNQFLKEMDGLQdKSENYHVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSKIKLEND 294
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238774  278 INYDRIARLCEDYTGSDIFELCKKAAYFPIREILEaekegKRVSVPRPLTQLDLEKVLATSK 339
Cdd:NF041006 295 VDLDELAEMTEGYTASDIRDIVQAAHMRVVKEMFE-----KGLGEPRPITMEDFKEVLKIRK 351
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
83-348 7.09e-53

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 187.42  E-value: 7.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774    83 DVEFGSIGGLESIKQALYELVILPLKRPELFaygKLLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMS 160
Cdd:TIGR01243 449 NVRWSDIGGLEEVKQELREAVEWPLKHPEIF---EKMGirPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILS 525
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   161 KWFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSN-MKTEFMALWDGFttDQNARVMVLAATNRPSEL 239
Cdd:TIGR01243 526 KWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTDrIVNQLLTEMDGI--QELSNVVVIAATNRPDIL 603
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   240 DEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPIREILEA---- 313
Cdd:TIGR01243 604 DPALLRpgRFDRLILVPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSpake 683
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 15238774   314 --EKEGKRVSVPRPLTQLDLEKVLatsKKTQVAASEY 348
Cdd:TIGR01243 684 klEVGEEEFLKDLKVEMRHFLEAL---KKVKPSVSKE 717
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
125-254 9.70e-46

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 153.90  E-value: 9.70e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   125 VLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEA 204
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 15238774   205 MSNMKTEFMALWDGFTTDQNaRVMVLAATNRPSELDEAILRRFPQSFEIG 254
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNS-KVIVIAATNRPDKLDPALLGRFDRIIEFP 129
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
121-246 6.57e-16

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 74.33  E-value: 6.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774    121 PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKV-----------------SNLMSKWFGDAQKLVSAVFSLAYKLQPA 183
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYidgedileevldqllliIVGGKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15238774    184 IIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALwdgfttdQNARVMVLAATNRPSELDEAILRR 246
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLK-------SEKNLTVILTTNDEKDLGPALLRR 136
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
277-313 2.86e-08

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 49.46  E-value: 2.86e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15238774   277 DINYDRIARLCEDYTGSDIFELCKKAAYFPIREILEA 313
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEA 37
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
125-145 1.68e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 39.76  E-value: 1.68e-03
                         10        20
                 ....*....|....*....|.
gi 15238774  125 VLLYGPPGTGKTMLAKAIARE 145
Cdd:NF038214  93 VLLLGPPGTGKTHLAIALGYA 113
 
Name Accession Description Interval E-value
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
88-253 4.83e-105

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 307.04  E-value: 4.83e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  88 SIGGLESIKQALYELVILPLKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQ 167
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 168 KLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFTTDQNARVMVLAATNRPSELDEAILRRF 247
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160

                ....*.
gi 15238774 248 PQSFEI 253
Cdd:cd19520 161 PKRFHI 166
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
83-309 1.48e-79

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 248.00  E-value: 1.48e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  83 DVEFGSIGGLESIKQALYELVILPLKRPELFA-YGklLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSK 161
Cdd:COG1222  74 DVTFDDIGGLDEQIEEIREAVELPLKNPELFRkYG--IEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSK 151
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 162 WFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSfLGQRRSTDNE--AMSNMKTEFMALWDGFTTDQNarVMVLAATNRPSEL 239
Cdd:COG1222 152 YIGEGARNVREVFELAREKAPSIIFIDEIDA-IAARRTDDGTsgEVQRTVNQLLAELDGFESRGD--VLIIAATNRPDLL 228
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238774 240 DEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPIRE 309
Cdd:COG1222 229 DPALLRpgRFDRVIEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIRE 300
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
89-253 2.77e-75

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 231.09  E-value: 2.77e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  89 IGGLESIKQALYELVILPLKRPELFAygKLLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQK 168
Cdd:cd19509   1 IAGLDDAKEALKEAVILPSLRPDLFP--GLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEK 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 169 LVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFTTDQNARVMVLAATNRPSELDEAILRRFP 248
Cdd:cd19509  79 IVRALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRRFE 158

                ....*
gi 15238774 249 QSFEI 253
Cdd:cd19509 159 KRIYI 163
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
23-336 2.83e-71

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 229.03  E-value: 2.83e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  23 AALSSLVLYVGLRQLDPNRDAAKKSLEHKREIAKRLGRPLIQTNQYEDVIACDVINPLHIDVEFGSIGGLESIKQALYEL 102
Cdd:COG0464  93 LLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAILDDLGGLEEVKEELREL 172
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 103 VILPLKRPELFA-YGklLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVSAVFSLAYKLQ 181
Cdd:COG0464 173 VALPLKRPELREeYG--LPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLA 250
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 182 PAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFTTDqnarVMVLAATNRPSELDEAILRRFPQSFEIGMPDCQER 261
Cdd:COG0464 251 PCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEELRSD----VVVIAATNRPDLLDPALLRRFDEIIFFPLPDAEER 326
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238774 262 AQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPIREileaekegkrvsVPRPLTQLDLEKVLA 336
Cdd:COG0464 327 LEIFRIHLRKRPLDEDVDLEELAEATEGLSGADIRNVVRRAALQALRL------------GREPVTTEDLLEALE 389
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
83-309 9.41e-66

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 214.31  E-value: 9.41e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   83 DVEFGSIGGLESIKQALYELVILPLKRPELFAYgklLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMS 160
Cdd:PRK03992 127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEE---VGiePPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQ 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  161 KWFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSfLGQRR-----STDNEAMSNMkTEFMALWDGFTTDQNARVMvlAATNR 235
Cdd:PRK03992 204 KFIGEGARLVRELFELAREKAPSIIFIDEIDA-IAAKRtdsgtSGDREVQRTL-MQLLAEMDGFDPRGNVKII--AATNR 279
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238774  236 PSELDEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPIRE 309
Cdd:PRK03992 280 IDILDPAILRpgRFDRIIEVPLPDEEGRLEILKIHTRKMNLADDVDLEELAELTEGASGADLKAICTEAGMFAIRD 355
cell_div_CdvC NF041006
cell division protein CdvC;
45-339 4.01e-65

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 212.29  E-value: 4.01e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   45 KKSLEHKREIAKRL-GRPLIQTNQYEDVIACDviNPlhiDVEFGSIGGLESIKQALYELVILPLKRPELFAygklLGPQK 123
Cdd:NF041006  65 KKRIEVLEELVPAEpAGPDVEKESDEELVVKE--KP---KVTFSDIVGLEDVKEALKEAIVYPSKRPDLFP----LGWPR 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  124 GVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVSAVFSLAYKL-----QPAIIFIDEVDSFLGQrR 198
Cdd:NF041006 136 GILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAREKskeegKPAIIFIDEIDALLGV-Y 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  199 STDNEAMSNMKTEFMALWDGFT-TDQNARVMVLAATNRPSELDEAILRRFPQSFEIGMPDCQERAQILKVVLKGESVESD 277
Cdd:NF041006 215 SSEVGGEVRVRNQFLKEMDGLQdKSENYHVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSKIKLEND 294
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238774  278 INYDRIARLCEDYTGSDIFELCKKAAYFPIREILEaekegKRVSVPRPLTQLDLEKVLATSK 339
Cdd:NF041006 295 VDLDELAEMTEGYTASDIRDIVQAAHMRVVKEMFE-----KGLGEPRPITMEDFKEVLKIRK 351
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
89-247 8.36e-63

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 199.31  E-value: 8.36e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  89 IGGLESIKQALYELVILPLKRPELFAygKLLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQK 168
Cdd:cd19524   2 IAGQDLAKQALQEMVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEK 79
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15238774 169 LVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFTTDQNARVMVLAATNRPSELDEAILRRF 247
Cdd:cd19524  80 LVRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRF 158
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
83-253 2.69e-58

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 188.27  E-value: 2.69e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  83 DVEFGSIGGLESIKQALYELVILPLKRPELFAygKLLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKW 162
Cdd:cd19525  18 PINWADIAGLEFAKKTIKEIVVWPMLRPDIFT--GLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKW 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 163 FGDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFTTDQNARVMVLAATNRPSELDEA 242
Cdd:cd19525  96 VGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEA 175
                       170
                ....*....|.
gi 15238774 243 ILRRFPQSFEI 253
Cdd:cd19525 176 ARRRLVKRLYI 186
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
83-348 7.09e-53

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 187.42  E-value: 7.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774    83 DVEFGSIGGLESIKQALYELVILPLKRPELFaygKLLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMS 160
Cdd:TIGR01243 449 NVRWSDIGGLEEVKQELREAVEWPLKHPEIF---EKMGirPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILS 525
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   161 KWFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSN-MKTEFMALWDGFttDQNARVMVLAATNRPSEL 239
Cdd:TIGR01243 526 KWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTDrIVNQLLTEMDGI--QELSNVVVIAATNRPDIL 603
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   240 DEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPIREILEA---- 313
Cdd:TIGR01243 604 DPALLRpgRFDRLILVPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSpake 683
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 15238774   314 --EKEGKRVSVPRPLTQLDLEKVLatsKKTQVAASEY 348
Cdd:TIGR01243 684 klEVGEEEFLKDLKVEMRHFLEAL---KKVKPSVSKE 717
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
83-253 1.18e-52

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 173.12  E-value: 1.18e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  83 DVEFGSIGGLESIKQALYELVILPLKRPELFAYGKLlgPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKW 162
Cdd:cd19521   3 NVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRK--PWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKW 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 163 FGDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFTTDqNARVMVLAATNRPSELDEA 242
Cdd:cd19521  81 MGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVGND-SQGVLVLGATNIPWQLDSA 159
                       170
                ....*....|.
gi 15238774 243 ILRRFPQSFEI 253
Cdd:cd19521 160 IRRRFEKRIYI 170
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
83-315 1.72e-51

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 183.57  E-value: 1.72e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774    83 DVEFGSIGGLESIKQALYELVILPLKRPELFaygKLLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMS 160
Cdd:TIGR01243 174 KVTYEDIGGLKEAKEKIREMVELPMKHPELF---EHLGiePPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMS 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   161 KWFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFTtdQNARVMVLAATNRPSELD 240
Cdd:TIGR01243 251 KYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGLK--GRGRVIVIGATNRPDALD 328
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15238774   241 EAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPIREILEAEK 315
Cdd:TIGR01243 329 PALRRpgRFDREIVIRVPDKRARKEILKVHTRNMPLAEDVDLDKLAEVTHGFVGADLAALAKEAAMAALRRFIREGK 405
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
88-253 1.95e-51

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 169.78  E-value: 1.95e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  88 SIGGLESIKQALYELVILPLKRPELFAYgklLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGD 165
Cdd:cd19503   1 DIGGLDEQIASLKELIELPLKYPELFRA---LGlkPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGE 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 166 AQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFttDQNARVMVLAATNRPSELDEAILR 245
Cdd:cd19503  78 SEKNLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGM--SSRGKVVVIAATNRPDAIDPALRR 155
                       170
                ....*....|
gi 15238774 246 --RFPQSFEI 253
Cdd:cd19503 156 pgRFDREVEI 165
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
86-253 9.78e-48

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 160.58  E-value: 9.78e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  86 FGSIGGLESIKQALYELVILPLKRPELFaygKLLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWF 163
Cdd:cd19502   2 YEDIGGLDEQIREIREVVELPLKHPELF---EELGiePPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 164 GDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQR----RSTDNEAMSNMkTEFMALWDGFttDQNARVMVLAATNRPSEL 239
Cdd:cd19502  79 GEGARLVRELFEMAREKAPSIIFIDEIDAIGAKRfdsgTGGDREVQRTM-LELLNQLDGF--DPRGNIKVIMATNRPDIL 155
                       170
                ....*....|....*.
gi 15238774 240 DEAILR--RFPQSFEI 253
Cdd:cd19502 156 DPALLRpgRFDRKIEF 171
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
95-253 7.12e-46

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 155.13  E-value: 7.12e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  95 IKQALYELVILPLKRPELFAYGKLLGpqKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVSAVF 174
Cdd:cd19481   1 LKASLREAVEAPRRGSRLRRYGLGLP--KGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 175 SLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSN-MKTEFMALWDGFTTDqnARVMVLAATNRPSELDEAILR--RFPQSF 251
Cdd:cd19481  79 ERARRLAPCILFIDEIDAIGRKRDSSGESGELRrVLNQLLTELDGVNSR--SKVLVIAATNRPDLLDPALLRpgRFDEVI 156

                ..
gi 15238774 252 EI 253
Cdd:cd19481 157 EF 158
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
125-254 9.70e-46

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 153.90  E-value: 9.70e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   125 VLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEA 204
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 15238774   205 MSNMKTEFMALWDGFTTDQNaRVMVLAATNRPSELDEAILRRFPQSFEIG 254
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNS-KVIVIAATNRPDKLDPALLGRFDRIIEFP 129
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
86-340 2.21e-44

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 154.27  E-value: 2.21e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  86 FGSIGGLESIKQALyELVILPLK-RPELFAYGKLlgPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFG 164
Cdd:COG1223   1 LDDVVGQEEAKKKL-KLIIKELRrRENLRKFGLW--PPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 165 DAQKLVSAVFSLAyKLQPAIIFIDEVDSfLGQRRSTDNEA--MSNMKTEFMALWDGFttdqNARVMVLAATNRPSELDEA 242
Cdd:COG1223  78 ETARNLRKLFDFA-RRAPCVIFFDEFDA-IAKDRGDQNDVgeVKRVVNALLQELDGL----PSGSVVIAATNHPELLDSA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 243 ILRRFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYfpiREILEAEKEgkrvsv 322
Cdd:COG1223 152 LWRRFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAKKLEGLSGADIEKVLKTALK---KAILEDREK------ 222
                       250
                ....*....|....*...
gi 15238774 323 prpLTQLDLEKVLATSKK 340
Cdd:COG1223 223 ---VTKEDLEEALKQRKE 237
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
83-308 3.67e-44

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 158.00  E-value: 3.67e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   83 DVEFGSIGGLESIKQALYELVILPLKRPELFaygKLLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMS 160
Cdd:PTZ00454 141 DVTYSDIGGLDIQKQEIREAVELPLTCPELY---EQIGidPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQ 217
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  161 KWFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEA---MSNMKTEFMALWDGFttDQNARVMVLAATNRPS 237
Cdd:PTZ00454 218 KYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGAdreVQRILLELLNQMDGF--DQTTNVKVIMATNRAD 295
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15238774  238 ELDEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPIR 308
Cdd:PTZ00454 296 TLDPALLRpgRLDRKIEFPLPDRRQKRLIFQTITSKMNLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVR 368
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
82-309 5.97e-44

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 159.37  E-value: 5.97e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774    82 IDVEFGSIGGLESIKQALYELVILpLKRPELFAygKLLG-PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMS 160
Cdd:TIGR01241  50 PKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFT--KLGAkIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVE 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   161 KWFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSF-------LG----QRRSTDNEAMSNMktefmalwDGFTTdqNARVMV 229
Cdd:TIGR01241 127 MFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVgrqrgagLGggndEREQTLNQLLVEM--------DGFGT--NTGVIV 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   230 LAATNRPSELDEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPI 307
Cdd:TIGR01241 197 IAATNRPDVLDPALLRpgRFDRQVVVDLPDIKGREEILKVHAKNKKLAPDVDLKAVARRTPGFSGADLANLLNEAALLAA 276

                  ..
gi 15238774   308 RE 309
Cdd:TIGR01241 277 RK 278
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
95-247 7.70e-44

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 149.74  E-value: 7.70e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  95 IKQALYELVILPLKRPELFAYGKLlGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVSAVF 174
Cdd:cd19511   1 VKRELKEAVEWPLKHPDAFKRLGI-RPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 175 SLAYKLQPAIIFIDEVDSFLGQRRSTD-----NEAMSNMKTEFmalwDGFTTDQNarVMVLAATNRPSELDEAILR--RF 247
Cdd:cd19511  80 QKARQAAPCIIFFDEIDSLAPRRGQSDssgvtDRVVSQLLTEL----DGIESLKG--VVVIAATNRPDMIDPALLRpgRL 153
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
89-253 1.91e-43

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 149.36  E-value: 1.91e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  89 IGGLESIKQALYELVILPLKRPELFAygKLLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQK 168
Cdd:cd19522   2 IADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 169 LVSAVFSLAYKLQPAIIFIDEVDSFLGQR-RSTDNEAMSNMKTEFMALWDGFT-----TDQNARVMVLAATNRPSELDEA 242
Cdd:cd19522  80 LVRLLFEMARFYAPTTIFIDEIDSICSRRgTSEEHEASRRVKSELLVQMDGVGgasenDDPSKMVMVLAATNFPWDIDEA 159
                       170
                ....*....|.
gi 15238774 243 ILRRFPQSFEI 253
Cdd:cd19522 160 LRRRLEKRIYI 170
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
89-254 4.60e-42

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 145.66  E-value: 4.60e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  89 IGGLESIKQALYELVILPLKRPELFaygKLLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDA 166
Cdd:cd19519   2 IGGCRKQLAQIREMVELPLRHPELF---KAIGikPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGES 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 167 QKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFttDQNARVMVLAATNRPSELDEAILR- 245
Cdd:cd19519  79 ESNLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGL--KQRAHVIVMAATNRPNSIDPALRRf 156
                       170
                ....*....|
gi 15238774 246 -RFPQSFEIG 254
Cdd:cd19519 157 gRFDREIDIG 166
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
86-340 6.67e-41

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 149.92  E-value: 6.67e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   86 FGSIGGLESIKQALYELVILPLKRPELF-AYGklLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFG 164
Cdd:PTZ00361 182 YADIGGLEQQIQEIKEAVELPLTHPELYdDIG--IKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLG 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  165 DAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDN----EAMSNMkTEFMALWDGFttDQNARVMVLAATNRPSELD 240
Cdd:PTZ00361 260 DGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSggekEIQRTM-LELLNQLDGF--DSRGDVKVIMATNRIESLD 336
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  241 EAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPIREileaekegK 318
Cdd:PTZ00361 337 PALIRpgRIDRKIEFPNPDEKTKRRIFEIHTSKMTLAEDVDLEEFIMAKDELSGADIKAICTEAGLLALRE--------R 408
                        250       260
                 ....*....|....*....|....*.
gi 15238774  319 RVSVprplTQLDL----EKVLATSKK 340
Cdd:PTZ00361 409 RMKV----TQADFrkakEKVLYRKKG 430
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
95-245 2.32e-39

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 138.01  E-value: 2.32e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  95 IKQALYELVILPLKRPELFaygKLLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVSA 172
Cdd:cd19529   1 VKQELKEAVEWPLLKPEVF---KRLGirPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIRE 77
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15238774 173 VFSLAYKLQPAIIFIDEVDSFLGQR-RSTDNEAMSNMKTEFMALWDGFttDQNARVMVLAATNRPSELDEAILR 245
Cdd:cd19529  78 IFRKARQVAPCVIFFDEIDSIAPRRgTTGDSGVTERVVNQLLTELDGL--EEMNGVVVIAATNRPDIIDPALLR 149
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
95-245 5.67e-39

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 137.26  E-value: 5.67e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  95 IKQALYELVILPLKRPELF-AYGklLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVSAV 173
Cdd:cd19528   1 VKRELQELVQYPVEHPDKFlKFG--MTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDI 78
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238774 174 FSLAYKLQPAIIFIDEVDSFLGQRRS---TDNEAMSNMKTEFMALWDGFTTDQNarVMVLAATNRPSELDEAILR 245
Cdd:cd19528  79 FDKARAAAPCVLFFDELDSIAKARGGnigDAGGAADRVINQILTEMDGMNTKKN--VFIIGATNRPDIIDPAILR 151
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
88-251 4.81e-37

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 132.63  E-value: 4.81e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  88 SIGGLESIKQALYELVILPLKRPELFAYGKLlGPQKGVLLYGPPGTGKTMLAKAIARE-----SEAVFINVKVSNLMSKW 162
Cdd:cd19517   1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKI-TPPRGVLFHGPPGTGKTLMARALAAEcskggQKVSFFMRKGADCLSKW 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 163 FGDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFttDQNARVMVLAATNRPSELDEA 242
Cdd:cd19517  80 VGEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGL--DNRGQVVVIGATNRPDALDPA 157
                       170
                ....*....|.
gi 15238774 243 ILR--RFPQSF 251
Cdd:cd19517 158 LRRpgRFDREF 168
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
81-308 9.71e-37

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 141.33  E-value: 9.71e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   81 HIDVEFGSIGGLESIKQALYELVILpLKRPELFAygKLLGP-QKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLM 159
Cdd:PRK10733 146 QIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQ--KLGGKiPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFV 222
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  160 SKWFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSF-------LGQRRSTDNEAMSNMKTEFmalwDGFttDQNARVMVLAA 232
Cdd:PRK10733 223 EMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVgrqrgagLGGGHDEREQTLNQMLVEM----DGF--EGNEGIIVIAA 296
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15238774  233 TNRPSELDEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAAYFPIR 308
Cdd:PRK10733 297 TNRPDVLDPALLRpgRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALFAAR 374
ftsH CHL00176
cell division protein; Validated
83-303 1.02e-36

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 141.34  E-value: 1.02e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   83 DVEFGSIGGLESIKQALYELVILpLKRPELF-AYGKllGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSK 161
Cdd:CHL00176 179 GITFRDIAGIEEAKEEFEEVVSF-LKKPERFtAVGA--KIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEM 255
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  162 WFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSfLGQRRST----DNEAMSNMKTEFMALWDGFttDQNARVMVLAATNRPS 237
Cdd:CHL00176 256 FVGVGAARVRDLFKKAKENSPCIVFIDEIDA-VGRQRGAgiggGNDEREQTLNQLLTEMDGF--KGNKGVIVIAATNRVD 332
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15238774  238 ELDEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCEDYTGSDIFELCKKAA 303
Cdd:CHL00176 333 ILDAALLRpgRFDRQITVSLPDREGRLDILKVHARNKKLSPDVSLELIARRTPGFSGADLANLLNEAA 400
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
84-247 4.93e-36

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 129.66  E-value: 4.93e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  84 VEFGSIGGLESIKQALYELVILpLKRPELFAYgklLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSK 161
Cdd:cd19501   1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTK---LGakIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEM 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 162 WFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSfLGQRRST----DNEAMSNMKTEFMALWDGFTTDQNarVMVLAATNRPS 237
Cdd:cd19501  77 FVGVGASRVRDLFEQAKKNAPCIVFIDEIDA-VGRKRGAglggGHDEREQTLNQLLVEMDGFESNTG--VIVIAATNRPD 153
                       170
                ....*....|..
gi 15238774 238 ELDEAILR--RF 247
Cdd:cd19501 154 VLDPALLRpgRF 165
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
89-253 1.73e-34

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 125.38  E-value: 1.73e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  89 IGGLESIKQALYELVILPLKRPElfAYGKLLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQK 168
Cdd:cd19523   2 IAGLGALKAAIKEEVLWPLLRPD--AFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 169 LVSAVFSLAYKLQPAIIFIDEVDSFLGQRRStDNEAMSNMKTEFMALWDGFTTDQNARVMVLAATNRPSELDEAILRRFP 248
Cdd:cd19523  80 ILQASFLAARCRQPSVLFISDLDALLSSQDD-EASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFS 158

                ....*
gi 15238774 249 QSFEI 253
Cdd:cd19523 159 KRLLV 163
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
92-245 2.01e-34

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 125.29  E-value: 2.01e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  92 LESIKQALYELVILPLKRPELFAYGKLLGPQkGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVS 171
Cdd:cd19530   1 LDHVREELTMSILRPIKRPDIYKALGIDLPT-GVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVR 79
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15238774 172 AVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWDGFTTDQNarVMVLAATNRPSELDEAILR 245
Cdd:cd19530  80 QVFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGLEERSN--VFVIAATNRPDIIDPAMLR 151
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
81-343 1.70e-33

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 131.70  E-value: 1.70e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  81 HIDVEFGSIGGLESIKQALYELVILpLKRPElfAYGKLLG--PqKGVLLYGPPGTGKTMLAKAIARE----------SEA 148
Cdd:COG0465 136 KPKVTFDDVAGVDEAKEELQEIVDF-LKDPE--KFTRLGAkiP-KGVLLVGPPGTGKTLLAKAVAGEagvpffsisgSDF 211
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 149 V--FINV---KVSNLmskwFGDAQKlvSAvfslayklqPAIIFIDEVDSfLGQRRS------------TDNEAMSNMkte 211
Cdd:COG0465 212 VemFVGVgasRVRDL----FEQAKK--NA---------PCIIFIDEIDA-VGRQRGaglggghdereqTLNQLLVEM--- 272
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 212 fmalwDGFTTDQNarVMVLAATNRPSELDEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYDRIARLCED 289
Cdd:COG0465 273 -----DGFEGNEG--VIVIAATNRPDVLDPALLRpgRFDRQVVVDLPDVKGREAILKVHARKKPLAPDVDLEVIARRTPG 345
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15238774 290 YTGSDIFELCKKAAyfpireILEAEKEGKRVsvprplTQLDLE----KVLA-TSKKTQV 343
Cdd:COG0465 346 FSGADLANLVNEAA------LLAARRNKKAV------TMEDFEeaidRVIAgPERKSRV 392
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
88-246 1.68e-32

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 120.20  E-value: 1.68e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  88 SIGGLESIKQALYELVILPLKRPELFAYgklLG--PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGD 165
Cdd:cd19518   1 DIGGMDSTLKELCELLIHPILPPEYFQH---LGvePPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGE 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 166 AQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALWD--GFTTDQNARVMVLAATNRPSELDEAi 243
Cdd:cd19518  78 SEEKIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDelNNEKTAGGPVLVIGATNRPDSLDPA- 156

                ...
gi 15238774 244 LRR 246
Cdd:cd19518 157 LRR 159
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
95-247 1.05e-31

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 118.00  E-value: 1.05e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  95 IKQALYELVILPLKRPELFAYGklLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVSAVF 174
Cdd:cd19527   1 VKKEILDTIQLPLEHPELFSSG--LRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVF 78
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15238774 175 SLAYKLQPAIIFIDEVDSFLGQR-RSTDNEA-MSNMKTEFMALWDGFTTDQNArVMVLAATNRPSELDEAILR--RF 247
Cdd:cd19527  79 QKARDAKPCVIFFDELDSLAPSRgNSGDSGGvMDRVVSQLLAELDGMSSSGQD-VFVIGATNRPDLLDPALLRpgRF 154
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
95-245 4.91e-30

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 113.29  E-value: 4.91e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  95 IKQALYELVILPLKRPELFAYGKLLGPqKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDAQKLVSAVF 174
Cdd:cd19526   1 VKKALEETIEWPSKYPKIFASSPLRLR-SGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLF 79
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238774 175 SLAYKLQPAIIFIDEVDSfLGQRRSTDNEAMSN-MKTEFMALWDGFTTDQNarVMVLAATNRPSELDEAILR 245
Cdd:cd19526  80 SRAQSAKPCILFFDEFDS-IAPKRGHDSTGVTDrVVNQLLTQLDGVEGLDG--VYVLAATSRPDLIDPALLR 148
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
90-254 6.00e-24

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 96.83  E-value: 6.00e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  90 GGLESIKQALYELVILPlkrpelfaygkllgPQKGVLLYGPPGTGKTMLAKAIARES---EAVFINVKVSNLMSKWFGDA 166
Cdd:cd00009   1 VGQEEAIEALREALELP--------------PPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAE 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 167 QKLVSAV---FSLAYKLQPAIIFIDEVDSFlgqRRSTDNEAMSNMKTEFmalwdgFTTDQNARVMVLAATNRPSE--LDE 241
Cdd:cd00009  67 LFGHFLVrllFELAEKAKPGVLFIDEIDSL---SRGAQNALLRVLETLN------DLRIDRENVRVIGATNRPLLgdLDR 137
                       170
                ....*....|...
gi 15238774 242 AILRRFPQSFEIG 254
Cdd:cd00009 138 ALYDRLDIRIVIP 150
ycf46 CHL00195
Ycf46; Provisional
83-336 2.74e-18

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 86.61  E-value: 2.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   83 DVEFGSIGGLESIKQALYelvilplKRPELFA-----YGkLLGPqKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSN 157
Cdd:CHL00195 224 NEKISDIGGLDNLKDWLK-------KRSTSFSkqasnYG-LPTP-RGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGK 294
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  158 LMSKWFGDAQKLVSAVFSLAYKLQPAIIFIDEVD-SFLGQRRSTDNeAMSNMKTEFMALWdgfTTDQNARVMVLAATNRP 236
Cdd:CHL00195 295 LFGGIVGESESRMRQMIRIAEALSPCILWIDEIDkAFSNSESKGDS-GTTNRVLATFITW---LSEKKSPVFVVATANNI 370
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  237 SELDEAILR--RFPQSFEIGMPDCQERAQILKVVLKGESVESDINYD--RIARLCEDYTGSDIFELCKKAAY-------- 304
Cdd:CHL00195 371 DLLPLEILRkgRFDEIFFLDLPSLEEREKIFKIHLQKFRPKSWKKYDikKLSKLSNKFSGAEIEQSIIEAMYiafyekre 450
                        250       260       270
                 ....*....|....*....|....*....|..
gi 15238774  305 FPIREILEAEKEgkrvsvPRPLTQLDLEKVLA 336
Cdd:CHL00195 451 FTTDDILLALKQ------FIPLAQTEKEQIEA 476
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
123-255 1.94e-16

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 76.76  E-value: 1.94e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 123 KGVLLYGPPGTGKTMLAKAI-----ARESEAvfinVKVSNLMSKWFGDAQKLVSAVFSLAYKLQPA--------IIFIDE 189
Cdd:cd19504  36 KGILLYGPPGTGKTLMARQIgkmlnAREPKI----VNGPEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFDE 111
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15238774 190 VDSFLGQRRST--DNEAMSNMKTEFMALWDGftTDQNARVMVLAATNRPSELDEAILRrfPQSFEIGM 255
Cdd:cd19504 112 IDAICKQRGSMagSTGVHDTVVNQLLSKIDG--VEQLNNILVIGMTNRKDLIDEALLR--PGRLEVQM 175
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
121-246 6.57e-16

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 74.33  E-value: 6.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774    121 PQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKV-----------------SNLMSKWFGDAQKLVSAVFSLAYKLQPA 183
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYidgedileevldqllliIVGGKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15238774    184 IIFIDEVDSFLGQRRSTDNEAMSNMKTEFMALwdgfttdQNARVMVLAATNRPSELDEAILRR 246
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLK-------SEKNLTVILTTNDEKDLGPALLRR 136
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
120-252 1.67e-15

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 73.33  E-value: 1.67e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 120 GPQKGVLLYGPPGTGKTMLAKAIARESE---AVFINVKVSNLMSkwfgDAQKLVSAVFSLAYKLQPA-IIFIDEVDSFLG 195
Cdd:cd19512  20 GLYRNILFYGPPGTGKTLFAKKLALHSGmdyAIMTGGDVAPMGR----EGVTAIHKVFDWANTSRRGlLLFVDEADAFLR 95
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 196 QRRSTdneamsNMKTEFMALWDGF---TTDQNARVMVLAATNRPSELDEAILRRFPQSFE 252
Cdd:cd19512  96 KRSTE------KISEDLRAALNAFlyrTGEQSNKFMLVLASNQPEQFDWAINDRIDEMVE 149
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
89-251 7.03e-15

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 71.63  E-value: 7.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  89 IGGLESIKQALyelvilpLKR-----PELFAYGklLGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWF 163
Cdd:cd19507   2 VGGLDNLKDWL-------KKRkaafsKQASAYG--LPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLV 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 164 GDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLG-QRRSTDNEAMSNMKTEFMAlWdgfTTDQNARVMVLAATNRPSELDEA 242
Cdd:cd19507  73 GESESRLRQMIQTAEAIAPCVLWIDEIEKGFSnADSKGDSGTSSRVLGTFLT-W---LQEKKKPVFVVATANNVQSLPPE 148
                       170
                ....*....|.
gi 15238774 243 ILR--RFPQSF 251
Cdd:cd19507 149 LLRkgRFDEIF 159
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
93-246 1.04e-12

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 66.32  E-value: 1.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  93 ESIKQALYELVILPLKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIA---------RESEAVFINVKVSNLMSKWF 163
Cdd:cd19508  23 SNLKSRLLDYVTTTLLFSDKNVNTNLITWNRLVLLHGPPGTGKTSLCKALAqklsirlssRYRYGQLIEINSHSLFSKWF 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 164 GDAQKLVSAVFSLAYKL---QPAIIF--IDEVDSFLGQR-----RSTDNEAMSNMKTEFMALwDGFTTDQNarVMVLAAT 233
Cdd:cd19508 103 SESGKLVTKMFQKIQELiddKDALVFvlIDEVESLAAARsasssGTEPSDAIRVVNAVLTQI-DRIKRYHN--NVILLTS 179
                       170
                ....*....|...
gi 15238774 234 NRPSELDEAILRR 246
Cdd:cd19508 180 NLLEKIDVAFVDR 192
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
95-251 6.91e-12

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 63.32  E-value: 6.91e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  95 IKQALYELVILPLKRPELFAYGKLLgpqKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFGDA--QKLVSA 172
Cdd:cd19506   2 VRQLLTLYGILPLGSQAVHEKAPLV---KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 173 VFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEAMS--NMKTEFMALWDGFTTDQnaRVMVLAATNRPSELDEAILRRFPQS 250
Cdd:cd19506  79 VLKVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDpkRLKKDLPKILKSLKPED--RVLIVGTTSRPFEADLKSFCKVYNK 156

                .
gi 15238774 251 F 251
Cdd:cd19506 157 I 157
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
124-247 1.99e-09

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 55.38  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   124 GVLLYGPPGTGKTMLAKAIAR----------------ESEAVFINVKVSNLMSKWfgDAQKLVSAVfslaykLQPAIIFI 187
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAalsnrpvfyvqltrdtTEEDLFGRRNIDPGGASW--VDGPLVRAA------REGEIAVL 72
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238774   188 DEVDSflgQRRSTDNEAMSNMKTEFMALWDGFTTDQ--NARVMVLAATNRP----SELDEAILRRF 247
Cdd:pfam07728  73 DEINR---ANPDVLNSLLSLLDERRLLLPDGGELVKaaPDGFRLIATMNPLdrglNELSPALRSRF 135
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
125-286 5.54e-09

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 56.71  E-value: 5.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 125 VLLYGPPGTGKTMLAKAIARESEAVFINVKV-SNLMskwfgdAQKLV-SAVFSLAY---KLQP-----AIIFIDEVDsfl 194
Cdd:COG0714  34 LLLEGVPGVGKTTLAKALARALGLPFIRIQFtPDLL------PSDILgTYIYDQQTgefEFRPgplfaNVLLADEIN--- 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 195 gqrRSTDN------EAMSNMKtefmalwdgFTTDQN-----ARVMVLAATNRPS-----ELDEAILRRFPQSFEIGMPDC 258
Cdd:COG0714 105 ---RAPPKtqsallEAMEERQ---------VTIPGGtyklpEPFLVIATQNPIEqegtyPLPEAQLDRFLLKLYIGYPDA 172
                       170       180       190
                ....*....|....*....|....*....|
gi 15238774 259 QERAQILKVVLKG--ESVESDINYDRIARL 286
Cdd:COG0714 173 EEEREILRRHTGRhlAEVEPVLSPEELLAL 202
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
125-194 1.91e-08

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 55.86  E-value: 1.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  125 VLLYGPPGTGKTMLAKAIARESE-------AVFINVKvsnlmskwfgDAQKLVSAVFSLAYKLQPAIIFIDEV------- 190
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDapfealsAVTSGVK----------DLREVIEEARQRRSAGRRTILFIDEIhrfnkaq 108

                 ....*
gi 15238774  191 -DSFL 194
Cdd:PRK13342 109 qDALL 113
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
277-313 2.86e-08

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 49.46  E-value: 2.86e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15238774   277 DINYDRIARLCEDYTGSDIFELCKKAAYFPIREILEA 313
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEA 37
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
125-194 3.57e-08

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 55.06  E-value: 3.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 125 VLLYGPPGTGKTMLAKAIARESEAVFINvkvsnlmskwfgdaqklVSAVFS---------------LAYKlQPAIIFIDE 189
Cdd:COG2256  52 MILWGPPGTGKTTLARLIANATDAEFVA-----------------LSAVTSgvkdirevieearerRAYG-RRTILFVDE 113
                        90
                ....*....|...
gi 15238774 190 V--------DSFL 194
Cdd:COG2256 114 IhrfnkaqqDALL 126
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
123-246 1.50e-07

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 50.43  E-value: 1.50e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 123 KGVLLYGPPGTGKTMLAKAIARESEavfINVKVSNLMSKWFGDAQK--LvsavfsLAYKLQPAIIFIDEVD-SFLGQRRS 199
Cdd:cd19510  24 RGYLLYGPPGTGKSSFIAALAGELD---YDICDLNLSEVVLTDDRLnhL------LNTAPKQSIILLEDIDaAFESREHN 94
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15238774 200 TDNEAMSNMKTE--FMALW---DGFTTdQNARVMVLaATNRPSELDEAILRR 246
Cdd:cd19510  95 KKNPSAYGGLSRvtFSGLLnalDGVAS-SEERIVFM-TTNHIERLDPALIRP 144
PRK04195 PRK04195
replication factor C large subunit; Provisional
121-191 8.35e-07

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 50.69  E-value: 8.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  121 PQKGVLLYGPPGTGKTMLAKAIARE--SEAVFIN-------------VKVSNLMSKWFGDAQKLvsavfslayklqpaiI 185
Cdd:PRK04195  38 PKKALLLYGPPGVGKTSLAHALANDygWEVIELNasdqrtadviervAGEAATSGSLFGARRKL---------------I 102

                 ....*.
gi 15238774  186 FIDEVD 191
Cdd:PRK04195 103 LLDEVD 108
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
116-145 1.46e-06

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 49.97  E-value: 1.46e-06
                        10        20        30
                ....*....|....*....|....*....|
gi 15238774 116 GKLLGpqKGVLLYGPPGTGKTMLAKAIARE 145
Cdd:COG1224  60 GKMAG--KGILIVGPPGTGKTALAVAIARE 87
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
91-144 3.32e-06

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 47.17  E-value: 3.32e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15238774  91 GLESIKQAlyelvILplkrpELFAYGKLLGPQKG--VLLYGPPGTGKTMLAKAIAR 144
Cdd:cd19500  14 GLEDVKER-----IL-----EYLAVRKLKGSMKGpiLCLVGPPGVGKTSLGKSIAR 59
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
119-244 1.08e-05

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 45.44  E-value: 1.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 119 LGPQKGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWF--------------GDAQKLVSAVFSLAYKLQPAI 184
Cdd:cd19505   9 LSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLLYNKPdfgnddwidgmlilKESLHRLNLQFELAKAMSPCI 88
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15238774 185 IFIDEVDSfLGQRRSTdNEAMSNMKTEFMALWDGFTTDQNAR----VMVLAATNRPSELDEAIL 244
Cdd:cd19505  89 IWIPNIHE-LNVNRST-QNLEEDPKLLLGLLLNYLSRDFEKSstrnILVIASTHIPQKVDPALI 150
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
125-240 1.54e-05

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 44.03  E-value: 1.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 125 VLLYGPPGTGKTMLAKAIARESEAvfinvKVSNLMskWFGDAQKLVSAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDNEA 204
Cdd:cd01120   1 ILITGPPGSGKTTLLLQFAEQALL-----SDEPVI--FISFLDTILEAIEDLIEEKKLDIIIIDSLSSLARASQGDRSSE 73
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15238774 205 MSNMKTEFMALwdgfttDQNARVMVLAATNRPSELD 240
Cdd:cd01120  74 LLEDLAKLLRA------ARNTGITVIATIHSDKFDI 103
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
114-145 1.96e-05

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 45.54  E-value: 1.96e-05
                        10        20        30
                ....*....|....*....|....*....|..
gi 15238774 114 AYGKLLGPQKGVLLYGPPGTGKTMLAKAIARE 145
Cdd:COG1484  91 ATLDFIERGENLILLGPPGTGKTHLAIALGHE 122
Bac_DnaA pfam00308
Bacterial dnaA protein;
125-275 3.05e-05

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 44.63  E-value: 3.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   125 VLLYGPPGTGKTMLAKAIARESEAVFINVKVSNLMSKWFgdAQKLVSAV-------FSLAYKlQPAIIFIDEVdSFLGQR 197
Cdd:pfam00308  37 LFIYGGVGLGKTHLLHAIGNYALQNAPNLRVVYLTAEEF--LNDFVDAIrdnktnqFKEKYR-NVDVLLIDDI-QFLAGK 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   198 RSTDNEAMsnmkTEFMALWDgfttdqNARVMVLAATNRPSEL---DEAILRRFPQSFEIGM--PDCQERAQILKVVLKGE 272
Cdd:pfam00308 113 EGTQEEFF----HTFNALHE------SGKQIVFSSDRPPKELeelEDRLRSRFQWGLVTDIepPDLETRLAILRKKAEAE 182

                  ...
gi 15238774   273 SVE 275
Cdd:pfam00308 183 GIE 185
PRK13341 PRK13341
AAA family ATPase;
126-193 3.27e-05

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 46.20  E-value: 3.27e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15238774  126 LLYGPPGTGKTMLAKAIARESEAVFINVK-----VSNLMSkwfgdaqKLVSAVFSLAYKLQPAIIFIDEVDSF 193
Cdd:PRK13341  56 ILYGPPGVGKTTLARIIANHTRAHFSSLNavlagVKDLRA-------EVDRAKERLERHGKRTILFIDEVHRF 121
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
125-145 4.01e-05

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 45.12  E-value: 4.01e-05
                         10        20
                 ....*....|....*....|.
gi 15238774  125 VLLYGPPGTGKTMLAKAIARE 145
Cdd:PRK00080  54 VLLYGPPGLGKTTLANIIANE 74
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
125-145 4.69e-05

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 43.26  E-value: 4.69e-05
                          10        20
                  ....*....|....*....|.
gi 15238774   125 VLLYGPPGTGKTMLAKAIARE 145
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANE 56
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
123-191 1.07e-04

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 42.75  E-value: 1.07e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15238774 123 KGVLLYGPPGTGKTMLAKAIARESEAVFINVKVSNlmskwFGDAQKLVSAVFSLAYKLQPAIIFIDEVD 191
Cdd:cd19498  47 KNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATK-----FTEVGYVGRDVESIIRDLVEGIVFIDEID 110
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
111-145 1.41e-04

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 43.45  E-value: 1.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15238774   111 ELFAYGKLLGpqKGVLLYGPPGTGKTMLAKAIARE 145
Cdd:pfam06068  41 EMIKEGKIAG--RAVLIAGPPGTGKTALAIAISKE 73
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
125-142 1.55e-04

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 43.88  E-value: 1.55e-04
                        10
                ....*....|....*...
gi 15238774 125 VLLYGPPGTGKTMLAKAI 142
Cdd:COG0606 214 LLMIGPPGSGKTMLARRL 231
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
125-142 1.64e-04

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 42.52  E-value: 1.64e-04
                          10
                  ....*....|....*...
gi 15238774   125 VLLYGPPGTGKTMLAKAI 142
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKRL 42
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
117-190 1.65e-04

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 43.39  E-value: 1.65e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238774 117 KLLGPQKGVLLYGPPGTGKTMLAKAIARESE-AVFINVKVSNLMSKWFGDAQKLVSAVFSLAYKlqPAIIFIDEV 190
Cdd:COG1373  15 KLLDNRKAVVITGPRQVGKTTLLKQLAKELEnILYINLDDPRLRALAEEDPDDLLEALKELYPG--KTYLFLDEI 87
Lon COG0466
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
91-144 1.69e-04

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440234 [Multi-domain]  Cd Length: 785  Bit Score: 43.85  E-value: 1.69e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15238774  91 GLESIKQAlyelvILplkrpELFAYGKLLGPQKG--VLLYGPPGTGKTMLAKAIAR 144
Cdd:COG0466 329 GLEKVKER-----IL-----EYLAVRKLKKKLKGpiLCLVGPPGVGKTSLGKSIAR 374
Sigma54_activat pfam00158
Sigma-54 interaction domain;
125-247 1.74e-04

Sigma-54 interaction domain;


Pssm-ID: 425491 [Multi-domain]  Cd Length: 168  Bit Score: 42.00  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   125 VLLYGPPGTGKTMLAKAIARES---EAVFINVkvsN--------LMSKWFG-------DAQKLVSAVFSLAYKlqpAIIF 186
Cdd:pfam00158  25 VLITGESGTGKELFARAIHQLSpraDGPFVAV---NcaaipeelLESELFGhekgaftGADSDRKGLFELADG---GTLF 98
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15238774   187 IDEVDS-----------FLgQRRstdneamsnmktEFMALwdGFTTDQNARVMVLAATNRPseLDEAILR-RF 247
Cdd:pfam00158  99 LDEIGElplelqakllrVL-QEG------------EFERV--GGTKPIKVDVRIIAATNRD--LEEAVAEgRF 154
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
125-191 1.75e-04

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 42.97  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 125 VLLYGPPGTGKTMLAKAIARE-------------SEAVFINVKVSNLMSKWfgdaqkLVSAVFSLAyKLQPAIIFIDEVD 191
Cdd:cd19497  53 ILLIGPTGSGKTLLAQTLAKIldvpfaiadattlTEAGYVGEDVENILLKL------LQAADYDVE-RAQRGIVYIDEID 125
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
38-145 2.02e-04

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 43.22  E-value: 2.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  38 DPNRDAAKKSLEHKREIAKRLGRPLIQTNQYEDVIACDVINPLHIDVEFGSIGGLESIKQALYEL------VILPLKRPE 111
Cdd:COG1401 131 ALERARLLLELADLEERAALETEVLEALEAELEELLAAPEDLSADALAAELSAAEELYSEDLESEddylkdLLREKFEET 210
                        90       100       110
                ....*....|....*....|....*....|....
gi 15238774 112 LFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIARE 145
Cdd:COG1401 211 LEAFLAALKTKKNVILAGPPGTGKTYLARRLAEA 244
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
125-145 2.54e-04

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 42.76  E-value: 2.54e-04
                        10        20
                ....*....|....*....|.
gi 15238774 125 VLLYGPPGTGKTMLAKAIARE 145
Cdd:COG2255  57 VLLYGPPGLGKTTLAHIIANE 77
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
125-191 4.06e-04

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 40.64  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   125 VLLYGPPGTGKTMLAKAIARE---SEAVFINVKVSNLMSKW--------------FGDAQKLVSAVFSLAYklqpAIIFI 187
Cdd:pfam07724   6 FLFLGPTGVGKTELAKALAELlfgDERALIRIDMSEYMEEHsvsrligappgyvgYEEGGQLTEAVRRKPY----SIVLI 81

                  ....
gi 15238774   188 DEVD 191
Cdd:pfam07724  82 DEIE 85
Parvo_NS1 pfam01057
Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses ...
116-143 4.47e-04

Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.


Pssm-ID: 426020  Cd Length: 271  Bit Score: 41.52  E-value: 4.47e-04
                          10        20
                  ....*....|....*....|....*...
gi 15238774   116 GKLLGPQKGVLLYGPPGTGKTMLAKAIA 143
Cdd:pfam01057 107 SKQFGKRNTVWFYGPASTGKTNLAQAIA 134
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
125-205 4.65e-04

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 39.12  E-value: 4.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   125 VLLYGPPGTGKTMLAKAIARESeAVFINVKVSNLMSK------WFGdaqklvsavfslaYKLQPAIIFIDevdsfLGQRR 198
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARAL-LKKLGLPKDSVYSRnpdddfWDG-------------YTGQPVVIIDD-----FGQNP 61

                  ....*..
gi 15238774   199 STDNEAM 205
Cdd:pfam00910  62 DGPDEAE 68
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
125-247 1.00e-03

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 40.89  E-value: 1.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 125 VLLYGPPGTGKTMLAKAIARES-EAVFIN------------VKVSNLMSKWFGDAQKLVsavfsLAYKlqpAIIFIDEVD 191
Cdd:cd17753  44 VLLLGDPGTAKSQFLKYVEKTAhRAVFTTgqgasavgltasVRKDPVTKEWTLEGGALV-----LADK---GVCLIDEFD 115
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15238774 192 SFLGQRRSTDNEAMSNMKTEFMALwdGFTTDQNARVMVLAATN------RPS-------ELDEAILRRF 247
Cdd:cd17753 116 KMNDQDRTSIHEAMEQQSISISKA--GIVTSLQARCSVIAAANpiggryNPTltfaqnvNLTEPILSRF 182
PRK08116 PRK08116
hypothetical protein; Validated
124-145 1.31e-03

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 40.39  E-value: 1.31e-03
                         10        20
                 ....*....|....*....|..
gi 15238774  124 GVLLYGPPGTGKTMLAKAIARE 145
Cdd:PRK08116 116 GLLLWGSVGTGKTYLAACIANE 137
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
125-245 1.40e-03

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 39.15  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 125 VLLYGPPGTGKTMLAKAIAR--ESEAVFINVKVSNLMSKWFGDAQKLVSAVFSL------------AYKLQPAIIFIDEV 190
Cdd:cd00267  28 VALVGPNGSGKSTLLRAIAGllKPTSGEILIDGKDIAKLPLEELRRRIGYVPQLsggqrqrvalarALLLNPDLLLLDEP 107
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15238774 191 DSFLgqrrstDNEAMSNMKTEFMALWDGFTTdqnarvmVLAATNRPSELDEAILR 245
Cdd:cd00267 108 TSGL------DPASRERLLELLRELAEEGRT-------VIIVTHDPELAELAADR 149
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
88-247 1.65e-03

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 40.02  E-value: 1.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  88 SIGGLESIKQALYELVILPLKRPeLFAYGKLLGpQKGVLLYGPPGTGKTMLAKAIARES-EAVFINVKVSN-------LM 159
Cdd:cd17706   9 SIYGHEDVKKAVLLQLFGGVQKI-LEDGTRIRG-DIHILLVGDPGTAKSQILKYVLKIApRGVYTSGKGSSgagltaaVV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 160 SKWFGDAQKLVSAVFSLAYKlqpAIIFIDEVDSFLGQRRSTDNEAMSNMKTEFMAlwDGFTTDQNARVMVLAATN----- 234
Cdd:cd17706  87 RDSETGEWYLEAGALVLADG---GVCCIDEFDKMKELDRTALHEAMEQQTISIAK--AGIVTTLNARCSILAAANpkggr 161
                       170       180
                ....*....|....*....|.
gi 15238774 235 -----RPSE---LDEAILRRF 247
Cdd:cd17706 162 ynpklSPIEninLPSPLLSRF 182
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
125-145 1.68e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 39.76  E-value: 1.68e-03
                         10        20
                 ....*....|....*....|.
gi 15238774  125 VLLYGPPGTGKTMLAKAIARE 145
Cdd:NF038214  93 VLLLGPPGTGKTHLAIALGYA 113
PRK06835 PRK06835
DNA replication protein DnaC; Validated
120-145 1.99e-03

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 39.88  E-value: 1.99e-03
                         10        20
                 ....*....|....*....|....*.
gi 15238774  120 GPQKGVLLYGPPGTGKTMLAKAIARE 145
Cdd:PRK06835 181 KNNENLLFYGNTGTGKTFLSNCIAKE 206
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
125-151 2.96e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 38.36  E-value: 2.96e-03
                        10        20
                ....*....|....*....|....*..
gi 15238774 125 VLLYGPPGTGKTMLAKAIARESEAVFI 151
Cdd:COG0645   2 ILVCGLPGSGKSTLARALAERLGAVRL 28
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
125-145 3.86e-03

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 39.06  E-value: 3.86e-03
                        10        20
                ....*....|....*....|.
gi 15238774 125 VLLYGPPGTGKTMLAKAIARE 145
Cdd:COG1474  54 VLIYGPTGTGKTAVAKYVLEE 74
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
116-144 4.17e-03

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 37.03  E-value: 4.17e-03
                          10        20
                  ....*....|....*....|....*....
gi 15238774   116 GKLLGPQKGVLLYGPPGTGKTMLAKAIAR 144
Cdd:pfam02367  15 AALLKPGDVILLSGDLGAGKTTFTRGLAR 43
AAA_22 pfam13401
AAA domain;
125-191 4.68e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 36.94  E-value: 4.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   125 VLLYGPPGTGKTMLAKAIARE-----SEAVFINVKVSN----LMSKWF----------GDAQKLVSAV--FSLAYKLQPA 183
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQlpevrDSVVFVDLPSGTspkdLLRALLralglplsgrLSKEELLAALqqLLLALAVAVV 87

                  ....*...
gi 15238774   184 IIfIDEVD 191
Cdd:pfam13401  88 LI-IDEAQ 94
PHA02244 PHA02244
ATPase-like protein
125-254 4.70e-03

ATPase-like protein


Pssm-ID: 107157 [Multi-domain]  Cd Length: 383  Bit Score: 38.95  E-value: 4.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  125 VLLYGPPGTGKTMLAKAIAR--ESEAVFINVKVSNLMSKWFGDAQ-KLVSAVFSLAYKlQPAIIFIDEVDSFLGQRRSTD 201
Cdd:PHA02244 122 VFLKGGAGSGKNHIAEQIAEalDLDFYFMNAIMDEFELKGFIDANgKFHETPFYEAFK-KGGLFFIDEIDASIPEALIII 200
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15238774  202 NEAMSNmktEFMALWDG-FTTDQNARVMVLAAT---------NRPSELDEAILRRFPQsFEIG 254
Cdd:PHA02244 201 NSAIAN---KFFDFADErVTAHEDFRVISAGNTlgkgadhiyVARNKIDGATLDRFAP-IEFD 259
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
125-190 5.16e-03

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 38.44  E-value: 5.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15238774   125 VLLYGPPGTGKTMLAKAIARESEAvfiNVKV-SNLMSKWFGDAQKLVSAvfslaykLQPA-IIFIDEV 190
Cdd:TIGR00635  33 LLLYGPPGLGKTTLAHIIANEMGV---NLKItSGPALEKPGDLAAILTN-------LEEGdVLFIDEI 90
MCM pfam00493
MCM P-loop domain;
125-247 5.29e-03

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 37.89  E-value: 5.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774   125 VLLYGPPGTGKTMLAKAIARESE-AVFINVKVS------------NLMSKWFGDAQKLVsavfsLAYKlqpAIIFIDEVD 191
Cdd:pfam00493  60 VLLVGDPGTAKSQLLKYVEKIAPrAVYTSGKGSsaagltaavvrdPVTGEFVLEAGALV-----LADG---GVCCIDEFD 131
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238774   192 SFLGQRRSTDNEAM-----SNMKTefmalwdGFTTDQNARVMVLAATNrPS--------------ELDEAILRRF 247
Cdd:pfam00493 132 KMNDEDRVALHEAMeqqtiSIAKA-------GIVATLNARCSILAAAN-PIfgrydpkksiaeniNLPPPLLSRF 198
rfc PRK00440
replication factor C small subunit; Reviewed
126-192 5.31e-03

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 38.70  E-value: 5.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  126 LLYGPPGTGKTMLAKAIARE---------------SEAVFINV---KVSNLM-SKWFGDAqklvsavfslAYKlqpaIIF 186
Cdd:PRK00440  42 LFAGPPGTGKTTAALALARElygedwrenflelnaSDERGIDVirnKIKEFArTAPVGGA----------PFK----IIF 107

                 ....*.
gi 15238774  187 IDEVDS 192
Cdd:PRK00440 108 LDEADN 113
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
88-234 7.36e-03

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 38.20  E-value: 7.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774  88 SIGGLESIKQALYELVI--LPLKRPElfayGKLLGPQKGVLLYGPPGTGKTMLAKAIARES-EAVFINVKVSN------- 157
Cdd:cd17761  10 SIYGHEDVKEAIALQLFggVPKVLPD----GTRIRGDIHILLVGDPGTAKSQLLKYVSKVApRAVYTTGKGSTaagltaa 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238774 158 -----LMSKWFGDAQKLVSAVFSLAYklqpaiifIDEVDSFLGQRRSTDNEAMSNMKTEFMALwdGFTTDQNARVMVLAA 232
Cdd:cd17761  86 vvrdeGTGEWYLEAGALVLADKGIAV--------VDEIDKMRKEDRSALHEAMEQQTISIAKA--GIVATLNARAAVLAA 155

                ..
gi 15238774 233 TN 234
Cdd:cd17761 156 AN 157
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
124-145 7.40e-03

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 38.03  E-value: 7.40e-03
                        10        20
                ....*....|....*....|..
gi 15238774 124 GVLLYGPPGTGKTMLAKAIARE 145
Cdd:COG0470  20 ALLLHGPPGIGKTTLALALARD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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