|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
26-462 |
0e+00 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 542.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 26 EVKKQLWLSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVTGFSFLMGTASALDTLCGQAYGAKKYGMLG 105
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 106 IQMQRAMFVLTLASIPLSIIWANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGV 185
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 186 TTSLHVLLCWVLVFKSGLGFQGAALANSISYWLNVVLLFCYVKFSPSCSLTWTGFSKEALRDILPFLRLAVPSALMVCLE 265
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 266 MWSFELLVLLSGLLPnPVLETSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICIAVAESIVIG 345
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 346 SVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVGVPSGLLLAFHF 425
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|....*..
gi 15237158 426 HVGGRGLWLGIICALVVQVFGLGLVTIFTNWDEEAKK 462
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
36-377 |
5.43e-86 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 267.96 E-value: 5.43e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 36 PLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIAtSFASVTGFSFLMGTASALDTLCGQAYGAKKYGMLGIQMQRAMFVL 115
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 116 TLASIPLSIIWANTEHLLVFFGQ-NKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVTTSLHVLLC 194
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 195 WVLVFK--SGLGFQGAALANSISYWLNVVLLFCYVKFSPSCSLTWTGFSKEALRDILPFLRLAVPSALMVCLEMWSFELL 272
Cdd:TIGR00797 160 YILIFGkfGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 273 VLLSGLLPNPVLetSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICIAVAESIVIGSVLILIR 352
Cdd:TIGR00797 240 ALLVARLGSIAL--AAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....*
gi 15237158 353 NIWGLAYSSELEVVSYVASMMPILA 377
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
26-442 |
7.87e-67 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 221.22 E-value: 7.87e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 26 EVKKQLWLSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVTgFSFLMGTASALDTLCGQAYGAKKYGMLG 105
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 106 IQMQRAMFVLTLASIPLSIIWANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGV 185
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 186 TTSLHVLLCWVLVF-KSG---LGFQGAALANSISYWLNVVLLFCYVKFSP--SCSLTWTGFSKEALRDILPFLRLAVPSA 259
Cdd:cd13131 160 ALVLNIPLNYVLIFgKFGlpaLGGAGAGLATAIVYWLMFLALAFYIRRHKrfRRYRLFARFWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 260 LMVCLEMWSFELLVLLSGllpnpVLETSVLS---ICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICI 336
Cdd:cd13131 240 LTIFFEVSLFAAVALLMG-----RLGTTVLAahqIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 337 AVAESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVGVP 416
Cdd:cd13131 315 GVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLP 394
|
410 420
....*....|....*....|....*.
gi 15237158 417 SGLLLAFHFHVGGRGLWLGIICALVV 442
Cdd:cd13131 395 LGYLLAFTTGLGAFGVWIGLIIGLAL 420
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
24-449 |
7.04e-63 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 210.39 E-value: 7.04e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 24 KEEVKKQLW-LSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVTgFSFLMGTASALDTLCGQAYGAKKYG 102
Cdd:COG0534 3 EGPILKLLLrLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDRE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 103 MLGIQMQRAMFVLTLASIPLSII-WANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVF 181
Cdd:COG0534 82 EARRVLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 182 CSGVTTSLHVLLCWVLVFKSGLGFQGAALANSISYWLNVVLLFCYVKFSPSC---SLTWTGFSKEALRDILpflRLAVPS 258
Cdd:COG0534 162 IMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLlrlRLRDLRPDRKILKRIL---RIGLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 259 ALMVCLEMWSFELLVLLSGLLPNPVLetSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICIAV 338
Cdd:COG0534 239 GLQQLAESLGFLVLNALVARLGTAAV--AAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLAL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 339 AESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVGVPSG 418
Cdd:COG0534 317 GIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLA 396
|
410 420 430
....*....|....*....|....*....|.
gi 15237158 419 LLLAFHFHvGGRGLWLGIICALVVQVFGLGL 449
Cdd:COG0534 397 YLLAFLGL-GLTGVWLALPIGEVLRALLLLL 426
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
29-456 |
4.22e-45 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 163.07 E-value: 4.22e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 29 KQLW-LSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVTgFSFLMGTASALDTLCGQAYGAKKYGMLGIQ 107
Cdd:cd13137 1 RRIWsLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 108 MQRAMFVLTLASIPLSII-WANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVT 186
Cdd:cd13137 80 LGQSLLLALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 187 TSLHVLLCWVLVFKS----GLGFQGAALANSISYWLNVVLLFCY---VKFSPSCSLTWTGFSKEALRDILpflRLAVPSA 259
Cdd:cd13137 160 NVLNIVLDYVLIFGLwgfpGLGVAGAALATVISRVVGALLLLFLllrGRLPIKISFKGFRLDRKIIKKLL---RIGLPAG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 260 LMVCLEMWSFELLVLLSGLLPNPVLetSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICIAVA 339
Cdd:cd13137 237 LEQLLRSLGFLVLLAIVASYGTAAL--AAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 340 ESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVGVPSGL 419
Cdd:cd13137 315 FMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAY 394
|
410 420 430
....*....|....*....|....*....|....*..
gi 15237158 420 LLAFHFHVGGRGLWLGIICALVVQVFGLGLVTIFTNW 456
Cdd:cd13137 395 LLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
24-449 |
2.36e-36 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 139.56 E-value: 2.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 24 KEEVKKQLWLSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFAsVTGFSFLMGTASALDTLCGQAYGAKKYGM 103
Cdd:PRK01766 8 KSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLNGAGRRER 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 104 LGIQMQRAMFVLTLASIPLSIIWANTEH-LLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFC 182
Cdd:PRK01766 87 IAHQVRQGLWLALFLSVLIMLVLYNAVPpILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 183 SGVTTSLHVLLCWVLVF-KSG---LGFQGAALANSISYWLNVVLLFCYVKFSPS--CSLTWTGFSKEALRDILPFLRLAV 256
Cdd:PRK01766 167 GFLGLLINIPLNYIFIYgKFGfpeLGGVGCGVATAIVYWVMFLAMLIYIKRARRfrDFRLFKGLYKPDWAVIKRLLKLGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 257 PSALMVCLEMWSFELLVLLSGllpnPVLETSVLS--ICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVI 334
Cdd:PRK01766 247 PIGLAIFFEVSLFAVVTLLVS----PLGTVTVAAhqIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 335 CIAVAESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVG 414
Cdd:PRK01766 323 AVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLG 402
|
410 420 430
....*....|....*....|....*....|....*
gi 15237158 415 VPSGLLLAFHFHVGGRGLWLGIICALVVQVFGLGL 449
Cdd:PRK01766 403 LPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
34-452 |
2.55e-36 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 139.00 E-value: 2.55e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 34 SGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASvTGFSFLMGTASALDTLCGQAYGAKKYGMLGIQMQRAMF 113
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIA-LLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 114 VLTLASIPLSII-WANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVTTSLHVL 192
Cdd:cd12082 80 LAILLGLLLAALlLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 193 LCWVLVFKSG---LGFQGAALANSISYWLNVVLLFCYVKFSPSCSLTWTGFSKEALRDILPFLRLAVPSALMVCLEMWSF 269
Cdd:cd12082 160 LDPLLIFGLGppeLGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 270 ELLVLLSGLLPNPVlETSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICIAVAESIVIGSVLI 349
Cdd:cd12082 240 LIIVAIVAAFGGAA-ALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 350 LIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVGVPSGLLLAFHfHVGG 429
Cdd:cd12082 319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYL-GLGL 397
|
410 420
....*....|....*....|...
gi 15237158 430 RGLWLGIICALVVQVFGLGLVTI 452
Cdd:cd12082 398 YGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
29-452 |
3.16e-34 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 133.42 E-value: 3.16e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 29 KQLW-LSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIAtSFASVTGFSFLMGTASALDTLCGQAYGAKKYGMLG-I 106
Cdd:cd13133 5 REILkIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGrV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 107 QMQRAMFVLTLASIPLSIIWANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVT 186
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 187 TSLHVLLCWVLVFKSG----LGFQGAALANSISYWLNVVLLFCYVkFSPS-----CSLTWTGFSKEALRDIlpfLRLAVP 257
Cdd:cd13133 164 VVVNIVLDYALIFGKLgfpaMGIAGAAIATVIAEAVSLLFFLLLL-FRRKnrrrfGLRRAWRFDRELLRRI---LRLGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 258 SALMVCLEMWSFELLVLLSGLLpnPVLETSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICIA 337
Cdd:cd13133 240 SGLQFFLDVGAFTVFFLLIGRL--GTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 338 VAESIVIGSVLILIRNIWGLAYSSEL---EVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVG 414
Cdd:cd13133 318 LAYMLLLGILFLLFPELLLSIFTPGAdfaLIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYL 397
|
410 420 430
....*....|....*....|....*....|....*...
gi 15237158 415 VPSGLLLAFhFHVGGRGLWLgiicALVVQVFGLGLVTI 452
Cdd:cd13133 398 LPPAYLLVV-LGAGLAGAWT----VETVYVIVLALIFL 430
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
36-196 |
5.34e-34 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 125.37 E-value: 5.34e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 36 PLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVTgFSFLMGTASALDTLCGQAYGAKKYGMLGIQMQRAMFVL 115
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 116 TLASIPLSII-WANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVTTSLHVLLC 194
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 15237158 195 WV 196
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
28-438 |
1.37e-25 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 108.74 E-value: 1.37e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 28 KKQLW-LSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVtGFSFLMGTASALDTLCGQAYGAKKYGMLGI 106
Cdd:cd13134 2 KLSLFaLAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 107 QMQRAMFVLTLASIPLSIIWANT-EHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGV 185
Cdd:cd13134 81 IAGVALLFNLLLGLVFSLLLLFFgAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 186 TTSLHVLLCWVLVFKSG----LGFQGAALANSISYWLNVVLLFCYVKFS---PSCSLTWTGFSKEALRDILpflRLAVPS 258
Cdd:cd13134 161 MNILNIVGNYLLIFGWFglpkLGVAGVAISTVISRAVGLVLLFILLFRKlkiRFRLKDLRPFPKKLLKKIL---KIGLPS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 259 ALmvclEMWSFELLVLLSGLLPNpVLETSVL---SICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVIC 335
Cdd:cd13134 238 AG----EELSYNLSQTVITAFIA-RLGTAALaarTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 336 IAVAESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVGV 415
Cdd:cd13134 313 IGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISV 392
|
410 420
....*....|....*....|...
gi 15237158 416 PSGLLLAFHFHVGGRGLWLGIIC 438
Cdd:cd13134 393 PLAYLLGIVLGLGLLGVWIAFAA 415
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
27-456 |
8.48e-25 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 106.39 E-value: 8.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 27 VKKQLWLSGPLIAVSLLQFCLQVISVMFVGH-LGSLPLSAASIATSFASVTgFSFLMGTASALDTLCGQAYGAKKYGMLG 105
Cdd:cd13138 2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 106 IQMQRAMFVLTLASIPLSII-WANTEHLLVFFGQNKSIATLAGSYAK---FMIPSIFAYGLLQCFnrfLQAQ-NNVFPVV 180
Cdd:cd13138 81 KAVGTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYLRicfLGIPFIFGYNAYSAI---LRGLgDSKTPLY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 181 FcSGVTTSLHVLLCWVLVFKSGLGFQGAALANSISYWLNVVLLFCYV---KFSPSCSLTWTGFSKEALRDILpflRLAVP 257
Cdd:cd13138 158 F-VIIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLrkkKLPFKLSLKDFRFDKEILKEIL---KIGLP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 258 SALMVCLEMWSFellvLLSGLLPNP--VLETSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVIC 335
Cdd:cd13138 234 SALQQSLVSISF----LIINSIVNSygVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGII 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 336 IAVAESIVIGS-VLILIRNIWGLaYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVG 414
Cdd:cd13138 310 ISLIIGLIIILlVFFFAPQLLGL-FTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVR 388
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 15237158 415 VPSGLLLAFHFHVGGRGLWLGIICALVVQVFGLGLVTIFTNW 456
Cdd:cd13138 389 IPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRW 430
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
27-434 |
2.28e-24 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 104.90 E-value: 2.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 27 VKKQLW-LSGPLIAVSLLQFCLQVISVMFVGHL-GSLPLSAASIATSFAS-VTGFSFLMGTASAldTLCGQAYGAKKYgm 103
Cdd:cd13143 2 IGKLFLkFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDR-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 104 lgiqmQRA--------MFVLTLASIPLSIIWANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNN 175
Cdd:cd13143 78 -----EKAnrifstalLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 176 VFPVVFCSGVTTSLHVLLCWVLVFKSGLGFQGAALANSISYWLNVVLLFCY-VKFSPSCSLTWtGFSKEALRDILPFLRL 254
Cdd:cd13143 153 PKLAMLGMLIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYfFRGKSLLKLSL-LRFKLSLKIIKEILAL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 255 AVPSALM---VCLEMWSFeLLVLLSGLLPNPVletSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVR 331
Cdd:cd13143 232 GFPSFLMqlsSSVVTIVL-NLTLLGYGGDIGV---AAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALK 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 332 VVICIAVAESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYY 411
Cdd:cd13143 308 LALIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQG 387
|
410 420
....*....|....*....|...
gi 15237158 412 LVGVPsgLLLAFHFHVGGRGLWL 434
Cdd:cd13143 388 LFLIP--LLLILPRLFGLDGIWL 408
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
27-437 |
6.03e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 104.20 E-value: 6.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 27 VKKQLWLSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIatSFASV-TGFSFLMGTASALDTLCGQAYGAKKYGMLG 105
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSI--SWPLIfLFISLGGGLTVAGTALVAQYTGAGDYDKAN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 106 IQMQRAMFVLTLASIPLSII--WANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCS 183
Cdd:cd13142 88 KVAGQTFSFVIILSLILAVLgyILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIM 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 184 GVTTSLHVLLCWVLVFK----SGLGFQGAALANSIS-----YWLNVVLLFCYVKFSPSCSLTWtgFSKEALRDILpflRL 254
Cdd:cd13142 168 FGSVLLNVILDPLLIFGigpfPGLGVAGAALATVISrgiaaVIGLYLLFKGRVGLKISLRDLK--PDWEWLKKIF---RI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 255 AVPSALMVCLEMWSFELLVLLSGLLPNPVLetSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVI 334
Cdd:cd13142 243 GLPSSIEQSARALGFTVMTALVAGFGTVVV--AAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 335 CIAVAESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVG 414
Cdd:cd13142 321 LLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIR 400
|
410 420
....*....|....*....|...
gi 15237158 415 VPSGLLLAFHFHVGGRGLWLGII 437
Cdd:cd13142 401 IPLAYLLAYVLGLGVTGIWIAMA 423
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
26-449 |
4.93e-20 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 92.50 E-value: 4.93e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 26 EVKKQLWLSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASI-ATSFASVTgfSFLMGTASALDTLCGQAYGAKKYGML 104
Cdd:PRK00187 8 ELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLgAASYSFVS--IFCVGVIAAVGTLVAIRHGAGDIEGA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 105 GIQMQRAMFV-LTLASIPLSIIWaNTEHLLVFFGQNKSIATLAGsyaKFMIPSIFAYGLLQCF---NRFLQAQNNVFPVV 180
Cdd:PRK00187 86 TRLAQAGLWLaWLLALVAALLLW-NLKPLLLLFGQAPQNVDAAM---QFLHLLPFALPGYLSFmalRGFTSALGRAGPVM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 181 FCSGVTTSLHVLLCWVLVFK----SGLGFQGAALANSISYWLNVVLLFCYVKFSPSCSL--TWTGFSKEALRDILPFLRL 254
Cdd:PRK00187 162 VISLAGAVANLLLNYALIEGwfglPKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAypLRKGLSRPSRAALRELWRL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 255 AVPSALMVCLEMWSFELLVLLSGLLPNPVLETSvlSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVI 334
Cdd:PRK00187 242 GLPIGGTYAVEVGLFTFAALCMGALGSTQLAAH--QIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 335 CIAVAESIVIGSVLILIRN-IWGL----AYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGS 409
Cdd:PRK00187 320 GFGAVVMLLFAGLFWLLPEaIIGLfldrNDPAFAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLAC 399
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 15237158 410 YYLVGVPSGLLLAFHFHVGGRGLWLGIICALVVQVFGLGL 449
Cdd:PRK00187 400 YWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAVALTL 439
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
257-416 |
5.69e-20 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 86.47 E-value: 5.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 257 PSALMVCLEMWSFELLVLLSGLLPnpVLETSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICI 336
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLG--AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 337 AVAESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSyYLVGVP 416
Cdd:pfam01554 79 GLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
28-437 |
4.08e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 77.33 E-value: 4.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 28 KKQLWLSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATS-FASVTGFSFLMGTASALdtLCGQAYGAKKYGMLGI 106
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTpFNTITGFLGSISIGFTI--LGSQSVGAKDIKRIND 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 107 QMQRAMFVLTLASIPLSIIWA-NTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGV 185
Cdd:cd13135 79 YAISSIVYNSIIGVILFLLWLfGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 186 TTSLHVLLCWVLVF-KSG---LGFQGAALANSISYWLNVVLLFCYVKFSPSCSLTWTGFS--KEALRDILPFLRLAVPSA 259
Cdd:cd13135 159 KNLLNVILDYVLIFgNFGfprLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKvlKANIRPYKFTIKLGLPLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 260 LMVCLemWSFELLVLLSGLLPNPVLETSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICIAVA 339
Cdd:cd13135 239 GEEFL--WNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 340 ESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCG---WQKIGAIInlGSYYLVGVp 416
Cdd:cd13135 317 IYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGdtkWMLYTQII--GTIIVVSV- 393
|
410 420
....*....|....*....|.
gi 15237158 417 sGLLLAFHFHVGGRGLWLGII 437
Cdd:cd13135 394 -ALLLIFVFKLGLAGVYITLF 413
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
24-226 |
4.63e-14 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 74.02 E-value: 4.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 24 KEEVKKQLWLSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVTgFSFLMGTASALDTLCGQAYGAKKYGM 103
Cdd:COG0534 225 RKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGAGDYDR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 104 LGIQMQRAMFVLTLASIPLSII-WANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFC 182
Cdd:COG0534 304 ARRAARLALLLALGIGLLLALLlFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMII 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15237158 183 SGVTTSLHVLLCWVLVFKSGLGFQGAALANSISYWLNVVLLFCY 226
Cdd:COG0534 384 SLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
27-405 |
4.84e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 73.71 E-value: 4.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 27 VKKQLW-LSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIAtSFASVTGFSFLMGTASALDTLCGQAYGAKK----- 100
Cdd:cd13140 3 ILKTLLrLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTA-GFFVWLAYALALLSKIGAQVKVSQSIGAKDekear 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 101 -YGMLGIQMQramFVLTLASIPLSIIWANTehLLVFFG-QNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFP 178
Cdd:cd13140 82 kYARNALQLN---LLLGILYGLLLLLFAKP--LIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 179 VVFCSGVTTSLHVLLCWVLVFKSG----LGFQGAALANSISYWLNVVLLFCYVK---FSPSCSLTWTGFSKEALRDILpf 251
Cdd:cd13140 157 PFIINAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKkkkGLFLKIRILKRPDRKYIKEIL-- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 252 lRLAVPSALMVCL-EMWSFELLVLLSGLLPNPVletSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAV 330
Cdd:cd13140 235 -KLGLPVALQSILfALISMILARIIASFGPVAI---AAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGY 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15237158 331 RVVICIAVAESIVIGSVLILI-RNIWGLaYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAII 405
Cdd:cd13140 311 KTALKIASAIGLFATLLLFFFgEPLFSL-FIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAII 385
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-436 |
1.33e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 72.64 E-value: 1.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 33 LSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVTgFSFLMGTASALDTLCGQAYGAKKYGMLGIQMQRAM 112
Cdd:cd13139 19 LAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 113 FVLTLASIPLSII-WANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVTTSLHV 191
Cdd:cd13139 98 LLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGLNI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 192 LLCWVLVFKSG----LGFQGAALANSISYWLNVvLLFCYVKFSPSCSLTwtgFSKEALRDILP----FLRLAVPSALMVC 263
Cdd:cd13139 178 ILDPLFIFGLGpipaMGVTGAAIATTIGRSIGV-LYQLYHLFKGKGRIQ---IRRRHLKLDWAiikkIIKIAVGGILQFL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 264 LEMWSFELLVLLSGLLPNPVLetSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICIAVAESIV 343
Cdd:cd13139 254 IASSSWIFLVRIIAEFGSTAL--AGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGI 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 344 IGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVGVPSGLLLAF 423
Cdd:cd13139 332 VSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLAR 411
|
410
....*....|...
gi 15237158 424 HFHVGGRGLWLGI 436
Cdd:cd13139 412 HLNLGPKGVFIAI 424
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
31-449 |
1.09e-11 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 66.43 E-value: 1.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 31 LWLSGPLIAVSLLQFCLQVISVMFVGHLGSL-PLSAASIATSFASV--TGFSFL-MGTASaldtLCGQAYGAKKYGMLGI 106
Cdd:cd13136 6 LALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNTlfWLFGFLrMGTTG----LVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 107 QMQRAMFVLTLASIPLSIIWAN-TEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGV 185
Cdd:cd13136 82 LLVRALLLALAIGLLLILLQSPlLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 186 TTSLHVLLCWVLVFKSGLGFQGAALANSISYWLNVVLLFCYVKFS---PSCSLTWTGFSKEALRDILP-----FLRlavp 257
Cdd:cd13136 162 GNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRvrlLGKSLSRRLPSKAALKRLFKlnrdiFIR---- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 258 salMVCLEMwSFELLVLLSGLLPNPVLETSVLSICLNTSGTMWMipFGLSGAASTRISNELGAGNPKVAKLAVRVVICIA 337
Cdd:cd13136 238 ---TLALLA-AFLFFTALAARLGDVILAANQILLQFWLLSSYFL--DGFAYAAEALVGRALGAGDRKAARRVARRLLQWG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 338 VAESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGA---IINLGSYYLvg 414
Cdd:cd13136 312 LGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRnsmLVSLAVFLP-- 389
|
410 420 430
....*....|....*....|....*....|....*
gi 15237158 415 vpsgLLLAFHFHVGGRGLWLGIICALVVQVFGLGL 449
Cdd:cd13136 390 ----LLFLLVPLWGNHGLWLALILFMLLRGLTLAL 420
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
130-445 |
3.71e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 61.65 E-value: 3.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 130 EHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVTTSLHVLLCWVLVFKSGLGFQGAA 209
Cdd:cd13146 113 EPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 210 LANSISYWLN---VVLLFCYVKFSPSCSLTWTGFSKEALRDIlpfLRLAVPSALMVCLEMWSFELLVLLSGLLPNPVLET 286
Cdd:cd13146 193 LATVLAQAISllyLLYVFLIGKSNVTIHIKLSNISSSVIVEI---LRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTA 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 287 SVLSICLNTSGTMWMipFGLSGAASTRISNELGAGNPKVAKLAVRVVICIAVAESIVIGSVLILIRNIWGLAYSSELEVV 366
Cdd:cd13146 270 FTLVGRLDQFILIPI--FAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVV 347
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15237158 367 SYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVGVPSGLLLAFHFHVGGRGLWLGIICALVVQVF 445
Cdd:cd13146 348 AYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFFTAL 426
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-445 |
2.97e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 58.78 E-value: 2.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 33 LSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVTgFSFLMGTASALDTLCGQAYGAKKYGMLGIQMQRAM 112
Cdd:cd13144 13 MSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANKAANNGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 113 FVLTLASIPLSII-WANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVTTSLHV 191
Cdd:cd13144 92 LLALLSYLLFLLLgLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIINI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 192 LLCWVLVF----KSGLGFQGAALANSISYWLNVVLLFCYVKFSP---SCSLTWTGFSKEALRDILpflRLAVPSALMVCL 264
Cdd:cd13144 172 ILDPILIFglfgFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNkdvQPDLRLFRPSLRIIKEIY---AVGLPSIIMQAI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 265 EmwSFELLVLLSGLLPNPVLETSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICIAVAESIVI 344
Cdd:cd13144 249 S--SVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIMLAG 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 345 GSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVGVPSGLLLAFH 424
Cdd:cd13144 327 GLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAWLLAKM 406
|
410 420
....*....|....*....|.
gi 15237158 425 FhvGGRGLWLGIICALVVQVF 445
Cdd:cd13144 407 F--GLNGVWWSFPIAEIVSFL 425
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-446 |
9.56e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 54.23 E-value: 9.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 33 LSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSaasiATSFASVTGF---SFLMGTASALDTLCGQAYGAKKYGMLGIQMQ 109
Cdd:cd13149 14 LTLPMIFGILAMLIFNLTDTFFVGKLGTKELA----AISFTFPVVLflnSLTIGLGIGASAVISRAIGAGDRNKAKRLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 110 RAMFVLTLASIPLSIIWANTEHLLVF-FGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVTTS 188
Cdd:cd13149 90 DSLILSLLLSVIVSLLGLFTIPPLFSlLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGAAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 189 LHVLLCWVLVF----KSGLGFQGAALANSISYWLNVV--LLFCYVKFSpscSLTWTGFS-KEALRDILPFLRLAVPSALM 261
Cdd:cd13149 170 VNVILDPILIFgfgpIPGMGIAGAAIATVISRALGLGaaLYFLHYHHR---LIDFSEPSlKALFRSWKDILSIGIPAALS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 262 VCLemwsfellvllsgllpNPVLETSVLSIcLNTSGT---------------MWMIPFGLSGAASTRISNELGAGNPKVA 326
Cdd:cd13149 247 NIL----------------TPLSAAFITAL-VATYGPaavaafgvatriesfAFIIVMALSSALGPFVGQNWGAGQYERV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 327 KLAVRVVICIAVAESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIIN 406
Cdd:cd13149 310 QEGLKISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLN 389
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 15237158 407 LGSYYLVGVPSGlLLAFHFHvGGRGLWLGIICALVVQVFG 446
Cdd:cd13149 390 LIRVFLLYIPLA-YVGSHLL-GFAGVFIGALAGNLIAGIL 427
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-231 |
5.20e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 51.93 E-value: 5.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 33 LSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIAtsfASVTGFSFLM------GTAsaldTLCGQAYGAKKYGMLGI 106
Cdd:cd13141 16 MALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLA---GNVMFFVMALtqvlnvGTA----ALVSHAVGRKDQGEANA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 107 QMQRAMFVLTLASIPLSII-WANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGV 185
Cdd:cd13141 89 VFNQSLLLAAVLGLVVLVLgYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQIL 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 15237158 186 TTSLHVLLCWVLVFKSG----LGFQGAALANSISYWLNVVLLFCYVKFSP 231
Cdd:cd13141 169 AVLLNIILAPILITGWGtgraLGVAGAGLASSISVAIAVVLLLYYFLRLE 218
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
143-224 |
2.58e-06 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 49.76 E-value: 2.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 143 ATLAGSYA-KFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVTTSLHVLLCWVLVFKsgLGFQGAALANSISYWLNVV 221
Cdd:cd13123 334 DTLMTASAlAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKP--LGHVGLALATSLSAWVNAL 411
|
...
gi 15237158 222 LLF 224
Cdd:cd13123 412 LLL 414
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
143-262 |
1.08e-05 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 47.84 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 143 ATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVTTSLHVLLCWVLVFKsgLGFQGAALANSISYWLNVVL 222
Cdd:COG0728 342 TALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPP--LGHAGLALATSLSALVNALL 419
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 15237158 223 LFCYvkfspscsLTWTGFSKEALRDILPFLRLAVPSALMV 262
Cdd:COG0728 420 LLVL--------LRRRLGGLPLRGILRTLLKLLLASLVMG 451
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
108-228 |
1.60e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 47.15 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 108 MQRAMFVLTLASIPLSIIWA--NTEHLLVFFGQNKSiatLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGV 185
Cdd:cd13128 285 LKKSFKYLFLISLPIAIGLFlfAEPIITLLFGEEYL---PAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLI 361
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 15237158 186 TTSLHVLLCWVLVFKsgLGFQGAALANSISYWLNVVLLFCYVK 228
Cdd:cd13128 362 GALLNVILNLLLIPK--YGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
28-216 |
1.75e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 47.12 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 28 KKQLWLSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIAT---SFASVTGFSFLMGTAsaldTLCGQAYGAKKYGML 104
Cdd:cd13137 226 KKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLrieSLAFMPGFGFSMAAS----TLVGQNLGAGDPDEA 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 105 ---GIQMQR-AMFVLTLASIplsIIWANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVV 180
Cdd:cd13137 302 rryGKRALRlGVLFMGLLGL---LLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPL 378
|
170 180 190
....*....|....*....|....*....|....*..
gi 15237158 181 FCSGVTT-SLHVLLCWVLVFKSGLGFQGAALANSISY 216
Cdd:cd13137 379 IINLISMwLVRLPLAYLLGFVLGLGLTGIWLAMFVDT 415
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
28-438 |
2.49e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 46.38 E-value: 2.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 28 KKQLW-LSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVT---GFSFLMGTASALdtlcGQAYGAKKYGM 103
Cdd:cd13147 8 KKAIIkLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIiglGNGLGAGASSAI----SRRIGAKDKEG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 104 LGIQMQRAMFVLTLASIPLSIIW-ANTEHLLVFFGQnKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFC 182
Cdd:cd13147 84 ADNAAVHSILLGLIISIILTIVLlPFLEPILVLMGA-GEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 183 SGVTTSLHVLLCWVLVFKSGLGFQGAALANSISYWLNVVLLFCYVKFSPSC--SLTWTGFS--KEALRDIlpfLRLAVPS 258
Cdd:cd13147 163 MVAGSILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKDTyvSLSLKNFKfdKKIVKDI---LKVGIPA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 259 AlmvcLEMwsfellvllsgllpnpvLETSVLSICLN-----TSGTM--------W------MIP-FGLSGAASTRISNEL 318
Cdd:cd13147 240 S----LEQ-----------------LIMSVLMIILNlilviVAGTDgvavytagWrivsfaIIPlIGIATAVTSVTGAAY 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 319 GAGNPKVAKLAVRVVICIAVAESIVIGSVLILIRN-IWGL-AYSSE--------LEVVSYVASMMPILALGnFLDSlqCV 388
Cdd:cd13147 299 GARNYEKLKTAYNYSIKLGLIIELIIAILIFIFAPqIAYLfTYSEEsahlapeiVAFLRIMCLFLPFVPFG-MMSS--SM 375
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 15237158 389 LSGVARGcgwqKIGAIINLGSYYLVGVPSGLLLAFHFHVGGRGLWLGIIC 438
Cdd:cd13147 376 FQGIGKG----LTSLIITILRELIFQVLFAYLFAIVLGLGLFGVWWGIVL 421
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
18-154 |
1.03e-04 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 44.54 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 18 GEKSSVKEEVKKQLWLSGP-LIAVSLLQFCLQVISVmFVGHLGSLPLSAASIATSFASVTgFSFLMGTASALDTLCGQAY 96
Cdd:TIGR00797 206 GLLKPDWEVLKRLLKLGLPiAFRVILESLSFALLAL-LVARLGSIALAAHQIALNVESLL-FMPAFGFGIAVSILVGQAL 283
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 15237158 97 GAKKYGMLGIQMQRAMFV-LTLASIPLSIIWANTEHLLVFFGQNKSIATLAGSYAKFMI 154
Cdd:TIGR00797 284 GAGDPKRAKEVARVALKLsLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-228 |
2.50e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 43.43 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 33 LSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVtGFSFLMGTASALDTLCGQAYGAK----KYGMLGIQM 108
Cdd:cd13135 233 LGLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENI-VLMPMYGYSSAALTLVGESIGKKdlkeALRIGNICL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 109 QRAMFVLTLASIPLSIIwanTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVTTS 188
Cdd:cd13135 312 GLGLLIYIAAAIVFLAF---PYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIGTI 388
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 15237158 189 LHVLLCWVLVFKSGLGFQGAALANSISYWLNVVLLFCYVK 228
Cdd:cd13135 389 IVVSVALLLIFVFKLGLAGVYITLFIDEIIRAIINFLKYR 428
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
31-224 |
3.49e-04 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 42.63 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 31 LWLSGPLIAVSLLQFCLQVISVMFVGHLgsLPLSAA---SIATSFASVTGFsFLMGTASALDTLCGQAYGAKKYGMLGIQ 107
Cdd:COG2244 176 LKYSLPLLLSGLLGLLLTNLDRLLLGAL--LGPAAVgiySAAYRLASLLLL-LITALSQVLFPRLSRLLAEGDREELRRL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 108 MQRAMFVLTLASIPLSI-IWANTEHLLVFFGQNKSIAtlAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVT 186
Cdd:COG2244 253 YRKALRLLLLLGLPLALgLALLAPPLLSLLFGPEYAE--AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIG 330
|
170 180 190
....*....|....*....|....*....|....*...
gi 15237158 187 TSLHVLLCWVLVFKsgLGFQGAALANSISYWLNVVLLF 224
Cdd:COG2244 331 AVLNLVLNLLLIPR--YGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
19-228 |
4.71e-04 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 42.45 E-value: 4.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 19 EKSSVKEEVKKQLWLSGPLIAVSLLQFCLQVI-SVMFVGHLGSLPLSAASIATSFASVTG---------FSFLMGTASAL 88
Cdd:cd13124 215 SKISTKEILKELLSYAIPITLSSLILPLLQLIdSFTVPRRLQAAGLSESEATALYGILTGraqplvqlpTVIATALSTSL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 89 DTLCGQAYGAKKYGMLGIQMQRAMFVLTLASIPLSI-IWANTEHL-LVFFGQnksiaTLAGSYAKFMIPSIFAYGLLQCF 166
Cdd:cd13124 295 VPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVgLAVLAEPInTLLFGD-----SEGGLILQILAPSILFLSLQQVT 369
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15237158 167 NRFLQAQNNVFPVVFCSGVTTSLHVLLCWVLVfkSGLGFQGAALANSISYWLNVVLLFCYVK 228
Cdd:cd13124 370 AAILQGLGKVKIPVINLLIGLLVKIVLNYVLI--PIFGIYGAAIATVIGFLVAALLNLRALK 429
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
24-125 |
3.31e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 39.82 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237158 24 KEEVKKQLWLSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVtGFSFLMGTASALDTLCGQAYGAKKYGM 103
Cdd:cd13133 227 RELLRRILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSL-AFLPMIGLGIAVSSLVGQALGAGRPDL 305
|
90 100
....*....|....*....|...
gi 15237158 104 LgIQMQRAMFVLTLA-SIPLSII 125
Cdd:cd13133 306 A-MRVTRRGLKLALAyMLLLGIL 327
|
|
| |
