|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
71-380 |
3.82e-61 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 210.33 E-value: 3.82e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 71 SDAIGAIEFDPTGEIIATGGIARKIRSYRLSSLL-ESRDDHVTASEsyICTPAKLSSLKWRPDFSGRvIGSGDYDGVVTE 149
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIkDGRDIHYPVVE--LASRSKLSGICWNSYIKSQ-VASSNFEGVVQV 559
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 150 YDVEKQVPVSERDEHGgRRIWSVDYTLYNGSLIgASGSDDGTVQMWDPRNG---GTLEETvrpgggAAICSVEFDPFGGS 226
Cdd:PLN00181 560 WDVARSQLVTEMKEHE-KRVWSIDYSSADPTLL-ASGSDDGSVKLWSINQGvsiGTIKTK------ANICCVQFPSESGR 631
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 227 SIAVGCADRNAYVYDIRRLVDPLIVLDGHTKTVTYARFMDSHTIVTGSTDGSLKQWDIDNG-----RRVVRTYRGHVNSR 301
Cdd:PLN00181 632 SLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSisginETPLHSFMGHTNVK 711
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 302 NFVGLSVwrHGGLVVSGSENNQVFVYDKRWEEPVWVCGLGHTNRFGS-----DRRFVSSVCLRQVDEdwcTLVAGGSDGA 376
Cdd:PLN00181 712 NFVGLSV--SDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVSGlevddASQFISSVCWRGQSS---TLVAANSTGN 786
|
....
gi 15242945 377 LEIF 380
Cdd:PLN00181 787 IKIL 790
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
56-379 |
1.90e-33 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 128.49 E-value: 1.90e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 56 WDLSLSAVVSSASTGSDAIGAIEFDPTGEIIATGGIARKIRSYRLSS--LLESRDDHvtasesyictPAKLSSLKWRPDf 133
Cdd:COG2319 105 WDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgkLLRTLTGH----------SGAVTSVAFSPD- 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 134 sGRVIGSGDYDGVVTEYDVEKQVPVSERDEHGGRrIWSVDYTLyNGSLIgASGSDDGTVQMWDPRNGGTLeeTVRPGGGA 213
Cdd:COG2319 174 -GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-VRSVAFSP-DGKLL-ASGSADGTVRLWDLATGKLL--RTLTGHSG 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 214 AICSVEFDPfGGSSIAVGCADRNAYVYDIRRLvDPLIVLDGHTKTVTYARF-MDSHTIVTGSTDGSLKQWDIDNGrRVVR 292
Cdd:COG2319 248 SVRSVAFSP-DGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFsPDGKLLASGSDDGTVRLWDLATG-KLLR 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 293 TYRGHVNSRNFVGLSvwRHGGLVVSGSENNQVFVYDKRWEEPVWVCGlGHTNRfgsdrrfVSSVClrqVDEDWCTLVAGG 372
Cdd:COG2319 325 TLTGHTGAVRSVAFS--PDGKTLASGSDDGTVRLWDLATGELLRTLT-GHTGA-------VTSVA---FSPDGRTLASGS 391
|
....*..
gi 15242945 373 SDGALEI 379
Cdd:COG2319 392 ADGTVRL 398
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
71-381 |
2.02e-28 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 112.43 E-value: 2.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 71 SDAIGAIEFDPTGEIIATGGIARKIRSYRLSSLLESRDD--HvtasesyictPAKLSSLKWRPDfsGRVIGSGDYDGVVT 148
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkgH----------TGPVRDVAASAD--GTYLASGSSDKTIR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 149 EYDVEKQVPVSERDEHGGrRIWSVDYtLYNGSLIgASGSDDGTVQMWDPRNGGTLeeTVRPGGGAAICSVEFDPFGGsSI 228
Cdd:cd00200 77 LWDLETGECVRTLTGHTS-YVSSVAF-SPDGRIL-SSSSRDKTIKVWDVETGKCL--TTLRGHTDWVNSVAFSPDGT-FV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 229 AVGCADRNAYVYDIRRLVdPLIVLDGHTKTVTYARFM-DSHTIVTGSTDGSLKQWDIDNGrRVVRTYRGHVNSRNFVGLS 307
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFS 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15242945 308 VWRHggLVVSGSENNQVFVYDKRWEEPVWVCGlGHTNRfgsdrrfVSSVClrqVDEDWCTLVAGGSDGALEIFS 381
Cdd:cd00200 229 PDGY--LLASGSEDGTIRVWDLRTGECVQTLS-GHTNS-------VTSLA---WSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
248-283 |
6.57e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.91 E-value: 6.57e-04
10 20 30
....*....|....*....|....*....|....*..
gi 15242945 248 PLIVLDGHTKTVTYARFM-DSHTIVTGSTDGSLKQWD 283
Cdd:smart00320 4 LLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
248-283 |
1.46e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.17 E-value: 1.46e-03
10 20 30
....*....|....*....|....*....|....*..
gi 15242945 248 PLIVLDGHTKTVTYARFM-DSHTIVTGSTDGSLKQWD 283
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
71-380 |
3.82e-61 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 210.33 E-value: 3.82e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 71 SDAIGAIEFDPTGEIIATGGIARKIRSYRLSSLL-ESRDDHVTASEsyICTPAKLSSLKWRPDFSGRvIGSGDYDGVVTE 149
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIkDGRDIHYPVVE--LASRSKLSGICWNSYIKSQ-VASSNFEGVVQV 559
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 150 YDVEKQVPVSERDEHGgRRIWSVDYTLYNGSLIgASGSDDGTVQMWDPRNG---GTLEETvrpgggAAICSVEFDPFGGS 226
Cdd:PLN00181 560 WDVARSQLVTEMKEHE-KRVWSIDYSSADPTLL-ASGSDDGSVKLWSINQGvsiGTIKTK------ANICCVQFPSESGR 631
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 227 SIAVGCADRNAYVYDIRRLVDPLIVLDGHTKTVTYARFMDSHTIVTGSTDGSLKQWDIDNG-----RRVVRTYRGHVNSR 301
Cdd:PLN00181 632 SLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSisginETPLHSFMGHTNVK 711
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 302 NFVGLSVwrHGGLVVSGSENNQVFVYDKRWEEPVWVCGLGHTNRFGS-----DRRFVSSVCLRQVDEdwcTLVAGGSDGA 376
Cdd:PLN00181 712 NFVGLSV--SDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVSGlevddASQFISSVCWRGQSS---TLVAANSTGN 786
|
....
gi 15242945 377 LEIF 380
Cdd:PLN00181 787 IKIL 790
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
56-379 |
1.90e-33 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 128.49 E-value: 1.90e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 56 WDLSLSAVVSSASTGSDAIGAIEFDPTGEIIATGGIARKIRSYRLSS--LLESRDDHvtasesyictPAKLSSLKWRPDf 133
Cdd:COG2319 105 WDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgkLLRTLTGH----------SGAVTSVAFSPD- 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 134 sGRVIGSGDYDGVVTEYDVEKQVPVSERDEHGGRrIWSVDYTLyNGSLIgASGSDDGTVQMWDPRNGGTLeeTVRPGGGA 213
Cdd:COG2319 174 -GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-VRSVAFSP-DGKLL-ASGSADGTVRLWDLATGKLL--RTLTGHSG 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 214 AICSVEFDPfGGSSIAVGCADRNAYVYDIRRLvDPLIVLDGHTKTVTYARF-MDSHTIVTGSTDGSLKQWDIDNGrRVVR 292
Cdd:COG2319 248 SVRSVAFSP-DGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFsPDGKLLASGSDDGTVRLWDLATG-KLLR 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 293 TYRGHVNSRNFVGLSvwRHGGLVVSGSENNQVFVYDKRWEEPVWVCGlGHTNRfgsdrrfVSSVClrqVDEDWCTLVAGG 372
Cdd:COG2319 325 TLTGHTGAVRSVAFS--PDGKTLASGSDDGTVRLWDLATGELLRTLT-GHTGA-------VTSVA---FSPDGRTLASGS 391
|
....*..
gi 15242945 373 SDGALEI 379
Cdd:COG2319 392 ADGTVRL 398
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
56-328 |
3.98e-30 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 119.63 E-value: 3.98e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 56 WDLSLSAVVSSASTGSDAIGAIEFDPTGEIIATGGIARKIRSYRLSS--LLESRDDHvtasesyictPAKLSSLKWRPDf 133
Cdd:COG2319 147 WDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATgkLLRTLTGH----------TGAVRSVAFSPD- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 134 sGRVIGSGDYDGVVTEYDVEKQVPVSERDEHGGRrIWSVDYTLyNGSLIgASGSDDGTVQMWDPRNGGTLeeTVRPGGGA 213
Cdd:COG2319 216 -GKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSP-DGRLL-ASGSADGTVRLWDLATGELL--RTLTGHSG 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 214 AICSVEFDPfGGSSIAVGCADRNAYVYDIRRLvDPLIVLDGHTKTVTYARFM-DSHTIVTGSTDGSLKQWDIDNGRRVvR 292
Cdd:COG2319 290 GVNSVAFSP-DGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELL-R 366
|
250 260 270
....*....|....*....|....*....|....*.
gi 15242945 293 TYRGHVNSRNfvGLSVWRHGGLVVSGSENNQVFVYD 328
Cdd:COG2319 367 TLTGHTGAVT--SVAFSPDGRTLASGSADGTVRLWD 400
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
71-381 |
2.02e-28 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 112.43 E-value: 2.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 71 SDAIGAIEFDPTGEIIATGGIARKIRSYRLSSLLESRDD--HvtasesyictPAKLSSLKWRPDfsGRVIGSGDYDGVVT 148
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkgH----------TGPVRDVAASAD--GTYLASGSSDKTIR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 149 EYDVEKQVPVSERDEHGGrRIWSVDYtLYNGSLIgASGSDDGTVQMWDPRNGGTLeeTVRPGGGAAICSVEFDPFGGsSI 228
Cdd:cd00200 77 LWDLETGECVRTLTGHTS-YVSSVAF-SPDGRIL-SSSSRDKTIKVWDVETGKCL--TTLRGHTDWVNSVAFSPDGT-FV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 229 AVGCADRNAYVYDIRRLVdPLIVLDGHTKTVTYARFM-DSHTIVTGSTDGSLKQWDIDNGrRVVRTYRGHVNSRNFVGLS 307
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFS 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15242945 308 VWRHggLVVSGSENNQVFVYDKRWEEPVWVCGlGHTNRfgsdrrfVSSVClrqVDEDWCTLVAGGSDGALEIFS 381
Cdd:cd00200 229 PDGY--LLASGSEDGTIRVWDLRTGECVQTLS-GHTNS-------VTSLA---WSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
55-381 |
5.32e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 110.77 E-value: 5.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 55 DWDLSLSAVVSSASTGSDAIGAIEFDPTGEIIATGGIARKIRSYRLSSLLESRDDHVTASEsyictpakLSSLKWRPDfs 134
Cdd:COG2319 20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA--------VLSVAFSPD-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 135 GRVIGSGDYDGVVTEYDVEKQVPVSERDEHGGRrIWSVDYTLyNGSLIgASGSDDGTVQMWDPRNGGTLeeTVRPGGGAA 214
Cdd:COG2319 90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGA-VRSVAFSP-DGKTL-ASGSADGTVRLWDLATGKLL--RTLTGHSGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 215 ICSVEFDPfGGSSIAVGCADRNAYVYDIRRLvDPLIVLDGHTKTVTYARF-MDSHTIVTGSTDGSLKQWDIDNGrRVVRT 293
Cdd:COG2319 165 VTSVAFSP-DGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFsPDGKLLASGSADGTVRLWDLATG-KLLRT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 294 YRGHVNSRNFVGLSvwRHGGLVVSGSENNQVFVYDKRWEEPVWVCGlGHTNRfgsdrrfVSSVCLRQVDEdwcTLVAGGS 373
Cdd:COG2319 242 LTGHSGSVRSVAFS--PDGRLLASGSADGTVRLWDLATGELLRTLT-GHSGG-------VNSVAFSPDGK---LLASGSD 308
|
....*...
gi 15242945 374 DGALEIFS 381
Cdd:COG2319 309 DGTVRLWD 316
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
56-286 |
3.34e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 102.68 E-value: 3.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 56 WDLSLSAVVSSASTGSDAIGAIEFDPTGEIIATGGIARKIRSYRLSS-----LLESRDDHVTasesyictpaklsSLKWR 130
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATgkllrTLTGHSGSVR-------------SVAFS 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 131 PDfsGRVIGSGDYDGVVTEYDVEKQVPVSERDEHGGRrIWSVDYTLyNGSLIgASGSDDGTVQMWDPRNGGTLeeTVRPG 210
Cdd:COG2319 256 PD--GRLLASGSADGTVRLWDLATGELLRTLTGHSGG-VNSVAFSP-DGKLL-ASGSDDGTVRLWDLATGKLL--RTLTG 328
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15242945 211 GGAAICSVEFDPfGGSSIAVGCADRNAYVYDIRRLVdPLIVLDGHTKTVTYARF-MDSHTIVTGSTDGSLKQWDIDN 286
Cdd:COG2319 329 HTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAFsPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
56-328 |
2.82e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 95.48 E-value: 2.82e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 56 WDLSLSAVVSSASTGSDAIGAIEFDPTGEIIATGGIARKIRSYRLSSLLESRDdhVTASESYIctpaklSSLKWRPDfsG 135
Cdd:cd00200 36 WDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT--LTGHTSYV------SSVAFSPD--G 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 136 RVIGSGDYDGVVTEYDVEKQVPVSERDEHGGRrIWSVDYTLYNGSLigASGSDDGTVQMWDPRNGGTLeeTVRPGGGAAI 215
Cdd:cd00200 106 RILSSSSRDKTIKVWDVETGKCLTTLRGHTDW-VNSVAFSPDGTFV--ASSSQDGTIKLWDLRTGKCV--ATLTGHTGEV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 216 CSVEFDPfGGSSIAVGCADRNAYVYDIRRLvDPLIVLDGHTKTVTYARFM-DSHTIVTGSTDGSLKQWDIDNGrRVVRTY 294
Cdd:cd00200 181 NSVAFSP-DGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSpDGYLLASGSEDGTIRVWDLRTG-ECVQTL 257
|
250 260 270
....*....|....*....|....*....|....
gi 15242945 295 RGHVNSrnFVGLSVWRHGGLVVSGSENNQVFVYD 328
Cdd:cd00200 258 SGHTNS--VTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
132-381 |
6.40e-13 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 69.55 E-value: 6.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 132 DFSGRVIGSGDYDGVVTEYDVEKQVPVSERDEHGGRRIWSVDYTLyngSLIGASGSDDGTVQMWDPRNGGtlEETVRPGG 211
Cdd:COG2319 3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPD---GARLAAGAGDLTLLLLDAAAGA--LLATLLGH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 212 GAAICSVEFDPfGGSSIAVGCADRNAYVYDIRRLVdPLIVLDGHTKTVTYARFM-DSHTIVTGSTDGSLKQWDIDNGrRV 290
Cdd:COG2319 78 TAAVLSVAFSP-DGRLLASASADGTVRLWDLATGL-LLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLATG-KL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 291 VRTYRGHvnSRNFVGLSVWRHGGLVVSGSENNQVFVYDKRWEEPVWVCGlGHTNRfgsdrrfVSSVClrqVDEDWCTLVA 370
Cdd:COG2319 155 LRTLTGH--SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGA-------VRSVA---FSPDGKLLAS 221
|
250
....*....|.
gi 15242945 371 GGSDGALEIFS 381
Cdd:COG2319 222 GSADGTVRLWD 232
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
251-381 |
4.97e-10 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 60.04 E-value: 4.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 251 VLDGHTKTVTYARF-MDSHTIVTGSTDGSLKQWDIDNGrRVVRTYRGHvnSRNFVGLSVWRHGGLVVSGSENNQVFVYDK 329
Cdd:cd00200 4 TLKGHTGGVTCVAFsPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 15242945 330 RWEEPVWVCGlGHTNRfgsdrrfVSSVCLRQvDEDWctLVAGGSDGALEIFS 381
Cdd:cd00200 81 ETGECVRTLT-GHTSY-------VSSVAFSP-DGRI--LSSSSRDKTIKVWD 121
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
195-341 |
3.82e-05 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 45.71 E-value: 3.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 195 WDPRNGGT-----LEETVR-------PGGGAAICSVEFDPFGGSSIAVGCADRNAYVYDIR-------RLVDPLIVLDGH 255
Cdd:PTZ00420 45 WEVEGGGLigairLENQMRkppviklKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhndesvkEIKDPQCILKGH 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 256 TKTVTYARF--MDSHTIVTGSTDGSLKQWDIDNGRRVVRTyrghVNSRNFVGLSvWRHGGLVVSGS-ENNQVFVYDKRWE 332
Cdd:PTZ00420 125 KKKISIIDWnpMNYYIMCSSGFDSFVNIWDIENEKRAFQI----NMPKKLSSLK-WNIKGNLLSGTcVGKHMHIIDPRKQ 199
|
170 180
....*....|....*....|....
gi 15242945 333 E---------------PVWVCGLG 341
Cdd:PTZ00420 200 EiassfhihdggkntkNIWIDGLG 223
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
137-288 |
2.22e-04 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 42.96 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 137 VIGSGDYDGVVTEYDVEKQVPVSERDEHGgRRIWSVDYTLyNGSLIgASGSDDGTVQMWDPRNGgtleetvrpgggAAIC 216
Cdd:PTZ00421 140 VLASAGADMVVNVWDVERGKAVEVIKCHS-DQITSLEWNL-DGSLL-CTTSKDKKLNIIDPRDG------------TIVS 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 217 SVEFDPFGGSS-----------IAVGCAD---RNAYVYDIRRLVDPLIVLDGHTKTVTYARFMDSHT---IVTGSTDGSL 279
Cdd:PTZ00421 205 SVEAHASAKSQrclwakrkdliITLGCSKsqqRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTnllYIGSKGEGNI 284
|
....*....
gi 15242945 280 KQWDIDNGR 288
Cdd:PTZ00421 285 RCFELMNER 293
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
248-283 |
6.57e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.91 E-value: 6.57e-04
10 20 30
....*....|....*....|....*....|....*..
gi 15242945 248 PLIVLDGHTKTVTYARFM-DSHTIVTGSTDGSLKQWD 283
Cdd:smart00320 4 LLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
248-283 |
1.46e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.17 E-value: 1.46e-03
10 20 30
....*....|....*....|....*....|....*..
gi 15242945 248 PLIVLDGHTKTVTYARFM-DSHTIVTGSTDGSLKQWD 283
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
|
|
| Ge1_WD40 |
pfam16529 |
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ... |
249-338 |
5.31e-03 |
|
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.
Pssm-ID: 465162 [Multi-domain] Cd Length: 328 Bit Score: 38.59 E-value: 5.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242945 249 LIVLDGHTKTVTYARFMDSHTIVTGSTDGSLKQWDI---DNGR-RVVRTYRGHV-----------NSRNFVGLSVWRHgg 313
Cdd:pfam16529 180 YIEIEEHSLLVDAAFSPDGTALATASLDGEVKFFQIylfDNRNpRCLHEWKPHDgkplsslffldNHKKPPEVQFWRF-- 257
|
90 100
....*....|....*....|....*
gi 15242945 314 lVVSGSENNQVFvydKRWEEPVWVC 338
Cdd:pfam16529 258 -AITGADNNSEL---KLWSCESWTC 278
|
|
| |
