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Conserved domains on  [gi|15242242|ref|NP_200011|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-427 2.40e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 126.68  E-value: 2.40e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 143 LLTQLDGHEKLVSGIALPSGSDKLYTGSKDETLRVWDCASGQCTGVLKL-GGEIGCVL--SEGPWLL-VGMPNLVKAWNI 218
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAasADGTYLAsGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 219 ETNAD-QSLSGPVGQVYSLVVGTD--LLFAGTQDGSILAWRynaaTNCFEPSASLTGHTLAVVTL-YVGANR-LYSGSMD 293
Cdd:cd00200  81 ETGECvRTLTGHTSYVSSVAFSPDgrILSSSSRDKTIKVWD----VETGKCLTTLRGHTDWVNSVaFSPDGTfVASSSQD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 294 KTIKVWSLDNLQCIQTLTDHSSVVMSlICWD---QFLLSCSLDNTVKIWaAIEGGNLEVTYT-HkeEHGVLALCgVHDae 369
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNS-VAFSpdgEKLLSSSSDGTIKLW-DLSTGKCLGTLRgH--ENGVNSVA-FSP-- 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15242242 370 aKPVLLCACN-DNTLRLYDLPSFTERGKIFAKQE-IRAIQIGP-GGIFFTGDGTGQVKVWK 427
Cdd:cd00200 230 -DGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNsVTSLAWSPdGKRLASGSADGTIRIWD 289
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 115-133 3.42e-05

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


:

Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 40.48  E-value: 3.42e-05
                          10
                  ....*....|....*....
gi 15242242   115 CNFWVDGNCTYGDKCRYLH 133
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-427 2.40e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.68  E-value: 2.40e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 143 LLTQLDGHEKLVSGIALPSGSDKLYTGSKDETLRVWDCASGQCTGVLKL-GGEIGCVL--SEGPWLL-VGMPNLVKAWNI 218
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAasADGTYLAsGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 219 ETNAD-QSLSGPVGQVYSLVVGTD--LLFAGTQDGSILAWRynaaTNCFEPSASLTGHTLAVVTL-YVGANR-LYSGSMD 293
Cdd:cd00200  81 ETGECvRTLTGHTSYVSSVAFSPDgrILSSSSRDKTIKVWD----VETGKCLTTLRGHTDWVNSVaFSPDGTfVASSSQD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 294 KTIKVWSLDNLQCIQTLTDHSSVVMSlICWD---QFLLSCSLDNTVKIWaAIEGGNLEVTYT-HkeEHGVLALCgVHDae 369
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNS-VAFSpdgEKLLSSSSDGTIKLW-DLSTGKCLGTLRgH--ENGVNSVA-FSP-- 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15242242 370 aKPVLLCACN-DNTLRLYDLPSFTERGKIFAKQE-IRAIQIGP-GGIFFTGDGTGQVKVWK 427
Cdd:cd00200 230 -DGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNsVTSLAWSPdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
142-426 6.80e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 6.80e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 142 ALLTQLDGHEKLVSGIAL-PSGSdKLYTGSKDETLRVWDCASGQCTGVLKlgGEIGCVLS-----EGPWLLVGMP-NLVK 214
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFsPDGK-TLASGSADGTVRLWDLATGKLLRTLT--GHSGAVTSvafspDGKLLASGSDdGTVR 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 215 AWNIETNAD-QSLSGPVGQVYSLVVGTD--LLFAGTQDGSILAWryNAATNcfEPSASLTGHTLAVVTLYVGAN--RLYS 289
Cdd:COG2319 188 LWDLATGKLlRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLW--DLATG--KLLRTLTGHSGSVRSVAFSPDgrLLAS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 290 GSMDKTIKVWSLDNLQCIQTLTDHSSVVMSlICW---DQFLLSCSLDNTVKIWAAIEGgnlEVTYTHKEEHG-VLALCGV 365
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLTGHSGGVNS-VAFspdGKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGaVRSVAFS 339

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15242242 366 HDAEakpVLLCACNDNTLRLYDLPSFTERGKIFA-KQEIRAIQIGP-GGIFFTGDGTGQVKVW 426
Cdd:COG2319 340 PDGK---TLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPdGRTLASGSADGTVRLW 399
PTZ00421 PTZ00421
coronin; Provisional
 243-338 2.72e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.42  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242  243 LFAGTQDGSILAWRYNA---ATNCFEPSASLTGHT--LAVVTLYVGA-NRLYSGSMDKTIKVWSLDNLQCIQTLTDHSSV 316
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeglTQNISDPIVHLQGHTkkVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVIKCHSDQ 170

                         90       100
                 ....*....|....*....|....*
gi 15242242  317 VMSLIcWD---QFLLSCSLDNTVKI 338
Cdd:PTZ00421 171 ITSLE-WNldgSLLCTTSKDKKLNI 194
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 115-133 3.42e-05

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 40.48  E-value: 3.42e-05
                          10
                  ....*....|....*....
gi 15242242   115 CNFWVDGNCTYGDKCRYLH 133
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 303-339 5.56e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 5.56e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15242242    303 NLQCIQTLTDHSSVVMSlICWD---QFLLSCSLDNTVKIW 339
Cdd:smart00320   1 SGELLKTLKGHTGPVTS-VAFSpdgKYLASGSDDGTIKLW 39
ZnF_C3H1 smart00356
zinc finger;
112-134 1.37e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.76  E-value: 1.37e-04
                           10        20
                   ....*....|....*....|...
gi 15242242    112 EKVCNFWVDGNCTYGDKCRYLHC 134
Cdd:smart00356   4 TELCKFFKRGYCPRGDRCKFAHP 26
WD40 pfam00400
WD domain, G-beta repeat;
305-339 1.52e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.52e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 15242242   305 QCIQTLTDHSSVVMSLiCWD---QFLLSCSLDNTVKIW 339
Cdd:pfam00400   2 KLLKTLEGHTGSVTSL-AFSpdgKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-427 2.40e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.68  E-value: 2.40e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 143 LLTQLDGHEKLVSGIALPSGSDKLYTGSKDETLRVWDCASGQCTGVLKL-GGEIGCVL--SEGPWLL-VGMPNLVKAWNI 218
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAasADGTYLAsGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 219 ETNAD-QSLSGPVGQVYSLVVGTD--LLFAGTQDGSILAWRynaaTNCFEPSASLTGHTLAVVTL-YVGANR-LYSGSMD 293
Cdd:cd00200  81 ETGECvRTLTGHTSYVSSVAFSPDgrILSSSSRDKTIKVWD----VETGKCLTTLRGHTDWVNSVaFSPDGTfVASSSQD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 294 KTIKVWSLDNLQCIQTLTDHSSVVMSlICWD---QFLLSCSLDNTVKIWaAIEGGNLEVTYT-HkeEHGVLALCgVHDae 369
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNS-VAFSpdgEKLLSSSSDGTIKLW-DLSTGKCLGTLRgH--ENGVNSVA-FSP-- 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15242242 370 aKPVLLCACN-DNTLRLYDLPSFTERGKIFAKQE-IRAIQIGP-GGIFFTGDGTGQVKVWK 427
Cdd:cd00200 230 -DGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNsVTSLAWSPdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
142-426 6.80e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 6.80e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 142 ALLTQLDGHEKLVSGIAL-PSGSdKLYTGSKDETLRVWDCASGQCTGVLKlgGEIGCVLS-----EGPWLLVGMP-NLVK 214
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFsPDGK-TLASGSADGTVRLWDLATGKLLRTLT--GHSGAVTSvafspDGKLLASGSDdGTVR 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 215 AWNIETNAD-QSLSGPVGQVYSLVVGTD--LLFAGTQDGSILAWryNAATNcfEPSASLTGHTLAVVTLYVGAN--RLYS 289
Cdd:COG2319 188 LWDLATGKLlRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLW--DLATG--KLLRTLTGHSGSVRSVAFSPDgrLLAS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 290 GSMDKTIKVWSLDNLQCIQTLTDHSSVVMSlICW---DQFLLSCSLDNTVKIWAAIEGgnlEVTYTHKEEHG-VLALCGV 365
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLTGHSGGVNS-VAFspdGKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGaVRSVAFS 339

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15242242 366 HDAEakpVLLCACNDNTLRLYDLPSFTERGKIFA-KQEIRAIQIGP-GGIFFTGDGTGQVKVW 426
Cdd:COG2319 340 PDGK---TLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPdGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
143-390 1.36e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 1.36e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 143 LLTQLDGHEKLVSGIALPSGSDKLYTGSKDETLRVWDCASGQCTGVLKlgGEIGCVLS-----EGPWLLVG-MPNLVKAW 216
Cdd:COG2319 154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT--GHTGAVRSvafspDGKLLASGsADGTVRLW 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 217 NIETNAD-QSLSGPVGQVYSLVVGTD--LLFAGTQDGSILAWryNAATNcfEPSASLTGHTLAVVTLYVGAN--RLYSGS 291
Cdd:COG2319 232 DLATGKLlRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLW--DLATG--ELLRTLTGHSGGVNSVAFSPDgkLLASGS 307

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 292 MDKTIKVWSLDNLQCIQTLTDHSSVVMSlICW---DQFLLSCSLDNTVKIWAAIEGGNLEVTYTHKEehGVLALCGVHDA 368
Cdd:COG2319 308 DDGTVRLWDLATGKLLRTLTGHTGAVRS-VAFspdGKTLASGSDDGTVRLWDLATGELLRTLTGHTG--AVTSVAFSPDG 384

                       250       260
                ....*....|....*....|..
gi 15242242 369 EakpVLLCACNDNTLRLYDLPS 390
Cdd:COG2319 385 R---TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
139-339 2.81e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 2.81e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 139 ESFALLTQLDGHEKLVSGIALPSGSDKLYTGSKDETLRVWDCASGQCtgVLKLGGEIGCVLS-----EGPWLLVGMP-NL 212
Cdd:COG2319 192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL--LRTLTGHSGSVRSvafspDGRLLASGSAdGT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 213 VKAWNIETNAD-QSLSGPVGQVYSLVVGTD--LLFAGTQDGSILAWryNAATNcfEPSASLTGHTLAVVTLYVGAN--RL 287
Cdd:COG2319 270 VRLWDLATGELlRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLW--DLATG--KLLRTLTGHTGAVRSVAFSPDgkTL 345

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15242242 288 YSGSMDKTIKVWSLDNLQCIQTLTDHSSVVMSlICW---DQFLLSCSLDNTVKIW 339
Cdd:COG2319 346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTS-VAFspdGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-387 7.48e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.66  E-value: 7.48e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 139 ESFALLTQLDGHEKLVSGIALPSGSDKLYTGSKDETLRVWDCASGQCTGVLKlG--GEIGCV--LSEGPWLLVGMPNL-V 213
Cdd:cd00200  39 ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT-GhtSYVSSVafSPDGRILSSSSRDKtI 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 214 KAWNIETN-ADQSLSGPVGQVYSLVVGTD--LLFAGTQDGSILAWRynaaTNCFEPSASLTGHTLAV--VTLYVGANRLY 288
Cdd:cd00200 118 KVWDVETGkCLTTLRGHTDWVNSVAFSPDgtFVASSSQDGTIKLWD----LRTGKCVATLTGHTGEVnsVAFSPDGEKLL 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 289 SGSMDKTIKVWSLDNLQCIQTLTDHSSVVMSLiCWDQ---FLLSCSLDNTVKIWAAIEGGNLEVTYTHkeEHGVLALCGV 365
Cdd:cd00200 194 SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV-AFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSGH--TNSVTSLAWS 270

                       250       260
                ....*....|....*....|..
gi 15242242 366 HDAeakPVLLCACNDNTLRLYD 387
Cdd:cd00200 271 PDG---KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
142-428 5.15e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 5.15e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 142 ALLTQLDGHEKLVSGIALPSGSDKLYTGSKDETLRVWDCASGQCTGVLKlggeigcvlsegpwllvgmpnlvkawnietn 221
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT------------------------------- 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 222 adqslsGPVGQVYSLVVGTD--LLFAGTQDGSILAWryNAATNcfEPSASLTGHTLAVVTLYVGAN--RLYSGSMDKTIK 297
Cdd:COG2319 118 ------GHTGAVRSVAFSPDgkTLASGSADGTVRLW--DLATG--KLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVR 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 298 VWSLDNLQCIQTLTDHSSVVMSLiCWD---QFLLSCSLDNTVKIWAAiEGGNLEVTYTHKEEhgvlalcGVHDAEAKP-- 372
Cdd:COG2319 188 LWDLATGKLLRTLTGHTGAVRSV-AFSpdgKLLASGSADGTVRLWDL-ATGKLLRTLTGHSG-------SVRSVAFSPdg 258

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15242242 373 -VLLCACNDNTLRLYDLPSFTERGKI-FAKQEIRAIQIGPGG-IFFTGDGTGQVKVWKW 428
Cdd:COG2319 259 rLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
215-426 2.18e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 2.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 215 AWNIETNADQSLSGPVGQVYSLVVGTDLLFAGTQDGSILAWRYNAATNcfEPSASLTGHTLAV--VTLYVGANRLYSGSM 292
Cdd:COG2319  21 LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG--ALLATLLGHTAAVlsVAFSPDGRLLASASA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 293 DKTIKVWSLDNLQCIQTLTDHSSVVMSlICWD---QFLLSCSLDNTVKIWAAIEGGNLEVTYTHKEehGVLALCGVHDAE 369
Cdd:COG2319  99 DGTVRLWDLATGLLLRTLTGHTGAVRS-VAFSpdgKTLASGSADGTVRLWDLATGKLLRTLTGHSG--AVTSVAFSPDGK 175

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15242242 370 akpVLLCACNDNTLRLYDLPSFTERGKIFA-KQEIRAIQIGPGG-IFFTGDGTGQVKVW 426
Cdd:COG2319 176 ---LLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGkLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
237-430 3.00e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 3.00e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 237 VVGTDLLFAGTQDGSILAWRYNAATNCFEPSASLTGHTLAVVTLYVGANRLYSGSMDKTIKVWSLDNLQCIQTLTDHSSV 316
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242 317 VMSLICW--DQFLLSCSLDNTVKIWAAIEGGNLEVTYTHKEehgvlalcGVHDAEAKP---VLLCACNDNTLRLYDLPSF 391
Cdd:COG2319  81 VLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTG--------AVRSVAFSPdgkTLASGSADGTVRLWDLATG 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 15242242 392 TERGKIFAKQE-IRAIQIGPGG-IFFTGDGTGQVKVWKWCT 430
Cdd:COG2319 153 KLLRTLTGHSGaVTSVAFSPDGkLLASGSDDGTVRLWDLAT 193
PTZ00421 PTZ00421
coronin; Provisional
 243-338 2.72e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.42  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242242  243 LFAGTQDGSILAWRYNA---ATNCFEPSASLTGHT--LAVVTLYVGA-NRLYSGSMDKTIKVWSLDNLQCIQTLTDHSSV 316
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeglTQNISDPIVHLQGHTkkVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVIKCHSDQ 170

                         90       100
                 ....*....|....*....|....*
gi 15242242  317 VMSLIcWD---QFLLSCSLDNTVKI 338
Cdd:PTZ00421 171 ITSLE-WNldgSLLCTTSKDKKLNI 194
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 115-133 3.42e-05

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 40.48  E-value: 3.42e-05
                          10
                  ....*....|....*....
gi 15242242   115 CNFWVDGNCTYGDKCRYLH 133
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 303-339 5.56e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 5.56e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15242242    303 NLQCIQTLTDHSSVVMSlICWD---QFLLSCSLDNTVKIW 339
Cdd:smart00320   1 SGELLKTLKGHTGPVTS-VAFSpdgKYLASGSDDGTIKLW 39
ZnF_C3H1 smart00356
zinc finger;
112-134 1.37e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.76  E-value: 1.37e-04
                           10        20
                   ....*....|....*....|...
gi 15242242    112 EKVCNFWVDGNCTYGDKCRYLHC 134
Cdd:smart00356   4 TELCKFFKRGYCPRGDRCKFAHP 26
WD40 pfam00400
WD domain, G-beta repeat;
305-339 1.52e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.52e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 15242242   305 QCIQTLTDHSSVVMSLiCWD---QFLLSCSLDNTVKIW 339
Cdd:pfam00400   2 KLLKTLEGHTGSVTSL-AFSpdgKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
143-179 1.89e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15242242   143 LLTQLDGHEKLVSGIALPSGSDKLYTGSKDETLRVWD 179
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 140-179 5.44e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 5.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15242242    140 SFALLTQLDGHEKLVSGIALPSGSDKLYTGSKDETLRVWD 179
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 113-133 6.64e-04

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 36.80  E-value: 6.64e-04
                          10        20
                  ....*....|....*....|.
gi 15242242   113 KVCNFWVDGNCTYGDKCRYLH 133
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSH 21
WD40 COG2319
WD40 repeat [General function prediction only];
139-182 4.78e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 4.78e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15242242 139 ESFALLTQLDGHEKLVSGIALPSGSDKLYTGSKDETLRVWDCAS 182
Cdd:COG2319 360 ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 264-300 5.73e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 5.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 15242242    264 FEPSASLTGHTLAVVTLYV--GANRLYSGSMDKTIKVWS 300
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
264-300 9.24e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 9.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15242242   264 FEPSASLTGHTLAVVTLYVGANR--LYSGSMDKTIKVWS 300
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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