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Conserved domains on  [gi|15241393|ref|NP_199929|]
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Ankyrin repeat family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-176 2.26e-17

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 82.31  E-value: 2.26e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393  44 DKNGFSPLHAAAAAGQVETVRATL--GVEKKLcrlKDRDGKTPLHVATMRGKIDVIREIVASCVDcLEDETVQGQTALHL 121
Cdd:COG0666 117 DKDGETPLHLAAYNGNLEIVKLLLeaGADVNA---QDNDGNTPLHLAAANGNLEIVKLLLEAGAD-VNARDNDGETPLHL 192

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15241393 122 AVLHLEIEAVIAIVElitetNRFDVlNKKDEQGNTALHLATWRKNRQVIEVLVQA 176
Cdd:COG0666 193 AAENGHLEIVKLLLE-----AGADV-NAKDNDGKTALDLAAENGNLEIVKLLLEA 241
PGG super family cl16503
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 269-376 1.28e-15

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


The actual alignment was detected with superfamily member pfam13962:

Pssm-ID: 433609  Cd Length: 114  Bit Score: 72.59  E-value: 1.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   269 EARSALLVVASLVATATFQASLTPPGGTWQDSSipavsqnttnvnttnqqAHTAGQSIMGTFngVAFTLFVFFNTIGFSV 348
Cdd:pfam13962   6 EARNTLLLVATLIATVTFAAGFTPPGGYWQDDD-----------------GPHAGKPILAKN--PAFKAFVISNAIAFFA 66

                          90       100       110
                  ....*....|....*....|....*....|...
gi 15241393   349 SLSMLNILTLGFP-----LRFQLQICMIAMYFS 376
Cdd:pfam13962  67 SLVAVVLLLSIVSdflrsLPRKLRIGLKLLWVA 99
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-176 2.26e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 82.31  E-value: 2.26e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393  44 DKNGFSPLHAAAAAGQVETVRATL--GVEKKLcrlKDRDGKTPLHVATMRGKIDVIREIVASCVDcLEDETVQGQTALHL 121
Cdd:COG0666 117 DKDGETPLHLAAYNGNLEIVKLLLeaGADVNA---QDNDGNTPLHLAAANGNLEIVKLLLEAGAD-VNARDNDGETPLHL 192

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15241393 122 AVLHLEIEAVIAIVElitetNRFDVlNKKDEQGNTALHLATWRKNRQVIEVLVQA 176
Cdd:COG0666 193 AAENGHLEIVKLLLE-----AGADV-NAKDNDGKTALDLAAENGNLEIVKLLLEA 241
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 269-376 1.28e-15

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


Pssm-ID: 433609  Cd Length: 114  Bit Score: 72.59  E-value: 1.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   269 EARSALLVVASLVATATFQASLTPPGGTWQDSSipavsqnttnvnttnqqAHTAGQSIMGTFngVAFTLFVFFNTIGFSV 348
Cdd:pfam13962   6 EARNTLLLVATLIATVTFAAGFTPPGGYWQDDD-----------------GPHAGKPILAKN--PAFKAFVISNAIAFFA 66

                          90       100       110
                  ....*....|....*....|....*....|...
gi 15241393   349 SLSMLNILTLGFP-----LRFQLQICMIAMYFS 376
Cdd:pfam13962  67 SLVAVVLLLSIVSdflrsLPRKLRIGLKLLWVA 99
Ank_2 pfam12796
Ankyrin repeats (3 copies);
51-145 1.50e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 1.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393    51 LHAAAAAGQVETVRATLGVEKKlCRLKDRDGKTPLHVATMRGKIDVIREIVaSCVDCleDETVQGQTALHLAVLHLEIEA 130
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADV--NLKDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 15241393   131 VIAIVELITETNRFD 145
Cdd:pfam12796  77 VKLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 49-212 9.66e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 50.76  E-value: 9.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   49 SPLHAAAAAGQVETVRATLGVEKKLCRLKDRDGKTPLHVATMRGKIDVIREIVASCVDClEDETVQGQTALHLAVLHLEI 128
Cdd:PHA02875  70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADP-DIPNTDKFSPLHLAVMMGDI 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393  129 EAviaiVELITETNRfdVLNKKDEQGNTALHLATWRKNRQVIEVLVQA---IPEESRSFEVNAM-NKMGLSAMDLLVMFP 204
Cdd:PHA02875 149 KG----IELLIDHKA--CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSganIDYFGKNGCVAALcYAIENNKIDIVRLFI 222


                 ....*...
gi 15241393  205 SEAGDREI 212
Cdd:PHA02875 223 KRGADCNI 230
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 49-203 2.56e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.00  E-value: 2.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393  49 SPLHAAAAAGQVETVratlgveKKLCRLKDRD-------GKTPLHVATMRGKIDVIREIvASCVDCLEDETV-----QGQ 116
Cdd:cd22192  19 SPLLLAAKENDVQAI-------KKLLKCPSCDlfqrgalGETALHVAALYDNLEAAVVL-MEAAPELVNEPMtsdlyQGE 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393 117 TALHLAVLHLEIEAVIA-------------------------------------------IVELITEtnRFDVLNKKDEQ 153
Cdd:cd22192  91 TALHIAVVNQNLNLVREliargadvvspratgtffrpgpknliyygehplsfaacvgneeIVRLLIE--HGADIRAQDSL 168

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15241393 154 GNTALHLATWRKNR----QVIEVLVQAIPEEsRSFEVNAM-NKMGLSAMDL------LVMF 203
Cdd:cd22192 169 GNTVLHILVLQPNKtfacQMYDLILSYDKED-DLQPLDLVpNNQGLTPFKLaakegnIVMF 228
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 80-107 3.39e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.39e-03
                           10        20
                   ....*....|....*....|....*...
gi 15241393     80 DGKTPLHVATMRGKIDVIREIVASCVDC 107
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-176 2.26e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 82.31  E-value: 2.26e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393  44 DKNGFSPLHAAAAAGQVETVRATL--GVEKKLcrlKDRDGKTPLHVATMRGKIDVIREIVASCVDcLEDETVQGQTALHL 121
Cdd:COG0666 117 DKDGETPLHLAAYNGNLEIVKLLLeaGADVNA---QDNDGNTPLHLAAANGNLEIVKLLLEAGAD-VNARDNDGETPLHL 192

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15241393 122 AVLHLEIEAVIAIVElitetNRFDVlNKKDEQGNTALHLATWRKNRQVIEVLVQA 176
Cdd:COG0666 193 AAENGHLEIVKLLLE-----AGADV-NAKDNDGKTALDLAAENGNLEIVKLLLEA 241
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-221 9.88e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.38  E-value: 9.88e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393  29 VVAGKILRQRSVFDLDKNGFSPLHAAAAAGQVETVRATLGVEKKLCRLKDRDGKTPLHVATMRGKIDVIREIVASCVDcL 108
Cdd:COG0666  35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-V 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393 109 EDETVQGQTALHLAVLHLEIEAVIAIVElitetNRFDVlNKKDEQGNTALHLATWRKNRQVIEVLVQAipeesrSFEVNA 188
Cdd:COG0666 114 NARDKDGETPLHLAAYNGNLEIVKLLLE-----AGADV-NAQDNDGNTPLHLAAANGNLEIVKLLLEA------GADVNA 181

                       170       180       190
                ....*....|....*....|....*....|...
gi 15241393 189 MNKMGLSAMDLLVMFpseaGDREIYEKLIEAGA 221
Cdd:COG0666 182 RDNDGETPLHLAAEN----GHLEIVKLLLEAGA 210
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 269-376 1.28e-15

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


Pssm-ID: 433609  Cd Length: 114  Bit Score: 72.59  E-value: 1.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   269 EARSALLVVASLVATATFQASLTPPGGTWQDSSipavsqnttnvnttnqqAHTAGQSIMGTFngVAFTLFVFFNTIGFSV 348
Cdd:pfam13962   6 EARNTLLLVATLIATVTFAAGFTPPGGYWQDDD-----------------GPHAGKPILAKN--PAFKAFVISNAIAFFA 66

                          90       100       110
                  ....*....|....*....|....*....|...
gi 15241393   349 SLSMLNILTLGFP-----LRFQLQICMIAMYFS 376
Cdd:pfam13962  67 SLVAVVLLLSIVSdflrsLPRKLRIGLKLLWVA 99
Ank_2 pfam12796
Ankyrin repeats (3 copies);
51-145 1.50e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 1.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393    51 LHAAAAAGQVETVRATLGVEKKlCRLKDRDGKTPLHVATMRGKIDVIREIVaSCVDCleDETVQGQTALHLAVLHLEIEA 130
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADV--NLKDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 15241393   131 VIAIVELITETNRFD 145
Cdd:pfam12796  77 VKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-221 8.69e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.75  E-value: 8.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393  42 DLDKNGFSPLHAAAAAGQVETVRATLGVEKKLCRLKDRDGKTPLHVATMRGKIDVIREIVASCVDCLEDETVQGQTALHL 121
Cdd:COG0666  14 ALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393 122 AVLHLEIEAVIAIVElitetNRFDVlNKKDEQGNTALHLATWRKNRQVIEVLVQAipeesrSFEVNAMNKMGLSAMdllv 201
Cdd:COG0666  94 AARNGDLEIVKLLLE-----AGADV-NARDKDGETPLHLAAYNGNLEIVKLLLEA------GADVNAQDNDGNTPL---- 157

                       170       180
                ....*....|....*....|
gi 15241393 202 MFPSEAGDREIYEKLIEAGA 221
Cdd:COG0666 158 HLAAANGNLEIVKLLLEAGA 177
Ank_2 pfam12796
Ankyrin repeats (3 copies);
85-175 4.74e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 4.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393    85 LHVATMRGKIDVIREIVASCVDClEDETVQGQTALHLAVLHLEIEAVIAIVElitetnrFDVLNKKDEqGNTALHLATWR 164
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLE-------HADVNLKDN-GRTALHYAARS 71

                          90
                  ....*....|.
gi 15241393   165 KNRQVIEVLVQ 175
Cdd:pfam12796  72 GHLEIVKLLLE 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
43-107 4.13e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.50  E-value: 4.13e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15241393    43 LDKNGFSPLHAAAAAGQVETVRAtLgVEKKLCRLKDrDGKTPLHVATMRGKIDVIREIVASCVDC 107
Cdd:pfam12796  26 QDKNGRTALHLAAKNGHLEIVKL-L-LEHADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADI 87
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 49-212 9.66e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 50.76  E-value: 9.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   49 SPLHAAAAAGQVETVRATLGVEKKLCRLKDRDGKTPLHVATMRGKIDVIREIVASCVDClEDETVQGQTALHLAVLHLEI 128
Cdd:PHA02875  70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADP-DIPNTDKFSPLHLAVMMGDI 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393  129 EAviaiVELITETNRfdVLNKKDEQGNTALHLATWRKNRQVIEVLVQA---IPEESRSFEVNAM-NKMGLSAMDLLVMFP 204
Cdd:PHA02875 149 KG----IELLIDHKA--CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSganIDYFGKNGCVAALcYAIENNKIDIVRLFI 222


                 ....*...
gi 15241393  205 SEAGDREI 212
Cdd:PHA02875 223 KRGADCNI 230
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-151 1.09e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.95  E-value: 1.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393  44 DKNGFSPLHAAAAAGQVETVRATL--GVEKKLcrlKDRDGKTPLHVATMRGKIDVIREIVASCVDcLEDETVQGQTALHL 121
Cdd:COG0666 183 DNDGETPLHLAAENGHLEIVKLLLeaGADVNA---KDNDGKTALDLAAENGNLEIVKLLLEAGAD-LNAKDKDGLTALLL 258

                        90       100       110
                ....*....|....*....|....*....|
gi 15241393 122 AVLHLEIEAVIAIVELITETNRFDVLNKKD 151
Cdd:COG0666 259 AAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 81-221 7.28e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 7.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   81 GKTPLHVaTMRGKIDVIREIVASCVDCLED---ETVQGQTALHLAVLHleiEAVIAIVELITETNRfDVlNKKDEQGNTA 157
Cdd:PHA03095  47 GKTPLHL-YLHYSSEKVKDIVRLLLEAGADvnaPERCGFTPLHLYLYN---ATTLDVIKLLIKAGA-DV-NAKDKVGRTP 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15241393  158 LH--LATWRKNRQVIEVLVQaipeesRSFEVNAMNKMGLSAMDLLVMFPSeaGDREIYEKLIEAGA 221
Cdd:PHA03095 121 LHvyLSGFNINPKVIRLLLR------KGADVNALDLYGMTPLAVLLKSRN--ANVELLRLLIDAGA 178
Ank_4 pfam13637
Ankyrin repeats (many copies);
49-98 1.42e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15241393    49 SPLHAAAAAGQVETVRATLgvEKKL-CRLKDRDGKTPLHVATMRGKIDVIR 98
Cdd:pfam13637   3 TALHAAAASGHLELLRLLL--EKGAdINAVDGNGETALHFAASNGNVEVLK 51
PHA02741 PHA02741
hypothetical protein; Provisional
 77-173 4.02e-04

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 41.18  E-value: 4.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   77 KDRDGKTPLHVATMRGKIDVIRE----IVASCVDCLEDET-VQGQTALHLAVLHLEIEAVIAIVELITETNRfDVLNKKD 151
Cdd:PHA02741  17 KNSEGENFFHEAARCGCFDIIARftpfIRGDCHAAALNATdDAGQMCIHIAAEKHEAQLAAEIIDHLIELGA-DINAQEM 95

                         90       100
                 ....*....|....*....|..
gi 15241393  152 EQGNTALHLATWRKNRQVIEVL 173
Cdd:PHA02741  96 LEGDTALHLAAHRRDHDLAEWL 117
PHA03095 PHA03095
ankyrin-like protein; Provisional
 44-222 5.94e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.93  E-value: 5.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   44 DKNGFSPLHAAAAAGQVETVRATLgVEKKL-CRLKDRDGKTPLHV--ATMRGKIDVIREIVASCVDcLEDETVQGQTALH 120
Cdd:PHA03095  80 ERCGFTPLHLYLYNATTLDVIKLL-IKAGAdVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGAD-VNALDLYGMTPLA 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393  121 laVLHLEIEAVIAIVELITETNrFDVLNKKDEqGNTALH--LATWRKNRQVIEVLVqaipeeSRSFEVNAMNKMGLSAMD 198
Cdd:PHA03095 158 --VLLKSRNANVELLRLLIDAG-ADVYAVDDR-FRSLLHhhLQSFKPRARIVRELI------RAGCDPAATDMLGNTPLH 227

                        170       180
                 ....*....|....*....|....
gi 15241393  199 LLVMFPSEAgdREIYEKLIEAGAQ 222
Cdd:PHA03095 228 SMATGSSCK--RSLVLPLLIAGIS 249
Ank_5 pfam13857
Ankyrin repeats (many copies);
36-88 6.35e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.71  E-value: 6.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 15241393    36 RQRSVFDLDKNGFSPLHAAAAAGQVETVRATLgVEKKLCRLKDRDGKTPLHVA 88
Cdd:pfam13857   5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLL-AYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 16-129 6.51e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 6.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   16 PLYNSFNPRSE--EYVVAGKILRQRSVFDLD--------KNGFSPLHAAAAAGQVETVRaTLGVEKKLCRLKDRDGKTPL 85
Cdd:PHA02875  61 PDVKYPDIESElhDAVEEGDVKAVEELLDLGkfaddvfyKDGMTPLHLATILKKLDIMK-LLIARGADPDIPNTDKFSPL 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 15241393   86 HVATMRGKIDVIrEIVASCVDCLEDETVQGQTALHLAVLHLEIE 129
Cdd:PHA02875 140 HLAVMMGDIKGI-ELLIDHKACLDIEDCCGCTPLIIAMAKGDIA 182
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 44-107 1.42e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 1.42e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15241393   44 DKNGFSPLHAAAAAGQVETVRATL--GVEKKLCrlkDRDGKTPLHVATMRGKIDVIrEIVASCVDC 107
Cdd:PTZ00322 112 DYDGRTPLHIACANGHVQVVRVLLefGADPTLL---DKDGKTPLELAEENGFREVV-QLLSRHSQC 173
Ank_4 pfam13637
Ankyrin repeats (many copies);
117-174 2.13e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 2.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15241393   117 TALHLAVLHLEIEAVIAIVElitetNRFDVlNKKDEQGNTALHLATWRKNRQVIEVLV 174
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLE-----KGADI-NAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 49-203 2.56e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.00  E-value: 2.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393  49 SPLHAAAAAGQVETVratlgveKKLCRLKDRD-------GKTPLHVATMRGKIDVIREIvASCVDCLEDETV-----QGQ 116
Cdd:cd22192  19 SPLLLAAKENDVQAI-------KKLLKCPSCDlfqrgalGETALHVAALYDNLEAAVVL-MEAAPELVNEPMtsdlyQGE 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393 117 TALHLAVLHLEIEAVIA-------------------------------------------IVELITEtnRFDVLNKKDEQ 153
Cdd:cd22192  91 TALHIAVVNQNLNLVREliargadvvspratgtffrpgpknliyygehplsfaacvgneeIVRLLIE--HGADIRAQDSL 168

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15241393 154 GNTALHLATWRKNR----QVIEVLVQAIPEEsRSFEVNAM-NKMGLSAMDL------LVMF 203
Cdd:cd22192 169 GNTVLHILVLQPNKtfacQMYDLILSYDKED-DLQPLDLVpNNQGLTPFKLaakegnIVMF 228
Ank_4 pfam13637
Ankyrin repeats (many copies);
83-131 3.04e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 3.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 15241393    83 TPLHVATMRGKIDVIREIVASCVDCleDETV-QGQTALHLAVLHLEIEAV 131
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADI--NAVDgNGETALHFAASNGNVEVL 50
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 80-107 3.39e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.39e-03
                           10        20
                   ....*....|....*....|....*...
gi 15241393     80 DGKTPLHVATMRGKIDVIREIVASCVDC 107
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 34-143 4.53e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 39.18  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   34 ILRQRSVFDLDKNGFSPLHAAAAAGQVETVRATLGVEKKLCRLKDRDGKTPLHVAtMR--GKIDVIREIVASCVDCLEDE 111
Cdd:PHA02874 241 LINNASINDQDIDGSTPLHHAINPPCDIDIIDILLYHKADISIKDNKGENPIDTA-FKyiNKDPVIKDIIANAVLIKEAD 319

                         90       100       110
                 ....*....|....*....|....*....|..
gi 15241393  112 TVQGQTALHlavlHLEIEAVIAIVELITETNR 143
Cdd:PHA02874 320 KLKDSDFLE----HIEIKDNKEFSDFIKECNE 347
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-195 6.60e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.49  E-value: 6.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   77 KDRDGKTPLHVATMR--GKIDVIREIVASCVDcLEDETVQGQTALHLAVLHLEIEavIAIVEL-------ITETNRFDVL 147
Cdd:PHA03100 102 PDNNGITPLLYAISKksNSYSIVEYLLDNGAN-VNIKNSDGENLLHLYLESNKID--LKILKLlidkgvdINAKNRVNYL 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15241393  148 -------NKKDEQGNTALHLATWRKNRQVIEVLVqaipeESRSFeVNAMNKMGLS 195
Cdd:PHA03100 179 lsygvpiNIKDVYGFTPLHYAVYNNNPEFVKYLL-----DLGAN-PNLVNKYGDT 227
Ank_2 pfam12796
Ankyrin repeats (3 copies);
119-221 9.14e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 35.48  E-value: 9.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241393   119 LHLAVLHLEIEAVIAIVELITEtnrfdvLNKKDEQGNTALHLATWRKNRQVIEVLVQaipeesrSFEVNAMNKmGLSAMd 198
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD------ANLQDKNGRTALHLAAKNGHLEIVKLLLE-------HADVNLKDN-GRTAL- 65

                          90       100
                  ....*....|....*....|...
gi 15241393   199 llvMFPSEAGDREIYEKLIEAGA 221
Cdd:pfam12796  66 ---HYAARSGHLEIVKLLLEKGA 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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