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Conserved domains on  [gi|15239172|ref|NP_199122|]
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Cyclin A3;1 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 80-215 1.47e-90

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410265  Cd Length: 136  Bit Score: 267.35  E-value: 1.47e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  80 DPQMCGPYVTSIFEYLRQLEVKSRPLVDYIEKIQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVN 159
Cdd:cd20562   1 DPQMCSLYATDIYLNLRVAELKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15239172 160 KQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQFE 215
Cdd:cd20562  81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 219-333 1.24e-63

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410210  Cd Length: 111  Bit Score: 197.86  E-value: 1.24e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDfeMSHLQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIRPkqHPWNVMLEEYTRYK 298
Cdd:cd20506   1 PTIKTFLRRFLRAAQAS--VPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNP--HPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15239172 299 AGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKF 333
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
 
Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 80-215 1.47e-90

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 267.35  E-value: 1.47e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  80 DPQMCGPYVTSIFEYLRQLEVKSRPLVDYIEKIQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVN 159
Cdd:cd20562   1 DPQMCSLYATDIYLNLRVAELKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15239172 160 KQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQFE 215
Cdd:cd20562  81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 219-333 1.24e-63

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 197.86  E-value: 1.24e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDfeMSHLQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIRPkqHPWNVMLEEYTRYK 298
Cdd:cd20506   1 PTIKTFLRRFLRAAQAS--VPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNP--HPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15239172 299 AGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKF 333
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 91-217 3.21e-56

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 179.25  E-value: 3.21e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172    91 IFEYLRQLEVKSRPLVDYIEKiQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTS 170
Cdd:pfam00134   2 IFQYLRELELKYLPKPDYMDQ-QPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 15239172   171 MLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQFELG 217
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
22-333 1.65e-52

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 179.59  E-value: 1.65e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  22 MEAAIDKERINkkrVVLGELPNlsnikksrKATTKQKKKSVSIPTIETLNSDID-TRSDDPQMCGPYVTSIFEYLRQLEV 100
Cdd:COG5024 125 MIDYILKKDEN---SLSPYELD--------ENQLALDEKQAESKRESQSWQDLDaTDQEDPLMVPEYASDIFEYLLKLEL 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 101 KSRPLVDYIEKiQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEI 180
Cdd:COG5024 194 IDLPNPNYLIK-QSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEV 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 181 TPPNVDDFCYITDNTYTKQEIVKMEADILLALQFELGNPTSNTFLRRFTRVAQEDFemshlQMEFLCSYLSELSMLDYQS 260
Cdd:COG5024 273 NCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDI-----FSRTPAKFSSEISPVDYKF 347

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15239172 261 VKFLPSTVAASAVFLARFIIRpkQHPWNVMLEEYT-RYKAGDLKECVAMIHDlYLSRKCGALEAIREKYKQHKF 333
Cdd:COG5024 348 IQISPSWCAAAAMYLSRKILS--QNQWDRTLIHYSgNYTNPDLKPLNESNKE-NLQNPSVHHDAIFPKYPSPTF 418
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 219-342 4.16e-43

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 145.46  E-value: 4.16e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172   219 PTSNTFLRRFTRVAQEDFEMshlQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIrpKQHPWNVMLEEYTRYK 298
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDL---ELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTL--NSPEWTETLEHYTGYS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 15239172   299 AGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKFKCVATMPVS 342
Cdd:pfam02984  76 EEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 126-209 1.69e-21

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 87.26  E-value: 1.69e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172    126 DWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDntYTKQEIVKME 205
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....
gi 15239172    206 ADIL 209
Cdd:smart00385  79 RLLL 82
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 223-311 3.90e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 61.45  E-value: 3.90e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172    223 TFLRRFTRVAQedfemSHLQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIrpKQHPWNVMLEEYTRY-KAGD 301
Cdd:smart00385   1 DFLRRVCKALN-----LDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTE--ETPPWTKELVHYTGYfTEEE 73

                           90
                   ....*....|
gi 15239172    302 LKECVAMIHD 311
Cdd:smart00385  74 ILRMERLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 80-215 1.47e-90

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 267.35  E-value: 1.47e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  80 DPQMCGPYVTSIFEYLRQLEVKSRPLVDYIEKIQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVN 159
Cdd:cd20562   1 DPQMCSLYATDIYLNLRVAELKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15239172 160 KQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQFE 215
Cdd:cd20562  81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 87-214 1.93e-67

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 208.26  E-value: 1.93e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  87 YVTSIFEYLRQLEVKSRPLVDYIEKiQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLL 166
Cdd:cd20504   2 YADDIYEYLRESELKHRPKPDYMRK-QPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15239172 167 GVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQF 214
Cdd:cd20504  81 GTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 84-214 1.03e-63

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 198.52  E-value: 1.03e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  84 CGPYVTSIFEYLRQLEVKSRPLVDYIEKiQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRL 163
Cdd:cd20507   1 VSEYVKDIYKYLRQLEKKYAIDPDYLSG-QPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15239172 164 QLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQF 214
Cdd:cd20507  80 QLVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 219-333 1.24e-63

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 197.86  E-value: 1.24e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDfeMSHLQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIRPkqHPWNVMLEEYTRYK 298
Cdd:cd20506   1 PTIKTFLRRFLRAAQAS--VPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNP--HPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15239172 299 AGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKF 333
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 91-217 3.21e-56

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 179.25  E-value: 3.21e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172    91 IFEYLRQLEVKSRPLVDYIEKiQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTS 170
Cdd:pfam00134   2 IFQYLRELELKYLPKPDYMDQ-QPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 15239172   171 MLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQFELG 217
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
22-333 1.65e-52

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 179.59  E-value: 1.65e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  22 MEAAIDKERINkkrVVLGELPNlsnikksrKATTKQKKKSVSIPTIETLNSDID-TRSDDPQMCGPYVTSIFEYLRQLEV 100
Cdd:COG5024 125 MIDYILKKDEN---SLSPYELD--------ENQLALDEKQAESKRESQSWQDLDaTDQEDPLMVPEYASDIFEYLLKLEL 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 101 KSRPLVDYIEKiQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEI 180
Cdd:COG5024 194 IDLPNPNYLIK-QSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEV 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 181 TPPNVDDFCYITDNTYTKQEIVKMEADILLALQFELGNPTSNTFLRRFTRVAQEDFemshlQMEFLCSYLSELSMLDYQS 260
Cdd:COG5024 273 NCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDI-----FSRTPAKFSSEISPVDYKF 347

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15239172 261 VKFLPSTVAASAVFLARFIIRpkQHPWNVMLEEYT-RYKAGDLKECVAMIHDlYLSRKCGALEAIREKYKQHKF 333
Cdd:COG5024 348 IQISPSWCAAAAMYLSRKILS--QNQWDRTLIHYSgNYTNPDLKPLNESNKE-NLQNPSVHHDAIFPKYPSPTF 418
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 80-214 6.96e-52

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 168.63  E-value: 6.96e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  80 DPQMCGPYVTSIFEYLRQLEVKSRPLVDYIEKiQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVN 159
Cdd:cd20568   1 DPLMVAEYVPEIFEYLRELELKTLPNPNYMDD-QKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVS 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15239172 160 KQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQF 214
Cdd:cd20568  80 LNKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 73-214 4.25e-51

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 166.66  E-value: 4.25e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  73 DIDT-RSDDPQMCGPYVTSIFEYLRQLEVKSRpLVDYIEKiQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDR 151
Cdd:cd20508   1 DIDEeNSDDPFQVSEYAKDIFDYMKEREEKFV-VPDYLEK-QTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDL 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15239172 152 FLSLKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQF 214
Cdd:cd20508  79 YLSKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDF 141
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 87-215 9.50e-51

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 165.62  E-value: 9.50e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  87 YVTSIFEYLRQLEVKSRPLVDYIEKiQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLL 166
Cdd:cd20561   4 YHEDIHTYLREMEVKCKPKVGYMKK-QPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLV 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15239172 167 GVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQFE 215
Cdd:cd20561  83 GTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 73-215 7.65e-49

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 161.93  E-value: 7.65e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  73 DIDTRSDDPQMCGPYVTSIFEYLRQLEVKSRPLVDYIEKiQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRF 152
Cdd:cd20560  22 DDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGYMRK-QPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRF 100

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15239172 153 LSLKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQFE 215
Cdd:cd20560 101 LSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 73-214 2.24e-47

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 157.51  E-value: 2.24e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  73 DIDT-RSDDPQMCGPYVTSIFEYLRQLEVKSRPLVDYIeKIQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDR 151
Cdd:cd20567   6 DIDEvDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYYM-SQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDR 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15239172 152 FLSLKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQF 214
Cdd:cd20567  85 FLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 80-214 1.48e-44

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 149.63  E-value: 1.48e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  80 DPQMCGPYVTSIFEYLRQLEVKSRPLVDYIEKiqKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVN 159
Cdd:cd20566   1 NPQLCSDYVKDIYQYLRQLEVQQSIRPHYLDG--KEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVS 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15239172 160 KQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQF 214
Cdd:cd20566  79 RKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 219-342 4.16e-43

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 145.46  E-value: 4.16e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172   219 PTSNTFLRRFTRVAQEDFEMshlQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIrpKQHPWNVMLEEYTRYK 298
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDL---ELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTL--NSPEWTETLEHYTGYS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 15239172   299 AGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKFKCVATMPVS 342
Cdd:pfam02984  76 EEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 84-214 8.73e-43

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 145.02  E-value: 8.73e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  84 CGPYVTSIFEYLRQLEVKSRPLVDYIEKiqKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRL 163
Cdd:cd20565   1 CSEYVKDIYAYLRQLEEEQAVRPKYLEG--QEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKML 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15239172 164 QLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQF 214
Cdd:cd20565  79 QLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 115-214 2.41e-38

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 133.21  E-value: 2.41e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 115 DVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKT-VNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITD 193
Cdd:cd20519  31 SLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTnVPKTQLQLIGITCLFIAAKLEEIYPPKLSEFAYVTD 110

                        90       100
                ....*....|....*....|.
gi 15239172 194 NTYTKQEIVKMEADILLALQF 214
Cdd:cd20519 111 GACTEDEILTMELIILKALNW 131
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 121-216 6.15e-31

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 112.80  E-value: 6.15e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 121 RGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQE 200
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                        90
                ....*....|....*.
gi 15239172 201 IVKMEADILLALQFEL 216
Cdd:cd20542  81 VLRMERRVLRRLRFDL 96
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 89-215 2.48e-29

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 110.47  E-value: 2.48e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  89 TSIFEYLRQLEVKSRPLVDYIEKIQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGV 168
Cdd:cd20515  24 DRVLQNLLSLEERYLPSASYFKCVQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGA 103

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15239172 169 TSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQFE 215
Cdd:cd20515 104 VCLFLASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 120-212 3.55e-28

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 105.49  E-value: 3.55e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 120 MRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQ 199
Cdd:cd20536   1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                        90
                ....*....|...
gi 15239172 200 EIVKMEADILLAL 212
Cdd:cd20536  81 QICNLECIILTKL 93
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 120-214 4.80e-27

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 103.77  E-value: 4.80e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 120 MRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRF-LSLKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTK 198
Cdd:cd20580  42 MRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSE 121

                        90
                ....*....|....*.
gi 15239172 199 QEIVKMEADILLALQF 214
Cdd:cd20580 122 DDILDMELIILKALKW 137
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 119-214 6.35e-27

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 103.42  E-value: 6.35e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 119 NMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSL-KTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYT 197
Cdd:cd20579  41 KMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATqENVVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACT 120

                        90
                ....*....|....*..
gi 15239172 198 KQEIVKMEADILLALQF 214
Cdd:cd20579 121 EDEILSMELIIMKALKW 137
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 219-333 9.92e-27

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 101.99  E-value: 9.92e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDFEMSHLQMeflcsYLSELSMLDY-QSVKFLPSTVAASAVFLARFIIRpkQHPWNVMLEEYTRY 297
Cdd:cd20505   1 PTSNWFLERFLKHSNADEKTKSLAM-----YLCELSLIDAdPYLKYLPSVIAAAAVCLANHTLG--NEVWPQKLARSTGY 73

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15239172 298 KAGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKF 333
Cdd:cd20505  74 SLEDLLPCLRDLHRTFLNAPSSPQQAIREKYKSSKY 109
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 80-215 1.93e-25

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 100.06  E-value: 1.93e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  80 DPQMCGPyvTSIFEYLRQLEVKSRPLVDYIEKIQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVN 159
Cdd:cd20575  17 DPRLLGD--QRVLQNLLRLEERYVPRVSYFQCVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTR 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15239172 160 KQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQFE 215
Cdd:cd20575  95 KAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 219-340 6.08e-25

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 97.38  E-value: 6.08e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDfemshLQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIRpKQHPWNVMLEEYTRYK 298
Cdd:cd20511   1 PTPYVFLVRFLKAAQSD-----KKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLN-KTPEWTSTLEFHTGYS 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15239172 299 AGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKFKCVATMP 340
Cdd:cd20511  75 ESQLMECARLMVRLHSKAGTGKLTAVYKKYSSSKFGAVALLP 116
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 120-212 1.48e-24

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 95.85  E-value: 1.48e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 120 MRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQ 199
Cdd:cd20521   3 MRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYKYE 82

                        90
                ....*....|...
gi 15239172 200 EIVKMEADILLAL 212
Cdd:cd20521  83 DVVRMMGEIVAAL 95
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 91-215 7.67e-24

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 95.82  E-value: 7.67e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  91 IFEYLRQLEVKSRPLVDYIEKIQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTS 170
Cdd:cd20573  25 VLQTMLKAEETCLPSVSYFKCVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATC 104

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15239172 171 MLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQFE 215
Cdd:cd20573 105 MFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 219-336 2.93e-22

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 89.98  E-value: 2.93e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDfemshLQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIRPKQhpWNVMLEEYTRYK 298
Cdd:cd20509   1 PLPLHFLRRFSKAGGAD-----AQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEPE--WTPTLEHYSTYS 73

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15239172 299 AGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKFKCV 336
Cdd:cd20509  74 EEDLLPIVQKMAKLVVKSQTSKYQAVKNKYSSSKFMRI 111
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 219-313 1.19e-21

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 87.75  E-value: 1.19e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDfemshLQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIRPkQHPWNVMLEEYTRYK 298
Cdd:cd20537   1 PTPLSFLRRYLSLLGLD-----EKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGE-PPPSPQLLQLVTGYS 74

                        90
                ....*....|....*
gi 15239172 299 AGDLKECVAMIHDLY 313
Cdd:cd20537  75 ENDLQECAKELLELL 89
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 126-209 1.69e-21

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 87.26  E-value: 1.69e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172    126 DWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDntYTKQEIVKME 205
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....
gi 15239172    206 ADIL 209
Cdd:smart00385  79 RLLL 82
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 80-214 1.88e-21

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 89.28  E-value: 1.88e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172  80 DPQMCgpYVTSIFEYLRQLEVKSRPLVDYIEKIQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVN 159
Cdd:cd20574  17 DPNLL--YDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTR 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15239172 160 KQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQF 214
Cdd:cd20574  95 KCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 119-214 4.35e-19

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 81.11  E-value: 4.35e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 119 NMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEITP--PNVDDFCYITDN-T 195
Cdd:cd20528   5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLNRYLCNsV 84

                        90
                ....*....|....*....
gi 15239172 196 YTKQEIVKMEADILLALQF 214
Cdd:cd20528  85 YSKQEYLQMELLILEFFQW 103
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 219-340 4.54e-17

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 76.17  E-value: 4.54e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAqedfemsHLQMEFL--CSYLSELSMLDYQSVKFLPSTVAASAVFLArfiIRPKQ-HPWNVMLEEYT 295
Cdd:cd20510   1 PLSYRFLRRYAKCA-------RASMETLtlARYILELSLMEYQFVQERASKLAAAALLLA---LKMKNlGEWTPTLEYYS 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15239172 296 RYKAGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKFKCVATMP 340
Cdd:cd20510  71 GYSAEDLLPLVRKLNAMLTKPPNKKLKTVRSKYSHKVFFEVAKIP 115
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 219-347 1.55e-16

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 74.85  E-value: 1.55e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDFEMSHLQMeflcsYLSELSMLDYQS-VKFLPSTVAASAVFLARFIIrpKQHPWNVMLEEYTRY 297
Cdd:cd20563   1 PTINQFLLQYLKRHEVCEKTENLAM-----YVAELSLLEVDPfLKYLPSLTAAAAYCLANYTV--NKVFWPETLAAFTGY 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15239172 298 KAGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKFKCVATMPVSPELPL 347
Cdd:cd20563  74 SLSEIVPCLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEPPAVLPL 123
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 124-212 8.24e-15

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 69.34  E-value: 8.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 124 LVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEITP--PNVDDFCYITDNTYTKQEI 201
Cdd:cd20559   2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELF 81

                        90
                ....*....|.
gi 15239172 202 VKMEADILLAL 212
Cdd:cd20559  82 IQMEMHILNTL 92
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 116-214 1.12e-14

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 69.13  E-value: 1.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 116 VTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNT 195
Cdd:cd20517   1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80

                        90
                ....*....|....*....
gi 15239172 196 YTKQEIVKMEADILLALQF 214
Cdd:cd20517  81 FTNLELINQEKDILEALKW 99
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 219-333 2.38e-14

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 68.31  E-value: 2.38e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDFEMSHLQMeflcsYLSELSMLDYQS-VKFLPSTVAASAVFLARFIIrpKQHPWNVMLEEYTRY 297
Cdd:cd20564   1 PTINQFLTQYFLHQQANCKVESLSM-----FLGELSLIDADPyLKYLPSVIAAAAFHLALYTV--TGQSWPESLVQKTGY 73

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15239172 298 KAGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKF 333
Cdd:cd20564  74 TLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKY 109
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 218-334 2.57e-14

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 68.41  E-value: 2.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 218 NPTSntFLRRFTRVAQEDFemshlQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIrpKQHPWNVMLEEYTRY 297
Cdd:cd20512   1 NPMN--FLRRISKADDYDI-----QTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKML--GRGDWNDNLVHYSGY 71

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15239172 298 KAGDLKECVAMIHDlYLSRKCGALEAIREKYKQHKFK 334
Cdd:cd20512  72 TESQLIPCADIMLE-YLVKPIKHHDAFFKKYSSKKFL 107
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 245-341 1.13e-13

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 66.49  E-value: 1.13e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 245 FLCSYLSELSMLDYQSVKFLPSTVAASAVFLARfIIRPKQHPWNVMLEEYTRYKAGDLKECVamihdLYLSRKC------ 318
Cdd:cd20522   1 CLASYICELSLLHTELGRYSPAVIAASCLLLAR-VLLNQALPWPSQLEEFTGFSLEDLLSCV-----LHLHKKCfhedsp 74

                        90       100
                ....*....|....*....|....*...
gi 15239172 319 -----GALEAIREKYKQHKFKCVATMPV 341
Cdd:cd20522  75 kdyrnVSLTAVKQRYEDERFLSISKIKV 102
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 124-205 4.43e-13

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 63.97  E-value: 4.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 124 LVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEItPPNVDDFCYITDntYTKQEIVK 203
Cdd:cd00043   2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEEL-PRTLKEIAKVSG--VSEKELRK 78


                ..
gi 15239172 204 ME 205
Cdd:cd00043  79 AE 80
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 223-311 3.90e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 61.45  E-value: 3.90e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172    223 TFLRRFTRVAQedfemSHLQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIrpKQHPWNVMLEEYTRY-KAGD 301
Cdd:smart00385   1 DFLRRVCKALN-----LDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTE--ETPPWTKELVHYTGYfTEEE 73

                           90
                   ....*....|
gi 15239172    302 LKECVAMIHD 311
Cdd:smart00385  74 ILRMERLLLE 83
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 219-309 3.65e-11

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 59.30  E-value: 3.65e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDFEMSHLQ-----------MEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIRPKQhPW 287
Cdd:cd20529   1 PTPAHFLEYYLSQGVLFVDDHDGLpsellekvkeyVRKYADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSP-TW 79

                        90       100
                ....*....|....*....|..
gi 15239172 288 NVMLEEYTRYKAGDLKECVAMI 309
Cdd:cd20529  80 PEELEKLTGYSEDELEPCVELL 101
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 125-213 1.33e-09

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 54.63  E-value: 1.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 125 VDWLVEVAEEYKLLSDTLYLAVSYIDRFLS---LKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDF-CYITDNTYTKQE 200
Cdd:cd20543   6 IDWILKVRSRYGFGPLTAYLAVNYLDRFLSsydLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLqVEEPKYVFEAKT 85

                        90
                ....*....|...
gi 15239172 201 IVKMEADILLALQ 213
Cdd:cd20543  86 IQRMELLVLSTLE 98
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 224-340 2.10e-09

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 54.89  E-value: 2.10e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 224 FLRRFTRVAQEDFEmSHLqmefLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIrpKQHPWNVMLEEYTRYKAGDLK 303
Cdd:cd20570   6 FLRRASKAGSADVE-KHT----LAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVL--DGGKWSLTQQYYTGYTEDDLK 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15239172 304 ECVAMIHD--LYLSRKCGALEAIREKYKQHKFKCVATMP 340
Cdd:cd20570  79 PIMQHMAKnvVKVNEGLTKHVAVKNKYASSKLMKISTIP 117
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 224-302 2.45e-07

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 49.12  E-value: 2.45e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15239172 224 FLRRFTRVAQEDFEMshlqmEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIRPKQhpWNVMLEEYTRYKAGDL 302
Cdd:cd20569   6 FLRRASKIGEVDVEQ-----HTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGE--WTPTLQHYMSYTEESL 77
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 125-216 3.90e-07

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 47.69  E-value: 3.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 125 VDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKY--EEITPPNVDDFCYITDNTYTKQEIV 202
Cdd:cd20526   6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTneEDEVIPSTKDLVRVSKCGCSVAEVL 85

                        90
                ....*....|....
gi 15239172 203 KMEADILLALQFEL 216
Cdd:cd20526  86 RMERIILDKLHWDL 99
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 219-314 6.81e-07

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 47.12  E-value: 6.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDFEMSHLqMEFLCSY---LSELSMLDYQSVKFLPSTVAASAVFLARFII-RPKQHPWNVMLEEY 294
Cdd:cd20721   1 PTILTFLRMYIERLSLESGAAHA-SRPLERLamfLAEISLLHYSFLQFRPSTVAAACLVLAEIMHnRPAAWAAEALSAEL 79

                        90       100
                ....*....|....*....|....
gi 15239172 295 ----TRYKAGDLKECVAMIHDLYL 314
Cdd:cd20721  80 aavlVHTRAPEVLRCVQALHQLVG 103
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 219-313 4.63e-06

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 44.65  E-value: 4.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDFEMSHL----QMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLArfiIRPKQH--PWNVMLE 292
Cdd:cd20722   1 PTLQFFLEHFSSLRLENRELSCAeearKARALARYLAELSLADYAFNQYPPSLLAICSLELA---DRMLQHrsPITERLS 77

                        90       100
                ....*....|....*....|.
gi 15239172 293 EYTRykaGDLKECVAMIHDLY 313
Cdd:cd20722  78 GYPQ---SALEDCVGKLRLLV 95
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 135-209 1.11e-05

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 43.50  E-value: 1.11e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15239172 135 YKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKY--EEITPPNVDDFCYITDNTYTKQEIVKMEADIL 209
Cdd:cd20523  15 YGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLMRMEGIIL 91
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 219-306 4.13e-05

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 42.27  E-value: 4.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 219 PTSNTFLRRFTRVAQEDFEMSHLQMEFLCSYLSE-----------LSMLDYQSVKFLPSTVAASAVFLarfIIRPKQHpw 287
Cdd:cd20520   2 PTPNSWLNLYLQLAQLNPPPKENDSAFLLPQYSLdrfvraaqlldLCILDIGSLQFSYSVLAASALYL---VSPDDEA-- 76

                        90
                ....*....|....*....
gi 15239172 288 nvmLEEYTRYKAGDLKECV 306
Cdd:cd20520  77 ---IEQVTGYSWEQLAPCV 92
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 124-214 9.49e-05

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 40.72  E-value: 9.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 124 LVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQR----LQLLGVTSMLIASKYEEITPPNVDDFCYITDntYTKQ 199
Cdd:cd20557   2 LRSFIARLLRRTRLSPSVVLLALVYLERLRRRLPEALLGqegsPYRLFLVALMLASKYLDDESYSNKSWAEISG--LPVR 79

                        90
                ....*....|....*
gi 15239172 200 EIVKMEADILLALQF 214
Cdd:cd20557  80 ELNAMEREFLEALDW 94
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 120-209 3.11e-04

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 39.42  E-value: 3.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 120 MRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKY--EEITPPNVDDFCYITDNTYT 197
Cdd:cd20583   1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFT 80

                        90
                ....*....|..
gi 15239172 198 KQEIVKMEADIL 209
Cdd:cd20583  81 VSDMMRMEKIIL 92
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 120-208 7.77e-04

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 38.29  E-value: 7.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239172 120 MRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKY--EEITPPNVDDFCYITDNTYT 197
Cdd:cd20584   1 LRDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCT 80

                        90
                ....*....|.
gi 15239172 198 KQEIVKMEADI 208
Cdd:cd20584  81 VSDLKRMEKII 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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