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Conserved domains on  [gi|15237581|ref|NP_198936|]
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AGAMOUS-like 75 [Arabidopsis thaliana]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 10083688)

MADS (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor)-box domain-containing protein functions as a transcription factor and may be involved in various important aspects of development and differentiation

CATH:  3.40.1810.10
Gene Ontology:  GO:0003700|GO:0046983
PubMed:  8875863|29802068|12949148
SCOP:  4001594

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 19-85 8.12e-19

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


:

Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 79.61  E-value: 8.12e-19
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15237581  19 TSLSNRLETIFKKASELCTLCDIEACVIYYGPDGELKTWPKEKEkVRDIALRYSLLNEALRRKKSVN 85
Cdd:cd00266  18 VTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSE-VEGVISRFEVLSALERKKKAVD 83
 
Name Accession Description Interval E-value
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 19-85 8.12e-19

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 79.61  E-value: 8.12e-19
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15237581  19 TSLSNRLETIFKKASELCTLCDIEACVIYYGPDGELKTWPKEKEkVRDIALRYSLLNEALRRKKSVN 85
Cdd:cd00266  18 VTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSE-VEGVISRFEVLSALERKKKAVD 83
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
19-57 2.51e-14

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 66.30  E-value: 2.51e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15237581    19 TSLSNRLETIFKKASELCTLCDIEACVIYYGPDGELKTW 57
Cdd:pfam00319  10 VTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
MADS smart00432
MADS domain;
19-54 5.52e-10

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 54.49  E-value: 5.52e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15237581     19 TSLSNRLETIFKKASELCTLCDIEACVIYYGPDGEL 54
Cdd:smart00432  18 VTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKL 53
 
Name Accession Description Interval E-value
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 19-85 8.12e-19

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 79.61  E-value: 8.12e-19
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15237581  19 TSLSNRLETIFKKASELCTLCDIEACVIYYGPDGELKTWPKEKEkVRDIALRYSLLNEALRRKKSVN 85
Cdd:cd00266  18 VTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSE-VEGVISRFEVLSALERKKKAVD 83
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 19-58 2.12e-14

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 66.77  E-value: 2.12e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15237581  19 TSLSNRLETIFKKASELCTLCDIEACVIYYGPDGELKTWP 58
Cdd:cd00120  18 VTFSKRRNGLFKKASELSVLCDAEVAVIVFSPSGKLYEFW 57
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
19-57 2.51e-14

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 66.30  E-value: 2.51e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15237581    19 TSLSNRLETIFKKASELCTLCDIEACVIYYGPDGELKTW 57
Cdd:pfam00319  10 VTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
MADS smart00432
MADS domain;
19-54 5.52e-10

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 54.49  E-value: 5.52e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15237581     19 TSLSNRLETIFKKASELCTLCDIEACVIYYGPDGEL 54
Cdd:smart00432  18 VTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKL 53
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 22-54 6.93e-04

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 37.92  E-value: 6.93e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 15237581  22 SNRLETIFKKASELCTLCDIEACVIYYGPDGEL 54
Cdd:cd00265  21 SKRRNGLLKKAHELSVLCDAEVALIIFSSSGKL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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