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Conserved domains on  [gi|15242713|ref|NP_198863|]
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RNI-like superfamily protein [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1563018)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 380-448 9.93e-05

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 43.86  E-value: 9.93e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15242713 380 QHLGRLRKLDLTRNEwLFDKEVVSMLA-SCNGLVEVVLRDCKHLTGAVLVALNKNCVKLKTLDI---LGCRLI 448
Cdd:cd09293  49 SNCNKLKKLILPGSK-LIDDEGLIALAqSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLgrhRNGHLI 120
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 225-345 3.12e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 42.31  E-value: 3.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242713 225 SCRKLKKLSLRSCGSIGEE--IGLCLK--NLEEIELRTCRSIVDVVLLKVSEICESLKSL---------LIHDGG----- 286
Cdd:cd09293  50 NCNKLKKLILPGSKLIDDEglIALAQScpNLQVLDLRACENITDSGIVALATNCPKLQTInlgrhrnghLITDVSlsalg 129

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15242713 287 ----------------SKDGLVQFMSNarCYDTLERLDLRLPMDLTDDHLVSLAA--NFKCLSTLRLTSCIFVTGFS 345
Cdd:cd09293 130 knctflqtvgfagcdvTDKGVWELASG--CSKSLERLSLNNCRNLTDQSIPAILAsnYFPNLSVLEFRGCPLITDFS 204
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 380-448 9.93e-05

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 43.86  E-value: 9.93e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15242713 380 QHLGRLRKLDLTRNEwLFDKEVVSMLA-SCNGLVEVVLRDCKHLTGAVLVALNKNCVKLKTLDI---LGCRLI 448
Cdd:cd09293  49 SNCNKLKKLILPGSK-LIDDEGLIALAqSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLgrhRNGHLI 120
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 225-345 3.12e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 42.31  E-value: 3.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242713 225 SCRKLKKLSLRSCGSIGEE--IGLCLK--NLEEIELRTCRSIVDVVLLKVSEICESLKSL---------LIHDGG----- 286
Cdd:cd09293  50 NCNKLKKLILPGSKLIDDEglIALAQScpNLQVLDLRACENITDSGIVALATNCPKLQTInlgrhrnghLITDVSlsalg 129

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15242713 287 ----------------SKDGLVQFMSNarCYDTLERLDLRLPMDLTDDHLVSLAA--NFKCLSTLRLTSCIFVTGFS 345
Cdd:cd09293 130 knctflqtvgfagcdvTDKGVWELASG--CSKSLERLSLNNCRNLTDQSIPAILAsnYFPNLSVLEFRGCPLITDFS 204
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 380-448 9.93e-05

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 43.86  E-value: 9.93e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15242713 380 QHLGRLRKLDLTRNEwLFDKEVVSMLA-SCNGLVEVVLRDCKHLTGAVLVALNKNCVKLKTLDI---LGCRLI 448
Cdd:cd09293  49 SNCNKLKKLILPGSK-LIDDEGLIALAqSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLgrhRNGHLI 120
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 225-345 3.12e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 42.31  E-value: 3.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242713 225 SCRKLKKLSLRSCGSIGEE--IGLCLK--NLEEIELRTCRSIVDVVLLKVSEICESLKSL---------LIHDGG----- 286
Cdd:cd09293  50 NCNKLKKLILPGSKLIDDEglIALAQScpNLQVLDLRACENITDSGIVALATNCPKLQTInlgrhrnghLITDVSlsalg 129

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15242713 287 ----------------SKDGLVQFMSNarCYDTLERLDLRLPMDLTDDHLVSLAA--NFKCLSTLRLTSCIFVTGFS 345
Cdd:cd09293 130 knctflqtvgfagcdvTDKGVWELASG--CSKSLERLSLNNCRNLTDQSIPAILAsnYFPNLSVLEFRGCPLITDFS 204
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 375-445 7.62e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 41.16  E-value: 7.62e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15242713 375 LATIGQHLGRLRKLDLTRNEWLFDKEVVSMLASCNGLVEVVL---RDCKHLTGAVLVALNKNCVKLKTLDILGC 445
Cdd:cd09293  70 LIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLgrhRNGHLITDVSLSALGKNCTFLQTVGFAGC 143
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 249-448 2.23e-03

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 39.62  E-value: 2.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242713 249 KNLEEIELRTCrSIVDVVLLKVSeICESLKSLLIHdgGSK----DGLVQFmsnARCYDTLERLDLRLPMDLTDDHLVSLA 324
Cdd:cd09293  28 SGLEWLELYMC-PISDPPLDQLS-NCNKLKKLILP--GSKliddEGLIAL---AQSCPNLQVLDLRACENITDSGIVALA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242713 325 ANFKCLSTL---RLTSCIFVTGFSLKALAlsfsssleelsllscnaieRERGLLATIGqhlgrLRKLDLTrnewlfDKEV 401
Cdd:cd09293 101 TNCPKLQTInlgRHRNGHLITDVSLSALG-------------------KNCTFLQTVG-----FAGCDVT------DKGV 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 15242713 402 VSmLASCNG--LVEVVLRDCKHLT-GAV--LVALNkNCVKLKTLDILGCRLI 448
Cdd:cd09293 151 WE-LASGCSksLERLSLNNCRNLTdQSIpaILASN-YFPNLSVLEFRGCPLI 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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