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Conserved domains on  [gi|15242570|ref|NP_198826|]
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Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Protein Classification

disease resistance family protein( domain architecture ID 1000118)

disease resistance family protein similar to Nicotiana glutinosa TMV resistance protein N; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein

Gene Ontology:  GO:0006952

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 12-943 2.74e-114

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 379.99  E-value: 2.74e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570    12 YDVFLSFRGEDTRHSIVSHLYEALTSRGIATFKDDKrLELGDHISEELQRAIEGSDFVVVVLSENYPTSRWCLMELQSIM 91
Cdd:PLN03210   13 YDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNE-IERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLEIV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570    92 ELQMEGRLGVFPVFYRVEPSAVRYQLGSFDlEGYQRDPQ--MADMVPKWRQALKLIADLSGVASGQCIDEATMVRKIVED 169
Cdd:PLN03210   92 RCKEELGQLVIPVFYGLDPSHVRKQTGDFG-EAFEKTCQnkTEDEKIQWKQALTDVANILGYHSQNWPNEAKMIEEIAND 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   170 ISKRKTLKHKIDFRNFVGVDTHLQGLKSLLDMDSnnDEVRMIGIWGMGGIGKTTIAKCLYDQLSSQFTASYFTqDIKGIH 249
Cdd:PLN03210  171 VLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLES--EEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI-DRAFIS 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   250 KELDL------------LHLQNRLLYNTLGD-DIMPWSVEAGREviaaRLGNHKVLLVLDGVDKLVQIHALAKETRWFGR 316
Cdd:PLN03210  248 KSMEIyssanpddynmkLHLQRAFLSEILDKkDIKIYHLGAMEE----RLKHRKVLIFIDDLDDQDVLDALAGQTQWFGS 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   317 QSRIIITTRDKGLLNSCGVKTIYDVkCLDDKD-SLQMFKQIAFEGGSPPSvDFEQLSIRAARLAHGLPSALQAYALFLRG 395
Cdd:PLN03210  324 GSRIIVITKDKHFLRAHGIDHIYEV-CLPSNElALEMFCRSAFKKNSPPD-GFMELASEVALRAGNLPLGLNVLGSYLRG 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   396 RanSPEEWEEAVCGLESTPDENIMEILKISYEGLAKAHQNA-FLHVACLFNGDTFRRVTSLLDVSRMESNLWMRVLAEKS 474
Cdd:PLN03210  402 R--DKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKAiFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKS 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   475 LINITSNgYVTLHKLVEQMGREIMLASG------KFIGDPETIHDTL----GMGQTESISLHICEmTCAFSMATGVFSRM 544
Cdd:PLN03210  480 LIHVRED-IVEMHSLLQEMGKEIVRAQSnepgerEFLVDAKDICDVLedntGTKKVLGITLDIDE-IDELHIHENAFKGM 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   545 YKLRFLKVY-KHVNERESMLQVIPE--DEYPSiNCLLLHWDAFPLSKFPLRFNTYCLVELNLRHSNLETLWSGVLKFGHL 621
Cdd:PLN03210  558 RNLLFLKFYtKKWDQKKEVRWHLPEgfDYLPP-KLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGL 636

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   622 RKLDVTGSKNLKQLPDLSCAEELDELLLEQCKRLKGIPESIAERSTLGRLNLSYYGGAKN-PMGVVIQkvsqtqritllf 700
Cdd:PLN03210  637 RNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEIlPTGINLK------------ 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   701 ptssvemQLMNISITGDIRFRVFADfegyaeyfsFSTEqkihatrtvsvhqaprlISELNKSTTlNIRRFsykengrPVT 780
Cdd:PLN03210  705 -------SLYRLNLSGCSRLKSFPD---------ISTN-----------------ISWLDLDET-AIEEF-------PSN 743

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   781 LHsfpdIPGLKQLELVNLNIQKLSDGIghfeflenldlsgndfENLPEDMNRLS-RLKTLCLRNCSKLKELP----ELTQ 855
Cdd:PLN03210  744 LR----LENLDELILCEMKSEKLWERV----------------QPLTPLMTMLSpSLTRLFLSDIPSLVELPssiqNLHK 803

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   856 VQSLTLSNCKNLRSLvkisdasqdPS---LYSLLELCLDNCKNVKSLSDQLSHfpkLAYLDLSSHDFKKLPSSIRDLTSL 932
Cdd:PLN03210  804 LEHLEIENCINLETL---------PTginLESLESLDLSGCSRLRTFPDISTN---ISDLNLSRTGIEEVPWWIEKFSNL 871

                         970
                  ....*....|.
gi 15242570   933 VTLCLNNCKKL 943
Cdd:PLN03210  872 SFLDMNGCNNL 882
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 12-943 2.74e-114

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 379.99  E-value: 2.74e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570    12 YDVFLSFRGEDTRHSIVSHLYEALTSRGIATFKDDKrLELGDHISEELQRAIEGSDFVVVVLSENYPTSRWCLMELQSIM 91
Cdd:PLN03210   13 YDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNE-IERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLEIV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570    92 ELQMEGRLGVFPVFYRVEPSAVRYQLGSFDlEGYQRDPQ--MADMVPKWRQALKLIADLSGVASGQCIDEATMVRKIVED 169
Cdd:PLN03210   92 RCKEELGQLVIPVFYGLDPSHVRKQTGDFG-EAFEKTCQnkTEDEKIQWKQALTDVANILGYHSQNWPNEAKMIEEIAND 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   170 ISKRKTLKHKIDFRNFVGVDTHLQGLKSLLDMDSnnDEVRMIGIWGMGGIGKTTIAKCLYDQLSSQFTASYFTqDIKGIH 249
Cdd:PLN03210  171 VLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLES--EEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI-DRAFIS 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   250 KELDL------------LHLQNRLLYNTLGD-DIMPWSVEAGREviaaRLGNHKVLLVLDGVDKLVQIHALAKETRWFGR 316
Cdd:PLN03210  248 KSMEIyssanpddynmkLHLQRAFLSEILDKkDIKIYHLGAMEE----RLKHRKVLIFIDDLDDQDVLDALAGQTQWFGS 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   317 QSRIIITTRDKGLLNSCGVKTIYDVkCLDDKD-SLQMFKQIAFEGGSPPSvDFEQLSIRAARLAHGLPSALQAYALFLRG 395
Cdd:PLN03210  324 GSRIIVITKDKHFLRAHGIDHIYEV-CLPSNElALEMFCRSAFKKNSPPD-GFMELASEVALRAGNLPLGLNVLGSYLRG 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   396 RanSPEEWEEAVCGLESTPDENIMEILKISYEGLAKAHQNA-FLHVACLFNGDTFRRVTSLLDVSRMESNLWMRVLAEKS 474
Cdd:PLN03210  402 R--DKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKAiFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKS 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   475 LINITSNgYVTLHKLVEQMGREIMLASG------KFIGDPETIHDTL----GMGQTESISLHICEmTCAFSMATGVFSRM 544
Cdd:PLN03210  480 LIHVRED-IVEMHSLLQEMGKEIVRAQSnepgerEFLVDAKDICDVLedntGTKKVLGITLDIDE-IDELHIHENAFKGM 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   545 YKLRFLKVY-KHVNERESMLQVIPE--DEYPSiNCLLLHWDAFPLSKFPLRFNTYCLVELNLRHSNLETLWSGVLKFGHL 621
Cdd:PLN03210  558 RNLLFLKFYtKKWDQKKEVRWHLPEgfDYLPP-KLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGL 636

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   622 RKLDVTGSKNLKQLPDLSCAEELDELLLEQCKRLKGIPESIAERSTLGRLNLSYYGGAKN-PMGVVIQkvsqtqritllf 700
Cdd:PLN03210  637 RNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEIlPTGINLK------------ 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   701 ptssvemQLMNISITGDIRFRVFADfegyaeyfsFSTEqkihatrtvsvhqaprlISELNKSTTlNIRRFsykengrPVT 780
Cdd:PLN03210  705 -------SLYRLNLSGCSRLKSFPD---------ISTN-----------------ISWLDLDET-AIEEF-------PSN 743

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   781 LHsfpdIPGLKQLELVNLNIQKLSDGIghfeflenldlsgndfENLPEDMNRLS-RLKTLCLRNCSKLKELP----ELTQ 855
Cdd:PLN03210  744 LR----LENLDELILCEMKSEKLWERV----------------QPLTPLMTMLSpSLTRLFLSDIPSLVELPssiqNLHK 803

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   856 VQSLTLSNCKNLRSLvkisdasqdPS---LYSLLELCLDNCKNVKSLSDQLSHfpkLAYLDLSSHDFKKLPSSIRDLTSL 932
Cdd:PLN03210  804 LEHLEIENCINLETL---------PTginLESLESLDLSGCSRLRTFPDISTN---ISDLNLSRTGIEEVPWWIEKFSNL 871

                         970
                  ....*....|.
gi 15242570   933 VTLCLNNCKKL 943
Cdd:PLN03210  872 SFLDMNGCNNL 882
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 12-177 5.27e-47

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 165.62  E-value: 5.27e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570     12 YDVFLSFRGEDTRHSIVSHLYEALTSRGIATFKDDKRLELGDHISEELQRAIEGSDFVVVVLSENYPTSRWCLMELQSIM 91
Cdd:pfam01582    1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570     92 ELQMEGRLGVFPVFYRVEPSAVRYQLGSF-DLEGYQRDPQMADMVPKWRQALKLIADLSGVASGQciDEATMVRKIVEDI 170
Cdd:pfam01582   81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFgKAFKKHKKVLTEEKVLKWRGALNEVANIWHSKSVS--DESKFWKKIAYDI 158


                   ....*..
gi 15242570    171 SKRKTLK 177
Cdd:pfam01582  159 SNKLNGT 165
TIR smart00255
Toll - interleukin 1 - resistance;
12-148 9.69e-32

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 120.89  E-value: 9.69e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570      12 YDVFLSFRG-EDTRHSIVSHLYEALTSRGIATFKDDKrlELGDHISEELQRAIEGSDFVVVVLSENYPTSRWCLMELQSI 90
Cdd:smart00255    2 YDVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDF--EPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15242570      91 MELQME-GRLGVFPVFYRVEPSAVRYQLGSF------DLEGYQRDPQMAdmvpKWRQALKLIADL 148
Cdd:smart00255   80 LENALEeGGLRVIPIFYEVIPSDVRKQPGKFrkvfkkNYLKWPEDEKEQ----FWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
756-957 6.56e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.46  E-value: 6.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  756 ISELNKSTTLNIRRFSYKENGRPVTLHSFPDIPGLKQLELVNLNiqklsdGIGHFEFLENLDLSGNDFENLPEDMNRLSR 835
Cdd:COG4886   64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTN 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  836 LKTLCLRNCsKLKELPEltqvqslTLSNCKNLRSLV----KISDASQDPS-LYSLLELCLDNCKnVKSLSDQLSHFPKLA 910
Cdd:COG4886  138 LKELDLSNN-QLTDLPE-------PLGNLTNLKSLDlsnnQLTDLPEELGnLTNLKELDLSNNQ-ITDLPEPLGNLTNLE 208

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 15242570  911 YLDLSSHDFKKLPSSIRDLTSLVTLCLNNCK--KLKSLEELPlSLQFLD 957
Cdd:COG4886  209 ELDLSGNQLTDLPEPLANLTNLETLDLSNNQltDLPELGNLT-NLEELD 256
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 781-949 2.55e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  781 LHSFPDipgLKQLELVNLNIQKLsDGIGHFEFLENLDLSGNDFENLpEDMNRLSRLKTLCL-RNC-SKLKELPELTQVQS 858
Cdd:cd21340   20 LSLCKN---LKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLgGNRiSVVEGLENLTNLEE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  859 LTLSN---------CKNLRSLV--------------KISDASQDPSLYSLLELCLDNCK--NVKSLSDQLSHFPKLAYLD 913
Cdd:cd21340   95 LHIENqrlppgeklTFDPRSLAalsnslrvlnisgnNIDSLEPLAPLRNLEQLDASNNQisDLEELLDLLSSWPSLRELD 174

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 15242570  914 LSSHDFKKLPsSIRDltSLVTLClnnckklKSLEEL 949
Cdd:cd21340  175 LTGNPVCKKP-KYRD--KIILAS-------KSLEVL 200
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 12-943 2.74e-114

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 379.99  E-value: 2.74e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570    12 YDVFLSFRGEDTRHSIVSHLYEALTSRGIATFKDDKrLELGDHISEELQRAIEGSDFVVVVLSENYPTSRWCLMELQSIM 91
Cdd:PLN03210   13 YDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNE-IERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLEIV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570    92 ELQMEGRLGVFPVFYRVEPSAVRYQLGSFDlEGYQRDPQ--MADMVPKWRQALKLIADLSGVASGQCIDEATMVRKIVED 169
Cdd:PLN03210   92 RCKEELGQLVIPVFYGLDPSHVRKQTGDFG-EAFEKTCQnkTEDEKIQWKQALTDVANILGYHSQNWPNEAKMIEEIAND 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   170 ISKRKTLKHKIDFRNFVGVDTHLQGLKSLLDMDSnnDEVRMIGIWGMGGIGKTTIAKCLYDQLSSQFTASYFTqDIKGIH 249
Cdd:PLN03210  171 VLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLES--EEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI-DRAFIS 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   250 KELDL------------LHLQNRLLYNTLGD-DIMPWSVEAGREviaaRLGNHKVLLVLDGVDKLVQIHALAKETRWFGR 316
Cdd:PLN03210  248 KSMEIyssanpddynmkLHLQRAFLSEILDKkDIKIYHLGAMEE----RLKHRKVLIFIDDLDDQDVLDALAGQTQWFGS 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   317 QSRIIITTRDKGLLNSCGVKTIYDVkCLDDKD-SLQMFKQIAFEGGSPPSvDFEQLSIRAARLAHGLPSALQAYALFLRG 395
Cdd:PLN03210  324 GSRIIVITKDKHFLRAHGIDHIYEV-CLPSNElALEMFCRSAFKKNSPPD-GFMELASEVALRAGNLPLGLNVLGSYLRG 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   396 RanSPEEWEEAVCGLESTPDENIMEILKISYEGLAKAHQNA-FLHVACLFNGDTFRRVTSLLDVSRMESNLWMRVLAEKS 474
Cdd:PLN03210  402 R--DKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKAiFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKS 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   475 LINITSNgYVTLHKLVEQMGREIMLASG------KFIGDPETIHDTL----GMGQTESISLHICEmTCAFSMATGVFSRM 544
Cdd:PLN03210  480 LIHVRED-IVEMHSLLQEMGKEIVRAQSnepgerEFLVDAKDICDVLedntGTKKVLGITLDIDE-IDELHIHENAFKGM 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   545 YKLRFLKVY-KHVNERESMLQVIPE--DEYPSiNCLLLHWDAFPLSKFPLRFNTYCLVELNLRHSNLETLWSGVLKFGHL 621
Cdd:PLN03210  558 RNLLFLKFYtKKWDQKKEVRWHLPEgfDYLPP-KLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGL 636

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   622 RKLDVTGSKNLKQLPDLSCAEELDELLLEQCKRLKGIPESIAERSTLGRLNLSYYGGAKN-PMGVVIQkvsqtqritllf 700
Cdd:PLN03210  637 RNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEIlPTGINLK------------ 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   701 ptssvemQLMNISITGDIRFRVFADfegyaeyfsFSTEqkihatrtvsvhqaprlISELNKSTTlNIRRFsykengrPVT 780
Cdd:PLN03210  705 -------SLYRLNLSGCSRLKSFPD---------ISTN-----------------ISWLDLDET-AIEEF-------PSN 743

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   781 LHsfpdIPGLKQLELVNLNIQKLSDGIghfeflenldlsgndfENLPEDMNRLS-RLKTLCLRNCSKLKELP----ELTQ 855
Cdd:PLN03210  744 LR----LENLDELILCEMKSEKLWERV----------------QPLTPLMTMLSpSLTRLFLSDIPSLVELPssiqNLHK 803

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   856 VQSLTLSNCKNLRSLvkisdasqdPS---LYSLLELCLDNCKNVKSLSDQLSHfpkLAYLDLSSHDFKKLPSSIRDLTSL 932
Cdd:PLN03210  804 LEHLEIENCINLETL---------PTginLESLESLDLSGCSRLRTFPDISTN---ISDLNLSRTGIEEVPWWIEKFSNL 871

                         970
                  ....*....|.
gi 15242570   933 VTLCLNNCKKL 943
Cdd:PLN03210  872 SFLDMNGCNNL 882
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 12-177 5.27e-47

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 165.62  E-value: 5.27e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570     12 YDVFLSFRGEDTRHSIVSHLYEALTSRGIATFKDDKRLELGDHISEELQRAIEGSDFVVVVLSENYPTSRWCLMELQSIM 91
Cdd:pfam01582    1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570     92 ELQMEGRLGVFPVFYRVEPSAVRYQLGSF-DLEGYQRDPQMADMVPKWRQALKLIADLSGVASGQciDEATMVRKIVEDI 170
Cdd:pfam01582   81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFgKAFKKHKKVLTEEKVLKWRGALNEVANIWHSKSVS--DESKFWKKIAYDI 158


                   ....*..
gi 15242570    171 SKRKTLK 177
Cdd:pfam01582  159 SNKLNGT 165
TIR smart00255
Toll - interleukin 1 - resistance;
12-148 9.69e-32

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 120.89  E-value: 9.69e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570      12 YDVFLSFRG-EDTRHSIVSHLYEALTSRGIATFKDDKrlELGDHISEELQRAIEGSDFVVVVLSENYPTSRWCLMELQSI 90
Cdd:smart00255    2 YDVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDF--EPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15242570      91 MELQME-GRLGVFPVFYRVEPSAVRYQLGSF------DLEGYQRDPQMAdmvpKWRQALKLIADL 148
Cdd:smart00255   80 LENALEeGGLRVIPIFYEVIPSDVRKQPGKFrkvfkkNYLKWPEDEKEQ----FWKKALYAVPSK 140
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 14-120 7.25e-21

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 88.91  E-value: 7.25e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570     14 VFLSFRGEDtrHSIVSHLYEALTSRGIATFKDDKRLELGDHISEELQRAIEGSDFVVVVLSENYPTSRWCLMELQSIMEL 93
Cdd:pfam13676    1 VFISYAGED--RAWAEWLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALAD 78

                           90       100
                   ....*....|....*....|....*..
gi 15242570     94 QmEGRLGVFPVfyRVEPSAVRYQLGSF 120
Cdd:pfam13676   79 P-EGRKRLIPV--RLECDLELPGLAGL 102
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
756-957 6.56e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.46  E-value: 6.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  756 ISELNKSTTLNIRRFSYKENGRPVTLHSFPDIPGLKQLELVNLNiqklsdGIGHFEFLENLDLSGNDFENLPEDMNRLSR 835
Cdd:COG4886   64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTN 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  836 LKTLCLRNCsKLKELPEltqvqslTLSNCKNLRSLV----KISDASQDPS-LYSLLELCLDNCKnVKSLSDQLSHFPKLA 910
Cdd:COG4886  138 LKELDLSNN-QLTDLPE-------PLGNLTNLKSLDlsnnQLTDLPEELGnLTNLKELDLSNNQ-ITDLPEPLGNLTNLE 208

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 15242570  911 YLDLSSHDFKKLPSSIRDLTSLVTLCLNNCK--KLKSLEELPlSLQFLD 957
Cdd:COG4886  209 ELDLSGNQLTDLPEPLANLTNLETLDLSNNQltDLPELGNLT-NLEELD 256
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
687-952 1.18e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 1.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  687 IQKVSQTQRITLLFPTSSVEMQLMNISITGDIRFRVFADFEGYAEYFSFSTEQKIHATRTVSVHQAPRLISELNKSTTLN 766
Cdd:COG4886    9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  767 IRRFSYKENGRPVTLHSFPDIPGLKQLELVNL---NIQKLSDGIGHFEFLENLDLSGNDFENLPEDMNRLSRLKTLCLRN 843
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNEELSNLTNLESLDLsgnQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  844 CsKLKELPEltqvqslTLSNCKNLRSLV----KISDASQD-PSLYSLLELCLDNCKnVKSLSDQLSHFPKLAYLDLSSHD 918
Cdd:COG4886  169 N-QLTDLPE-------ELGNLTNLKELDlsnnQITDLPEPlGNLTNLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNQ 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 15242570  919 FKKLPsSIRDLTSLVTLCLNNCK--------KLKSLEELPLS 952
Cdd:COG4886  240 LTDLP-ELGNLTNLEELDLSNNQltdlpplaNLTNLKTLDLS 280
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
756-979 1.74e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 1.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  756 ISELNKSTTLNIRRFSykengrpvtLHSFPD-IPGLKQLELVNL---NIQKLSDGIGHFEFLENLDLSGNDFENLPEDMN 831
Cdd:COG4886  109 LSNLTNLESLDLSGNQ---------LTDLPEeLANLTNLKELDLsnnQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELG 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  832 RLSRLKTLCLRNCsKLKELPEltqvqslTLSNCKNLRSLV----KISDASQD-PSLYSLLELCLDNCKnVKSLSDqLSHF 906
Cdd:COG4886  180 NLTNLKELDLSNN-QITDLPE-------PLGNLTNLEELDlsgnQLTDLPEPlANLTNLETLDLSNNQ-LTDLPE-LGNL 249

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15242570  907 PKLAYLDLSSHDFKKLPSSIrDLTSLVTLCLNNCK----KLKSLEELPLSLQFLDAKGCDSLEADDLEHFKGRVNRE 979
Cdd:COG4886  250 TNLEELDLSNNQLTDLPPLA-NLTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325
COG4916 COG4916
Uncharacterized conserved protein [Function unknown];
12-135 2.38e-17

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443944 [Multi-domain]  Cd Length: 236  Bit Score: 82.47  E-value: 2.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   12 YDVFLSFRGEDtRHsIVSHLYEALTSRGIATF--KDDKRLELGDHISEELQRAIEG-SDFVVVVLSENYPTSRWCLMELQ 88
Cdd:COG4916    1 YDVALSFAGED-RE-FVERVAEALKARGIKVFydENEEAELWGKDLDEYLQDIYRSeSRFVVVFLSKDYVEKKWTGLERR 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 15242570   89 SIMELQM-EGRLGVFPVFY-RVEPSAVRYQLGSFDLEGYQrDPQMADMV 135
Cdd:COG4916   79 AALARAMqRKKEYILPIRLdDTEIPGILATIGYIDLRNRT-PEEIADLI 126
PLN03194 PLN03194
putative disease resistance protein; Provisional
 13-114 3.35e-14

putative disease resistance protein; Provisional


Pssm-ID: 215626 [Multi-domain]  Cd Length: 187  Bit Score: 72.16  E-value: 3.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570    13 DVFLSFRGEDTRHSIVSHLYEALTSRGIATFKDDKRLELGDHISEELQRAIEGSDFVVVVLSENYPTSRWCLMELQsime 92
Cdd:PLN03194   28 DVFINHRGIDTKRTIATLLYDHLSRLNLRPFLDNKNMKPGDKLFDKINSAIRNCKVGVAVFSPRYCESYFCLHELA---- 103

                          90       100
                  ....*....|....*....|..
gi 15242570    93 LQMEGRLGVFPVFYRVEPSAVR 114
Cdd:PLN03194  104 LIMESKKRVIPIFCDVKPSQLR 125
NB-ARC pfam00931
NB-ARC domain;
221-427 1.73e-13

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 71.26  E-value: 1.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570    221 KTTIAKCLY---DQLSSQFTASYFTQDIKGIHKELDLLHLQNRLLYNTLGDDIMPWSVEAGREVIAarLGNHKVLLVLDG 297
Cdd:pfam00931   31 KTTLAAQIFndfDEVEGHFDSVAWVVVSKTFTISTLQQTILQNLGLSEDDWDNKEEGELARKIRRA--LLTKRFLLVLDD 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570    298 VDKLVQIHALAKETRWFGRQSRIIITTRDKGLLNSCGVK-TIYDVKCLDDKDSLQMFKQIAFEGGSPPSVDFEQLSIRAA 376
Cdd:pfam00931  109 VWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGGPsDPHEVELLEPDEAWELFENKVFPKTLGECELLEDVAKEIV 188

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 15242570    377 RLAHGLPSALQAYALFLRGRaNSPEEWEEAVCGLESTPD------ENIMEILKISYE 427
Cdd:pfam00931  189 EKCRGLPLALKVLGGLLSCK-KTVEEWKHVYDVLQSELKsnsyslNSVRSILQLSYE 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
753-939 8.34e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 8.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  753 PRLISELNKSTTLNIRRfsykeNGrpvtLHSFPD----IPGLKQLELVNLNIQKLSDGIGHFEFLENLDLSGNDFENLPE 828
Cdd:COG4886  152 PEPLGNLTNLKSLDLSN-----NQ----LTDLPEelgnLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  829 DMNRLSRLKTLCLRNCsKLKELPE---LTQVQSLTLSNCknlrslvKISDASQDPSLYSLLELCLDNCKNVKSLSDQLSH 905
Cdd:COG4886  223 PLANLTNLETLDLSNN-QLTDLPElgnLTNLEELDLSNN-------QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                        170       180       190
                 ....*....|....*....|....*....|....
gi 15242570  906 FPKLAYLDLSSHDFKKLPSSIRDLTSLVTLCLNN 939
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
598-940 1.27e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  598 LVELNLRHSNLETLWSGVLKFGHLRKLDVTGSK---------NLKQLPDLSCAEEldellleqckRLKGIPESIAERSTL 668
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQltdlpeplgNLTNLKSLDLSNN----------QLTDLPEELGNLTNL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  669 GRLNLSYyggakNpmgvviqkvsqtqRITLLfptssvemqlmnisitgdirfrvfadfegyaeyfsfsteqkihatrtvs 748
Cdd:COG4886  185 KELDLSN-----N-------------QITDL------------------------------------------------- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  749 vhqaPRLISELNKSTTLNIRrfsykENGrpvtLHSFPD-IPGLKQLELVNLNIQKLSD--GIGHFEFLENLDLSGNDFEN 825
Cdd:COG4886  198 ----PEPLGNLTNLEELDLS-----GNQ----LTDLPEpLANLTNLETLDLSNNQLTDlpELGNLTNLEELDLSNNQLTD 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  826 LPEDMNrLSRLKTLCLRNCS----KLKELPELTQVQSLTLSNCKNLRSLVKISDASQDPSLYSLLELCLDNCKNVKSLSD 901
Cdd:COG4886  265 LPPLAN-LTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 15242570  902 QLSHFPKLAYLDLSSHDFKKLPSSIRDLTSLVTLCLNNC 940
Cdd:COG4886  344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382
LRR_3 pfam07725
Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the ...
 597-615 8.55e-05

Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the pfam00560 model.


Pssm-ID: 429621 [Multi-domain]  Cd Length: 20  Bit Score: 40.40  E-value: 8.55e-05
                           10
                   ....*....|....*....
gi 15242570    597 CLVELNLRHSNLETLWSGV 615
Cdd:pfam07725    1 NLVELNMPYSKLEKLWEGV 19
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 790-939 1.18e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   790 LKQLELVNLNIQKLSDGIGHF---EFLENLDLSGNDF-ENLPEDMNRLSRLKTLCLRNCSKLKELPEltqvqslTLSNCK 865
Cdd:PLN00113  451 MPSLQMLSLARNKFFGGLPDSfgsKRLENLDLSRNQFsGAVPRKLGSLSELMQLKLSENKLSGEIPD-------ELSSCK 523

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15242570   866 NLRSLvkisDASQDpslysllelcldncKNVKSLSDQLSHFPKLAYLDLSSHDFK-KLPSSIRDLTSLVTLCLNN 939
Cdd:PLN00113  524 KLVSL----DLSHN--------------QLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISH 580
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 781-949 2.55e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  781 LHSFPDipgLKQLELVNLNIQKLsDGIGHFEFLENLDLSGNDFENLpEDMNRLSRLKTLCL-RNC-SKLKELPELTQVQS 858
Cdd:cd21340   20 LSLCKN---LKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLgGNRiSVVEGLENLTNLEE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570  859 LTLSN---------CKNLRSLV--------------KISDASQDPSLYSLLELCLDNCK--NVKSLSDQLSHFPKLAYLD 913
Cdd:cd21340   95 LHIENqrlppgeklTFDPRSLAalsnslrvlnisgnNIDSLEPLAPLRNLEQLDASNNQisDLEELLDLLSSWPSLRELD 174

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 15242570  914 LSSHDFKKLPsSIRDltSLVTLClnnckklKSLEEL 949
Cdd:cd21340  175 LTGNPVCKKP-KYRD--KIILAS-------KSLEVL 200
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 787-984 7.06e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 7.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   787 IPGLKQLELVNLNIQ-KLSDGIGHFEFLENLDLSGNDFE-NLPEDMNRLSRLKTLCLRNCSKLKELP-ELTQVQSLTLS- 862
Cdd:PLN00113  139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVGQIPrELGQMKSLKWIy 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242570   863 -NCKNLRSLVKIsdasQDPSLYSL--LELCLDNCKNvkSLSDQLSHFPKLAYLDLSSHDFK-KLPSSIRDLTSLVTLCLN 938
Cdd:PLN00113  219 lGYNNLSGEIPY----EIGGLTSLnhLDLVYNNLTG--PIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLS 292

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 15242570   939 NCKKLKSLEELPLSLQfldakgcdSLEADDL--EHFKGRVNREVSAQP 984
Cdd:PLN00113  293 DNSLSGEIPELVIQLQ--------NLEILHLfsNNFTGKIPVALTSLP 332
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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