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Conserved domains on  [gi|15240973|ref|NP_198683|]
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Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/kelch-repeat protein( domain architecture ID 17778853)

F-box/kelch-repeat protein may be a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
9-51 9.95e-18

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438923  Cd Length: 45  Bit Score: 74.91  E-value: 9.95e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15240973   9 PSLPDDLILSCVARVSRLYYPALSLVSKSFRSLIASPELYKTR 51
Cdd:cd22152   3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
68-254 6.86e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.47  E-value: 6.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240973  68 SNTWHEGPRLRVKLMSCTACVLDEKIYV-SGRCKDGDSMTFQVFDTNTQTWDPL-SVPcseTKHDFHYKIVRFDGKLHLV 145
Cdd:COG3055  99 TNTWTKLAPMPTPRGGATALLLDGKIYVvGGWDDGGNVAWVEVYDPATGTWTQLaPLP---TPRDHLAAAVLPDGKILVI 175
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240973 146 S-YKGVDAYNSKEGRWDLVTPSIEHNKYLYDcyrniGNVWYTIVKGDISTSVWWYHSEEREWRDlkgmvgLPKFPIDACl 224
Cdd:COG3055 176 GgRNGSGFSNTWTTLAPLPTARAGHAAAVLG-----GKILVFGGESGFSDEVEAYDPATNTWTA------LGELPTPRH- 243
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 15240973 225 rmvdygGKMAVLWDDYL--------PGRRKKMIWCAEI 254
Cdd:COG3055 244 ------GHAAVLTDGKVyviggetkPGVRTPLVTSAEV 275
 
Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
9-51 9.95e-18

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 74.91  E-value: 9.95e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15240973   9 PSLPDDLILSCVARVSRLYYPALSLVSKSFRSLIASPELYKTR 51
Cdd:cd22152   3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
68-254 6.86e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.47  E-value: 6.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240973  68 SNTWHEGPRLRVKLMSCTACVLDEKIYV-SGRCKDGDSMTFQVFDTNTQTWDPL-SVPcseTKHDFHYKIVRFDGKLHLV 145
Cdd:COG3055  99 TNTWTKLAPMPTPRGGATALLLDGKIYVvGGWDDGGNVAWVEVYDPATGTWTQLaPLP---TPRDHLAAAVLPDGKILVI 175
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240973 146 S-YKGVDAYNSKEGRWDLVTPSIEHNKYLYDcyrniGNVWYTIVKGDISTSVWWYHSEEREWRDlkgmvgLPKFPIDACl 224
Cdd:COG3055 176 GgRNGSGFSNTWTTLAPLPTARAGHAAAVLG-----GKILVFGGESGFSDEVEAYDPATNTWTA------LGELPTPRH- 243
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 15240973 225 rmvdygGKMAVLWDDYL--------PGRRKKMIWCAEI 254
Cdd:COG3055 244 ------GHAAVLTDGKVyviggetkPGVRTPLVTSAEV 275
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
10-50 6.36e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 45.22  E-value: 6.36e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15240973    10 SLPDDLILSCVARVSRLYYPALSLVSKSFRSLIASPELYKT 50
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
FBOX smart00256
A Receptor for Ubiquitination Targets;
11-51 5.78e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 39.73  E-value: 5.78e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15240973     11 LPDDLILSCVARVSRLYYPALSLVSKSFRSLIASPELYKTR 51
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
81-123 9.84e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 39.24  E-value: 9.84e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15240973    81 LMSCTACVLDEKIYVSGRCKDGD---SMTFQVFDTNTQTWDPLSVP 123
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGdlsSSDVLVYDPETNVWTEVPRL 47
 
Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
9-51 9.95e-18

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 74.91  E-value: 9.95e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15240973   9 PSLPDDLILSCVARVSRLYYPALSLVSKSFRSLIASPELYKTR 51
Cdd:cd22152   3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
68-254 6.86e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.47  E-value: 6.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240973  68 SNTWHEGPRLRVKLMSCTACVLDEKIYV-SGRCKDGDSMTFQVFDTNTQTWDPL-SVPcseTKHDFHYKIVRFDGKLHLV 145
Cdd:COG3055  99 TNTWTKLAPMPTPRGGATALLLDGKIYVvGGWDDGGNVAWVEVYDPATGTWTQLaPLP---TPRDHLAAAVLPDGKILVI 175
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240973 146 S-YKGVDAYNSKEGRWDLVTPSIEHNKYLYDcyrniGNVWYTIVKGDISTSVWWYHSEEREWRDlkgmvgLPKFPIDACl 224
Cdd:COG3055 176 GgRNGSGFSNTWTTLAPLPTARAGHAAAVLG-----GKILVFGGESGFSDEVEAYDPATNTWTA------LGELPTPRH- 243
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 15240973 225 rmvdygGKMAVLWDDYL--------PGRRKKMIWCAEI 254
Cdd:COG3055 244 ------GHAAVLTDGKVyviggetkPGVRTPLVTSAEV 275
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
10-50 6.36e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 45.22  E-value: 6.36e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15240973    10 SLPDDLILSCVARVSRLYYPALSLVSKSFRSLIASPELYKT 50
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
70-165 1.07e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 45.92  E-value: 1.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240973  70 TWHEGPRLRVKLMSCTACVLDEKIYVSGRCKDGDSM-TFQVFDTNTQTWDPL-SVPcseTKHDFHYKIVRFDGKLHLVS- 146
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASnSFEVYDPATNTWSELaPLP---GPPRHHAAAVAQDGKLYVFGg 78
                        90       100
                ....*....|....*....|....*....
gi 15240973 147 ----------YKGVDAYNSKEGRWDLVTP 165
Cdd:COG3055  79 ftganpsstpLNDVYVYDPATNTWTKLAP 107
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
10-51 2.99e-05

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 40.67  E-value: 2.99e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15240973  10 SLPDDLILSCVARVSRLYYPALSLVSKSFRSlIASPELYKTR 51
Cdd:cd22143   4 SLPDEILSIIFSHLPQSDLYNLLFVNKHFYS-LALPELWRSI 44
FBOX smart00256
A Receptor for Ubiquitination Targets;
11-51 5.78e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 39.73  E-value: 5.78e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15240973     11 LPDDLILSCVARVSRLYYPALSLVSKSFRSLIASPELYKTR 51
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
81-123 9.84e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 39.24  E-value: 9.84e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15240973    81 LMSCTACVLDEKIYVSGRCKDGD---SMTFQVFDTNTQTWDPLSVP 123
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGdlsSSDVLVYDPETNVWTEVPRL 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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