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Conserved domains on  [gi|15240889|ref|NP_198651|]
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Disease resistance protein (NBS-LRR class) family [Arabidopsis thaliana]

Protein Classification

disease resistance family protein( domain architecture ID 1000118)

disease resistance family protein similar to Nicotiana glutinosa TMV resistance protein N; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein

Gene Ontology:  GO:0006952

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 1-831 0e+00

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 633.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889     1 MTEKIATDVSNMLNnYSPSRDFDGLIGMDAHMKEMESLLCLDSDEVRMIGIWGPSGIGKTTIARVLYSQFSENFELSIFM 80
Cdd:PLN03210  163 MIEEIANDVLGKLN-LTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889    81 GNI---KELMYTRPVCSDEYSAKIQLQKQFLSQIINHKDMELHHLGVAQDRLNDKKVLIVLDSIDQSIQLDAIAKETRWF 157
Cdd:PLN03210  242 DRAfisKSMEIYSSANPDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWF 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   158 GHGSRIIITTQDQKLLKAHGINHIYKVEFPSAYEAYQMFCMYAFGQNFPNDGFEELAWEVTKLLGHLPLGLRVMGSHFRG 237
Cdd:PLN03210  322 GSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRG 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   238 MSRHEWVNALPRLKIRLDASIQSILKFSYDALC-EEDKDLFLHIACLFNNQEMVEVEDYLALSFLDVRQGFHLLAEKSLI 316
Cdd:PLN03210  402 RDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNnKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLI 481

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   317 NLKFlstncTRIEMHNLLVQLGKDIVRHKPGhqsicEPGKRQFLIDARDICEVLTDNTGNRNVVGIFLEVRNLScQLNIS 396
Cdd:PLN03210  482 HVRE-----DIVEMHSLLQEMGKEIVRAQSN-----EPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEID-ELHIH 550

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   397 ERAFDGMSNLKFLRFHDPYDDESDKL--YLPQGLNNLPQKLRLIEWSRFPMTCLPSNFCTKYLVEIRMKNSKLQNLWQGN 474
Cdd:PLN03210  551 ENAFKGMRNLLFLKFYTKKWDQKKEVrwHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGV 630

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   475 QPLGNLKRMDLSESKHLKELPDLSTATNLEYLIMSGCISLVELPSSIGKLRKLLMLSLRGCSKLEALPTNINLESLDYLD 554
Cdd:PLN03210  631 HSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLN 710

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   555 LTDCLLIKKFPEISTNIKDLKLTKTAIK---------------------------------------------------- 582
Cdd:PLN03210  711 LSGCSRLKSFPDISTNISWLDLDETAIEefpsnlrlenldelilcemkseklwervqpltplmtmlspsltrlflsdips 790

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   583 --EVPSTIKSWSHLRKLEMSYSENLKELP--------HALDI---------------ITTLYINDTEMQEIPQWVKKISH 637
Cdd:PLN03210  791 lvELPSSIQNLHKLEHLEIENCINLETLPtginleslESLDLsgcsrlrtfpdistnISDLNLSRTGIEEVPWWIEKFSN 870

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   638 LQTLGLEGCKRLVTIPQLSDSLSQLV---VTNCESLERLNF---------SFQNHPERF-----LWFLNCFKLNNEAREF 700
Cdd:PLN03210  871 LSFLDMNGCNNLQRVSLNISKLKHLEtvdFSDCGALTEASWngspsevamATDNIHSKLpstvcINFINCFNLDQEALLQ 950

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   701 IQTSSTHAILPSREVPANFTYRANGSSIM-VNLNH-RPLSTTLRFKACVLlvkkIDNDKEEAADRRTTVIPRIRENDKIG 778
Cdd:PLN03210  951 QQSIFKQLILSGEEVPSYFTHRTTGASLTnIPLLHiSPCQPFFRFRACAV----VDSESFFIISVSFDIQVCCRFIDRLG 1026

                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15240889   779 --VDVPWRYRFHVPTILEDHLLTFQ----IEADVTSnKLLFSFD--------IKDNNQAVIKECGVL 831
Cdd:PLN03210 1027 nhFDSPYQPHVFSVTKKGSHLVIFDccfpLNEDNAP-LAELNYDhvdiqfrlTNKNSQLKLKGCGIR 1092
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 1-831 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 633.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889     1 MTEKIATDVSNMLNnYSPSRDFDGLIGMDAHMKEMESLLCLDSDEVRMIGIWGPSGIGKTTIARVLYSQFSENFELSIFM 80
Cdd:PLN03210  163 MIEEIANDVLGKLN-LTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889    81 GNI---KELMYTRPVCSDEYSAKIQLQKQFLSQIINHKDMELHHLGVAQDRLNDKKVLIVLDSIDQSIQLDAIAKETRWF 157
Cdd:PLN03210  242 DRAfisKSMEIYSSANPDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWF 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   158 GHGSRIIITTQDQKLLKAHGINHIYKVEFPSAYEAYQMFCMYAFGQNFPNDGFEELAWEVTKLLGHLPLGLRVMGSHFRG 237
Cdd:PLN03210  322 GSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRG 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   238 MSRHEWVNALPRLKIRLDASIQSILKFSYDALC-EEDKDLFLHIACLFNNQEMVEVEDYLALSFLDVRQGFHLLAEKSLI 316
Cdd:PLN03210  402 RDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNnKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLI 481

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   317 NLKFlstncTRIEMHNLLVQLGKDIVRHKPGhqsicEPGKRQFLIDARDICEVLTDNTGNRNVVGIFLEVRNLScQLNIS 396
Cdd:PLN03210  482 HVRE-----DIVEMHSLLQEMGKEIVRAQSN-----EPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEID-ELHIH 550

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   397 ERAFDGMSNLKFLRFHDPYDDESDKL--YLPQGLNNLPQKLRLIEWSRFPMTCLPSNFCTKYLVEIRMKNSKLQNLWQGN 474
Cdd:PLN03210  551 ENAFKGMRNLLFLKFYTKKWDQKKEVrwHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGV 630

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   475 QPLGNLKRMDLSESKHLKELPDLSTATNLEYLIMSGCISLVELPSSIGKLRKLLMLSLRGCSKLEALPTNINLESLDYLD 554
Cdd:PLN03210  631 HSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLN 710

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   555 LTDCLLIKKFPEISTNIKDLKLTKTAIK---------------------------------------------------- 582
Cdd:PLN03210  711 LSGCSRLKSFPDISTNISWLDLDETAIEefpsnlrlenldelilcemkseklwervqpltplmtmlspsltrlflsdips 790

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   583 --EVPSTIKSWSHLRKLEMSYSENLKELP--------HALDI---------------ITTLYINDTEMQEIPQWVKKISH 637
Cdd:PLN03210  791 lvELPSSIQNLHKLEHLEIENCINLETLPtginleslESLDLsgcsrlrtfpdistnISDLNLSRTGIEEVPWWIEKFSN 870

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   638 LQTLGLEGCKRLVTIPQLSDSLSQLV---VTNCESLERLNF---------SFQNHPERF-----LWFLNCFKLNNEAREF 700
Cdd:PLN03210  871 LSFLDMNGCNNLQRVSLNISKLKHLEtvdFSDCGALTEASWngspsevamATDNIHSKLpstvcINFINCFNLDQEALLQ 950

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   701 IQTSSTHAILPSREVPANFTYRANGSSIM-VNLNH-RPLSTTLRFKACVLlvkkIDNDKEEAADRRTTVIPRIRENDKIG 778
Cdd:PLN03210  951 QQSIFKQLILSGEEVPSYFTHRTTGASLTnIPLLHiSPCQPFFRFRACAV----VDSESFFIISVSFDIQVCCRFIDRLG 1026

                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15240889   779 --VDVPWRYRFHVPTILEDHLLTFQ----IEADVTSnKLLFSFD--------IKDNNQAVIKECGVL 831
Cdd:PLN03210 1027 nhFDSPYQPHVFSVTKKGSHLVIFDccfpLNEDNAP-LAELNYDhvdiqfrlTNKNSQLKLKGCGIR 1092
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
477-676 2.89e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.89e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 477 LGNLKRMDLSESKHLKELpdlstaTNLEYLIMSGCiSLVELPSSIGKLRKLLMLSLRGCsKLEALPTNI-NLESLDYLDL 555
Cdd:COG4886  95 LTNLTELDLSGNEELSNL------TNLESLDLSGN-QLTDLPEELANLTNLKELDLSNN-QLTDLPEPLgNLTNLKSLDL 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 556 TDCllikkfpeistnikdlkltktAIKEVPSTIKSWSHLRKLEMSYSeNLKELPHALDIIT---TLYINDTEMQEIPQWV 632
Cdd:COG4886 167 SNN---------------------QLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTnleELDLSGNQLTDLPEPL 224

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 15240889 633 KKISHLQTLGLEGCKrLVTIPQLSdslsqlvvtNCESLERLNFS 676
Cdd:COG4886 225 ANLTNLETLDLSNNQ-LTDLPELG---------NLTNLEELDLS 258
NB-ARC pfam00931
NB-ARC domain;
41-267 1.15e-13

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 71.64  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889    41 LDSDEVRMIGIWGPSGIGKTTIARVLYSQFSE---NFELSIFMGNIKelmyTRPVCSDEYSAKIQLQKQflSQIINHKDM 117
Cdd:pfam00931  13 SEKDEPGIVGIHGMGGVGKTTLAAQIFNDFDEvegHFDSVAWVVVSK----TFTISTLQQTILQNLGLS--EDDWDNKEE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   118 elhhlGVAQDR----LNDKKVLIVLDSIDQSIQLDAIAKETRWFGHGSRIIITTQDQKLLKAHGINH-IYKVEFPSAYEA 192
Cdd:pfam00931  87 -----GELARKirraLLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGGPSdPHEVELLEPDEA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   193 YQMFCMYAFGQNF-PNDGFEELAWEVTKLLGHLPLGLRVMGSHFRGMSR-HEWVNALPRLKIRLDA------SIQSILKF 264
Cdd:pfam00931 162 WELFENKVFPKTLgECELLEDVAKEIVEKCRGLPLALKVLGGLLSCKKTvEEWKHVYDVLQSELKSnsyslnSVRSILQL 241


                  ...
gi 15240889   265 SYD 267
Cdd:pfam00931 242 SYE 244
GMPK cd00071
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), ...
 48-78 1.82e-03

Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine diphosphate (GDP). It plays an essential role in the biosynthesis of guanosine triphosphate (GTP). This enzyme is also important for the activation of some antiviral and anticancer agents, such as acyclovir, ganciclovir, carbovir, and thiopurines.


Pssm-ID: 238026  Cd Length: 137  Bit Score: 39.44  E-value: 1.82e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 15240889  48 MIGIWGPSGIGKTTIARVLYSQFSENFELSI 78
Cdd:cd00071   1 LIVLSGPSGVGKSTLLKRLLEEFDPNFGFSV 31
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 1-831 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 633.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889     1 MTEKIATDVSNMLNnYSPSRDFDGLIGMDAHMKEMESLLCLDSDEVRMIGIWGPSGIGKTTIARVLYSQFSENFELSIFM 80
Cdd:PLN03210  163 MIEEIANDVLGKLN-LTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889    81 GNI---KELMYTRPVCSDEYSAKIQLQKQFLSQIINHKDMELHHLGVAQDRLNDKKVLIVLDSIDQSIQLDAIAKETRWF 157
Cdd:PLN03210  242 DRAfisKSMEIYSSANPDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWF 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   158 GHGSRIIITTQDQKLLKAHGINHIYKVEFPSAYEAYQMFCMYAFGQNFPNDGFEELAWEVTKLLGHLPLGLRVMGSHFRG 237
Cdd:PLN03210  322 GSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRG 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   238 MSRHEWVNALPRLKIRLDASIQSILKFSYDALC-EEDKDLFLHIACLFNNQEMVEVEDYLALSFLDVRQGFHLLAEKSLI 316
Cdd:PLN03210  402 RDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNnKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLI 481

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   317 NLKFlstncTRIEMHNLLVQLGKDIVRHKPGhqsicEPGKRQFLIDARDICEVLTDNTGNRNVVGIFLEVRNLScQLNIS 396
Cdd:PLN03210  482 HVRE-----DIVEMHSLLQEMGKEIVRAQSN-----EPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEID-ELHIH 550

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   397 ERAFDGMSNLKFLRFHDPYDDESDKL--YLPQGLNNLPQKLRLIEWSRFPMTCLPSNFCTKYLVEIRMKNSKLQNLWQGN 474
Cdd:PLN03210  551 ENAFKGMRNLLFLKFYTKKWDQKKEVrwHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGV 630

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   475 QPLGNLKRMDLSESKHLKELPDLSTATNLEYLIMSGCISLVELPSSIGKLRKLLMLSLRGCSKLEALPTNINLESLDYLD 554
Cdd:PLN03210  631 HSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLN 710

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   555 LTDCLLIKKFPEISTNIKDLKLTKTAIK---------------------------------------------------- 582
Cdd:PLN03210  711 LSGCSRLKSFPDISTNISWLDLDETAIEefpsnlrlenldelilcemkseklwervqpltplmtmlspsltrlflsdips 790

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   583 --EVPSTIKSWSHLRKLEMSYSENLKELP--------HALDI---------------ITTLYINDTEMQEIPQWVKKISH 637
Cdd:PLN03210  791 lvELPSSIQNLHKLEHLEIENCINLETLPtginleslESLDLsgcsrlrtfpdistnISDLNLSRTGIEEVPWWIEKFSN 870

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   638 LQTLGLEGCKRLVTIPQLSDSLSQLV---VTNCESLERLNF---------SFQNHPERF-----LWFLNCFKLNNEAREF 700
Cdd:PLN03210  871 LSFLDMNGCNNLQRVSLNISKLKHLEtvdFSDCGALTEASWngspsevamATDNIHSKLpstvcINFINCFNLDQEALLQ 950

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   701 IQTSSTHAILPSREVPANFTYRANGSSIM-VNLNH-RPLSTTLRFKACVLlvkkIDNDKEEAADRRTTVIPRIRENDKIG 778
Cdd:PLN03210  951 QQSIFKQLILSGEEVPSYFTHRTTGASLTnIPLLHiSPCQPFFRFRACAV----VDSESFFIISVSFDIQVCCRFIDRLG 1026

                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15240889   779 --VDVPWRYRFHVPTILEDHLLTFQ----IEADVTSnKLLFSFD--------IKDNNQAVIKECGVL 831
Cdd:PLN03210 1027 nhFDSPYQPHVFSVTKKGSHLVIFDccfpLNEDNAP-LAELNYDhvdiqfrlTNKNSQLKLKGCGIR 1092
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
477-676 2.89e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.89e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 477 LGNLKRMDLSESKHLKELpdlstaTNLEYLIMSGCiSLVELPSSIGKLRKLLMLSLRGCsKLEALPTNI-NLESLDYLDL 555
Cdd:COG4886  95 LTNLTELDLSGNEELSNL------TNLESLDLSGN-QLTDLPEELANLTNLKELDLSNN-QLTDLPEPLgNLTNLKSLDL 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 556 TDCllikkfpeistnikdlkltktAIKEVPSTIKSWSHLRKLEMSYSeNLKELPHALDIIT---TLYINDTEMQEIPQWV 632
Cdd:COG4886 167 SNN---------------------QLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTnleELDLSGNQLTDLPEPL 224

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 15240889 633 KKISHLQTLGLEGCKrLVTIPQLSdslsqlvvtNCESLERLNFS 676
Cdd:COG4886 225 ANLTNLETLDLSNNQ-LTDLPELG---------NLTNLEELDLS 258
NB-ARC pfam00931
NB-ARC domain;
41-267 1.15e-13

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 71.64  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889    41 LDSDEVRMIGIWGPSGIGKTTIARVLYSQFSE---NFELSIFMGNIKelmyTRPVCSDEYSAKIQLQKQflSQIINHKDM 117
Cdd:pfam00931  13 SEKDEPGIVGIHGMGGVGKTTLAAQIFNDFDEvegHFDSVAWVVVSK----TFTISTLQQTILQNLGLS--EDDWDNKEE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   118 elhhlGVAQDR----LNDKKVLIVLDSIDQSIQLDAIAKETRWFGHGSRIIITTQDQKLLKAHGINH-IYKVEFPSAYEA 192
Cdd:pfam00931  87 -----GELARKirraLLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGGPSdPHEVELLEPDEA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889   193 YQMFCMYAFGQNF-PNDGFEELAWEVTKLLGHLPLGLRVMGSHFRGMSR-HEWVNALPRLKIRLDA------SIQSILKF 264
Cdd:pfam00931 162 WELFENKVFPKTLgECELLEDVAKEIVEKCRGLPLALKVLGGLLSCKKTvEEWKHVYDVLQSELKSnsyslnSVRSILQL 241


                  ...
gi 15240889   265 SYD 267
Cdd:pfam00931 242 SYE 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
416-750 2.73e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 2.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 416 DDESDKLYLPQGLNNLPQKLRLIEWSRFPMTCLPSNFCTKYLVEIRMKNSKLQNLWQGNQPLGNLKRMDLSESKhLKELP 495
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ-LTDLP 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 496 D-LSTATNLEYLIMSGCiSLVELPSSIGKLRKLLMLSLRGCsKLEALPTNI-NLESLDYLDLTDCLLIKKFPEIS--TNI 571
Cdd:COG4886 153 EpLGNLTNLKSLDLSNN-QLTDLPEELGNLTNLKELDLSNN-QITDLPEPLgNLTNLEELDLSGNQLTDLPEPLAnlTNL 230

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 572 KDLKLTKTAIKEVPStIKSWSHLRKLEMSYSeNLKELPHALDI--ITTLYINDTEMQEIpqwvkKISHLQTLGLEGCKRL 649
Cdd:COG4886 231 ETLDLSNNQLTDLPE-LGNLTNLEELDLSNN-QLTDLPPLANLtnLKTLDLSNNQLTDL-----KLKELELLLGLNSLLL 303

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 650 VTIPQLSDSLSQLVVTNCESLERLNFSFQNHPERFLWFLNCFKLNNEAREFIQTSSTHAILPSREVPANFTYRANGSSIM 729
Cdd:COG4886 304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                       330       340
                ....*....|....*....|.
gi 15240889 730 VNLNHRPLSTTLRFKACVLLV 750
Cdd:COG4886 384 LLLLTLLLLLLTTTAGVLLLT 404
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
430-676 3.31e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 3.31e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 430 NLPQKLRLIEWSRFPMTCLPSNFCTKYLVEIRMKNSKLQNLWQGNQPLGNLKRMDLSESKHLKELPDLSTATNLEYLIMS 509
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 510 GCISLVELPSSIGKLRKLLMLSLRGCSKLEALPtniNLESldyLDLTDCLLIKKFPEIS--TNIKDLKLTKTAIKEVPST 587
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT---NLES---LDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEP 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 588 IKSWSHLRKLEMSYSeNLKELPHA---LDIITTLYINDTEMQEIPQWVKKISHLQTLGLEGCKrlvtIPQLSDSLSqlvv 664
Cdd:COG4886 155 LGNLTNLKSLDLSNN-QLTDLPEElgnLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ----LTDLPEPLA---- 225

                       250
                ....*....|..
gi 15240889 665 tNCESLERLNFS 676
Cdd:COG4886 226 -NLTNLETLDLS 236
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 710-747 1.61e-06

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 47.44  E-value: 1.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15240889   710 LPSREVPANFTYRANGSSIMVNLNHRPLSTT-LRFKACV 747
Cdd:pfam20160   1 LPGSQIPEWFNHQSTGSSISIKLPENWYNDNfLGFAVCA 39
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
16-143 4.25e-06

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 49.85  E-value: 4.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889  16 YSPSRdfdgLIGMDAHMKEMESLL--CLDSDEVRMIGIWGPSGIGKTTIARVLYSQFSENFElsifmgniKELMYTRPV- 92
Cdd:COG1474  23 YVPDR----LPHREEEIEELASALrpALRGERPSNVLIYGPTGTGKTAVAKYVLEELEEEAE--------ERGVDVRVVy 90

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15240889  93 --CSDEYSakiqlQKQFLSQIINH--KDMELHHLGVAQDRL----------NDKKVLIVLDSIDQ 143
Cdd:COG1474  91 vnCRQAST-----RYRVLSRILEElgSGEDIPSTGLSTDELfdrlyealdeRDGVLVVVLDEIDY 150
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 48-86 2.59e-04

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 44.28  E-value: 2.59e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15240889  48 MIgIWGPSGIGKTTIARVLYSQFSENFE-LSIFMGNIKEL 86
Cdd:COG2256  52 MI-LWGPPGTGKTTLARLIANATDAEFVaLSAVTSGVKDI 90
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 48-86 4.24e-04

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 43.53  E-value: 4.24e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 15240889   48 MIgIWGPSGIGKTTIARVLYSQFSENFE-LSIFMGNIKEL 86
Cdd:PRK13342  39 MI-LWGPPGTGKTTLARIIAGATDAPFEaLSAVTSGVKDL 77
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 43-73 8.79e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 41.36  E-value: 8.79e-04
                        10        20        30
                ....*....|....*....|....*....|.
gi 15240889  43 SDEVRMIGIWGPSGIGKTTIARVLYSQFSEN 73
Cdd:COG0572   4 SGKPRIIGIAGPSGSGKTTFARRLAEQLGAD 34
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
399-664 1.29e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 1.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 399 AFDGMSNLKFLRFHDpyddesDKL-YLPQGLNNLPqKLRLIEWSRFPMTCLPSNFCT-KYLVEIRMKNSKLQNLWQGNQP 476
Cdd:COG4886 154 PLGNLTNLKSLDLSN------NQLtDLPEELGNLT-NLKELDLSNNQITDLPEPLGNlTNLEELDLSGNQLTDLPEPLAN 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 477 LGNLKRMDLSESKhLKELPDLSTATNLEYLIMSGCiSLVELPSSiGKLRKLLMLSLRGCS----KLEALPTNINLESLDY 552
Cdd:COG4886 227 LTNLETLDLSNNQ-LTDLPELGNLTNLEELDLSNN-QLTDLPPL-ANLTNLKTLDLSNNQltdlKLKELELLLGLNSLLL 303

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240889 553 LdLTDCLLIKKFPEISTNIKDLKLTKTAIKEVPSTIKSWSHLRKLEMSYSENLKELPHALDIITTLYINDTEMQEIPQWV 632
Cdd:COG4886 304 L-LLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382

                       250       260       270
                ....*....|....*....|....*....|..
gi 15240889 633 KKISHLQTLGLEGCKRLVTIPQLSDSLSQLVV 664
Cdd:COG4886 383 ALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
GMPK cd00071
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), ...
 48-78 1.82e-03

Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine diphosphate (GDP). It plays an essential role in the biosynthesis of guanosine triphosphate (GTP). This enzyme is also important for the activation of some antiviral and anticancer agents, such as acyclovir, ganciclovir, carbovir, and thiopurines.


Pssm-ID: 238026  Cd Length: 137  Bit Score: 39.44  E-value: 1.82e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 15240889  48 MIGIWGPSGIGKTTIARVLYSQFSENFELSI 78
Cdd:cd00071   1 LIVLSGPSGVGKSTLLKRLLEEFDPNFGFSV 31
LRR_3 pfam07725
Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the ...
 456-475 3.71e-03

Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the pfam00560 model.


Pssm-ID: 429621 [Multi-domain]  Cd Length: 20  Bit Score: 35.39  E-value: 3.71e-03
                          10        20
                  ....*....|....*....|
gi 15240889   456 YLVEIRMKNSKLQNLWQGNQ 475
Cdd:pfam07725   1 NLVELNMPYSKLEKLWEGVK 20
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 51-95 4.92e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 37.20  E-value: 4.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15240889    51 IWGPSGIGKTTIARVLYSQFSEnfelsiFMGNIKELMYTRPVCSD 95
Cdd:pfam00910   3 LYGPPGCGKSTLAKYLARALLK------KLGLPKDSVYSRNPDDD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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