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Conserved domains on  [gi|15239318|ref|NP_198469|]
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F-box and associated interaction domains-containing protein [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 17779305)

F-box protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 215-384 6.23e-77

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


:

Pssm-ID: 254394  Cd Length: 159  Bit Score: 237.51  E-value: 6.23e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239318   215 GVSLKGNTYWFAREinirgeRIDDPPDFLICFDFTTERFGPRLHLPFHSHSDDTVILSSVREEQLAVLIKRFDLWRMEIW 294
Cdd:pfam07734   1 GVSLKGNTYWLARE------KETNEEDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIW 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239318   295 VTTKIEPKEVSWNKlFLAVDMIPLITA-FQFCNVSFFIDEKKNVVVVLGKDVLNTRNIANIIGNDGYFKQVDlgestNKY 373
Cdd:pfam07734  75 VTTKIEPNAVSWSK-FLTVDMPPLPGLfFHFFAGSFFIDEEKKVAVVCDKDKEKKTNTIYIIGEDGYFKEVD-----SSY 148

                         170
                  ....*....|.
gi 15239318   374 CYPLVCSYVPS 384
Cdd:pfam07734 149 CSPLVCSYVPS 159
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 4-42 5.00e-12

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438928  Cd Length: 39  Bit Score: 60.17  E-value: 5.00e-12
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15239318   4 SDLPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSNDHSF 42
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
 
Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 215-384 6.23e-77

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 237.51  E-value: 6.23e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239318   215 GVSLKGNTYWFAREinirgeRIDDPPDFLICFDFTTERFGPRLHLPFHSHSDDTVILSSVREEQLAVLIKRFDLWRMEIW 294
Cdd:pfam07734   1 GVSLKGNTYWLARE------KETNEEDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIW 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239318   295 VTTKIEPKEVSWNKlFLAVDMIPLITA-FQFCNVSFFIDEKKNVVVVLGKDVLNTRNIANIIGNDGYFKQVDlgestNKY 373
Cdd:pfam07734  75 VTTKIEPNAVSWSK-FLTVDMPPLPGLfFHFFAGSFFIDEEKKVAVVCDKDKEKKTNTIYIIGEDGYFKEVD-----SSY 148

                         170
                  ....*....|.
gi 15239318   374 CYPLVCSYVPS 384
Cdd:pfam07734 149 CSPLVCSYVPS 159
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 112-340 4.07e-38

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 138.65  E-value: 4.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239318   112 IFHCNGLLLllgFTDDGiKLVVTNPHLGQTRWIKPRKANYQF--CDKYAIGYekkkNNSLRTNKMLLFHKESFCFRIYWF 189
Cdd:TIGR01640   1 VVPCDGLIC---FSYGK-RLVVWNPSTGQSRWLPTPKSRRSNkeSDTYFLGY----DPIEKQYKVLCFSDRSGNRNQSEH 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239318   190 EIYNFNSASWNVFYFTRDWELPYSQGVSLKGNTYWFAREINirgeriDDPPDFLICFDFTTERFGPRLHLPFH-SHSDDT 268
Cdd:TIGR01640  73 QVYTLGSNSWRTIECSPPHHPLKSRGVCINGVLYYLAYTLK------TNPDYFIVSFDVSSERFKEFIPLPCGnSDSVDY 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15239318   269 VILSSVReEQLAVLIKRFDLWRMEIWVTTkiEPKEVSWNKLFlAVDMIPLITAFQFCNVSFFIDEKKNVVVV 340
Cdd:TIGR01640 147 LSLINYK-GKLAVLKQKKDTNNFDLWVLN--DAGKQEWSKLF-TVPIPPLPDLVDDNFLSGFTDKGEIVLCC 214
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 4-42 5.00e-12

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 60.17  E-value: 5.00e-12
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15239318   4 SDLPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSNDHSF 42
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 3-45 1.66e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 47.53  E-value: 1.66e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15239318     3 MSDLPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSNDHSFTRK 45
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
FBOX smart00256
A Receptor for Ubiquitination Targets;
6-46 2.26e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.05  E-value: 2.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15239318      6 LPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSNDHSFTRKL 46
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 215-384 6.23e-77

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 237.51  E-value: 6.23e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239318   215 GVSLKGNTYWFAREinirgeRIDDPPDFLICFDFTTERFGPRLHLPFHSHSDDTVILSSVREEQLAVLIKRFDLWRMEIW 294
Cdd:pfam07734   1 GVSLKGNTYWLARE------KETNEEDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIW 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239318   295 VTTKIEPKEVSWNKlFLAVDMIPLITA-FQFCNVSFFIDEKKNVVVVLGKDVLNTRNIANIIGNDGYFKQVDlgestNKY 373
Cdd:pfam07734  75 VTTKIEPNAVSWSK-FLTVDMPPLPGLfFHFFAGSFFIDEEKKVAVVCDKDKEKKTNTIYIIGEDGYFKEVD-----SSY 148

                         170
                  ....*....|.
gi 15239318   374 CYPLVCSYVPS 384
Cdd:pfam07734 149 CSPLVCSYVPS 159
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 112-340 4.07e-38

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 138.65  E-value: 4.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239318   112 IFHCNGLLLllgFTDDGiKLVVTNPHLGQTRWIKPRKANYQF--CDKYAIGYekkkNNSLRTNKMLLFHKESFCFRIYWF 189
Cdd:TIGR01640   1 VVPCDGLIC---FSYGK-RLVVWNPSTGQSRWLPTPKSRRSNkeSDTYFLGY----DPIEKQYKVLCFSDRSGNRNQSEH 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239318   190 EIYNFNSASWNVFYFTRDWELPYSQGVSLKGNTYWFAREINirgeriDDPPDFLICFDFTTERFGPRLHLPFH-SHSDDT 268
Cdd:TIGR01640  73 QVYTLGSNSWRTIECSPPHHPLKSRGVCINGVLYYLAYTLK------TNPDYFIVSFDVSSERFKEFIPLPCGnSDSVDY 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15239318   269 VILSSVReEQLAVLIKRFDLWRMEIWVTTkiEPKEVSWNKLFlAVDMIPLITAFQFCNVSFFIDEKKNVVVV 340
Cdd:TIGR01640 147 LSLINYK-GKLAVLKQKKDTNNFDLWVLN--DAGKQEWSKLF-TVPIPPLPDLVDDNFLSGFTDKGEIVLCC 214
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 4-42 5.00e-12

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 60.17  E-value: 5.00e-12
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15239318   4 SDLPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSNDHSF 42
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 3-45 1.66e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 47.53  E-value: 1.66e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15239318     3 MSDLPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSNDHSFTRK 45
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
FBOX smart00256
A Receptor for Ubiquitination Targets;
6-46 2.26e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.05  E-value: 2.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15239318      6 LPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSNDHSFTRKL 46
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 4-38 5.88e-06

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 42.82  E-value: 5.88e-06
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15239318   4 SDLPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSN 38
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 3-47 9.67e-06

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 42.47  E-value: 9.67e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15239318     3 MSDLPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSNDHSFTRKLF 47
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 3-36 6.70e-05

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 40.24  E-value: 6.70e-05
                        10        20        30
                ....*....|....*....|....*....|....
gi 15239318   3 MSDLPNDLVEEIISRVPVKSIRAVSSTCKNWNTL 36
Cdd:cd22152   2 IPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSL 35
F-box_FBXO24 cd22098
F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called ...
 5-46 3.36e-04

F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438870  Cd Length: 47  Bit Score: 38.46  E-value: 3.36e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15239318   5 DLPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSNDHSFTRKL 46
Cdd:cd22098   4 DLPPEILDRIISFLPVKDIVSLGQTCRYFHEVCNSEAVWRRL 45
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 4-47 3.73e-03

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 3.73e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15239318   4 SDLPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSNDHSFTRKLF 47
Cdd:cd22132   2 PLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKELF 45
F-box_ScMFB1-like cd22146
F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and ...
 5-42 4.02e-03

F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and similar proteins; ScMFB1 is a novel mitochondria-associated F-box protein that functions to increase mitochondrial connectivity in yeast. ScMFB1 acts as a key component of a Skp1-Cdc53/Cullin-F-box protein (SCF) ubiquitin ligase complex machinery that regulates mitochondrial dynamics throughout the yeast's entire life cycle. It interacts with Skp1p in an F-box-dependent manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438917  Cd Length: 42  Bit Score: 34.92  E-value: 4.02e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15239318   5 DLPNDLVEEIISRVPVKSIRAVSSTCKNWNTLSNDHSF 42
Cdd:cd22146   3 GLPLEILFEILIYLDIPDILNLSKTCRFLYVLLNDEIL 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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