zinc metalloproteinase-like protein [Arabidopsis thaliana]
SprT family zinc-dependent metalloprotease( domain architecture ID 10996102)
SprT family zinc-dependent metalloprotease, which contains an HExxH motif characteristic of zinc metallopeptidases
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
YgjP-like super family | cl19237 | YgjP-like, metallopeptidase domain; This is a conserved domain containing the catalytic ... |
144-329 | 1.59e-64 | ||||
YgjP-like, metallopeptidase domain; This is a conserved domain containing the catalytic zinc-metallopeptidase (HExxH) catalytic motif. Proteins containing this domain are found in some archaebacteria, as well as Helicobacter pylori. The proteins are 190-240 amino acids long, with the C terminus being the most conserved region, containing three conserved histidines. This domain is found in YgjP from E. coli, a predicted metal-dependent hydrolase that hydrolyses UTP to UMP and diphosphate in vitro; and in MJ0123 from Methanocaldococcus jannaschii (also referred to as projannalysin). The actual alignment was detected with superfamily member pfam08325: Pssm-ID: 473153 Cd Length: 190 Bit Score: 209.88 E-value: 1.59e-64
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PUB_WLM | cd10463 | PNGase/UBA or UBX (PUB) domain of the Wss1p-like metalloprotease (WLM) family; The PUB domain ... |
497-597 | 3.52e-44 | ||||
PNGase/UBA or UBX (PUB) domain of the Wss1p-like metalloprotease (WLM) family; The PUB domain functions as a p97 (also known as valosin-containing protein or VCP) adaptor by interacting with the D1 and/or D2 ATPase domains. The type II AAA+ ATPase p97 is involved in a variety of cellular processes such as the deglycosylation of ERAD substrates, membrane fusion, transcription factor activation and cell cycle regulation through differential binding to specific adaptor proteins. WLM domains are found mostly in plant proteins, belonging to the Zincin-like superfamily of Zn-dependent peptidases that are linked to the ubiquitin signaling pathway through its fusion with the ubiquitin-binding PUB, ubiquitin-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation. : Pssm-ID: 198421 Cd Length: 96 Bit Score: 152.54 E-value: 3.52e-44
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Name | Accession | Description | Interval | E-value | ||||
WLM | pfam08325 | WLM domain; This is a predicted metallopeptidase domain called WLM (Wss1p-like ... |
144-329 | 1.59e-64 | ||||
WLM domain; This is a predicted metallopeptidase domain called WLM (Wss1p-like metalloproteases). These are linked to the Ub-system by virtue of fusions with the UB-binding PUG (PUB), Ub-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation. Pssm-ID: 311984 Cd Length: 190 Bit Score: 209.88 E-value: 1.59e-64
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PUB_WLM | cd10463 | PNGase/UBA or UBX (PUB) domain of the Wss1p-like metalloprotease (WLM) family; The PUB domain ... |
497-597 | 3.52e-44 | ||||
PNGase/UBA or UBX (PUB) domain of the Wss1p-like metalloprotease (WLM) family; The PUB domain functions as a p97 (also known as valosin-containing protein or VCP) adaptor by interacting with the D1 and/or D2 ATPase domains. The type II AAA+ ATPase p97 is involved in a variety of cellular processes such as the deglycosylation of ERAD substrates, membrane fusion, transcription factor activation and cell cycle regulation through differential binding to specific adaptor proteins. WLM domains are found mostly in plant proteins, belonging to the Zincin-like superfamily of Zn-dependent peptidases that are linked to the ubiquitin signaling pathway through its fusion with the ubiquitin-binding PUB, ubiquitin-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation. Pssm-ID: 198421 Cd Length: 96 Bit Score: 152.54 E-value: 3.52e-44
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PUB | pfam09409 | PUB domain; The PUB (also known as PUG) domain is found in peptide N-glycanase where it ... |
509-593 | 2.21e-15 | ||||
PUB domain; The PUB (also known as PUG) domain is found in peptide N-glycanase where it functions as a AAA ATPase binding domain. This domain is also found on other proteins linked to the ubiquitin-proteasome system. Pssm-ID: 462790 Cd Length: 80 Bit Score: 71.15 E-value: 2.21e-15
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PUG | smart00580 | domain in protein kinases, N-glycanases and other nuclear proteins; |
513-581 | 7.74e-12 | ||||
domain in protein kinases, N-glycanases and other nuclear proteins; Pssm-ID: 197798 Cd Length: 57 Bit Score: 60.39 E-value: 7.74e-12
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Name | Accession | Description | Interval | E-value | ||||
WLM | pfam08325 | WLM domain; This is a predicted metallopeptidase domain called WLM (Wss1p-like ... |
144-329 | 1.59e-64 | ||||
WLM domain; This is a predicted metallopeptidase domain called WLM (Wss1p-like metalloproteases). These are linked to the Ub-system by virtue of fusions with the UB-binding PUG (PUB), Ub-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation. Pssm-ID: 311984 Cd Length: 190 Bit Score: 209.88 E-value: 1.59e-64
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PUB_WLM | cd10463 | PNGase/UBA or UBX (PUB) domain of the Wss1p-like metalloprotease (WLM) family; The PUB domain ... |
497-597 | 3.52e-44 | ||||
PNGase/UBA or UBX (PUB) domain of the Wss1p-like metalloprotease (WLM) family; The PUB domain functions as a p97 (also known as valosin-containing protein or VCP) adaptor by interacting with the D1 and/or D2 ATPase domains. The type II AAA+ ATPase p97 is involved in a variety of cellular processes such as the deglycosylation of ERAD substrates, membrane fusion, transcription factor activation and cell cycle regulation through differential binding to specific adaptor proteins. WLM domains are found mostly in plant proteins, belonging to the Zincin-like superfamily of Zn-dependent peptidases that are linked to the ubiquitin signaling pathway through its fusion with the ubiquitin-binding PUB, ubiquitin-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation. Pssm-ID: 198421 Cd Length: 96 Bit Score: 152.54 E-value: 3.52e-44
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PUB | cd09212 | PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins; The PUB domain is found in p97 adaptor ... |
498-597 | 3.38e-21 | ||||
PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins; The PUB domain is found in p97 adaptor proteins such as PNGase, UBXD1 (UBX domain-containing protein 1), and RNF31 (RING finger protein 31). It functions as a p97 (also known as valosin-containing protein or VCP) adaptor by interacting with the D1 and/or D2 ATPase domains. The p97, a type II AAA+ ATPase, is involved in a variety of cellular processes such as the deglycosylation of ERAD substrates, membrane fusion, transcription factor activation and cell cycle regulation through differential binding to specific adaptor proteins. The PUB domain in UBX-domain protein 1 (UBXD1), which is widely expressed in higher eukaryotes (except for fungi) and which is involved in substrate recruitment to p97, interacts strongly with the C-terminus of p97. Peptide:N-glycanase (PNGase), a deglycosylating enzyme that functions in proteasome-dependent degradation of misfolded glycoproteins which are translocated from the endoplasmic reticulum (ER) to the cytosol during ERAD, associates with the ubiquitin-proteasome system proteins mediated by the N-terminal PUB domain. PNGase is present in all eukaryotic organisms; however, the yeast PNGase ortholog does not contain the PUB domain. The RNF31 protein, also known as HOIP or Zibra, contains an N-terminal PUB domain similar to those in PNGase and UBXD1, suggesting its association with p97. Pssm-ID: 198416 Cd Length: 96 Bit Score: 88.59 E-value: 3.38e-21
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PUB | pfam09409 | PUB domain; The PUB (also known as PUG) domain is found in peptide N-glycanase where it ... |
509-593 | 2.21e-15 | ||||
PUB domain; The PUB (also known as PUG) domain is found in peptide N-glycanase where it functions as a AAA ATPase binding domain. This domain is also found on other proteins linked to the ubiquitin-proteasome system. Pssm-ID: 462790 Cd Length: 80 Bit Score: 71.15 E-value: 2.21e-15
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PUG | smart00580 | domain in protein kinases, N-glycanases and other nuclear proteins; |
513-581 | 7.74e-12 | ||||
domain in protein kinases, N-glycanases and other nuclear proteins; Pssm-ID: 197798 Cd Length: 57 Bit Score: 60.39 E-value: 7.74e-12
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PUB_UBA_plant | cd10461 | PNGase/UBA or UBX (PUB) domain of plant Ubiquitin-associated (UBA) domain containing proteins; ... |
494-584 | 1.13e-10 | ||||
PNGase/UBA or UBX (PUB) domain of plant Ubiquitin-associated (UBA) domain containing proteins; The PUB domain functions as a p97 (also known as valosin-containing protein or VCP) adaptor by interacting with the D1 and/or D2 ATPase domains. The type II AAA+ ATPase p97 is involved in a variety of cellular processes such as the deglycosylation of ERAD substrates, membrane fusion, transcription factor activation and cell cycle regulation through differential binding to specific adaptor proteins. The UBA domain, along with UBL (ubiquitin-like) domain, has been implicated in proteasomal degradation by associating with substrates destined for degradation as well as with subunits of the proteasome, thus regulating protein turnover. This family contains only plant UBA domain-containing proteins. Pssm-ID: 198419 Cd Length: 107 Bit Score: 58.98 E-value: 1.13e-10
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PUB_UBA | cd10462 | PNGase/UBA or UBX (PUB) domain of Ubiquitin-associated (UBA) domain containing proteins; The ... |
492-564 | 6.32e-07 | ||||
PNGase/UBA or UBX (PUB) domain of Ubiquitin-associated (UBA) domain containing proteins; The PUB domain functions as a p97 (also known as valosin-containing protein or VCP) adaptor by interacting with the D1 and/or D2 ATPase domains. The type II AAA+ ATPase p97 is involved in a variety of cellular processes such as the deglycosylation of ERAD substrates, membrane fusion, transcription factor activation and cell cycle regulation through differential binding to specific adaptor proteins. The UBA domain, along with UBL (ubiquitin-like) domain, has been implicated in proteasomal degradation by associating with substrates destined for degradation as well as with subunits of the proteasome, thus regulating protein turnover. Pssm-ID: 198420 Cd Length: 100 Bit Score: 47.87 E-value: 6.32e-07
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PUB_PNGase | cd10459 | PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase); This ... |
515-565 | 1.05e-06 | ||||
PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase); This PUB (PNGase/UBA or UBX) domain is found in the p97 adaptor protein PNGase (Peptide:N-glycanase). The PUB domain functions as a p97 (also known as valosin-containing protein or VCP) adaptor by interacting with the D1 and/or D2 ATPase domains. The type II AAA+ ATPase p97 is involved in a variety of cellular processes such as the deglycosylation of ERAD substrates, membrane fusion, transcription factor activation and cell cycle regulation through differential binding to specific adaptor proteins. Peptide:N-glycanase (PNGase), a deglycosylating enzyme that functions in proteasome-dependent degradation of misfolded glycoproteins which are translocated from the endoplasmic reticulum (ER) to the cytosol during ERAD, associates with the ubiquitin-proteasome system proteins mediated by the N-terminal PUB domain. PNGase is present in all eukaryotic organisms; however, the yeast PNGase ortholog does not contain the PUB domain. The mammalian PNGase binds a considerable number of proteins via its PUB domain; these include ERAD E3 enzyme, the autocrine motility factor receptor (AMFR or gp78), SAKS and Derlin-1. Pssm-ID: 198417 Cd Length: 93 Bit Score: 46.88 E-value: 1.05e-06
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PUB_UBXD1 | cd10460 | PNGase/UBA or UBX (PUB) domain of UBXD1; This PUB domain is found in p97 adaptor protein ... |
517-582 | 3.34e-06 | ||||
PNGase/UBA or UBX (PUB) domain of UBXD1; This PUB domain is found in p97 adaptor protein UBXD1 (UBX domain-containing protein 1, also called UBXD6). It functions as a p97 (also known as valosin-containing protein or VCP) adaptor by interacting with the D1 and/or D2 ATPase domains. The type II AAA+ ATPase p97 is involved in a variety of cellular processes such as the deglycosylation of ERAD substrates, membrane fusion, transcription factor activation and cell cycle regulation through differential binding to specific adaptor proteins. The PUB domain in UBX-domain protein 1 (UBXD1), which is widely expressed in higher eukaryotes, except for fungi, and which is involved in substrate recruitment to p97, interacts strongly with the C-terminus of p97. UBXD1 also interacts with HRD1 and HERP, both components of the ERAD pathway, via p97. It is possibly involved in aggresome formation; aggresomes are perinuclear compartments that contain misfolded proteins colocalized with centrosome markers. Pssm-ID: 198418 Cd Length: 102 Bit Score: 45.70 E-value: 3.34e-06
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Blast search parameters | ||||
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