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Conserved domains on  [gi|15239390|ref|NP_197914|]
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ACT-like superfamily protein [Arabidopsis thaliana]

Protein Classification

phosphoglycerate dehydrogenase( domain architecture ID 10141585)

phosphoglycerate dehydrogenase catalyzes the oxidation of D-3-phosphoglycerate to 3- phosphohydroxypyruvate, the first step in serine biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ACT_ACR_2 cd04925
ACT domain-containing protein which is composed almost entirely of four ACT domain repeats ...
 135-208 2.20e-42

ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the second ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


:

Pssm-ID: 153197  Cd Length: 74  Bit Score: 145.27  E-value: 2.20e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15239390 135 TAIEMTGTDRPGLFSEIFAAFADLHCNVMEAHAWSHNARLACIAYVSDDNTHTPIDDPSRLASIEDHLSTVIRA 208
Cdd:cd04925   1 TAIELTGTDRPGLLSEVFAVLADLHCNVVEARAWTHNGRLACVIYVRDEETGAPIDDPIRLASIEDRLDNVLRG 74
ACT_ACR_1 cd04895
ACT domain-containing protein which is composed almost entirely of four ACT domain repeats ...
 37-108 5.33e-42

ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the N-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


:

Pssm-ID: 153167 [Multi-domain]  Cd Length: 72  Bit Score: 144.13  E-value: 5.33e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15239390  37 CTVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLTDKSVINHIKHAIGTSR 108
Cdd:cd04895   1 CTLVKVDSARKPGILLEAVQVLTDLDLCITKAYISSDGGWFMDVFHVTDQLGNKLTDDSLIAYIEKSLGTSR 72
ACT_ACR_3 cd04897
ACT domain-containing protein which is composed almost entirely of four ACT domain repeats ...
 296-370 4.62e-41

ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the third ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


:

Pssm-ID: 153169 [Multi-domain]  Cd Length: 75  Bit Score: 141.79  E-value: 4.62e-41
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15239390 296 YSIVTVKSKDRRRLMFDTICTLVDMQYVIFHAALRSDGADAFQEYFIRHIDGRALNTEGEKERVIKCLEAAIERR 370
Cdd:cd04897   1 YSVVTVQCRDRPKLLFDVVCTLTDMDYVVFHATIDTDGDDAHQEYYIRHKDGRTLSTEGERQRVIKCLEAAIERR 75
ACT_ACR_4 cd04926
C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed ...
 374-445 1.89e-36

C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


:

Pssm-ID: 153198  Cd Length: 72  Bit Score: 129.39  E-value: 1.89e-36
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15239390 374 GVKLELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYVRDISGNKIDMEFVESVKKEMRPIHL 445
Cdd:cd04926   1 GVRLELRTEDRVGLLSDVTRVFRENGLTVTRAEISTQGDMAVNVFYVTDANGNPVDPKTIEAVRQEIGPACL 72
 
Name Accession Description Interval E-value
ACT_ACR_2 cd04925
ACT domain-containing protein which is composed almost entirely of four ACT domain repeats ...
 135-208 2.20e-42

ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the second ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153197  Cd Length: 74  Bit Score: 145.27  E-value: 2.20e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15239390 135 TAIEMTGTDRPGLFSEIFAAFADLHCNVMEAHAWSHNARLACIAYVSDDNTHTPIDDPSRLASIEDHLSTVIRA 208
Cdd:cd04925   1 TAIELTGTDRPGLLSEVFAVLADLHCNVVEARAWTHNGRLACVIYVRDEETGAPIDDPIRLASIEDRLDNVLRG 74
ACT_ACR_1 cd04895
ACT domain-containing protein which is composed almost entirely of four ACT domain repeats ...
 37-108 5.33e-42

ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the N-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153167 [Multi-domain]  Cd Length: 72  Bit Score: 144.13  E-value: 5.33e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15239390  37 CTVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLTDKSVINHIKHAIGTSR 108
Cdd:cd04895   1 CTLVKVDSARKPGILLEAVQVLTDLDLCITKAYISSDGGWFMDVFHVTDQLGNKLTDDSLIAYIEKSLGTSR 72
ACT_ACR_3 cd04897
ACT domain-containing protein which is composed almost entirely of four ACT domain repeats ...
 296-370 4.62e-41

ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the third ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153169 [Multi-domain]  Cd Length: 75  Bit Score: 141.79  E-value: 4.62e-41
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15239390 296 YSIVTVKSKDRRRLMFDTICTLVDMQYVIFHAALRSDGADAFQEYFIRHIDGRALNTEGEKERVIKCLEAAIERR 370
Cdd:cd04897   1 YSVVTVQCRDRPKLLFDVVCTLTDMDYVVFHATIDTDGDDAHQEYYIRHKDGRTLSTEGERQRVIKCLEAAIERR 75
ACT_ACR_4 cd04926
C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed ...
 374-445 1.89e-36

C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153198  Cd Length: 72  Bit Score: 129.39  E-value: 1.89e-36
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15239390 374 GVKLELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYVRDISGNKIDMEFVESVKKEMRPIHL 445
Cdd:cd04926   1 GVRLELRTEDRVGLLSDVTRVFRENGLTVTRAEISTQGDMAVNVFYVTDANGNPVDPKTIEAVRQEIGPACL 72
GlnD COG2844
UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, ...
 27-211 1.25e-13

UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones, Signal transduction mechanisms];


Pssm-ID: 442092 [Multi-domain]  Cd Length: 864  Bit Score: 73.64  E-value: 1.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  27 VYIDNDSIQDCTVVKVNSENKQGLLLEVVQILTDMNLIITKSYI-SSDGGWFMDVFHVKDEHGNKLTDKSVINHIKHAIG 105
Cdd:COG2844 669 VLIRPDPDRGGTEVFVYTPDRPGLFARIAGALAALGLNILDARIhTTRDGYALDTFIVLDPDGEPIDDPDRLERIEQALE 748

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390 106 ----------------TSRRESDFIKASEAnnnSLEPQLADHgeHTAIEMTGTDRPGLFSEIFAAFADLHCNVmeahaws 169
Cdd:COG2844 749 ealsgevplpeplarrLSRRLRHFPVPPRV---TFDNDASNR--YTVLEVSALDRPGLLYDIARVLADLGLNI------- 816

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 15239390 170 HNARLACIA-------YVSDDNTHtPIDDPSRLASIEDHLSTVIRATAD 211
Cdd:COG2844 817 HSAKIATLGervedvfYVTDLDGQ-KLTDPERQEALREALLEALDEEAE 864
GlnD COG2844
UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, ...
 23-104 1.90e-10

UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones, Signal transduction mechanisms];


Pssm-ID: 442092 [Multi-domain]  Cd Length: 864  Bit Score: 63.24  E-value: 1.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  23 PPcRVYIDNDSIQDCTVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLTDKSVINHIKH 102
Cdd:COG2844 775 PP-RVTFDNDASNRYTVLEVSALDRPGLLYDIARVLADLGLNIHSAKIATLGERVEDVFYVTDLDGQKLTDPERQEALRE 853


                ..
gi 15239390 103 AI 104
Cdd:COG2844 854 AL 855
PRK05092 PRK05092
PII uridylyl-transferase; Provisional
 23-104 1.99e-08

PII uridylyl-transferase; Provisional


Pssm-ID: 235342 [Multi-domain]  Cd Length: 931  Bit Score: 57.19  E-value: 1.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390   23 PPcRVYIDNDSIQDCTVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLTDKSVINHIKH 102
Cdd:PRK05092 830 PP-RVTIDNEASNRFTVIEVNGRDRPGLLYDLTRALSDLNLNIASAHIATYGERAVDVFYVTDLFGLKITNEARQAAIRR 908


                 ..
gi 15239390  103 AI 104
Cdd:PRK05092 909 AL 910
PRK05092 PRK05092
PII uridylyl-transferase; Provisional
 62-214 1.97e-07

PII uridylyl-transferase; Provisional


Pssm-ID: 235342 [Multi-domain]  Cd Length: 931  Bit Score: 53.72  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390   62 NLIITKSYISSDGgWFMDVFHVKDEHGNKLTDKSVINHIKHAI------------------GTSRRESDFIKASEAN-NN 122
Cdd:PRK05092 759 NIVDARIFTTTDG-RALDTFWIQDAFGRDEDEPRRLARLAKAIedalsgevrlpealakrtKPKKRARAFHVPPRVTiDN 837

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  123 SLEpqladhGEHTAIEMTGTDRPGLFSEIFAAFADLHCNVMEAHAWSHNARLACIAYVSdDNTHTPIDDPSRLASIEDHL 202
Cdd:PRK05092 838 EAS------NRFTVIEVNGRDRPGLLYDLTRALSDLNLNIASAHIATYGERAVDVFYVT-DLFGLKITNEARQAAIRRAL 910

                        170
                 ....*....|....*
gi 15239390  203 STVI---RATADPAS 214
Cdd:PRK05092 911 LAALaegEAEARAAR 925
UTase_glnD TIGR01693
[Protein-PII] uridylyltransferase; This model describes GlnD, the uridylyltransferase ...
 17-93 3.07e-07

[Protein-PII] uridylyltransferase; This model describes GlnD, the uridylyltransferase/uridylyl-removing enzyme for the nitrogen regulatory protein PII. Not all homologs of PII share the property of uridylyltransferase modification on the characteristic Tyr residue (see Prosite pattern PS00496 and document PDOC00439), but the modification site is preserved in the PII homolog of all species with a member of this family. [Central intermediary metabolism, Nitrogen metabolism, Regulatory functions, Protein interactions]


Pssm-ID: 273761 [Multi-domain]  Cd Length: 850  Bit Score: 53.18  E-value: 3.07e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15239390    17 GERIYGPPCRVYIDNDSIQDCTVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLTD 93
Cdd:TIGR01693 759 RLQHFAVPPRVTILNTASRKATIMEVRALDRPGLLARVGRTLEELGLSIQSAKITTFGEKAEDVFYVTDLFGLKLTD 835
PRK05092 PRK05092
PII uridylyl-transferase; Provisional
 292-429 8.16e-06

PII uridylyl-transferase; Provisional


Pssm-ID: 235342 [Multi-domain]  Cd Length: 931  Bit Score: 48.71  E-value: 8.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  292 EERGYSIVTVKSKDRRRLmFDTICtlvdmqyvifhAALRSDGA---DAfQEYFIRhiDGRALNT----------EGEKER 358
Cdd:PRK05092 728 PARGVTEVTVLAADHPGL-FSRIA-----------GACAAAGAnivDA-RIFTTT--DGRALDTfwiqdafgrdEDEPRR 792

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  359 VIKcLEAAIER------RVCEGVK------------------------------LELCAENRVGLLSDITRVLRENGLTV 402
Cdd:PRK05092 793 LAR-LAKAIEDalsgevRLPEALAkrtkpkkrarafhvpprvtidneasnrftvIEVNGRDRPGLLYDLTRALSDLNLNI 871

                        170       180
                 ....*....|....*....|....*..
gi 15239390  403 VRADVETQGQKSLNAFYVRDISGNKID 429
Cdd:PRK05092 872 ASAHIATYGERAVDVFYVTDLFGLKIT 898
PRK03381 PRK03381
PII uridylyl-transferase; Provisional
 377-425 1.41e-05

PII uridylyl-transferase; Provisional


Pssm-ID: 235123 [Multi-domain]  Cd Length: 774  Bit Score: 47.68  E-value: 1.41e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 15239390  377 LELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYVRDISG 425
Cdd:PRK03381 710 LEVRAADRPGLLARLARALERAGVDVRWARVATLGADVVDVFYVTGAAG 758
UTase_glnD TIGR01693
[Protein-PII] uridylyltransferase; This model describes GlnD, the uridylyltransferase ...
 377-428 3.67e-05

[Protein-PII] uridylyltransferase; This model describes GlnD, the uridylyltransferase/uridylyl-removing enzyme for the nitrogen regulatory protein PII. Not all homologs of PII share the property of uridylyltransferase modification on the characteristic Tyr residue (see Prosite pattern PS00496 and document PDOC00439), but the modification site is preserved in the PII homolog of all species with a member of this family. [Central intermediary metabolism, Nitrogen metabolism, Regulatory functions, Protein interactions]


Pssm-ID: 273761 [Multi-domain]  Cd Length: 850  Bit Score: 46.64  E-value: 3.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15239390   377 LELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYVRDISGNKI 428
Cdd:TIGR01693 782 MEVRALDRPGLLARVGRTLEELGLSIQSAKITTFGEKAEDVFYVTDLFGLKL 833
ACT pfam01842
ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to ...
 377-429 6.57e-04

ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95, which is inhibited by serine. Aspartokinase EC:2.7.2.4, which is regulated by lysine. Acetolactate synthase small regulatory subunit, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51. formyltetrahydrofolate deformylase EC:3.5.1.10, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5


Pssm-ID: 426468 [Multi-domain]  Cd Length: 66  Bit Score: 38.06  E-value: 6.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 15239390   377 LELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYVRDISGNKID 429
Cdd:pfam01842   3 LEVLVPDRPGLLARVLGALADRGINITSIEQGTSEDKGGIVFVVIVVDEEDLE 55
ACT pfam01842
ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to ...
 38-94 7.18e-04

ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95, which is inhibited by serine. Aspartokinase EC:2.7.2.4, which is regulated by lysine. Acetolactate synthase small regulatory subunit, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51. formyltetrahydrofolate deformylase EC:3.5.1.10, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5


Pssm-ID: 426468 [Multi-domain]  Cd Length: 66  Bit Score: 38.06  E-value: 7.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15239390    38 TVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDG--GWFMDVFHVKDEHGNKLTDK 94
Cdd:pfam01842   1 TVLEVLVPDRPGLLARVLGALADRGINITSIEQGTSEdkGGIVFVVIVVDEEDLEEVLE 59
ACT pfam01842
ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to ...
 135-170 9.55e-04

ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95, which is inhibited by serine. Aspartokinase EC:2.7.2.4, which is regulated by lysine. Acetolactate synthase small regulatory subunit, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51. formyltetrahydrofolate deformylase EC:3.5.1.10, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5


Pssm-ID: 426468 [Multi-domain]  Cd Length: 66  Bit Score: 37.67  E-value: 9.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15239390   135 TAIEMTGTDRPGLFSEIFAAFADLHCNVMEAHAWSH 170
Cdd:pfam01842   1 TVLEVLVPDRPGLLARVLGALADRGINITSIEQGTS 36
 
Name Accession Description Interval E-value
ACT_ACR_2 cd04925
ACT domain-containing protein which is composed almost entirely of four ACT domain repeats ...
 135-208 2.20e-42

ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the second ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153197  Cd Length: 74  Bit Score: 145.27  E-value: 2.20e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15239390 135 TAIEMTGTDRPGLFSEIFAAFADLHCNVMEAHAWSHNARLACIAYVSDDNTHTPIDDPSRLASIEDHLSTVIRA 208
Cdd:cd04925   1 TAIELTGTDRPGLLSEVFAVLADLHCNVVEARAWTHNGRLACVIYVRDEETGAPIDDPIRLASIEDRLDNVLRG 74
ACT_ACR_1 cd04895
ACT domain-containing protein which is composed almost entirely of four ACT domain repeats ...
 37-108 5.33e-42

ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the N-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153167 [Multi-domain]  Cd Length: 72  Bit Score: 144.13  E-value: 5.33e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15239390  37 CTVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLTDKSVINHIKHAIGTSR 108
Cdd:cd04895   1 CTLVKVDSARKPGILLEAVQVLTDLDLCITKAYISSDGGWFMDVFHVTDQLGNKLTDDSLIAYIEKSLGTSR 72
ACT_ACR_3 cd04897
ACT domain-containing protein which is composed almost entirely of four ACT domain repeats ...
 296-370 4.62e-41

ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the third ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153169 [Multi-domain]  Cd Length: 75  Bit Score: 141.79  E-value: 4.62e-41
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15239390 296 YSIVTVKSKDRRRLMFDTICTLVDMQYVIFHAALRSDGADAFQEYFIRHIDGRALNTEGEKERVIKCLEAAIERR 370
Cdd:cd04897   1 YSVVTVQCRDRPKLLFDVVCTLTDMDYVVFHATIDTDGDDAHQEYYIRHKDGRTLSTEGERQRVIKCLEAAIERR 75
ACT_ACR_4 cd04926
C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed ...
 374-445 1.89e-36

C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153198  Cd Length: 72  Bit Score: 129.39  E-value: 1.89e-36
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15239390 374 GVKLELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYVRDISGNKIDMEFVESVKKEMRPIHL 445
Cdd:cd04926   1 GVRLELRTEDRVGLLSDVTRVFRENGLTVTRAEISTQGDMAVNVFYVTDANGNPVDPKTIEAVRQEIGPACL 72
ACT_ACR-UUR-like_2 cd04899
C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase ...
 375-441 5.65e-20

C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; This ACT domain family, ACT_ACR-UUR-like_2, includes the second of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; including those enzymes similar to the GlnD found in enteric Escherichia coli and those found in photosynthetic, nitrogen-fixing bacterium Rhodospirillum rubrum. Also included in this CD are the second and fourth ACT domains of a novel protein composed almost entirely of ACT domain repeats, the ACR protein. These ACR proteins, found in Arabidopsis and Oryza, are proposed to function as novel regulatory or sensor proteins in plants. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153171 [Multi-domain]  Cd Length: 70  Bit Score: 83.66  E-value: 5.65e-20
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15239390 375 VKLELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYVRDISGNKIDMEFVESVKKEMR 441
Cdd:cd04899   1 TVLELTALDRPGLLADVTRVLAELGLNIHSAKIATLGERAEDVFYVTDADGQPLDPERQEALRAALG 67
ACT_ACR-UUR-like_2 cd04899
C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase ...
 135-206 1.09e-19

C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; This ACT domain family, ACT_ACR-UUR-like_2, includes the second of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; including those enzymes similar to the GlnD found in enteric Escherichia coli and those found in photosynthetic, nitrogen-fixing bacterium Rhodospirillum rubrum. Also included in this CD are the second and fourth ACT domains of a novel protein composed almost entirely of ACT domain repeats, the ACR protein. These ACR proteins, found in Arabidopsis and Oryza, are proposed to function as novel regulatory or sensor proteins in plants. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153171 [Multi-domain]  Cd Length: 70  Bit Score: 82.89  E-value: 1.09e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15239390 135 TAIEMTGTDRPGLFSEIFAAFADLHCNVMEAHAWSHNARLACIAYVSDDNTHTpiDDPSRLASIEDHLSTVI 206
Cdd:cd04899   1 TVLELTALDRPGLLADVTRVLAELGLNIHSAKIATLGERAEDVFYVTDADGQP--LDPERQEALRAALGEAL 70
ACT_UUR-ACR-like cd04873
ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) ...
 135-206 2.67e-16

ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; This ACT domain family, ACT_UUR_ACR-like, includes the two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; including those enzymes similar to the GlnD found in enteric Escherichia coli and those found in photosynthetic, nitrogen-fixing bacterium Rhodospirillum rubrum. Also included in this CD are the four ACT domains of a novel protein composed almost entirely of ACT domain repeats (the ACR protein) and like proteins. These ACR proteins, found in Arabidopsis and Oryza, are proposed to function as novel regulatory or sensor proteins in plants. This CD also includes the first of the two ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein and related domains, as well as, the N-terminal ACT domain of a yet characterized Arabidopsis/Oryza predicted tyrosine kinase. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153145 [Multi-domain]  Cd Length: 70  Bit Score: 73.35  E-value: 2.67e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15239390 135 TAIEMTGTDRPGLFSEIFAAFADLHCNVMEAHAWSHNARLACIAYVSDDNTHtpIDDPSRLASIEDHLSTVI 206
Cdd:cd04873   1 TVVEVYAPDRPGLLADITRVLADLGLNIHDARISTTGERALDVFYVTDSDGR--PLDPERIARLEEALEDAL 70
ACT_UUR-ACR-like cd04873
ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) ...
 38-107 1.08e-14

ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; This ACT domain family, ACT_UUR_ACR-like, includes the two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; including those enzymes similar to the GlnD found in enteric Escherichia coli and those found in photosynthetic, nitrogen-fixing bacterium Rhodospirillum rubrum. Also included in this CD are the four ACT domains of a novel protein composed almost entirely of ACT domain repeats (the ACR protein) and like proteins. These ACR proteins, found in Arabidopsis and Oryza, are proposed to function as novel regulatory or sensor proteins in plants. This CD also includes the first of the two ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein and related domains, as well as, the N-terminal ACT domain of a yet characterized Arabidopsis/Oryza predicted tyrosine kinase. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153145 [Multi-domain]  Cd Length: 70  Bit Score: 68.73  E-value: 1.08e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  38 TVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLtDKSVINHIKHAIGTS 107
Cdd:cd04873   1 TVVEVYAPDRPGLLADITRVLADLGLNIHDARISTTGERALDVFYVTDSDGRPL-DPERIARLEEALEDA 69
ACT_UUR-ACR-like cd04873
ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) ...
 377-441 1.58e-14

ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; This ACT domain family, ACT_UUR_ACR-like, includes the two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; including those enzymes similar to the GlnD found in enteric Escherichia coli and those found in photosynthetic, nitrogen-fixing bacterium Rhodospirillum rubrum. Also included in this CD are the four ACT domains of a novel protein composed almost entirely of ACT domain repeats (the ACR protein) and like proteins. These ACR proteins, found in Arabidopsis and Oryza, are proposed to function as novel regulatory or sensor proteins in plants. This CD also includes the first of the two ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein and related domains, as well as, the N-terminal ACT domain of a yet characterized Arabidopsis/Oryza predicted tyrosine kinase. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153145 [Multi-domain]  Cd Length: 70  Bit Score: 68.34  E-value: 1.58e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15239390 377 LELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYVRDISGNKIDMEFVESVKKEMR 441
Cdd:cd04873   3 VEVYAPDRPGLLADITRVLADLGLNIHDARISTTGERALDVFYVTDSDGRPLDPERIARLEEALE 67
GlnD COG2844
UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, ...
 27-211 1.25e-13

UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones, Signal transduction mechanisms];


Pssm-ID: 442092 [Multi-domain]  Cd Length: 864  Bit Score: 73.64  E-value: 1.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  27 VYIDNDSIQDCTVVKVNSENKQGLLLEVVQILTDMNLIITKSYI-SSDGGWFMDVFHVKDEHGNKLTDKSVINHIKHAIG 105
Cdd:COG2844 669 VLIRPDPDRGGTEVFVYTPDRPGLFARIAGALAALGLNILDARIhTTRDGYALDTFIVLDPDGEPIDDPDRLERIEQALE 748

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390 106 ----------------TSRRESDFIKASEAnnnSLEPQLADHgeHTAIEMTGTDRPGLFSEIFAAFADLHCNVmeahaws 169
Cdd:COG2844 749 ealsgevplpeplarrLSRRLRHFPVPPRV---TFDNDASNR--YTVLEVSALDRPGLLYDIARVLADLGLNI------- 816

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 15239390 170 HNARLACIA-------YVSDDNTHtPIDDPSRLASIEDHLSTVIRATAD 211
Cdd:COG2844 817 HSAKIATLGervedvfYVTDLDGQ-KLTDPERQEALREALLEALDEEAE 864
ACT_UUR-ACR-like cd04873
ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) ...
 297-367 1.49e-10

ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; This ACT domain family, ACT_UUR_ACR-like, includes the two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; including those enzymes similar to the GlnD found in enteric Escherichia coli and those found in photosynthetic, nitrogen-fixing bacterium Rhodospirillum rubrum. Also included in this CD are the four ACT domains of a novel protein composed almost entirely of ACT domain repeats (the ACR protein) and like proteins. These ACR proteins, found in Arabidopsis and Oryza, are proposed to function as novel regulatory or sensor proteins in plants. This CD also includes the first of the two ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein and related domains, as well as, the N-terminal ACT domain of a yet characterized Arabidopsis/Oryza predicted tyrosine kinase. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153145 [Multi-domain]  Cd Length: 70  Bit Score: 57.17  E-value: 1.49e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15239390 297 SIVTVKSKDRRRLMFDTICTLVDMQYVIFHAALRSDGADAFQEYFIRHIDGRALNTEgEKERVIKCLEAAI 367
Cdd:cd04873   1 TVVEVYAPDRPGLLADITRVLADLGLNIHDARISTTGERALDVFYVTDSDGRPLDPE-RIARLEEALEDAL 70
GlnD COG2844
UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, ...
 23-104 1.90e-10

UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones, Signal transduction mechanisms];


Pssm-ID: 442092 [Multi-domain]  Cd Length: 864  Bit Score: 63.24  E-value: 1.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  23 PPcRVYIDNDSIQDCTVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLTDKSVINHIKH 102
Cdd:COG2844 775 PP-RVTFDNDASNRYTVLEVSALDRPGLLYDIARVLADLGLNIHSAKIATLGERVEDVFYVTDLDGQKLTDPERQEALRE 853


                ..
gi 15239390 103 AI 104
Cdd:COG2844 854 AL 855
ACT_ACR-UUR-like_2 cd04899
C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase ...
 38-104 9.65e-09

C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; This ACT domain family, ACT_ACR-UUR-like_2, includes the second of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; including those enzymes similar to the GlnD found in enteric Escherichia coli and those found in photosynthetic, nitrogen-fixing bacterium Rhodospirillum rubrum. Also included in this CD are the second and fourth ACT domains of a novel protein composed almost entirely of ACT domain repeats, the ACR protein. These ACR proteins, found in Arabidopsis and Oryza, are proposed to function as novel regulatory or sensor proteins in plants. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153171 [Multi-domain]  Cd Length: 70  Bit Score: 51.69  E-value: 9.65e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  38 TVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLTDK---SVINHIKHAI 104
Cdd:cd04899   1 TVLELTALDRPGLLADVTRVLAELGLNIHSAKIATLGERAEDVFYVTDADGQPLDPErqeALRAALGEAL 70
GlnD COG2844
UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, ...
 277-441 1.19e-08

UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones, Signal transduction mechanisms];


Pssm-ID: 442092 [Multi-domain]  Cd Length: 864  Bit Score: 57.84  E-value: 1.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390 277 DHKERKTTIVSIGNCEERGYSIVTVKSKDRRRLmFDTIC--------TLVDMQyvIFHaalRSDGA--DAFQeyfIRHID 346
Cdd:COG2844 660 RADDSGKPLVLIRPDPDRGGTEVFVYTPDRPGL-FARIAgalaalglNILDAR--IHT---TRDGYalDTFI---VLDPD 730

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390 347 GRALNTEGEKERVIKCLEAA----------IERRVCEGVK--------------------LELCAENRVGLLSDITRVLR 396
Cdd:COG2844 731 GEPIDDPDRLERIEQALEEAlsgevplpepLARRLSRRLRhfpvpprvtfdndasnrytvLEVSALDRPGLLYDIARVLA 810

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 15239390 397 ENGLTVVRADVETQGQKSLNAFYVRDISGNKI-DMEFVESVKKEMR 441
Cdd:COG2844 811 DLGLNIHSAKIATLGERVEDVFYVTDLDGQKLtDPERQEALREALL 856
PRK05092 PRK05092
PII uridylyl-transferase; Provisional
 23-104 1.99e-08

PII uridylyl-transferase; Provisional


Pssm-ID: 235342 [Multi-domain]  Cd Length: 931  Bit Score: 57.19  E-value: 1.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390   23 PPcRVYIDNDSIQDCTVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLTDKSVINHIKH 102
Cdd:PRK05092 830 PP-RVTIDNEASNRFTVIEVNGRDRPGLLYDLTRALSDLNLNIASAHIATYGERAVDVFYVTDLFGLKITNEARQAAIRR 908


                 ..
gi 15239390  103 AI 104
Cdd:PRK05092 909 AL 910
ACT_ACR_4 cd04926
C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed ...
 45-107 6.34e-08

C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the C-terminal ACT domain, of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products have been described (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) and are represented in this CD. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153198  Cd Length: 72  Bit Score: 49.66  E-value: 6.34e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15239390  45 ENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKlTDKSVINHIKHAIGTS 107
Cdd:cd04926   9 EDRVGLLSDVTRVFRENGLTVTRAEISTQGDMAVNVFYVTDANGNP-VDPKTIEAVRQEIGPA 70
ACT_UUR-like_1 cd04900
ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the ...
 143-206 1.15e-07

ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; This ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; including those enzymes similar to the GlnD found in enteric Escherichia coli and those found in photosynthetic, nitrogen-fixing bacterium Rhodospirillum rubrum. Also included in this CD is the N-terminal ACT domain of a yet characterized Arabidopsis/Oryza predicted tyrosine kinase. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153172 [Multi-domain]  Cd Length: 73  Bit Score: 49.01  E-value: 1.15e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15239390 143 DRPGLFSEIFAAFADLHCNVMEA--HAWSHNARLAcIAYVSDDNtHTPIDDPSRLASIEDHLSTVI 206
Cdd:cd04900  10 DRPGLFARIAGALDQLGLNILDAriFTTRDGYALD-TFVVLDPD-GEPIGERERLARIREALEDAL 73
PRK05092 PRK05092
PII uridylyl-transferase; Provisional
 62-214 1.97e-07

PII uridylyl-transferase; Provisional


Pssm-ID: 235342 [Multi-domain]  Cd Length: 931  Bit Score: 53.72  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390   62 NLIITKSYISSDGgWFMDVFHVKDEHGNKLTDKSVINHIKHAI------------------GTSRRESDFIKASEAN-NN 122
Cdd:PRK05092 759 NIVDARIFTTTDG-RALDTFWIQDAFGRDEDEPRRLARLAKAIedalsgevrlpealakrtKPKKRARAFHVPPRVTiDN 837

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  123 SLEpqladhGEHTAIEMTGTDRPGLFSEIFAAFADLHCNVMEAHAWSHNARLACIAYVSdDNTHTPIDDPSRLASIEDHL 202
Cdd:PRK05092 838 EAS------NRFTVIEVNGRDRPGLLYDLTRALSDLNLNIASAHIATYGERAVDVFYVT-DLFGLKITNEARQAAIRRAL 910

                        170
                 ....*....|....*
gi 15239390  203 STVI---RATADPAS 214
Cdd:PRK05092 911 LAALaegEAEARAAR 925
glnD PRK00275
PII uridylyl-transferase; Provisional
 24-93 2.82e-07

PII uridylyl-transferase; Provisional


Pssm-ID: 234709 [Multi-domain]  Cd Length: 895  Bit Score: 53.14  E-value: 2.82e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390   24 PCRVYIDNDSIQDCTVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLTD 93
Cdd:PRK00275 801 PTQVTISNDAQRPVTVLEIIAPDRPGLLARIGRIFLEFDLSLQNAKIATLGERVEDVFFITDADNQPLSD 870
UTase_glnD TIGR01693
[Protein-PII] uridylyltransferase; This model describes GlnD, the uridylyltransferase ...
 17-93 3.07e-07

[Protein-PII] uridylyltransferase; This model describes GlnD, the uridylyltransferase/uridylyl-removing enzyme for the nitrogen regulatory protein PII. Not all homologs of PII share the property of uridylyltransferase modification on the characteristic Tyr residue (see Prosite pattern PS00496 and document PDOC00439), but the modification site is preserved in the PII homolog of all species with a member of this family. [Central intermediary metabolism, Nitrogen metabolism, Regulatory functions, Protein interactions]


Pssm-ID: 273761 [Multi-domain]  Cd Length: 850  Bit Score: 53.18  E-value: 3.07e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15239390    17 GERIYGPPCRVYIDNDSIQDCTVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHVKDEHGNKLTD 93
Cdd:TIGR01693 759 RLQHFAVPPRVTILNTASRKATIMEVRALDRPGLLARVGRTLEELGLSIQSAKITTFGEKAEDVFYVTDLFGLKLTD 835
PRK05092 PRK05092
PII uridylyl-transferase; Provisional
 292-429 8.16e-06

PII uridylyl-transferase; Provisional


Pssm-ID: 235342 [Multi-domain]  Cd Length: 931  Bit Score: 48.71  E-value: 8.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  292 EERGYSIVTVKSKDRRRLmFDTICtlvdmqyvifhAALRSDGA---DAfQEYFIRhiDGRALNT----------EGEKER 358
Cdd:PRK05092 728 PARGVTEVTVLAADHPGL-FSRIA-----------GACAAAGAnivDA-RIFTTT--DGRALDTfwiqdafgrdEDEPRR 792

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239390  359 VIKcLEAAIER------RVCEGVK------------------------------LELCAENRVGLLSDITRVLRENGLTV 402
Cdd:PRK05092 793 LAR-LAKAIEDalsgevRLPEALAkrtkpkkrarafhvpprvtidneasnrftvIEVNGRDRPGLLYDLTRALSDLNLNI 871

                        170       180
                 ....*....|....*....|....*..
gi 15239390  403 VRADVETQGQKSLNAFYVRDISGNKID 429
Cdd:PRK05092 872 ASAHIATYGERAVDVFYVTDLFGLKIT 898
PRK03381 PRK03381
PII uridylyl-transferase; Provisional
 377-425 1.41e-05

PII uridylyl-transferase; Provisional


Pssm-ID: 235123 [Multi-domain]  Cd Length: 774  Bit Score: 47.68  E-value: 1.41e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 15239390  377 LELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYVRDISG 425
Cdd:PRK03381 710 LEVRAADRPGLLARLARALERAGVDVRWARVATLGADVVDVFYVTGAAG 758
UTase_glnD TIGR01693
[Protein-PII] uridylyltransferase; This model describes GlnD, the uridylyltransferase ...
 377-428 3.67e-05

[Protein-PII] uridylyltransferase; This model describes GlnD, the uridylyltransferase/uridylyl-removing enzyme for the nitrogen regulatory protein PII. Not all homologs of PII share the property of uridylyltransferase modification on the characteristic Tyr residue (see Prosite pattern PS00496 and document PDOC00439), but the modification site is preserved in the PII homolog of all species with a member of this family. [Central intermediary metabolism, Nitrogen metabolism, Regulatory functions, Protein interactions]


Pssm-ID: 273761 [Multi-domain]  Cd Length: 850  Bit Score: 46.64  E-value: 3.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15239390   377 LELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYVRDISGNKI 428
Cdd:TIGR01693 782 MEVRALDRPGLLARVGRTLEELGLSIQSAKITTFGEKAEDVFYVTDLFGLKL 833
ACT cd02116
ACT domains are commonly involved in specifically binding an amino acid or other small ligand ...
 137-186 2.14e-04

ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Members of this CD belong to the superfamily of ACT regulatory domains. Pairs of ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme. The ACT domain has been detected in a number of diverse proteins; some of these proteins are involved in amino acid and purine biosynthesis, phenylalanine hydroxylation, regulation of bacterial metabolism and transcription, and many remain to be characterized. ACT domain-containing enzymes involved in amino acid and purine synthesis are in many cases allosteric enzymes with complex regulation enforced by the binding of ligands. The ACT domain is commonly involved in the binding of a small regulatory molecule, such as the amino acids L-Ser and L-Phe in the case of D-3-phosphoglycerate dehydrogenase and the bifunctional chorismate mutase-prephenate dehydratase enzyme (P-protein), respectively. Aspartokinases typically consist of two C-terminal ACT domains in a tandem repeat, but the second ACT domain is inserted within the first, resulting in, what is normally the terminal beta strand of ACT2, formed from a region N-terminal of ACT1. ACT domain repeats have been shown to have nonequivalent ligand-binding sites with complex regulatory patterns such as those seen in the bifunctional enzyme, aspartokinase-homoserine dehydrogenase (ThrA). In other enzymes, such as phenylalanine hydroxylases, the ACT domain appears to function as a flexible small module providing allosteric regulation via transmission of conformational changes, these conformational changes are not necessarily initiated by regulatory ligand binding at the ACT domain itself. ACT domains are present either singularly, N- or C-terminal, or in pairs present C-terminal or between two catalytic domains. Unique to cyanobacteria are four ACT domains C-terminal to an aspartokinase domain. A few proteins are composed almost entirely of ACT domain repeats as seen in the four ACT domain protein, the ACR protein, found in higher plants; and the two ACT domain protein, the glycine cleavage system transcriptional repressor (GcvR) protein, found in some bacteria. Also seen are single ACT domain proteins similar to the Streptococcus pneumoniae ACT domain protein (uncharacterized pdb structure 1ZPV) found in both bacteria and archaea. Purportedly, the ACT domain is an evolutionarily mobile ligand binding regulatory module that has been fused to different enzymes at various times.


Pssm-ID: 153139 [Multi-domain]  Cd Length: 60  Bit Score: 39.20  E-value: 2.14e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 15239390 137 IEMTGTDRPGLFSEIFAAFADLHCNVMEAHAW-SHNARLACIAYVSDDNTH 186
Cdd:cd02116   1 LTVSGPDRPGLLAKVLSVLAEAGINITSIEQRtSGDGGEADIFIVVDGDGD 51
ACT pfam01842
ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to ...
 377-429 6.57e-04

ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95, which is inhibited by serine. Aspartokinase EC:2.7.2.4, which is regulated by lysine. Acetolactate synthase small regulatory subunit, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51. formyltetrahydrofolate deformylase EC:3.5.1.10, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5


Pssm-ID: 426468 [Multi-domain]  Cd Length: 66  Bit Score: 38.06  E-value: 6.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 15239390   377 LELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYVRDISGNKID 429
Cdd:pfam01842   3 LEVLVPDRPGLLARVLGALADRGINITSIEQGTSEDKGGIVFVVIVVDEEDLE 55
ACT pfam01842
ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to ...
 38-94 7.18e-04

ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95, which is inhibited by serine. Aspartokinase EC:2.7.2.4, which is regulated by lysine. Acetolactate synthase small regulatory subunit, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51. formyltetrahydrofolate deformylase EC:3.5.1.10, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5


Pssm-ID: 426468 [Multi-domain]  Cd Length: 66  Bit Score: 38.06  E-value: 7.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15239390    38 TVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDG--GWFMDVFHVKDEHGNKLTDK 94
Cdd:pfam01842   1 TVLEVLVPDRPGLLARVLGALADRGINITSIEQGTSEdkGGIVFVVIVVDEEDLEEVLE 59
ACT pfam01842
ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to ...
 135-170 9.55e-04

ACT domain; This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95, which is inhibited by serine. Aspartokinase EC:2.7.2.4, which is regulated by lysine. Acetolactate synthase small regulatory subunit, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51. formyltetrahydrofolate deformylase EC:3.5.1.10, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5


Pssm-ID: 426468 [Multi-domain]  Cd Length: 66  Bit Score: 37.67  E-value: 9.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15239390   135 TAIEMTGTDRPGLFSEIFAAFADLHCNVMEAHAWSH 170
Cdd:pfam01842   1 TVLEVLVPDRPGLLARVLGALADRGINITSIEQGTS 36
PRK03381 PRK03381
PII uridylyl-transferase; Provisional
 373-420 6.26e-03

PII uridylyl-transferase; Provisional


Pssm-ID: 235123 [Multi-domain]  Cd Length: 774  Bit Score: 39.20  E-value: 6.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 15239390  373 EGVKLELCAENRVGLLSDITRVLRENGLTVVRADVETQGQKSLNAFYV 420
Cdd:PRK03381 598 HMVEVTVVAPDRRGLLSKAAGVLALHRLRVRSASVRSHDGVAVLEFVV 645
ACT_ACR-like_1 cd04894
ACT domain-containing protein which is composed almost entirely of four ACT domain repeats ...
 38-83 7.95e-03

ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein); This CD includes the N-terminal ACT domain of a novel type of ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein). ACR proteins, found only in Arabidopsis and Oryza, as yet, are proposed to function as novel regulatory or sensor proteins in plants. Nine ACR gene products (ACR1-8 in Arabidopsis and OsARC1-9 in Oryza) have been described, however, the ACR-like sequences in this CD are distinct from those characterized. This CD includes the Oryza sativa ACR-like protein (Os05g0113000) encoded on chromosome 5 and the Arabidopsis thaliana predicted gene product, At2g39570. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153166  Cd Length: 69  Bit Score: 35.19  E-value: 7.95e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15239390  38 TVVKVNSENKQGLLLEVVQILTDMNLIITKSYISSDGGWFMDVFHV 83
Cdd:cd04894   1 SVITINCPDKTGLGCDLCRIILEFGLNITRGDDSTDGRWCYIVFWV 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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