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Conserved domains on  [gi|15239384|ref|NP_197911|]
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F-box protein (DUF295) [Arabidopsis thaliana]

Protein Classification

DUF295 domain-containing protein( domain architecture ID 13289336)

DUF295 domain-containing protein similar to Arabidopsis thaliana F-box/kelch-repeat protein At2g24250

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF295 pfam03478
Protein of unknown function (DUF295); This domain is found in plant proteins of unknown ...
 320-374 7.62e-13

Protein of unknown function (DUF295); This domain is found in plant proteins of unknown function. It can be found in association with F-box domain pfam00646.


:

Pssm-ID: 460939 [Multi-domain]  Cd Length: 57  Bit Score: 62.61  E-value: 7.62e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15239384   320 VEVDSLGDEALLLDLG--ITVPADSDLGIEPNSIYFTRHDRVANQKRSSPDICVFNI 374
Cdd:pfam03478   1 VEVKSLGDRALFLGRNcsLSVSASDFPGLKGNCIYFLTDDDDEVYKDEGRDIGVYDL 57
PLN03215 super family cl31986
ascorbic acid mannose pathway regulator 1; Provisional
 14-354 1.24e-05

ascorbic acid mannose pathway regulator 1; Provisional


The actual alignment was detected with superfamily member PLN03215:

Pssm-ID: 178754 [Multi-domain]  Cd Length: 373  Bit Score: 46.87  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384   14 WSEIPMDILRSVFERL-SFVDLHRAKIVCSHWYScSKQSFLRKT---RSPLVILFSDDGDCTLynpEEARVYKSKRD--L 87
Cdd:PLN03215   4 WSTLPEELLHMIAGRLfSNVELKRFRSICRSWRS-SVSGVGKKNpfrTRPLILFNPINPSETL---TDDRSYISRPGafL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384   88 SRYRFL------ANSGNWFLVLDprsnlyiIDLFSEKKINLPPLdsfkgykynlkkvgarkfkelvSEYPTSFHHHAKDL 161
Cdd:PLN03215  80 SRAAFFrvtlssSPSKGWLIKSD-------MDVNSGRFHLLNPL----------------------SRLPLRHSSESVDL 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384  162 RGLLwVDEKKEEYVVVWYFRNK-----YTMDSLAFCKNGEDHY-------REMPTHYGLHDISDMVLQRGDHIYLSTSCK 229
Cdd:PLN03215 131 LEFT-VSEIREAYQVLDWAKRRetrpgYQRSALVKVKEGDNHRdgvlgigRDGKINYWDGNVLKALKQMGYHFSDIIVHK 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384  230 YLQKLDLSRQEGIRTKNDDIISRYQlpcrpTNYKLVYDAKCWCSYNIAVTSSGEVLFVLSIFSQSTRRRI---------- 299
Cdd:PLN03215 210 GQTYALDSIGIVYWINSDLEFSRFG-----TSLDENITDGCWTGDRRFVECCGELYIVERLPKESTWKRKadgfeysrtv 284

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15239384  300 -FFLYKEDPNPSpseviykNLVEVDSLGDEALLL--DLGITVPADSDLGIEPNSIYFT 354
Cdd:PLN03215 285 gFKVYKFDDELA-------KWMEVKTLGDNAFVMatDTCFSVLAHEFYGCLPNSIYFT 335
 
Name Accession Description Interval E-value
DUF295 pfam03478
Protein of unknown function (DUF295); This domain is found in plant proteins of unknown ...
 320-374 7.62e-13

Protein of unknown function (DUF295); This domain is found in plant proteins of unknown function. It can be found in association with F-box domain pfam00646.


Pssm-ID: 460939 [Multi-domain]  Cd Length: 57  Bit Score: 62.61  E-value: 7.62e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15239384   320 VEVDSLGDEALLLDLG--ITVPADSDLGIEPNSIYFTRHDRVANQKRSSPDICVFNI 374
Cdd:pfam03478   1 VEVKSLGDRALFLGRNcsLSVSASDFPGLKGNCIYFLTDDDDEVYKDEGRDIGVYDL 57
PLN03215 PLN03215
ascorbic acid mannose pathway regulator 1; Provisional
 14-354 1.24e-05

ascorbic acid mannose pathway regulator 1; Provisional


Pssm-ID: 178754 [Multi-domain]  Cd Length: 373  Bit Score: 46.87  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384   14 WSEIPMDILRSVFERL-SFVDLHRAKIVCSHWYScSKQSFLRKT---RSPLVILFSDDGDCTLynpEEARVYKSKRD--L 87
Cdd:PLN03215   4 WSTLPEELLHMIAGRLfSNVELKRFRSICRSWRS-SVSGVGKKNpfrTRPLILFNPINPSETL---TDDRSYISRPGafL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384   88 SRYRFL------ANSGNWFLVLDprsnlyiIDLFSEKKINLPPLdsfkgykynlkkvgarkfkelvSEYPTSFHHHAKDL 161
Cdd:PLN03215  80 SRAAFFrvtlssSPSKGWLIKSD-------MDVNSGRFHLLNPL----------------------SRLPLRHSSESVDL 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384  162 RGLLwVDEKKEEYVVVWYFRNK-----YTMDSLAFCKNGEDHY-------REMPTHYGLHDISDMVLQRGDHIYLSTSCK 229
Cdd:PLN03215 131 LEFT-VSEIREAYQVLDWAKRRetrpgYQRSALVKVKEGDNHRdgvlgigRDGKINYWDGNVLKALKQMGYHFSDIIVHK 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384  230 YLQKLDLSRQEGIRTKNDDIISRYQlpcrpTNYKLVYDAKCWCSYNIAVTSSGEVLFVLSIFSQSTRRRI---------- 299
Cdd:PLN03215 210 GQTYALDSIGIVYWINSDLEFSRFG-----TSLDENITDGCWTGDRRFVECCGELYIVERLPKESTWKRKadgfeysrtv 284

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15239384  300 -FFLYKEDPNPSpseviykNLVEVDSLGDEALLL--DLGITVPADSDLGIEPNSIYFT 354
Cdd:PLN03215 285 gFKVYKFDDELA-------KWMEVKTLGDNAFVMatDTCFSVLAHEFYGCLPNSIYFT 335
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 14-49 2.08e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 41.37  E-value: 2.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15239384    14 WSEIPMDILRSVFERLSFVDLHRAKIVCSHWYSCSK 49
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 15-49 5.75e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 37.04  E-value: 5.75e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15239384  15 SEIPMDILRSVFERLSFVDLHRAKIVCSHWYSCSK 49
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
17-56 1.60e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.88  E-value: 1.60e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15239384     17 IPMDILRSVFERLSFVDLHRAKIVCSHWYS-CSKQSFLRKT 56
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSlIDSHDFWFKL 41
 
Name Accession Description Interval E-value
DUF295 pfam03478
Protein of unknown function (DUF295); This domain is found in plant proteins of unknown ...
 320-374 7.62e-13

Protein of unknown function (DUF295); This domain is found in plant proteins of unknown function. It can be found in association with F-box domain pfam00646.


Pssm-ID: 460939 [Multi-domain]  Cd Length: 57  Bit Score: 62.61  E-value: 7.62e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15239384   320 VEVDSLGDEALLLDLG--ITVPADSDLGIEPNSIYFTRHDRVANQKRSSPDICVFNI 374
Cdd:pfam03478   1 VEVKSLGDRALFLGRNcsLSVSASDFPGLKGNCIYFLTDDDDEVYKDEGRDIGVYDL 57
PLN03215 PLN03215
ascorbic acid mannose pathway regulator 1; Provisional
 14-354 1.24e-05

ascorbic acid mannose pathway regulator 1; Provisional


Pssm-ID: 178754 [Multi-domain]  Cd Length: 373  Bit Score: 46.87  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384   14 WSEIPMDILRSVFERL-SFVDLHRAKIVCSHWYScSKQSFLRKT---RSPLVILFSDDGDCTLynpEEARVYKSKRD--L 87
Cdd:PLN03215   4 WSTLPEELLHMIAGRLfSNVELKRFRSICRSWRS-SVSGVGKKNpfrTRPLILFNPINPSETL---TDDRSYISRPGafL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384   88 SRYRFL------ANSGNWFLVLDprsnlyiIDLFSEKKINLPPLdsfkgykynlkkvgarkfkelvSEYPTSFHHHAKDL 161
Cdd:PLN03215  80 SRAAFFrvtlssSPSKGWLIKSD-------MDVNSGRFHLLNPL----------------------SRLPLRHSSESVDL 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384  162 RGLLwVDEKKEEYVVVWYFRNK-----YTMDSLAFCKNGEDHY-------REMPTHYGLHDISDMVLQRGDHIYLSTSCK 229
Cdd:PLN03215 131 LEFT-VSEIREAYQVLDWAKRRetrpgYQRSALVKVKEGDNHRdgvlgigRDGKINYWDGNVLKALKQMGYHFSDIIVHK 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239384  230 YLQKLDLSRQEGIRTKNDDIISRYQlpcrpTNYKLVYDAKCWCSYNIAVTSSGEVLFVLSIFSQSTRRRI---------- 299
Cdd:PLN03215 210 GQTYALDSIGIVYWINSDLEFSRFG-----TSLDENITDGCWTGDRRFVECCGELYIVERLPKESTWKRKadgfeysrtv 284

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15239384  300 -FFLYKEDPNPSpseviykNLVEVDSLGDEALLL--DLGITVPADSDLGIEPNSIYFT 354
Cdd:PLN03215 285 gFKVYKFDDELA-------KWMEVKTLGDNAFVMatDTCFSVLAHEFYGCLPNSIYFT 335
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 14-49 2.08e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 41.37  E-value: 2.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15239384    14 WSEIPMDILRSVFERLSFVDLHRAKIVCSHWYSCSK 49
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 14-53 2.15e-04

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 38.62  E-value: 2.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15239384    14 WSEIPMDILRSVFERLSFVDLHRAKIVCSHWYSCSKQSFL 53
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSL 40
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 15-49 5.75e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 37.04  E-value: 5.75e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15239384  15 SEIPMDILRSVFERLSFVDLHRAKIVCSHWYSCSK 49
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 14-56 6.96e-04

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 37.19  E-value: 6.96e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15239384  14 WSEIPMDILRSVFERLSFVD-LHRAKIVCSHWYSCSKQSFLRKT 56
Cdd:cd22164   2 WLDLPDDLTASILSRLGAIDiLTNAQKVCKLWRRICKDPSMWRV 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
17-56 1.60e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.88  E-value: 1.60e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15239384     17 IPMDILRSVFERLSFVDLHRAKIVCSHWYS-CSKQSFLRKT 56
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSlIDSHDFWFKL 41
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 14-55 2.31e-03

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 35.67  E-value: 2.31e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15239384  14 WSEIPMDILRSVFERLSFVDLHRAKIVCSHWYSCSKQSFLRK 55
Cdd:cd22132   1 WPLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWK 42
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 14-47 2.67e-03

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 35.69  E-value: 2.67e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 15239384  14 WSEIPMDILRSVFERLSFVDLHRAKIVCSHWYSC 47
Cdd:cd22104   1 WANLPSVVLVHIFSYLPPRDRLRASSTCRRWREA 34
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 14-45 7.66e-03

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 33.92  E-value: 7.66e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 15239384  14 WSEIPMDILRSVFERLSFVDLHRAKIVCSHWY 45
Cdd:cd22114   1 WDSLPDELLLGIFSCLCLPDLLKVSQVCKRWY 32
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
 14-47 9.54e-03

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 33.80  E-value: 9.54e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 15239384  14 WSEIPMDILRSVFERLSFVDLHRAKIVCSHWYSC 47
Cdd:cd22111   1 AARLPSRVLEVIFSYLDLPDLRNCSLVCKSWYRL 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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