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Conserved domains on  [gi|15241153|ref|NP_197469|]
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Leucine-rich repeat (LRR) family protein [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 121-308 1.11e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 102.17  E-value: 1.11e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 121 ITSLEGISKASStLKELYVSKNEVNKIMEIEHLHNLQILELGSNRLRVMENLENFTKLEELWLGRNRIKVVnlcglkcik 200
Cdd:cd21340  14 ITKIDNLSLCKN-LKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVV--------- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 201 kislqsnrltsmKGFEECVALEELYLSHNGISKMEGL-------SALVN-LRVLDVSNNKLTSVDDIQNLTKLEDLWLND 272
Cdd:cd21340  84 ------------EGLENLTNLEELHIENQRLPPGEKLtfdprslAALSNsLRVLNISGNNIDSLEPLAPLRNLEQLDASN 151

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 15241153 273 NQIESLEAITEAVtGSKEKLTTIYLENNPCAKSSDY 308
Cdd:cd21340 152 NQISDLEELLDLL-SSWPSLRELDLTGNPVCKKPKY 186
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 121-308 1.11e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.17  E-value: 1.11e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 121 ITSLEGISKASStLKELYVSKNEVNKIMEIEHLHNLQILELGSNRLRVMENLENFTKLEELWLGRNRIKVVnlcglkcik 200
Cdd:cd21340  14 ITKIDNLSLCKN-LKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVV--------- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 201 kislqsnrltsmKGFEECVALEELYLSHNGISKMEGL-------SALVN-LRVLDVSNNKLTSVDDIQNLTKLEDLWLND 272
Cdd:cd21340  84 ------------EGLENLTNLEELHIENQRLPPGEKLtfdprslAALSNsLRVLNISGNNIDSLEPLAPLRNLEQLDASN 151

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 15241153 273 NQIESLEAITEAVtGSKEKLTTIYLENNPCAKSSDY 308
Cdd:cd21340 152 NQISDLEELLDLL-SSWPSLRELDLTGNPVCKKPKY 186
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-300 1.51e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 1.51e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  17 NNVLDLTSYQLHSLDTVELPPNLIELDLTANRLSGLDSRIAQLSTLKKLSLRQNLIDDSAVEPLSHWDALSDLEELVLRD 96
Cdd:COG4886  26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  97 NKlakvpDVSIFTKLLVYDISFNEITSLEGISKASSTLKELYVSKNEVNKI-MEIEHLHNLQILELGSNRLRVM-ENLEN 174
Cdd:COG4886 106 NE-----ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGN 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 175 FTKLEELWLGRNRIKVV--NLCGLKCIKKISLQSNRLTSM-KGFEECVALEELYLSHNGISKMEGLSALVNLRVLDVSNN 251
Cdd:COG4886 181 LTNLKELDLSNNQITDLpePLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 15241153 252 KLTSVDDIQNLTKLEDLWLNDNQIESLEAITEAVTGSKEKLTTIYLENN 300
Cdd:COG4886 261 QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
20-284 2.25e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 55.55  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153   20 LDLTSYQLHSLDTveLPPNLIELDLTANRLSGLDsriAQLSTLKKLSLRQNLIDDSAVEPlshwdalSDLEELVLRDNKL 99
Cdd:PRK15387 247 LEVSGNQLTSLPV--LPPGLLELSIFSNPLTHLP---ALPSGLCKLWIFGNQLTSLPVLP-------PGLQELSVSDNQL 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  100 AKVPDV-SIFTKLLVYDisfNEITSLEGIskaSSTLKELYVSKNEVNKIMEIEhlhnlqilelgsnrlrvmenlenfTKL 178
Cdd:PRK15387 315 ASLPALpSELCKLWAYN---NQLTSLPTL---PSGLQELSVSDNQLASLPTLP------------------------SEL 364

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  179 EELWLGRNRIkvVNLCGLKC-IKKISLQSNRLTSMKGFEEcvALEELYLSHNGISKMEGLSAlvNLRVLDVSNNKLTSVD 257
Cdd:PRK15387 365 YKLWAYNNRL--TSLPALPSgLKELIVSGNRLTSLPVLPS--ELKELMVSGNRLTSLPMLPS--GLLSLSVYRNQLTRLP 438

                        250       260       270
                 ....*....|....*....|....*....|...
gi 15241153  258 D------IQNLTKLEDLWLNDNQIESLEAITEA 284
Cdd:PRK15387 439 EslihlsSETTVNLEGNPLSERTLQALREITSA 471
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 242-283 6.03e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 6.03e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15241153   242 NLRVLDVSNNKLTSVDDIQNLTKLEDLWLNDN-QIESLEAITE 283
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 121-308 1.11e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.17  E-value: 1.11e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 121 ITSLEGISKASStLKELYVSKNEVNKIMEIEHLHNLQILELGSNRLRVMENLENFTKLEELWLGRNRIKVVnlcglkcik 200
Cdd:cd21340  14 ITKIDNLSLCKN-LKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVV--------- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 201 kislqsnrltsmKGFEECVALEELYLSHNGISKMEGL-------SALVN-LRVLDVSNNKLTSVDDIQNLTKLEDLWLND 272
Cdd:cd21340  84 ------------EGLENLTNLEELHIENQRLPPGEKLtfdprslAALSNsLRVLNISGNNIDSLEPLAPLRNLEQLDASN 151

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 15241153 273 NQIESLEAITEAVtGSKEKLTTIYLENNPCAKSSDY 308
Cdd:cd21340 152 NQISDLEELLDLL-SSWPSLRELDLTGNPVCKKPKY 186
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-300 1.51e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 1.51e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  17 NNVLDLTSYQLHSLDTVELPPNLIELDLTANRLSGLDSRIAQLSTLKKLSLRQNLIDDSAVEPLSHWDALSDLEELVLRD 96
Cdd:COG4886  26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  97 NKlakvpDVSIFTKLLVYDISFNEITSLEGISKASSTLKELYVSKNEVNKI-MEIEHLHNLQILELGSNRLRVM-ENLEN 174
Cdd:COG4886 106 NE-----ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGN 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 175 FTKLEELWLGRNRIKVV--NLCGLKCIKKISLQSNRLTSM-KGFEECVALEELYLSHNGISKMEGLSALVNLRVLDVSNN 251
Cdd:COG4886 181 LTNLKELDLSNNQITDLpePLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 15241153 252 KLTSVDDIQNLTKLEDLWLNDNQIESLEAITEAVTGSKEKLTTIYLENN 300
Cdd:COG4886 261 QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-300 9.49e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 9.49e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  38 NLIELDLTANRLSGLDSRIAQLSTLKKLSLRQNLIDDSAVEPLSHWDALSDLEELVLRDNKLAKVPDVSIFTKLLVYDIS 117
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 118 FNEITSLEGISKASSTLKELYVSKNEvnkimEIEHLHNLQILELGSNRLRVM-ENLENFTKLEELWLGRNRIKVV--NLC 194
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpePLG 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 195 GLKCIKKISLQSNRLTSM-KGFEECVALEELYLSHNGISKM-EGLSALVNLRVLDVSNNKLTSV-DDIQNLTKLEDLWLN 271
Cdd:COG4886 157 NLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLS 236

                       250       260
                ....*....|....*....|....*....
gi 15241153 272 DNQIESLEAIteavtGSKEKLTTIYLENN 300
Cdd:COG4886 237 NNQLTDLPEL-----GNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-281 9.39e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 9.39e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153   2 NSEKEDEPLEEIGDSNNVLDLTSYQLHSLDTVELPPNLIELDLTANRLSGLDSRIAQLSTLKKLSLRQNLIDDsAVEPLS 81
Cdd:COG4886  78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD-LPEPLG 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  82 HwdaLSDLEELVLRDNKLAKVPD-VSIFTKLLVYDISFNEITSLEGISKASSTLKELYVSKNEVNKI-MEIEHLHNLQIL 159
Cdd:COG4886 157 N---LTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 160 ELGSNRLRVMENLENFTKLEELWLGRNRIKVV-NLCGLKCIKKISLQSNRLTSM--KGFEECVALEELYLSHNGISKMEG 236
Cdd:COG4886 234 DLSNNQLTDLPELGNLTNLEELDLSNNQLTDLpPLANLTNLKTLDLSNNQLTDLklKELELLLGLNSLLLLLLLLNLLEL 313

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 15241153 237 LSALVNLRVLDVSNNKLTSVDDIQNLTKLEDLWLNDNQIESLEAI 281
Cdd:COG4886 314 LILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-301 1.46e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 1.46e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  19 VLDLTSYQLHSL-DTVELPPNLIELDLTANRLSGLDSRIAQLSTLKKLSLRQNLIDD--SAVEPLSHwdalsdLEELVLR 95
Cdd:COG4886 117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDlpEELGNLTN------LKELDLS 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  96 DNKLAKVPD-VSIFTKLLVYDISFNEITSLEGISKASSTLKELYVSKNEVNKIMEIEHLHNLQILELGSNRLRVMENLEN 174
Cdd:COG4886 191 NNQITDLPEpLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 175 FTKLEELWLGRNRIKVVNLCGLKCIKKISLQSNRLTSMKGFEECVALEELYLSHNGISKMEGLSALVNLRVLDVSNNKLT 254
Cdd:COG4886 271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 15241153 255 SVDDIQNLTKLEDLWLNDNQIESLEAITEAVTGSKEKLTTIYLENNP 301
Cdd:COG4886 351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-292 2.47e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 2.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  19 VLDLTSYQLHSLDTvELP--PNLIELDLTANRLSGLDSRIAQLSTLKKLSLRQNLIDDSAvEPLSHwdaLSDLEELVLRD 96
Cdd:COG4886 140 ELDLSNNQLTDLPE-PLGnlTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLP-EPLGN---LTNLEELDLSG 214

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  97 NKLAKVPD-VSIFTKLLVYDISFNEITSLEGISKASStLKELYVSKNEVNKIMEIEHLHNLQILELGSNRLRVMENLENF 175
Cdd:COG4886 215 NQLTDLPEpLANLTNLETLDLSNNQLTDLPELGNLTN-LEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELE 293

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 176 TKLEELWLGRNRIKVVNLCGLKCIKKISLQSNRLTSMKGFEECVALEELYLSHNGISKMEGLSALVNLRVLDVSNNKLTS 255
Cdd:COG4886 294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 15241153 256 VDDIQNLTKLEDLWLNDNQIESLEAITEAVTGSKEKL 292
Cdd:COG4886 374 LLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-301 5.17e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 5.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 109 TKLLVYDISFNEITSLEGISKASSTLKELYVSKNEVNKIMEIEHLHNLQILELGSNRLRVMENLENFTKLEELWLGRNRI 188
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 189 KVVNLCGLKCIKKISLQSNRLTSMKGFEECVALEELYLSHNGISKM-EGLSALVNLRVLDVSNNKLTSV-DDIQNLTKLE 266
Cdd:COG4886  83 SLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLK 162

                       170       180       190
                ....*....|....*....|....*....|....*
gi 15241153 267 DLWLNDNQIESLeaitEAVTGSKEKLTTIYLENNP 301
Cdd:COG4886 163 SLDLSNNQLTDL----PEELGNLTNLKELDLSNNQ 193
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
20-284 2.25e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 55.55  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153   20 LDLTSYQLHSLDTveLPPNLIELDLTANRLSGLDsriAQLSTLKKLSLRQNLIDDSAVEPlshwdalSDLEELVLRDNKL 99
Cdd:PRK15387 247 LEVSGNQLTSLPV--LPPGLLELSIFSNPLTHLP---ALPSGLCKLWIFGNQLTSLPVLP-------PGLQELSVSDNQL 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  100 AKVPDV-SIFTKLLVYDisfNEITSLEGIskaSSTLKELYVSKNEVNKIMEIEhlhnlqilelgsnrlrvmenlenfTKL 178
Cdd:PRK15387 315 ASLPALpSELCKLWAYN---NQLTSLPTL---PSGLQELSVSDNQLASLPTLP------------------------SEL 364

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  179 EELWLGRNRIkvVNLCGLKC-IKKISLQSNRLTSMKGFEEcvALEELYLSHNGISKMEGLSAlvNLRVLDVSNNKLTSVD 257
Cdd:PRK15387 365 YKLWAYNNRL--TSLPALPSgLKELIVSGNRLTSLPVLPS--ELKELMVSGNRLTSLPMLPS--GLLSLSVYRNQLTRLP 438

                        250       260       270
                 ....*....|....*....|....*....|...
gi 15241153  258 D------IQNLTKLEDLWLNDNQIESLEAITEA 284
Cdd:PRK15387 439 EslihlsSETTVNLEGNPLSERTLQALREITSA 471
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-251 3.10e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 3.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  19 VLDLTSYQLHSL-DTVELPPNLIELDLTANRLSGLDSRIAQLSTLKKLSLRQNLIDDsavepLSHWDALSDLEELVLRDN 97
Cdd:COG4886 186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTD-----LPELGNLTNLEELDLSNN 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  98 KLAKVPDVSIFTKLLVYDISFNEITSLEGISKASSTLKELYVSKNEVNKIMEIEHLHNLQILELGSNRLRVMENLENFTK 177
Cdd:COG4886 261 QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15241153 178 LEELWLGRNRIKVVNLCGLKCIKKISLQSNRLTSMKGFEECVALEELYLSHNGISKMEGLSALVNLRVLDVSNN 251
Cdd:COG4886 341 ALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 62-224 3.79e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 3.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  62 LKKLSLRQNLIddSAVEPLSHwdaLSDLEELVLRDNKLAKVPDVSIFTKLLVYDISFNEITSLEGISKASStLKELYVSK 141
Cdd:cd21340  26 LKVLYLYDNKI--TKIENLEF---LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTN-LEELHIEN 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 142 NEVNKIMEIE--------HLHNLQILELGSNRLRVMENLENFTKLEELWLGRNRIKVVN-----LCGLKCIKKISLQSNR 208
Cdd:cd21340 100 QRLPPGEKLTfdprslaaLSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelldlLSSWPSLRELDLTGNP 179

                       170       180
                ....*....|....*....|.
gi 15241153 209 LTSMKGFEE-----CVALEEL 224
Cdd:cd21340 180 VCKKPKYRDkiilaSKSLEVL 200
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 19-254 1.03e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153   19 VLDLTSYQLHSLDTVELPP--NLIELDLTANRLSG-LDSRIAQLSTLKKLSLRQNLIDDSAVEPLSHwdaLSDLEELVLR 95
Cdd:PLN00113 192 FLTLASNQLVGQIPRELGQmkSLKWIYLGYNNLSGeIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGN---LKNLQYLFLY 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153   96 DNKLAKVPDVSIF--TKLLVYDISFNeitSLEG-ISKASSTLKELYV----SKNEVNKIME-IEHLHNLQILELGSNRL- 166
Cdd:PLN00113 269 QNKLSGPIPPSIFslQKLISLDLSDN---SLSGeIPELVIQLQNLEIlhlfSNNFTGKIPVaLTSLPRLQVLQLWSNKFs 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  167 -RVMENLENFTKLEELWLGRNRIK---VVNLCGLKCIKKISLQSNRLTSM--KGFEECVALEELYLSHNGISK--MEGLS 238
Cdd:PLN00113 346 gEIPKNLGKHNNLTVLDLSTNNLTgeiPEGLCSSGNLFKLILFSNSLEGEipKSLGACRSLRRVRLQDNSFSGelPSEFT 425

                        250
                 ....*....|....*.
gi 15241153  239 ALVNLRVLDVSNNKLT 254
Cdd:PLN00113 426 KLPLVYFLDISNNNLQ 441
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-300 2.88e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 2.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153   38 NLIELDLTANRLSG-LDSRIAQLSTLKKLSLRQNLIDDSAVEPLShwdALSDLEELVLRDNKLA-KVP-DVSIFTKLLVY 114
Cdd:PLN00113 285 KLISLDLSDNSLSGeIPELVIQLQNLEILHLFSNNFTGKIPVALT---SLPRLQVLQLWSNKFSgEIPkNLGKHNNLTVL 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  115 DISFNEIT---------------------SLEG-ISK---ASSTLKELYVSKNEVNKIM--EIEHLHNLQILELGSNRL- 166
Cdd:PLN00113 362 DLSTNNLTgeipeglcssgnlfklilfsnSLEGeIPKslgACRSLRRVRLQDNSFSGELpsEFTKLPLVYFLDISNNNLq 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  167 -RVMENLENFTKLEELWLGRNRI--KVVNLCGLKCIKKISLQSNRLTSM--KGFEECVALEELYLSHNGISKM--EGLSA 239
Cdd:PLN00113 442 gRINSRKWDMPSLQMLSLARNKFfgGLPDSFGSKRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKLSGEipDELSS 521

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15241153  240 LVNLRVLDVSNNKLTS--VDDIQNLTKLEDLWLNDNQiesLEAITEAVTGSKEKLTTIYLENN 300
Cdd:PLN00113 522 CKKLVSLDLSHNQLSGqiPASFSEMPVLSQLDLSQNQ---LSGEIPKNLGNVESLVQVNISHN 581
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 56-284 7.00e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 7.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  56 IAQLSTLKKLSLRQNLIDDSAVEPL-SHWDALSDLEELVLRDNKLAKVPDVSI--------FTKLLVYDISFNEIT---- 122
Cdd:cd00116  19 LPKLLCLQVLRLEGNTLGEEAAKALaSALRPQPSLKELCLSLNETGRIPRGLQsllqgltkGCGLQELDLSDNALGpdgc 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 123 -SLEGISKaSSTLKELYVSKNEVNKIME-------IEHLHNLQILELGSNRL------RVMENLENFTKLEELWLGRNRI 188
Cdd:cd00116  99 gVLESLLR-SSSLQELKLNNNGLGDRGLrllakglKDLPPALEKLVLGRNRLegasceALAKALRANRDLKELNLANNGI 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 189 KV-------VNLCGLKCIKKISLQSNRLTSmkgfEECVALEElylshngiskmeGLSALVNLRVLDVSNNKLTSVD---- 257
Cdd:cd00116 178 GDagiralaEGLKANCNLEVLDLNNNGLTD----EGASALAE------------TLASLKSLEVLNLGDNNLTDAGaaal 241

                       250       260       270
                ....*....|....*....|....*....|
gi 15241153 258 ---DIQNLTKLEDLWLNDNQIESLEAITEA 284
Cdd:cd00116 242 asaLLSPNISLLTLSLSCNDITDDGAKDLA 271
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
26-215 1.81e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 46.31  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153   26 QLHSLDTveLPPNLIELDLTANRLSGLDsriAQLSTLKKLSLRQNLIDDSAVEPlshwdalSDLEELVLRDNKLAKVPDV 105
Cdd:PRK15387 293 QLTSLPV--LPPGLQELSVSDNQLASLP---ALPSELCKLWAYNNQLTSLPTLP-------SGLQELSVSDNQLASLPTL 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  106 -SIFTKLLVYDisfNEITSLEGIskaSSTLKELYVSKN----------EVNKIM-EIEHLHNLQILELGSNRLRVMENle 173
Cdd:PRK15387 361 pSELYKLWAYN---NRLTSLPAL---PSGLKELIVSGNrltslpvlpsELKELMvSGNRLTSLPMLPSGLLSLSVYRN-- 432

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 15241153  174 NFTKLEELWLGRNRIKVVNLCGlKCIKKISLQSNR-LTSMKGF 215
Cdd:PRK15387 433 QLTRLPESLIHLSSETTVNLEG-NPLSERTLQALReITSAPGY 474
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 242-283 6.03e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 6.03e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15241153   242 NLRVLDVSNNKLTSVDDIQNLTKLEDLWLNDN-QIESLEAITE 283
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
221-275 8.22e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 8.22e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15241153   221 LEELYLSHNGISKMEG--LSALVNLRVLDVSNNKLTSV--DDIQNLTKLEDLWLNDNQI 275
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 221-261 1.60e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 1.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15241153   221 LEELYLSHNGISKMEGLSALVNLRVLDVS-NNKLTSVDDIQN 261
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 109-300 2.34e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 2.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 109 TKLLVYDISFNEItSLEGIS------KASSTLKELYVSKNEV-NKIME--IEHL-HNLQI--LELGSNRLR------VME 170
Cdd:COG5238 180 NSVETVYLGCNQI-GDEGIEelaealTQNTTVTTLWLKRNPIgDEGAEilAEALkGNKSLttLDLSNNQIGdegviaLAE 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 171 NLENFTKLEELWLGRNRIKV-------VNLCGLKCIKKISLQSNRLTS------MKGFEECVALEELYLSHNGISK---- 233
Cdd:COG5238 259 ALKNNTTVETLYLSGNQIGAegaialaKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAqgai 338

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15241153 234 --MEGLSALVNLRVLDVSNNKLTS------VDDIQNLTKLEDLWLNDNQIESLEAITEAVTGSKEKLTTIYLENN 300
Cdd:COG5238 339 alAKALQENTTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGN 413
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 34-223 7.10e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 7.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  34 ELPPNLIELDLTANRLSGLDSRIA-----QLSTLKKLSLRQNLIDDSAVEPLSH-WDALSDLEELVLRDNKLAKvpdvsi 107
Cdd:cd00116 134 DLPPALEKLVLGRNRLEGASCEALakalrANRDLKELNLANNGIGDAGIRALAEgLKANCNLEVLDLNNNGLTD------ 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 108 ftkllvydisfneitslEGISKASSTLKelyvsknevnkimeieHLHNLQILELGSNRLR-------VMENLENFTKLEE 180
Cdd:cd00116 208 -----------------EGASALAETLA----------------SLKSLEVLNLGDNNLTdagaaalASALLSPNISLLT 254

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 15241153 181 LWLGRNRIK---VVNLCGL----KCIKKISLQSNRLTSMKGFEECVALEE 223
Cdd:cd00116 255 LSLSCNDITddgAKDLAEVlaekESLLELDLRGNKFGEEGAQLLAESLLE 304
LRR_9 pfam14580
Leucine-rich repeat;
226-323 9.90e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 9.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153   226 LSHNGISKMEGLSALVNLRVLDVSNNKLTSVDD--IQNLTKLEDLWLNDNQIESLEAItEAVTGSKeKLTTIYLENNPCA 303
Cdd:pfam14580  49 FSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEglGEALPNLTELILTNNNLQELGDL-DPLASLK-KLTFLSLLRNPVT 126

                          90       100
                  ....*....|....*....|
gi 15241153   304 KSSDYVAAVRQIFPNVEQID 323
Cdd:pfam14580 127 NKPHYRLYVIYKVPQLRLLD 146
LRR_8 pfam13855
Leucine rich repeat;
200-253 1.06e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15241153   200 KKISLQSNRLTSMKG--FEECVALEELYLSHNGISKMEG--LSALVNLRVLDVSNNKL 253
Cdd:pfam13855   4 RSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 37-275 2.17e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 2.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153  37 PNLIELDLTANRLSGLDS----RIAQLSTLKKLSLRQNLIDDSAVEPL--SHWDALSDLEELVLRDNKLakvpdvsiftk 110
Cdd:cd00116  81 CGLQELDLSDNALGPDGCgvleSLLRSSSLQELKLNNNGLGDRGLRLLakGLKDLPPALEKLVLGRNRL----------- 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 111 llvydisfnEITSLEGISKA---SSTLKELYVSKNEVNK------IMEIEHLHNLQILELGSNRLR------VMENLENF 175
Cdd:cd00116 150 ---------EGASCEALAKAlraNRDLKELNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTdegasaLAETLASL 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241153 176 TKLEELWLGRNrikvvnLCGLKCIKKISLQSNRLTSmkgfeecvALEELYLSHNGI------SKMEGLSALVNLRVLDVS 249
Cdd:cd00116 221 KSLEVLNLGDN------NLTDAGAAALASALLSPNI--------SLLTLSLSCNDItddgakDLAEVLAEKESLLELDLR 286

                       250       260       270
                ....*....|....*....|....*....|...
gi 15241153 250 NNKLTSVDD-------IQNLTKLEDLWLNDNQI 275
Cdd:cd00116 287 GNKFGEEGAqllaeslLEPGNELESLWVKDDSF 319
LRR_8 pfam13855
Leucine rich repeat;
242-301 6.63e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 6.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15241153   242 NLRVLDVSNNKLTSVDD--IQNLTKLEDLWLNDNQIESLEAitEAVTGSKeKLTTIYLENNP 301
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSP--GAFSGLP-SLRYLDLSGNR 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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