|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
373-893 |
6.64e-177 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 544.78 E-value: 6.64e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 373 KVTKQPSLLQGgELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWEN 452
Cdd:PLN03142 158 RLLVQPSCIKG-KMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGITGPHMVVAPKSTLGNWMN 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 453 EFALWAPSISAFLYDGSKEKRTEIRAR-IAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGT 531
Cdd:PLN03142 237 EIRRFCPVLRAVKFHGNPEERAHQREElLVAGKFDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRL 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 532 gYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTpfaecgsASLTDEEEllIINRLHHVIRPFLLRRK 611
Cdd:PLN03142 317 -FSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQI-------SGENDQQE--VVQQLHKVLRPFLLRRL 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 612 KSEVEKFLPGKTQVILKCDMSAWQKLYYKQVTDVGRVGLHSGnGKSKSLQNLTMQLRKCCNHPYLFVGADYN--MCKKPE 689
Cdd:PLN03142 387 KSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLDVVNAG-GERKRLLNIAMQLRKCCNHPYLFQGAEPGppYTTGEH 465
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 690 IVRASGKFELLDRLLPKLKKAGHRILLFSQMTRLIDLLEIYLSLNDYMYLRLDGSTKTDQRGILLKQFNEPDSPYFMFLL 769
Cdd:PLN03142 466 LVENSGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVFLL 545
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 770 STRAGGLGLNLQTADTIIIFDSDWNPQMDQQAEDRAHRIGQKKEVRVFVLVSIGSIEEVILERAKQKMGIDAKVIQAGLF 849
Cdd:PLN03142 546 STRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRL 625
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 30687235 850 --NTTSTAQDRREML----EEIMSKGTSSLgedvpSEREINRLAARTEEE 893
Cdd:PLN03142 626 aeQKTVNKDELLQMVrygaEMVFSSKDSTI-----TDEDIDRIIAKGEEA 670
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
301-845 |
1.74e-135 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 425.02 E-value: 1.74e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 301 LGAAVQRQKDAKLSENTKLLKGSESDLSDVDAPEDVLPAQDIEIIDSDNNDDSNDLLEGERQFNLAIHSIQEKVTKQPSL 380
Cdd:COG0553 158 LLGRLLLLALLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRRLREALESLPAG 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 381 LQGgELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDlHGPHLILAPKAVLPNWENEFALWAPS 460
Cdd:COG0553 238 LKA-TLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGL-ARPVLIVAPTSLVGNWQRELAKFAPG 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 461 ISAFLYDGSKEkRTEIRARIAggKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECA---LAKTLgtgyRIKR 537
Cdd:COG0553 316 LRVLVLDGTRE-RAKGANPFE--DADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKrakAVRAL----KARH 388
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 538 RLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAEcgsaslTDEEELliiNRLHHVIRPFLLRRKKSEVEK 617
Cdd:COG0553 389 RLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEK------GDEEAL---ERLRRLLRPFLLRRTKEDVLK 459
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 618 FLPGKTQVILKCDMSAWQKLYYKQVTDVGRVGLHSGNGKSKSLQNLT--MQLRKCCNHPYLFVGadynmcKKPEIVRASG 695
Cdd:COG0553 460 DLPEKTEETLYVELTPEQRALYEAVLEYLRRELEGAEGIRRRGLILAalTRLRQICSHPALLLE------EGAELSGRSA 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 696 KFELLDRLLPKLKKAGHRILLFSQMTRLIDLLEIYLSLNDYMYLRLDGSTKTDQRGILLKQFNEPDSPYFmFLLSTRAGG 775
Cdd:COG0553 534 KLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPV-FLISLKAGG 612
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 776 LGLNLQTADTIIIFDSDWNPQMDQQAEDRAHRIGQKKEVRVFVLVSIGSIEEVILERAKQKMGIDAKVIQ 845
Cdd:COG0553 613 EGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
383-612 |
9.78e-124 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 377.48 E-value: 9.78e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 383 GGELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSIS 462
Cdd:cd17996 1 GGTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 463 AFLYDGSKEKRTEIRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTGYRIKRRLLLT 542
Cdd:cd17996 81 KIVYKGTPDVRKKLQSQIRAGKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTYYHARYRLLLT 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30687235 543 GTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGSAS---LTDEEELLIINRLHHVIRPFLLRRKK 612
Cdd:cd17996 161 GTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTGEQVkieLNEEETLLIIRRLHKVLRPFLLRRLK 233
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
389-677 |
8.02e-103 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 324.25 E-value: 8.02e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 389 YQLEGLQWMVSLYNNDY-NGILADEMGLGKTIQTIALIAYLLESKDLHG-PHLILAPKAVLPNWENEFALWA--PSISAF 464
Cdd:pfam00176 1 YQIEGVNWMLSLENNLGrGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 465 LYDGSKEKR-TEIRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgYRIKRRLLLTG 543
Cdd:pfam00176 81 VLHGNKRPQeRWKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKS-LKTRNRWILTG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 544 TPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGSAsltdeeelLIINRLHHVIRPFLLRRKKSEVEKFLPGKT 623
Cdd:pfam00176 160 TPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGK--------KGVSRLHKLLKPFLLRRTKKDVEKSLPPKV 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 30687235 624 QVILKCDMSAWQKLYYKQVT---DVGRVGL-HSGNGKSKSLQNLTMQLRKCCNHPYLF 677
Cdd:pfam00176 232 EYILFCRLSKLQRKLYQTFLlkkDLNAIKTgEGGREIKASLLNILMRLRKICNHPGLI 289
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
368-612 |
3.73e-95 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 302.37 E-value: 3.73e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 368 HSIQEKVTKQPSLLQGGELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVL 447
Cdd:cd18063 6 HAITERVEKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 448 PNWENEFALWAPSISAFLYDGSKEKRTEIRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAK 527
Cdd:cd18063 86 SNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 528 TLGTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGS-ASLTDEEELLIINRLHHVIRPF 606
Cdd:cd18063 166 VLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGErVDLNEEETILIIRRLHKVLRPF 245
|
....*.
gi 30687235 607 LLRRKK 612
Cdd:cd18063 246 LLRRLK 251
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
368-612 |
7.41e-94 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 298.88 E-value: 7.41e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 368 HSIQEKVTKQPSLLQGGELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVL 447
Cdd:cd18062 6 HAVTEKVEKQSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 448 PNWENEFALWAPSISAFLYDGSKEKRTEIRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAK 527
Cdd:cd18062 86 SNWVYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 528 TLGTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGS-ASLTDEEELLIINRLHHVIRPF 606
Cdd:cd18062 166 VLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEkVDLNEEETILIIRRLHKVLRPF 245
|
....*.
gi 30687235 607 LLRRKK 612
Cdd:cd18062 246 LLRRLK 251
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
383-612 |
2.19e-92 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 294.29 E-value: 2.19e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 383 GGELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLEsKDLHGPHLILAPKAVLPNWENEFALWAPSIS 462
Cdd:cd18009 1 GGVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRE-RGVWGPFLVIAPLSTLPNWVNEFARFTPSVP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 463 AFLYDGSKEKRTEIRARI-----AGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgYRIKR 537
Cdd:cd18009 80 VLLYHGTKEERERLRKKImkregTLQDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKT-FNSDN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 538 RLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNtpFAECGSAS-----LTDEEELLIINRLHHVIRPFLLRRKK 612
Cdd:cd18009 159 RLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFD--FSSLSDNAadisnLSEEREQNIVHMLHAILKPFLLRRLK 236
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
383-612 |
3.09e-89 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 285.37 E-value: 3.09e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 383 GGELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSIS 462
Cdd:cd17997 1 GGTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 463 AFLYDGSKEKRTEI-RARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgYRIKRRLLL 541
Cdd:cd17997 81 VVVLIGDKEERADIiRDVLLPGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRL-FNSRNRLLL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30687235 542 TGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTpfaecgSASLTDEEELliINRLHHVIRPFLLRRKK 612
Cdd:cd17997 160 TGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNV------NNCDDDNQEV--VQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
386-565 |
1.84e-81 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 262.50 E-value: 1.84e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSISAFL 465
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEIRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLgTGYRIKRRLLLTGTP 545
Cdd:cd17919 81 YHGSQRERAQIRAKEKLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKAL-KALRAKRRLLLTGTP 159
|
170 180
....*....|....*....|
gi 30687235 546 IQNSLQELWSLLNFLLPHIF 565
Cdd:cd17919 160 LQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
385-610 |
5.97e-78 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 254.59 E-value: 5.97e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 385 ELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSISAF 464
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 465 LYDGSKEKRTEIR---------ARIaggKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLgTGYRI 535
Cdd:cd17993 81 VYLGDIKSRDTIReyefyfsqtKKL---KFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEAL-KEFKT 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30687235 536 KRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEwfntpfaecgsasLTDEEELLIINRLHHVIRPFLLRR 610
Cdd:cd17993 157 NNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEE-------------EHDEEQEKGIADLHKELEPFILRR 218
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
386-610 |
2.15e-76 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 250.35 E-value: 2.15e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSISAFL 465
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEIRARIAG-GKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgYRIKRRLLLTGT 544
Cdd:cd18003 81 YYGSAKERKLKRQGWMKpNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLN-FNTQRRLLLTGT 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30687235 545 PIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGSASLTDEEELLIinRLHHVIRPFLLRR 610
Cdd:cd18003 160 PLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTAMSEGSQEENEELVR--RLHKVLRPFLLRR 223
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
378-622 |
1.34e-72 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 240.72 E-value: 1.34e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 378 PSLLQGGELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALW 457
Cdd:cd18064 8 PSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 458 APSISAFLYDGSKEKRTE-IRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgYRIK 536
Cdd:cd18064 88 VPTLRAVCLIGDKDQRAAfVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVRE-FKTT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 537 RRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTpfaecgSASLTDEEellIINRLHHVIRPFLLRRKKSEVE 616
Cdd:cd18064 167 NRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDT------NNCLGDQK---LVERLHMVLRPFLLRRIKADVE 237
|
....*.
gi 30687235 617 KFLPGK 622
Cdd:cd18064 238 KSLPPK 243
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
378-612 |
7.37e-71 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 235.68 E-value: 7.37e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 378 PSLLQGGELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALW 457
Cdd:cd18065 8 PSYVKGGTLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 458 APSISAFLYDGSKEKRTE-IRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgYRIK 536
Cdd:cd18065 88 VPSLRAVCLIGDKDARAAfIRDVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVRE-FKTT 166
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30687235 537 RRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTpfaecgSASLTDEEellIINRLHHVIRPFLLRRKK 612
Cdd:cd18065 167 NRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDT------KNCLGDQK---LVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
386-610 |
6.22e-69 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 229.83 E-value: 6.22e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPsISAFL 465
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEIR----------ARIAGG--KFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgY 533
Cdd:cd17995 80 YHGSGESRQIIQqyemyfkdaqGRKKKGvyKFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKK-L 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30687235 534 RIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFntpfaecgsASLTDEEElliINRLHHVIRPFLLRR 610
Cdd:cd17995 159 TLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF---------GDLKTAEQ---VEKLQALLKPYMLRR 223
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
386-610 |
2.39e-66 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 222.77 E-value: 2.39e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSISAFL 465
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEIRA-------RIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLgTGYRIKRR 538
Cdd:cd18002 81 YWGNPKDRKVLRKfwdrknlYTRDAPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTL-LSFHCRNR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30687235 539 LLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPF-AECGSASLTDEEELliiNRLHHVIRPFLLRR 610
Cdd:cd18002 160 LLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIeSHAENKTGLNEHQL---KRLHMILKPFMLRR 229
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
376-610 |
1.66e-65 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 221.03 E-value: 1.66e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 376 KQPSLL--QGGELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENE 453
Cdd:cd18054 9 KQPSYIggENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 454 FALWAPSISAFLYDGSKEKRTEIR------ARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAK 527
Cdd:cd18054 89 FEIWAPEINVVVYIGDLMSRNTIReyewihSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 528 TLgTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPfAECGSASltdeeelliinrLHHVIRPFL 607
Cdd:cd18054 169 TL-IDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKG-RENGYQS------------LHKVLEPFL 234
|
...
gi 30687235 608 LRR 610
Cdd:cd18054 235 LRR 237
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
384-612 |
4.22e-64 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 216.28 E-value: 4.22e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 384 GELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLhGPHLILAPKAVLPNWENEFALWAPSISA 463
Cdd:cd18012 3 ATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRK-GPSLVVAPTSLIYNWEEEAAKFAPELKV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 464 FLYDGSKEKRTEIRARiagGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgYRIKRRLLLTG 543
Cdd:cd18012 82 LVIHGTKRKREKLRAL---EDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKA-LKADHRLALTG 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30687235 544 TPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPfaecgSASLTDEEELliiNRLHHVIRPFLLRRKK 612
Cdd:cd18012 158 TPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKP-----IEKDGDEEAL---EELKKLISPFILRRLK 218
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
386-610 |
3.35e-61 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 208.06 E-value: 3.35e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSISAFL 465
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEIRARI-AGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLgTGYRIKRRLLLTGT 544
Cdd:cd18006 81 YMGDKEKRLDLQQDIkSTNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTL-SEFSVDFRLLLTGT 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30687235 545 PIQNSLQELWSLLNFLLPHIFNSihNFEEWFNTPFAECGSASLTDEEelliinrLHHVIRPFLLRR 610
Cdd:cd18006 160 PIQNSLQELYALLSFIEPNVFPK--DKLDDFIKAYSETDDESETVEE-------LHLLLQPFLLRR 216
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
386-565 |
1.88e-59 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 201.84 E-value: 1.88e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDlHGPHLILAPKAVLPNWENEFALWAPSISAFL 465
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGI-PGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEIRARIAGG--KFNVLITHYDLIM---RDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgYRIKRRLL 540
Cdd:cd17998 80 YYGSQEERKHLRYDILKGleDFDVIVTTYNLATsnpDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMT-INANFRLL 158
|
170 180
....*....|....*....|....*
gi 30687235 541 LTGTPIQNSLQELWSLLNFLLPHIF 565
Cdd:cd17998 159 LTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
694-820 |
1.25e-56 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 191.54 E-value: 1.25e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 694 SGKFELLDRLLPKLKKAGHRILLFSQMTRLIDLLEIYLSLNDYMYLRLDGSTKTDQRGILLKQFNEPDSPyFMFLLSTRA 773
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDI-RVFLLSTKA 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 30687235 774 GGLGLNLQTADTIIIFDSDWNPQMDQQAEDRAHRIGQKKEVRVFVLV 820
Cdd:cd18793 89 GGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
386-610 |
3.54e-55 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 189.96 E-value: 3.54e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSISAFL 465
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSkekrteirariaggkfNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLgTGYRIKRRLLLTGTP 545
Cdd:cd17994 81 YVGD----------------HVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRIL-NSYKIGYKLLLTGTP 143
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30687235 546 IQNSLQELWSLLNFLLPHIFNSIHNFEEWFntpfaecgsASLTDEEElliINRLHHVIRPFLLRR 610
Cdd:cd17994 144 LQNNLEELFHLLNFLTPERFNNLQGFLEEF---------ADISKEDQ---IKKLHDLLGPHMLRR 196
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
386-610 |
7.03e-54 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 187.94 E-value: 7.03e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLynNDYN--GILADEMGLGKTIQTIALIA---YLLES--KDLHGPHLILAPKAVLPNWENEFALWA 458
Cdd:cd17999 1 LRPYQQEGINWLAFL--NKYNlhGILCDDMGLGKTLQTLCILAsdhHKRANsfNSENLPSLVVCPPTLVGHWVAEIKKYF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 459 P--SISAFLYDGSKEKRTEIRARiaGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLgTGYRIK 536
Cdd:cd17999 79 PnaFLKPLAYVGPPQERRRLREQ--GEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAV-KQLKAN 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30687235 537 RRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGSA---SLTDEEELLIINRLHHVIRPFLLRR 610
Cdd:cd17999 156 HRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSkasAKEQEAGALALEALHKQVLPFLLRR 232
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
376-610 |
3.23e-53 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 186.02 E-value: 3.23e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 376 KQPSLLQGGE---LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWEN 452
Cdd:cd18053 8 KQPSYIGGHEgleLRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 453 EFALWAPSISAFLYDGSKEKRTEIRA------RIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALA 526
Cdd:cd18053 88 EIQTWAPQMNAVVYLGDINSRNMIRThewmhpQTKRLKFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 527 KTLgTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPfAECGSASltdeeelliinrLHHVIRPF 606
Cdd:cd18053 168 KTL-IDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKG-REYGYAS------------LHKELEPF 233
|
....
gi 30687235 607 LLRR 610
Cdd:cd18053 234 LLRR 237
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
386-610 |
7.94e-53 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 184.88 E-value: 7.94e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPhLILAPKAVLPNWENEFALWAPSISAFL 465
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSV-LVVMPTSLIPHWVKEFAKWTPGLRVKV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDG-SKEKRTEIRARIAGGkFNVLITHYDLIMRDKAFLKKID-----WNYMIVDEGHRLKNHECALAKTLgTGYRIKRRL 539
Cdd:cd18001 80 FHGtSKKERERNLERIQRG-GGVLLTTYGMVLSNTEQLSADDhdefkWDYVILDEGHKIKNSKTKSAKSL-REIPAKNRI 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30687235 540 LLTGTPIQNSLQELWSLLNFLLPH-IFNSIHNFEEWFNTPFAECGSASLTDEEELL---IINRLHHVIRPFLLRR 610
Cdd:cd18001 158 ILTGTPIQNNLKELWALFDFACNGsLLGTRKTFKMEFENPITRGRDKDATQGEKALgseVAENLRQIIKPYFLRR 232
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
386-610 |
2.40e-50 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 177.90 E-value: 2.40e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSISAFL 465
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEIRAR--------IAGG------------KFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECAL 525
Cdd:cd18055 81 YTGDKDSRAIIRENefsfddnaVKGGkkafkmkreaqvKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 526 AKTLgTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFntpfaecgsASLTDEEElliINRLHHVIRP 605
Cdd:cd18055 161 FRVL-NGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF---------ADISKEDQ---IKKLHDLLGP 227
|
....*
gi 30687235 606 FLLRR 610
Cdd:cd18055 228 HMLRR 232
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
386-610 |
1.38e-48 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 172.56 E-value: 1.38e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSISAFL 465
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEIR--------------------ARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECAL 525
Cdd:cd18057 81 YTGDKESRSVIRenefsfednairsgkkvfrmKKEAQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 526 AKTLGTgYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFntpfaecgsASLTDEEElliINRLHHVIRP 605
Cdd:cd18057 161 FRVLNS-YKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF---------ADISKEDQ---IKKLHDLLGP 227
|
....*
gi 30687235 606 FLLRR 610
Cdd:cd18057 228 HMLRR 232
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
386-562 |
1.96e-47 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 167.89 E-value: 1.96e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSISAFL 465
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 ------YDGSKEK-----RTEIRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKN--HECALA-KTLGT 531
Cdd:cd18000 81 lhssgsGTGSEEKlgsieRKSQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNpdAEITLAcKQLRT 160
|
170 180 190
....*....|....*....|....*....|.
gi 30687235 532 GYRIkrrlLLTGTPIQNSLQELWSLLNFLLP 562
Cdd:cd18000 161 PHRL----ILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
386-610 |
3.83e-47 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 168.30 E-value: 3.83e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLeSKDLHGPHLILAPKAVLPNWENEFALWApSISAFL 465
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIF-LMGIRGPFLIIAPLSTITNWEREFRTWT-EMNAIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRT-----EIRARIAGG-------KFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgY 533
Cdd:cd18058 79 YHGSQISRQmiqqyEMYYRDEQGnplsgifKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKL-M 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30687235 534 RIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFntpfaecgsASLTDEEElliINRLHHVIRPFLLRR 610
Cdd:cd18058 158 ALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEF---------GDLKTEEQ---VKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
386-610 |
4.66e-47 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 168.32 E-value: 4.66e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSISAFL 465
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEIRAR--------IAGG------------KFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECAL 525
Cdd:cd18056 81 YVGDKDSRAIIRENefsfednaIRGGkkasrmkkeasvKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 526 AKTLgTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFntpfaecgsASLTDEEElliINRLHHVIRP 605
Cdd:cd18056 161 FRVL-NGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEF---------ADIAKEDQ---IKKLHDMLGP 227
|
....*
gi 30687235 606 FLLRR 610
Cdd:cd18056 228 HMLRR 232
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
386-610 |
7.69e-47 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 167.94 E-value: 7.69e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLL-------ESKDLH-------------GPHLILAPKA 445
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVLgktgtrrDRENNRprfkkkppassakKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 446 VLPNWENEFALWApSISAFLYDGSKEKRtEIRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECAL 525
Cdd:cd18005 81 VLYNWKDELDTWG-HFEVGVYHGSRKDD-ELEGRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSKL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 526 AKTLGTgYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGSASLTDEEELLIINRLHHVI-- 603
Cdd:cd18005 159 TQAMKE-LKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAvk 237
|
....*...
gi 30687235 604 -RPFLLRR 610
Cdd:cd18005 238 lSKFFLRR 245
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
386-610 |
3.16e-45 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 162.51 E-value: 3.16e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIaYLLESKDLHGPHLILAPKAVLPNWENEFALWApSISAFL 465
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFL-YEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEIRA----------RIAGG--KFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgY 533
Cdd:cd18059 79 YHGSQASRRTIQLyemyfkdpqgRVIKGsyKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKM-M 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30687235 534 RIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFntpfaecgsASLTDEEElliINRLHHVIRPFLLRR 610
Cdd:cd18059 158 DLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEF---------GDLKTEEQ---VQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
386-610 |
1.27e-44 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 160.99 E-value: 1.27e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLeSKDLHGPHLILAPKAVLPNWENEFALWApSISAFL 465
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVY-NVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEI----------RARIAGG--KFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgY 533
Cdd:cd18060 79 YHGSLASRQMIqqyemyckdsRGRLIPGayKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKH-M 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30687235 534 RIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFntpfaecgsASLTDEEElliINRLHHVIRPFLLRR 610
Cdd:cd18060 158 DLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDF---------GDLKTEEQ---VQKLQAILKPMMLRR 222
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
386-610 |
6.06e-44 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 159.76 E-value: 6.06e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVS--LYNNDYNG---ILADEMGLGKTIQTIALIAYLLESKDLHGPH----LILAPKAVLPNWENEFAL 456
Cdd:cd18004 1 LRPHQREGVQFLYDclTGRRGYGGggaILADEMGLGKTLQAIALVWTLLKQGPYGKPTakkaLIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 457 WAPS--ISAFLYDGSKEKR-TEIRARIAGGKFNVLITHYDLIMR-DKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTg 532
Cdd:cd18004 81 WLGLrrIKVVTADGNAKDVkASLDFFSSASTYPVLIISYETLRRhAEKLSKKISIDLLICDEGHRLKNSESKTTKALNS- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 533 YRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGSASLTDEEELLIINRLHHVIR---PFLLR 609
Cdd:cd18004 160 LPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSEltsRFILR 239
|
.
gi 30687235 610 R 610
Cdd:cd18004 240 R 240
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
386-610 |
8.40e-43 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 156.29 E-value: 8.40e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSlynndYNGILADEMGLGKTIQTIALIA---------------YLLESKDLHGPH--LILAPKAVLP 448
Cdd:cd18008 1 LLPYQKQGLAWMLP-----RGGILADEMGLGKTIQALALILatrpqdpkipeeleeNSSDPKKLYLSKttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 449 NWENEFA--LWAPSISAFLYDGSKEKRTEIRARiaggKFNVLITHYDLIMRD----------------KAFLKKIDWNYM 510
Cdd:cd18008 76 QWKDEIEkhTKPGSLKVYVYHGSKRIKSIEELS----DYDIVITTYGTLASEfpknkkgggrdskekeASPLHRIRWYRV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 511 IVDEGHRLKNHECALAK---TLgtgyRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFaecgsasl 587
Cdd:cd18008 152 ILDEAHNIKNRSTKTSRavcAL----KAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPF-------- 219
|
250 260
....*....|....*....|...
gi 30687235 588 tDEEELLIINRLHHVIRPFLLRR 610
Cdd:cd18008 220 -SKNDRKALERLQALLKPILLRR 241
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
386-610 |
4.89e-39 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 144.76 E-value: 4.89e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESkDLHGPHLILAPKAVLPNWENEFALWApSISAFL 465
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLT-GIRGPFLIIAPLSTIANWEREFRTWT-DLNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 466 YDGSKEKRTEI----------RARIAGG--KFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTgY 533
Cdd:cd18061 79 YHGSLISRQMIqqyemyfrdsQGRIIRGayRFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKL-M 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30687235 534 RIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFntpfaecgsASLTDEEElliINRLHHVIRPFLLRR 610
Cdd:cd18061 158 NLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF---------GDLKTEEQ---VQKLQAILKPMMLRR 222
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
386-610 |
2.35e-35 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 134.59 E-value: 2.35e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQW-----MVSLYNNDYNGILADEMGLGKTIQTIALIAYLLE-----SKDLHGPHLILAPKAVLPNWENEFA 455
Cdd:cd18066 1 LRPHQREGIEFlyecvMGMRVNERFGAILADEMGLGKTLQCISLIWTLLRqgpygGKPVIKRALIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 456 LWAPS--ISAFLYDGSKEkrteIRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLgTGY 533
Cdd:cd18066 81 KWLGSerIKVFTVDQDHK----VEEFIASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTAL-TSL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 534 RIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGSASLTDEEELLIINR---LHHVIRPFLLRR 610
Cdd:cd18066 156 SCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARaaeLTRLTGLFILRR 235
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
386-594 |
1.15e-31 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 124.33 E-value: 1.15e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWM-----VSLYNNDYNG--ILADEMGLGKTIQTIALI-AYLLESKDLHGPhLILAPKAVLPNWENEFALW 457
Cdd:cd18007 1 LKPHQVEGVRFLwsnlvGTDVGSDEGGgcILAHTMGLGKTLQVITFLhTYLAAAPRRSRP-LVLCPASTLYNWEDEFKKW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 458 APSISAFLYDGSkEKRTEIRARIAGGKFN-------VLITHYDL--------------IMRDKAFLKKIDWNYMIVDEGH 516
Cdd:cd18007 80 LPPDLRPLLVLV-SLSASKRADARLRKINkwhkeggVLLIGYELfrnlasnattdprlKQEFIAALLDPGPDLLVLDEGH 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 517 RLKNHECALAKTLgTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAE--CGSASLTDEEELL 594
Cdd:cd18007 159 RLKNEKSQLSKAL-SKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAgqCVDSTEEDVRLML 237
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
386-610 |
4.05e-31 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 122.58 E-value: 4.05e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWM----VSLYNNDYNG-ILADEMGLGKTIQTIALIAYLL----ESKDLHGPHLILAPKAVLPNWENEFAL 456
Cdd:cd18067 1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMWTLLrqspQCKPEIDKAIVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 457 W-APSISAFLYDGSKEKRTEIR----ARIAGGKFN--VLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTL 529
Cdd:cd18067 81 WlGGRLQPLAIDGGSKKEIDRKlvqwASQQGRRVStpVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 530 gTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGSASLTDEEELLIINRLHHVI---RPF 606
Cdd:cd18067 161 -DSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELIsivNRC 239
|
....
gi 30687235 607 LLRR 610
Cdd:cd18067 240 IIRR 243
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
385-562 |
5.18e-31 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 121.06 E-value: 5.18e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 385 ELRSYQLEGLQWMVSLYNNdynGILADEMGLGKTIQTIALIAYLLeSKDLHGPHLILAP-KAVLPNWENEFALWAPS--- 460
Cdd:smart00487 8 PLRPYQKEAIEALLSGLRD---VILAAPTGSGKTLAALLPALEAL-KRGKGGRVLVLVPtRELAEQWAEELKKLGPSlgl 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 461 ISAFLYDGskEKRTEIRARIAGGKFNVLITHYDLIMRD--KAFLKKIDWNYMIVDEGHRLKN--HECALAKTLGTGYRIK 536
Cdd:smart00487 84 KVVGLYGG--DSKREQLRKLESGKTDILVTTPGRLLDLleNDKLSLSNVDLVILDEAHRLLDggFGDQLEKLLKLLPKNV 161
|
170 180
....*....|....*....|....*....
gi 30687235 537 RRLLLTGTP---IQNSLQELWSLLNFLLP 562
Cdd:smart00487 162 QLLLLSATPpeeIENLLELFLNDPVFIDV 190
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
386-610 |
1.66e-30 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 120.00 E-value: 1.66e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSlynndYNG--ILADEMGLGKTIQTIALIAYLLESkdlhGPHLILAPKAVLPNWENEFALWAPSISA 463
Cdd:cd18010 1 LLPFQREGVCFALR-----RGGrvLIADEMGLGKTVQAIAIAAYYREE----WPLLIVCPSSLRLTWADEIERWLPSLPP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 464 ---FLYDGSKEKRTEIRARIaggkfnvLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGT-GYRIKRRL 539
Cdd:cd18010 72 ddiQVIVKSKDGLRDGDAKV-------VIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPlLKRAKRVI 144
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30687235 540 LLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEE-----WFNTPFAECGSASLTDEEELLIINRlhhvirpFLLRR 610
Cdd:cd18010 145 LLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRrycaaKQGGFGWDYSGSSNLEELHLLLLAT-------IMIRR 213
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
695-809 |
1.26e-28 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 110.76 E-value: 1.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 695 GKFELLDRLLPKLKkaGHRILLFSQMTRLIDLlEIYLSLNDYMYLRLDGSTKTDQRGILLKQFNEPDSPyfmFLLSTRAG 774
Cdd:pfam00271 1 EKLEALLELLKKER--GGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKID---VLVATDVA 74
|
90 100 110
....*....|....*....|....*....|....*
gi 30687235 775 GLGLNLQTADTIIIFDSDWNPQMDQQAEDRAHRIG 809
Cdd:pfam00271 75 ERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
386-560 |
1.80e-27 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 112.18 E-value: 1.80e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNND-------------YN----------------GILADEMGLGKTIQTIALIaylleskdLHG 436
Cdd:cd18071 1 LLPHQKQALAWMVSRENSQdlppfweeavglfLNtitnfsqkkrpelvrgGILADDMGLGKTLTTISLI--------LAN 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 437 PHLILAPKAVLPNWENEFA--LWAPSISAFLYDGSKEKRTEIRAriagGKFNVLITHYDLIMRDKAF-----LKKIDWNY 509
Cdd:cd18071 73 FTLIVCPLSVLSNWETQFEehVKPGQLKVYTYHGGERNRDPKLL----SKYDIVLTTYNTLASDFGAkgdspLHTINWLR 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 30687235 510 MIVDEGHRLKNHECALAKTLgTGYRIKRRLLLTGTPIQNSLQELWSLLNFL 560
Cdd:cd18071 149 VVLDEGHQIRNPNAQQTKAV-LNLSSERRWVLTGTPIQNSPKDLGSLLSFL 198
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
386-589 |
1.97e-23 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 100.73 E-value: 1.97e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWM---------VSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPH--LILAPKAVLPNWENEF 454
Cdd:cd18068 1 LKPHQVDGVQFMwdccceslkKTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLLCEKLENFSrvLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 455 ALWAPSI----SAFLYDGSKEKRTEIRARIAGGKFN---VLITHYDLIM-----RDKAFLKKIDWNYM-----------I 511
Cdd:cd18068 81 EKWQEGLkdeeKIEVNELATYKRPQERSYKLQRWQEeggVMIIGYDMYRilaqeRNVKSREKLKEIFNkalvdpgpdfvV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 512 VDEGHRLKNHECALAKTLgTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPF--AECGSASLTD 589
Cdd:cd18068 161 CDEGHILKNEASAVSKAM-NSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIqnGQCADSTLVD 239
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
408-568 |
3.75e-23 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 98.52 E-value: 3.75e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 408 ILADEMGLGKTIQTIALIAYLLESkDLHGPHLILAPKAVLPNWENEfaLWA-PSISAFLYDGSKEKRTEIRARIAGGKFN 486
Cdd:cd18011 21 LLADEVGLGKTIEAGLIIKELLLR-GDAKRVLILCPASLVEQWQDE--LQDkFGLPFLILDRETAAQLRRLIGNPFEEFP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 487 VLITHYDLIMRDK---AFLKKIDWNYMIVDEGHRLKNHECA-------LAKTLGTgyRIKRRLLLTGTPIQNSLQELWSL 556
Cdd:cd18011 98 IVIVSLDLLKRSEerrGLLLSEEWDLVVVDEAHKLRNSGGGketkrykLGRLLAK--RARHVLLLTATPHNGKEEDFRAL 175
|
170
....*....|..
gi 30687235 557 LNFLLPHIFNSI 568
Cdd:cd18011 176 LSLLDPGRFAVL 187
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
386-578 |
1.43e-22 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 97.58 E-value: 1.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMvslYNN------DYNG------ILADEMGLGKTIQTIALIAYLLESKDLHGPhLILAPKAVLPNWENE 453
Cdd:cd18069 1 LKPHQIGGIRFL---YDNiiesleRYKGssgfgcILAHSMGLGKTLQVISFLDVLLRHTGAKTV-LAIVPVNTLQNWLSE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 454 FALWAPSISA------------FLYDGSKEKRTEIRA----RIAGGkfnVLITHYDLimrdkaFLKKIDWNYMIVDEGHR 517
Cdd:cd18069 77 FNKWLPPPEAlpnvrprpfkvfILNDEHKTTAARAKViedwVKDGG---VLLMGYEM------FRLRPGPDVVICDEGHR 147
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30687235 518 LKNHECALAKTLGTgYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTP 578
Cdd:cd18069 148 IKNCHASTSQALKN-IRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERP 207
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
386-610 |
1.19e-21 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 95.24 E-value: 1.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYN-NDYNGILADEMGLGKTIQTIALIAY--------------LLESKDLH--------GPHLILA 442
Cdd:cd18072 1 LLLHQKQALAWLLWRERqKPRGGILADDMGLGKTLTMIALILAqkntqnrkeeekekALTEWESKkdstlvpsAGTLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 443 PKAVLPNWENEFALWAPS--ISAFLYDG-SKEKRTEIRARiaggkFNVLITHYDLIMRDKAFLKK---------IDWNYM 510
Cdd:cd18072 81 PASLVHQWKNEVESRVASnkLRVCLYHGpNRERIGEVLRD-----YDIVITTYSLVAKEIPTYKEesrssplfrIAWARI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 511 IVDEGHRLKNH--ECALAKTlgtGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGsaslt 588
Cdd:cd18072 156 ILDEAHNIKNPkvQASIAVC---KLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQVDNKSRKGG----- 227
|
250 260
....*....|....*....|..
gi 30687235 589 deeelliiNRLHHVIRPFLLRR 610
Cdd:cd18072 228 --------ERLNILTKSLLLRR 241
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
725-809 |
2.51e-21 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 88.81 E-value: 2.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 725 DLLEIYLSLNDYMYLRLDGSTKTDQRGILLKQFNEPDSPyfmFLLSTRAGGLGLNLQTADTIIIFDSDWNPQMDQQAEDR 804
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIK---VLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77
|
....*
gi 30687235 805 AHRIG 809
Cdd:smart00490 78 AGRAG 82
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
386-560 |
5.04e-19 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 87.02 E-value: 5.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSlynNDYNGILADeMGLGKTIQTIALIAYLLESkDLHGPHLILAPKAVLPN-WENEFALWA--PSIS 462
Cdd:cd18013 1 PHPYQKVAINFIIE---HPYCGLFLD-MGLGKTVTTLTALSDLQLD-DFTRRVLVIAPLRVARStWPDEVEKWNhlRNLT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 463 AFLYDGSKEKRTeiraRIAGGKFNVLITHYDLIMR-DKAFLKKIDWNYMIVDEGHRLKNHECALAKTL-GTGYRIKRRLL 540
Cdd:cd18013 76 VSVAVGTERQRS----KAANTPADLYVINRENLKWlVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALrKVRPVIKRLIG 151
|
170 180
....*....|....*....|
gi 30687235 541 LTGTPIQNSLQELWSLLNFL 560
Cdd:cd18013 152 LTGTPSPNGLMDLWAQIALL 171
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
386-565 |
6.13e-18 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 84.70 E-value: 6.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLynndyNGILADEMGLGKTIQTIALI------------AYLLESKDLHGPH-------------LI 440
Cdd:cd18070 1 LLPYQRRAVNWMLVP-----GGILADEMGLGKTVEVLALIllhprpdndldaADDDSDEMVCCPDclvaetpvsskatLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 441 LAPKAVLPNWENEFALWAP-SISAFLYDGSKE---KRTEIRARIAggKFNVLITHYDLI--------------------- 495
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPsSLKVLTYQGVKKdgaLASPAPEILA--EYDIVVTTYDVLrtelhyaeanrsnrrrrrqkr 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30687235 496 -MRDKAFLKKIDWNYMIVDEGHRLknhECALAKTLGTGYRIKR--RLLLTGTPIQNSLQELWSLLNFLLPHIF 565
Cdd:cd18070 154 yEAPPSPLVLVEWWRVCLDEAQMV---ESSTSKAAEMARRLPRvnRWCVSGTPIQRGLDDLFGLLSFLGVEPF 223
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
386-545 |
4.75e-12 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 64.63 E-value: 4.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMVSLYNNDYnGILADEMGLGKTIQTIALIAYLLEskdlhGPHLILAPKAVLPN-WENEFALWAPSISAF 464
Cdd:cd17926 1 LRPYQEEALEAWLAHKNNRR-GILVLPTGSGKTLTALALIAYLKE-----LRTLIVVPTDALLDqWKERFEDFLGDSSIG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 465 LYDGSKEKRTEIRariaggkfNVLITHYDLIMRDKAFLKKI--DWNYMIVDEGHRLKnhecalAKTLG---TGYRIKRRL 539
Cdd:cd17926 75 LIGGGKKKDFDDA--------NVVVATYQSLSNLAEEEKDLfdQFGLLIVDEAHHLP------AKTFSeilKELNAKYRL 140
|
....*.
gi 30687235 540 LLTGTP 545
Cdd:cd17926 141 GLTATP 146
|
|
| SnAC |
pfam14619 |
Snf2-ATP coupling, chromatin remodelling complex; This domain appears to play a crucial role ... |
898-964 |
7.07e-12 |
|
Snf2-ATP coupling, chromatin remodelling complex; This domain appears to play a crucial role in chromatin remodelling for yeast SWI/SNF. It binds histones. It is required for mobilising nucleosomes and lies within the catalytic subunit of the yeast SWI/SNF. It is found to be universally conserved.
Pssm-ID: 464219 [Multi-domain] Cd Length: 69 Bit Score: 61.51 E-value: 7.07e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30687235 898 EQMDEERRKKENYKTRLMEEKEVPEWAYTSETQEDK----TNAKNHFGslTGKRKRKEAVYSDSLSDLQWM 964
Cdd:pfam14619 1 ERRREEAEQLPPLPSRLMEESELPEWYLKDDDEEKKedkeELDEQVYG--RGKRKRKEVSYSDGLTEEQWL 69
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
385-546 |
1.86e-08 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 54.60 E-value: 1.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 385 ELRSYQLEGLQ-WMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESkdLHGPH-LILAP-KAVLPNWENEFALWAPSi 461
Cdd:pfam04851 3 ELRPYQIEAIEnLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKK--GPIKKvLFLVPrKDLLEQALEEFKKFLPN- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 462 saflYDGSKEKRTEIRARIAGGKFNVLITHYDLIMRD--KAFLKKID--WNYMIVDEGHRL--KNHECALAKtlgtgYRI 535
Cdd:pfam04851 80 ----YVEIGEIISGDKKDESVDDNKIVVTTIQSLYKAleLASLELLPdfFDVIIIDEAHRSgaSSYRNILEY-----FKP 150
|
170
....*....|.
gi 30687235 536 KRRLLLTGTPI 546
Cdd:pfam04851 151 AFLLGLTATPE 161
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
405-544 |
1.94e-08 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 54.33 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 405 YNGILADEMGLGKTIqtIALIAYLLESKDLHGPHLILAP-KAVLPNWENEF-ALWAPSISAFLYDGSKEKrtEIRARIAG 482
Cdd:cd00046 2 ENVLITAPTGSGKTL--AALLAALLLLLKKGKKVLVLVPtKALALQTAERLrELFGPGIRVAVLVGGSSA--EEREKNKL 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30687235 483 GKFNVLITHYDLIMRDKAFLKKI---DWNYMIVDEGHR-LKNHECALAKTLGTGYRIK---RRLLLTGT 544
Cdd:cd00046 78 GDADIIIATPDMLLNLLLREDRLflkDLKLIIVDEAHAlLIDSRGALILDLAVRKAGLknaQVILLSAT 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
384-545 |
2.18e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 58.11 E-value: 2.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 384 GELRSYQLEGL-QWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLhgphLILAP-KAVLPNWENEFALWAPSI 461
Cdd:COG1061 79 FELRPYQQEALeALLAALERGGGRGLVVAPTGTGKTVLALALAAELLRGKRV----LVLVPrRELLEQWAEELRRFLGDP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 462 SAflYDGSKEKRteirariaggkFNVLITHYDLIMRdKAFLKKI--DWNYMIVDEGHRlknhecALAKTLGTG---YRIK 536
Cdd:COG1061 155 LA--GGGKKDSD-----------APITVATYQSLAR-RAHLDELgdRFGLVIIDEAHH------AGAPSYRRIleaFPAA 214
|
....*....
gi 30687235 537 RRLLLTGTP 545
Cdd:COG1061 215 YRLGLTATP 223
|
|
| DpdE |
NF041062 |
protein DpdE; |
409-573 |
6.36e-07 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 53.82 E-value: 6.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 409 LADEMGLGKTIQTIALI-AYLLESKDLHGphLILAPKAVLPNWenefalwapsisaflydgskekRTEIRARIAGGKF-- 485
Cdd:NF041062 175 LADEVGLGKTIEAGLVIrQHLLDNPDARV--LVLVPDALVRQW----------------------RRELRDKFFLDDFpg 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 486 -NVLITHYDLIMRDKAFLKKIDwnYMIVDEGHRLKNHECALAKTLGTGYR--------IKRRLLLTGTPIQNSLQELWSL 556
Cdd:NF041062 231 aRVRVLSHEEPERWEPLLDAPD--LLVVDEAHQLARLAWSGDPPERARYRelaalahaAPRLLLLSATPVLGNEETFLAL 308
|
170
....*....|....*....
gi 30687235 557 LNFLLPHIF--NSIHNFEE 573
Cdd:NF041062 309 LHLLDPDLYplDDLEAFRE 327
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
764-812 |
6.73e-05 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 42.31 E-value: 6.73e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 30687235 764 YFMFLLSTRAGGLGLNLQTADTIIIFDSDWNPQMDQQAEDRAHRIGQKK 812
Cdd:cd18785 22 SLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDE 70
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
700-810 |
1.85e-04 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 45.53 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 700 LDRLLPKLKKAGHRILLFSQMTRLIDLLEIYLSLNDYMYLRLDGSTKTDQRGILLKQFNEPDSPyfmFLLSTRAGGLGLN 779
Cdd:PTZ00110 366 LKMLLQRIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSP---IMIATDVASRGLD 442
|
90 100 110
....*....|....*....|....*....|.
gi 30687235 780 LQTADTIIIFDsdwnpqMDQQAEDRAHRIGQ 810
Cdd:PTZ00110 443 VKDVKYVINFD------FPNQIEDYVHRIGR 467
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
414-548 |
1.38e-03 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 40.69 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 414 GLGKTIqtIALIAYL--LESKDLHGPHLILAP-----KAVLPNWENEFALWAPSISAfLYDGSKekRTEIRARIAGGkfN 486
Cdd:pfam00270 24 GSGKTL--AFLLPALeaLDKLDNGPQALVLAPtrelaEQIYEELKKLGKGLGLKVAS-LLGGDS--RKEQLEKLKGP--D 96
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30687235 487 VLI-TH--YDLIMRDKAFLKKIdwNYMIVDEGHRL--KNHECALAKTLGTGYRIKRRLLLTGTPIQN 548
Cdd:pfam00270 97 ILVgTPgrLLDLLQERKLLKNL--KLLVLDEAHRLldMGFGPDLEEILRRLPKKRQILLLSATLPRN 161
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
742-836 |
1.95e-03 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 42.02 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 742 DGSTKTDQRGILlKQFNEPDspyFMFLLSTRAGGLGLNLQTADTIIIFDSDWNP-QMDQqaedRAHRIGQKKEVRVFVLV 820
Cdd:COG1111 393 KGLTQKEQIEIL-ERFRAGE---FNVLVATSVAEEGLDIPEVDLVIFYEPVPSEiRSIQ----RKGRTGRKREGRVVVLI 464
|
90
....*....|....*.
gi 30687235 821 SIGSIEEVILERAKQK 836
Cdd:COG1111 465 AKGTRDEAYYWSSRRK 480
|
|
| DEXHc_XPB |
cd18029 |
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ... |
386-544 |
5.54e-03 |
|
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350787 [Multi-domain] Cd Length: 169 Bit Score: 38.82 E-value: 5.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 386 LRSYQLEGLQWMvslYNNDY--NGILADEMGLGKTIQTIALIAYLLESKdlhgphLILAPKAV-LPNWENEFALWAP--- 459
Cdd:cd18029 9 LRPYQEKALSKM---FGNGRarSGVIVLPCGAGKTLVGITAACTIKKST------LVLCTSAVsVEQWRRQFLDWTTidd 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30687235 460 -SISAFlydgSKEKRTEIRARIaggkfnVLITHYDLIMRDKA----------FLKKIDWNYMIVDEGHRLKNHecALAKT 528
Cdd:cd18029 80 eQIGRF----TSDKKEIFPEAG------VTVSTYSMLANTRKrspesekfmeFITEREWGLIILDEVHVVPAP--MFRRV 147
|
170
....*....|....*.
gi 30687235 529 LGTgYRIKRRLLLTGT 544
Cdd:cd18029 148 LTL-QKAHCKLGLTAT 162
|
|
| |
