NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15239586|ref|NP_197387|]
View 

inosine-uridine preferring nucleoside hydrolase family protein [Arabidopsis thaliana]

Protein Classification

nucleoside hydrolase( domain architecture ID 10119093)

nucleoside hydrolase cleaves the N-glycosidic bond in nucleosides to generate ribose and the respective base, similar to Bacillus anthracis inosine-uridine preferring nucleoside hydrolase

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
nuc_hydro_TvIAG cd02647
nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring ...
 46-396 4.16e-82

nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. Nucleoside hydrolases vary in their substrate specificity. This group contains eukaryotic and bacterial proteins similar to the purine specific inosine-adenosine-guanosine-preferring nucleoside hydrolase (IAG-NH) from T. vivax. T. vivax IAG-NH is of the order of a thousand to ten thousand fold more specific towards the naturally occurring purine nucleosides, than towards the pyrimidine nucleosides.


:

Pssm-ID: 239113 [Multi-domain]  Cd Length: 312  Bit Score: 266.98  E-value: 4.16e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  46 FAILYLLKLnkSEFDLVGITLSAnAWTNAGH--AVNQVYDLLHMMD-RDDIPVGVGGEGGIsddgtihsdvgGYFPIIEQ 122
Cdd:cd02647  15 VALLLLLKN--EKVDLKGIGVSG-IDADCYVepAVSVTRKLIDRLGqRDAIPVGKGGSRAV-----------NPFPRSWR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 123 GMTTtgecryrqaipkglgglldidsnygFRKQFLPQGNRRY---TPLQQPTAQKVIVDKISEG--PTTVILLGSHTNFA 197
Cdd:cd02647  81 RDAA-------------------------FSVDHLPILNERYtveTPLAEETAQLVLIEKIKASlePVTLLVTGPLTNLA 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 198 LFLMSNPHLKHNIQHIYIMGGGVrsqnptgccpanstvaecqprqcGNRGNLFTdYTSNPYSEFNIFADPFAAYQVFHSG 277
Cdd:cd02647 136 RALDSDPDISSNIEEVYIMGGGV-----------------------DAPGNVFT-PPSNGTAEFNIFWDPLAAKTVFDSG 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 278 VPVTLVPLDATNTIPINQKFFETFENNYQ-----RTYEAQYVFLSLKIArdtwfddEFYKSYFMWDSFTAGVAVSiMRNS 352
Cdd:cd02647 192 LKITLVPLDATNTVPLTREFLETDRQRFAaqrlpASDLAGQGYALVKPL-------EFNSTYYMWDVLTTLVLGA-KEVD 263

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 15239586 353 ANKNNKNGENDFAEM-EYMNI--------TVVTSNKPYgrsdGSNPFFDNRRT 396
Cdd:cd02647 264 NTKESLILEVDTDGLsAGQTVtspngrplTLVTSNNSY----GSNRFFDDYLE 312
nuc_hydro_TvIAG cd02647
nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring ...
 509-867 4.96e-79

nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. Nucleoside hydrolases vary in their substrate specificity. This group contains eukaryotic and bacterial proteins similar to the purine specific inosine-adenosine-guanosine-preferring nucleoside hydrolase (IAG-NH) from T. vivax. T. vivax IAG-NH is of the order of a thousand to ten thousand fold more specific towards the naturally occurring purine nucleosides, than towards the pyrimidine nucleosides.


:

Pssm-ID: 239113 [Multi-domain]  Cd Length: 312  Bit Score: 258.50  E-value: 4.96e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 509 KPVVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIVSPtgwanaatidVVYDLLHmmgRDDIPVGLGDMLALNQSDpifpp 588
Cdd:cd02647   1 KNVIFDHDGNVDDLVALLLLLKNE--KVDLKGIGVSG----------IDADCYV---EPAVSVTRKLIDRLGQRD----- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 589 vggckyvkAIPRGCGGFLDSdtlyglaRDLPRSPRRYTAeNSVTHGaPRDTDRPELRQPLAIEVWQNL--TKSGNGVSKI 666
Cdd:cd02647  61 --------AIPVGKGGSRAV-------NPFPRSWRRDAA-FSVDHL-PILNERYTVETPLAEETAQLVliEKIKASLEPV 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 667 TVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINreksDKGNIFTIPSNAYAEFNMFLDPLAAKTVLESALNITLVPL 746
Cdd:cd02647 124 TLLVTGPLTNLARALDSDPDISSNIEEVYIMGGGVD----APGNVFTPPSNGTAEFNIFWDPLAAKTVFDSGLKITLVPL 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 747 ATQHKLSSFQTMLdrlysstKTPEARFVKRLLVRLQALHQKHRR---------YTHIDMFLGEVLGAvllggddaslkpk 817
Cdd:cd02647 200 DATNTVPLTREFL-------ETDRQRFAAQRLPASDLAGQGYALvkplefnstYYMWDVLTTLVLGA------------- 259

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15239586 818 mraehiKVIAEGDESRDGKILIDKL-RGKQIKI-----LERVDLISISES---FASRLD 867
Cdd:cd02647 260 ------KEVDNTKESLILEVDTDGLsAGQTVTSpngrpLTLVTSNNSYGSnrfFDDYLE 312
 
Name Accession Description Interval E-value
nuc_hydro_TvIAG cd02647
nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring ...
 46-396 4.16e-82

nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. Nucleoside hydrolases vary in their substrate specificity. This group contains eukaryotic and bacterial proteins similar to the purine specific inosine-adenosine-guanosine-preferring nucleoside hydrolase (IAG-NH) from T. vivax. T. vivax IAG-NH is of the order of a thousand to ten thousand fold more specific towards the naturally occurring purine nucleosides, than towards the pyrimidine nucleosides.


Pssm-ID: 239113 [Multi-domain]  Cd Length: 312  Bit Score: 266.98  E-value: 4.16e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  46 FAILYLLKLnkSEFDLVGITLSAnAWTNAGH--AVNQVYDLLHMMD-RDDIPVGVGGEGGIsddgtihsdvgGYFPIIEQ 122
Cdd:cd02647  15 VALLLLLKN--EKVDLKGIGVSG-IDADCYVepAVSVTRKLIDRLGqRDAIPVGKGGSRAV-----------NPFPRSWR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 123 GMTTtgecryrqaipkglgglldidsnygFRKQFLPQGNRRY---TPLQQPTAQKVIVDKISEG--PTTVILLGSHTNFA 197
Cdd:cd02647  81 RDAA-------------------------FSVDHLPILNERYtveTPLAEETAQLVLIEKIKASlePVTLLVTGPLTNLA 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 198 LFLMSNPHLKHNIQHIYIMGGGVrsqnptgccpanstvaecqprqcGNRGNLFTdYTSNPYSEFNIFADPFAAYQVFHSG 277
Cdd:cd02647 136 RALDSDPDISSNIEEVYIMGGGV-----------------------DAPGNVFT-PPSNGTAEFNIFWDPLAAKTVFDSG 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 278 VPVTLVPLDATNTIPINQKFFETFENNYQ-----RTYEAQYVFLSLKIArdtwfddEFYKSYFMWDSFTAGVAVSiMRNS 352
Cdd:cd02647 192 LKITLVPLDATNTVPLTREFLETDRQRFAaqrlpASDLAGQGYALVKPL-------EFNSTYYMWDVLTTLVLGA-KEVD 263

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 15239586 353 ANKNNKNGENDFAEM-EYMNI--------TVVTSNKPYgrsdGSNPFFDNRRT 396
Cdd:cd02647 264 NTKESLILEVDTDGLsAGQTVtspngrplTLVTSNNSY----GSNRFFDDYLE 312
nuc_hydro_TvIAG cd02647
nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring ...
 509-867 4.96e-79

nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. Nucleoside hydrolases vary in their substrate specificity. This group contains eukaryotic and bacterial proteins similar to the purine specific inosine-adenosine-guanosine-preferring nucleoside hydrolase (IAG-NH) from T. vivax. T. vivax IAG-NH is of the order of a thousand to ten thousand fold more specific towards the naturally occurring purine nucleosides, than towards the pyrimidine nucleosides.


Pssm-ID: 239113 [Multi-domain]  Cd Length: 312  Bit Score: 258.50  E-value: 4.96e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 509 KPVVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIVSPtgwanaatidVVYDLLHmmgRDDIPVGLGDMLALNQSDpifpp 588
Cdd:cd02647   1 KNVIFDHDGNVDDLVALLLLLKNE--KVDLKGIGVSG----------IDADCYV---EPAVSVTRKLIDRLGQRD----- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 589 vggckyvkAIPRGCGGFLDSdtlyglaRDLPRSPRRYTAeNSVTHGaPRDTDRPELRQPLAIEVWQNL--TKSGNGVSKI 666
Cdd:cd02647  61 --------AIPVGKGGSRAV-------NPFPRSWRRDAA-FSVDHL-PILNERYTVETPLAEETAQLVliEKIKASLEPV 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 667 TVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINreksDKGNIFTIPSNAYAEFNMFLDPLAAKTVLESALNITLVPL 746
Cdd:cd02647 124 TLLVTGPLTNLARALDSDPDISSNIEEVYIMGGGVD----APGNVFTPPSNGTAEFNIFWDPLAAKTVFDSGLKITLVPL 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 747 ATQHKLSSFQTMLdrlysstKTPEARFVKRLLVRLQALHQKHRR---------YTHIDMFLGEVLGAvllggddaslkpk 817
Cdd:cd02647 200 DATNTVPLTREFL-------ETDRQRFAAQRLPASDLAGQGYALvkplefnstYYMWDVLTTLVLGA------------- 259

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15239586 818 mraehiKVIAEGDESRDGKILIDKL-RGKQIKI-----LERVDLISISES---FASRLD 867
Cdd:cd02647 260 ------KEVDNTKESLILEVDTDGLsAGQTVTSpngrpLTLVTSNNSYGSnrfFDDYLE 312
URH1 COG1957
Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; ...
 46-384 1.82e-34

Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Inosine-uridine nucleoside N-ribohydrolase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441560 [Multi-domain]  Cd Length: 310  Bit Score: 134.13  E-value: 1.82e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  46 FAILYLLKLnkSEFDLVGITLSA-NawTNAGHAVNQVYDLLHMMDRDDIPVGVGGEGgisddgtihsdvggyfPIIEQGM 124
Cdd:COG1957  17 LALLLALAS--PEIDLLGITTVAgN--VPLEQTTRNALKLLELAGRTDVPVAAGAAR----------------PLVRPLV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 125 TTT---GECryrqaipkGLGGLldidsnygfrkqFLPQGNRrytPLQQPTAQKVIVDKI--SEGPTTVILLGSHTNFALF 199
Cdd:COG1957  77 TAEhvhGED--------GLGGV------------DLPEPTR---PPEPEHAVDFIIETLraAPGEVTLVALGPLTNLALA 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 200 LMSNPHLKHNIQHIYIMGGGVRSqnptgccpanstvaecqprqcgnRGNLftdytsNPYSEFNIFADPFAAYQVFHSGVP 279
Cdd:COG1957 134 LRKDPELAERIKRIVIMGGAFFV-----------------------PGNV------TPVAEFNIYVDPEAAKIVFASGIP 184

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 280 VTLVPLDATNTIPINQKFFETFENnyQRTYEAQYVFLSLKIARDTWFDDEFYKSYFMWDSFTAGVAVsimrnsanknnkn 359
Cdd:COG1957 185 ITMVGLDVTHQALLTPEDLARLAA--LGTPLGRFLADLLDFYLDFYRERYGLDGCPLHDPLAVAYLL------------- 249

                       330       340
                ....*....|....*....|....*.
gi 15239586 360 gENDFAEMEYMNITVVTSNKP-YGRS 384
Cdd:COG1957 250 -DPELFTTRPAPVDVETDGELtRGQT 274
IU_nuc_hydro pfam01156
Inosine-uridine preferring nucleoside hydrolase;
46-384 1.24e-29

Inosine-uridine preferring nucleoside hydrolase;


Pssm-ID: 460086 [Multi-domain]  Cd Length: 253  Bit Score: 118.46  E-value: 1.24e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586    46 FAILYLLKLNksEFDLVGITLSAnAWTNAGHAVNQVYDLLHMMDRDDIPVGVGgeggisddgtihsdvggyfpiieqgmt 125
Cdd:pfam01156  13 LALLLALASP--EIELLGITTVA-GNVSLEQTTRNALRLLELGGRDDIPVYAG--------------------------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   126 ttgecryrqaipkglgglldidsnygfrkqflpqgnrrytplqqptaqkvivDKISEGPT-TVILLGSHTNFALFLMSNP 204
Cdd:pfam01156  63 ----------------------------------------------------EAIREPGEvTLVATGPLTNLALALRLDP 90

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   205 HLKHNIQHIYIMGGGVrsqnptgccpanstvaecqprqcGNRGNlftdytSNPYSEFNIFADPFAAYQVFHSGVPVTLVP 284
Cdd:pfam01156  91 ELAKKIKELVIMGGAF-----------------------GVRGN------VTPAAEFNIFVDPEAAKIVFTSGLPITMVP 141

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   285 LDATNTIPINQKFFEtfennyqrTYEAQYVFLSLKIARDTWFDDEFYKSYF------MWDSFTAGVAVsimrnsanknnk 358
Cdd:pfam01156 142 LDVTHQALLTPEDLE--------RLAALGTPLGRFLADLLRFYAEFYRERFgidgppLHDPLAVAVAL------------ 201

                         330       340
                  ....*....|....*....|....*..
gi 15239586   359 ngENDFAEMEYMNITVVTSNKP-YGRS 384
Cdd:pfam01156 202 --DPELFTTRRLNVDVETTGGLtRGQT 226
IU_nuc_hydro pfam01156
Inosine-uridine preferring nucleoside hydrolase;
511-854 2.58e-24

Inosine-uridine preferring nucleoside hydrolase;


Pssm-ID: 460086 [Multi-domain]  Cd Length: 253  Bit Score: 103.06  E-value: 2.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   511 VVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIVSPtGWANAA-TIDVVYDLLHMMGRDDIPVGLGDMLalnqsdpifppv 589
Cdd:pfam01156   1 VIIDTDPGIDDALALLLALASP--EIELLGITTVA-GNVSLEqTTRNALRLLELGGRDDIPVYAGEAI------------ 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   590 ggckyvkaiprgcggfldsdtlyglardlprsprrytaensvthgaprdtdrpelRQPlaievwqnltksgngvSKITVL 669
Cdd:pfam01156  66 -------------------------------------------------------REP----------------GEVTLV 74

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   670 TNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINReksdKGNIftipsNAYAEFNMFLDPLAAKTVLESALNITLVPLATQ 749
Cdd:pfam01156  75 ATGPLTNLALALRLDPELAKKIKELVIMGGAFGV----RGNV-----TPAAEFNIFVDPEAAKIVFTSGLPITMVPLDVT 145

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   750 HKLSSFQTMLDRlYSSTKTPEARFVKRLLVRLQALHQKHRRYTHidMFLGEVLG-AVLLggdDASLKPKMRAeHIKVIAE 828
Cdd:pfam01156 146 HQALLTPEDLER-LAALGTPLGRFLADLLRFYAEFYRERFGIDG--PPLHDPLAvAVAL---DPELFTTRRL-NVDVETT 218

                         330       340       350
                  ....*....|....*....|....*....|
gi 15239586   829 GDESRdGKILID----KLRGKQIKILERVD 854
Cdd:pfam01156 219 GGLTR-GQTVVDdrggWGKPPNVRVATDVD 247
URH1 COG1957
Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; ...
 509-854 5.06e-23

Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Inosine-uridine nucleoside N-ribohydrolase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441560 [Multi-domain]  Cd Length: 310  Bit Score: 100.61  E-value: 5.06e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 509 KPVVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIVSP------TGWANAATIdvvydlLHMMGRDDIPVGLGDmlalnqS 582
Cdd:COG1957   3 RKVIIDTDPGIDDALALLLALASP--EIDLLGITTVAgnvpleQTTRNALKL------LELAGRTDVPVAAGA------A 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 583 DPIFPPVGGCKYVkaipRGCGGFLDSDtlyglardLPRSPRRYTAENsvthgaprdtdrpelrqplAIEVWQNLTKSGNG 662
Cdd:COG1957  69 RPLVRPLVTAEHV----HGEDGLGGVD--------LPEPTRPPEPEH-------------------AVDFIIETLRAAPG 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 663 vsKITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINReksdKGNIftipsNAYAEFNMFLDPLAAKTVLESALNIT 742
Cdd:COG1957 118 --EVTLVALGPLTNLALALRKDPELAERIKRIVIMGGAFFV----PGNV-----TPVAEFNIYVDPEAAKIVFASGIPIT 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 743 LVPL-AT-QHKLSsfQTMLDRLySSTKTPEARFVKRLLVRLQALHqkHRRYTHIDMFLGEVLGAVLLggddasLKP---K 817
Cdd:COG1957 187 MVGLdVThQALLT--PEDLARL-AALGTPLGRFLADLLDFYLDFY--RERYGLDGCPLHDPLAVAYL------LDPelfT 255

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 15239586 818 MRAEHIKVIAEGDESRdGKILIDKL----RGKQIKILERVD 854
Cdd:COG1957 256 TRPAPVDVETDGELTR-GQTVVDWRgvtgRPPNARVALDVD 295
PRK10768 PRK10768
ribonucleoside hydrolase RihC; Provisional
 181-303 5.26e-19

ribonucleoside hydrolase RihC; Provisional


Pssm-ID: 182713 [Multi-domain]  Cd Length: 304  Bit Score: 88.81  E-value: 5.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  181 SEGPTTVILLGSHTNFALFLMSNPHLKHNIQHIYIMGGGVrsqnptgccpanstvaecqprqcgNRGNLftdytsNPYSE 260
Cdd:PRK10768 114 APEPVTLVAIGPLTNIALLLSTYPEVKPYIKRIVLMGGSA------------------------GRGNV------TPNAE 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 15239586  261 FNIFADPFAAYQVFHSGVPVTLVPLDATNTIPINQKFFETFEN 303
Cdd:PRK10768 164 FNIAVDPEAAAIVFRSGIPIVMCGLDVTNQALLTPDYLATLPE 206
rihA PRK10443
ribonucleoside hydrolase 1; Provisional
 509-751 5.20e-09

ribonucleoside hydrolase 1; Provisional


Pssm-ID: 182465 [Multi-domain]  Cd Length: 311  Bit Score: 58.53  E-value: 5.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  509 KPVVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIVSPTGWANAATIDVVYDLLHMMGRDDIPVGLGdmlalnqsdpifpp 588
Cdd:PRK10443   3 LPIILDCDPGHDDAIALVLALASP--ELDVKAVTTSAGNQTPEKTLRNALRMLTLLNRTDIPVAGG-------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  589 vggckyvKAIPrgcggfldsdtlygLARDLprsprrYTAENsvTHGAPrDTDRPELRQP-------LAIEVW-QNLTKSG 660
Cdd:PRK10443  67 -------AVKP--------------LMREL------IIADN--VHGES-GLDGPALPEPtfapqncTAVELMaKTLRESA 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  661 ngvSKITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINreksdKGNifTIPSnayAEFNMFLDPLAAKTVLESALN 740
Cdd:PRK10443 117 ---EPVTLVSTGPQTNVALLLASHPELHSKIARIVIMGGAMG-----LGN--WTPA---AEFNIYVDPEAAEIVFQSGIP 183

                        250
                 ....*....|.
gi 15239586  741 ITLVPLATQHK 751
Cdd:PRK10443 184 IVMAGLDVTHK 194
 
Name Accession Description Interval E-value
nuc_hydro_TvIAG cd02647
nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring ...
 46-396 4.16e-82

nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. Nucleoside hydrolases vary in their substrate specificity. This group contains eukaryotic and bacterial proteins similar to the purine specific inosine-adenosine-guanosine-preferring nucleoside hydrolase (IAG-NH) from T. vivax. T. vivax IAG-NH is of the order of a thousand to ten thousand fold more specific towards the naturally occurring purine nucleosides, than towards the pyrimidine nucleosides.


Pssm-ID: 239113 [Multi-domain]  Cd Length: 312  Bit Score: 266.98  E-value: 4.16e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  46 FAILYLLKLnkSEFDLVGITLSAnAWTNAGH--AVNQVYDLLHMMD-RDDIPVGVGGEGGIsddgtihsdvgGYFPIIEQ 122
Cdd:cd02647  15 VALLLLLKN--EKVDLKGIGVSG-IDADCYVepAVSVTRKLIDRLGqRDAIPVGKGGSRAV-----------NPFPRSWR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 123 GMTTtgecryrqaipkglgglldidsnygFRKQFLPQGNRRY---TPLQQPTAQKVIVDKISEG--PTTVILLGSHTNFA 197
Cdd:cd02647  81 RDAA-------------------------FSVDHLPILNERYtveTPLAEETAQLVLIEKIKASlePVTLLVTGPLTNLA 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 198 LFLMSNPHLKHNIQHIYIMGGGVrsqnptgccpanstvaecqprqcGNRGNLFTdYTSNPYSEFNIFADPFAAYQVFHSG 277
Cdd:cd02647 136 RALDSDPDISSNIEEVYIMGGGV-----------------------DAPGNVFT-PPSNGTAEFNIFWDPLAAKTVFDSG 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 278 VPVTLVPLDATNTIPINQKFFETFENNYQ-----RTYEAQYVFLSLKIArdtwfddEFYKSYFMWDSFTAGVAVSiMRNS 352
Cdd:cd02647 192 LKITLVPLDATNTVPLTREFLETDRQRFAaqrlpASDLAGQGYALVKPL-------EFNSTYYMWDVLTTLVLGA-KEVD 263

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 15239586 353 ANKNNKNGENDFAEM-EYMNI--------TVVTSNKPYgrsdGSNPFFDNRRT 396
Cdd:cd02647 264 NTKESLILEVDTDGLsAGQTVtspngrplTLVTSNNSY----GSNRFFDDYLE 312
nuc_hydro_TvIAG cd02647
nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring ...
 509-867 4.96e-79

nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. Nucleoside hydrolases vary in their substrate specificity. This group contains eukaryotic and bacterial proteins similar to the purine specific inosine-adenosine-guanosine-preferring nucleoside hydrolase (IAG-NH) from T. vivax. T. vivax IAG-NH is of the order of a thousand to ten thousand fold more specific towards the naturally occurring purine nucleosides, than towards the pyrimidine nucleosides.


Pssm-ID: 239113 [Multi-domain]  Cd Length: 312  Bit Score: 258.50  E-value: 4.96e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 509 KPVVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIVSPtgwanaatidVVYDLLHmmgRDDIPVGLGDMLALNQSDpifpp 588
Cdd:cd02647   1 KNVIFDHDGNVDDLVALLLLLKNE--KVDLKGIGVSG----------IDADCYV---EPAVSVTRKLIDRLGQRD----- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 589 vggckyvkAIPRGCGGFLDSdtlyglaRDLPRSPRRYTAeNSVTHGaPRDTDRPELRQPLAIEVWQNL--TKSGNGVSKI 666
Cdd:cd02647  61 --------AIPVGKGGSRAV-------NPFPRSWRRDAA-FSVDHL-PILNERYTVETPLAEETAQLVliEKIKASLEPV 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 667 TVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINreksDKGNIFTIPSNAYAEFNMFLDPLAAKTVLESALNITLVPL 746
Cdd:cd02647 124 TLLVTGPLTNLARALDSDPDISSNIEEVYIMGGGVD----APGNVFTPPSNGTAEFNIFWDPLAAKTVFDSGLKITLVPL 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 747 ATQHKLSSFQTMLdrlysstKTPEARFVKRLLVRLQALHQKHRR---------YTHIDMFLGEVLGAvllggddaslkpk 817
Cdd:cd02647 200 DATNTVPLTREFL-------ETDRQRFAAQRLPASDLAGQGYALvkplefnstYYMWDVLTTLVLGA------------- 259

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15239586 818 mraehiKVIAEGDESRDGKILIDKL-RGKQIKI-----LERVDLISISES---FASRLD 867
Cdd:cd02647 260 ------KEVDNTKESLILEVDTDGLsAGQTVTSpngrpLTLVTSNNSYGSnrfFDDYLE 312
URH1 COG1957
Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; ...
 46-384 1.82e-34

Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Inosine-uridine nucleoside N-ribohydrolase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441560 [Multi-domain]  Cd Length: 310  Bit Score: 134.13  E-value: 1.82e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  46 FAILYLLKLnkSEFDLVGITLSA-NawTNAGHAVNQVYDLLHMMDRDDIPVGVGGEGgisddgtihsdvggyfPIIEQGM 124
Cdd:COG1957  17 LALLLALAS--PEIDLLGITTVAgN--VPLEQTTRNALKLLELAGRTDVPVAAGAAR----------------PLVRPLV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 125 TTT---GECryrqaipkGLGGLldidsnygfrkqFLPQGNRrytPLQQPTAQKVIVDKI--SEGPTTVILLGSHTNFALF 199
Cdd:COG1957  77 TAEhvhGED--------GLGGV------------DLPEPTR---PPEPEHAVDFIIETLraAPGEVTLVALGPLTNLALA 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 200 LMSNPHLKHNIQHIYIMGGGVRSqnptgccpanstvaecqprqcgnRGNLftdytsNPYSEFNIFADPFAAYQVFHSGVP 279
Cdd:COG1957 134 LRKDPELAERIKRIVIMGGAFFV-----------------------PGNV------TPVAEFNIYVDPEAAKIVFASGIP 184

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 280 VTLVPLDATNTIPINQKFFETFENnyQRTYEAQYVFLSLKIARDTWFDDEFYKSYFMWDSFTAGVAVsimrnsanknnkn 359
Cdd:COG1957 185 ITMVGLDVTHQALLTPEDLARLAA--LGTPLGRFLADLLDFYLDFYRERYGLDGCPLHDPLAVAYLL------------- 249

                       330       340
                ....*....|....*....|....*.
gi 15239586 360 gENDFAEMEYMNITVVTSNKP-YGRS 384
Cdd:COG1957 250 -DPELFTTRPAPVDVETDGELtRGQT 274
IU_nuc_hydro pfam01156
Inosine-uridine preferring nucleoside hydrolase;
46-384 1.24e-29

Inosine-uridine preferring nucleoside hydrolase;


Pssm-ID: 460086 [Multi-domain]  Cd Length: 253  Bit Score: 118.46  E-value: 1.24e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586    46 FAILYLLKLNksEFDLVGITLSAnAWTNAGHAVNQVYDLLHMMDRDDIPVGVGgeggisddgtihsdvggyfpiieqgmt 125
Cdd:pfam01156  13 LALLLALASP--EIELLGITTVA-GNVSLEQTTRNALRLLELGGRDDIPVYAG--------------------------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   126 ttgecryrqaipkglgglldidsnygfrkqflpqgnrrytplqqptaqkvivDKISEGPT-TVILLGSHTNFALFLMSNP 204
Cdd:pfam01156  63 ----------------------------------------------------EAIREPGEvTLVATGPLTNLALALRLDP 90

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   205 HLKHNIQHIYIMGGGVrsqnptgccpanstvaecqprqcGNRGNlftdytSNPYSEFNIFADPFAAYQVFHSGVPVTLVP 284
Cdd:pfam01156  91 ELAKKIKELVIMGGAF-----------------------GVRGN------VTPAAEFNIFVDPEAAKIVFTSGLPITMVP 141

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   285 LDATNTIPINQKFFEtfennyqrTYEAQYVFLSLKIARDTWFDDEFYKSYF------MWDSFTAGVAVsimrnsanknnk 358
Cdd:pfam01156 142 LDVTHQALLTPEDLE--------RLAALGTPLGRFLADLLRFYAEFYRERFgidgppLHDPLAVAVAL------------ 201

                         330       340
                  ....*....|....*....|....*..
gi 15239586   359 ngENDFAEMEYMNITVVTSNKP-YGRS 384
Cdd:pfam01156 202 --DPELFTTRRLNVDVETTGGLtRGQT 226
nuc_hydro_IU_UC_XIUA cd02651
nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, ...
 46-303 2.34e-25

nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains proteins similar to nucleoside hydrolases which hydrolyze both pyrimidine and purine ribonucleosides: the inosine-uridine preferring nucleoside hydrolase from Crithidia fasciculata, the inosine-uridine-xanthosine preferring nucleoside hydrolase RihC from Escherichia coli and the xanthosine-inosine-uridine-adenosine-preferring nucleoside hydrolase RihC from Salmonella enterica serovar Typhimurium. This group also contains proteins similar to the pyrimidine-specific uridine-cytidine preferring nucleoside hydrolases URH1 from Saccharomyces cerevisiae, E. coli RihA and E. coli RihB. E. coli RihA is equally efficient with uridine and cytidine, E. coli RihB prefers cytidine over uridine. S. cerevisiae URH1 prefers uridine over cytidine.


Pssm-ID: 239117 [Multi-domain]  Cd Length: 302  Bit Score: 107.25  E-value: 2.34e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  46 FAILylLKLNKSEFDLVGITLSANawtNAGHA--VNQVYDLLHMMDRDDIPVGVGGEggisddgtihsdvggyFPIIEQG 123
Cdd:cd02651  14 VAIL--LALFHPELDLLGITTVAG---NVPLEktTRNALKLLTLLGRTDVPVAAGAA----------------RPLVRPL 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 124 MTTT---GEcryrqaipKGLGGlldIDsnygfrkqfLPQGNRRytpLQQPTAQKVIVDKI--SEGPTTVILLGSHTNFAL 198
Cdd:cd02651  73 ITASdihGE--------SGLDG---AD---------LPPPPRR---PEDIHAVDAIIDTLraSPEPITLVATGPLTNIAL 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 199 FLMSNPHLKHNIQHIYIMGGGVrsqnptgccpanstvaecqprqcgNRGNLftdytsNPYSEFNIFADPFAAYQVFHSGV 278
Cdd:cd02651 130 LLRKYPELAERIKEIVLMGGAL------------------------GRGNI------TPAAEFNIFVDPEAAKIVFNSGI 179

                       250       260
                ....*....|....*....|....*
gi 15239586 279 PVTLVPLDATNTIPINQKFFETFEN 303
Cdd:cd02651 180 PITMVPLDVTHKALATPEVIERIRA 204
IU_nuc_hydro pfam01156
Inosine-uridine preferring nucleoside hydrolase;
511-854 2.58e-24

Inosine-uridine preferring nucleoside hydrolase;


Pssm-ID: 460086 [Multi-domain]  Cd Length: 253  Bit Score: 103.06  E-value: 2.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   511 VVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIVSPtGWANAA-TIDVVYDLLHMMGRDDIPVGLGDMLalnqsdpifppv 589
Cdd:pfam01156   1 VIIDTDPGIDDALALLLALASP--EIELLGITTVA-GNVSLEqTTRNALRLLELGGRDDIPVYAGEAI------------ 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   590 ggckyvkaiprgcggfldsdtlyglardlprsprrytaensvthgaprdtdrpelRQPlaievwqnltksgngvSKITVL 669
Cdd:pfam01156  66 -------------------------------------------------------REP----------------GEVTLV 74

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   670 TNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINReksdKGNIftipsNAYAEFNMFLDPLAAKTVLESALNITLVPLATQ 749
Cdd:pfam01156  75 ATGPLTNLALALRLDPELAKKIKELVIMGGAFGV----RGNV-----TPAAEFNIFVDPEAAKIVFTSGLPITMVPLDVT 145

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   750 HKLSSFQTMLDRlYSSTKTPEARFVKRLLVRLQALHQKHRRYTHidMFLGEVLG-AVLLggdDASLKPKMRAeHIKVIAE 828
Cdd:pfam01156 146 HQALLTPEDLER-LAALGTPLGRFLADLLRFYAEFYRERFGIDG--PPLHDPLAvAVAL---DPELFTTRRL-NVDVETT 218

                         330       340       350
                  ....*....|....*....|....*....|
gi 15239586   829 GDESRdGKILID----KLRGKQIKILERVD 854
Cdd:pfam01156 219 GGLTR-GQTVVDdrggWGKPPNVRVATDVD 247
URH1 COG1957
Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; ...
 509-854 5.06e-23

Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Inosine-uridine nucleoside N-ribohydrolase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441560 [Multi-domain]  Cd Length: 310  Bit Score: 100.61  E-value: 5.06e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 509 KPVVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIVSP------TGWANAATIdvvydlLHMMGRDDIPVGLGDmlalnqS 582
Cdd:COG1957   3 RKVIIDTDPGIDDALALLLALASP--EIDLLGITTVAgnvpleQTTRNALKL------LELAGRTDVPVAAGA------A 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 583 DPIFPPVGGCKYVkaipRGCGGFLDSDtlyglardLPRSPRRYTAENsvthgaprdtdrpelrqplAIEVWQNLTKSGNG 662
Cdd:COG1957  69 RPLVRPLVTAEHV----HGEDGLGGVD--------LPEPTRPPEPEH-------------------AVDFIIETLRAAPG 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 663 vsKITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINReksdKGNIftipsNAYAEFNMFLDPLAAKTVLESALNIT 742
Cdd:COG1957 118 --EVTLVALGPLTNLALALRKDPELAERIKRIVIMGGAFFV----PGNV-----TPVAEFNIYVDPEAAKIVFASGIPIT 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 743 LVPL-AT-QHKLSsfQTMLDRLySSTKTPEARFVKRLLVRLQALHqkHRRYTHIDMFLGEVLGAVLLggddasLKP---K 817
Cdd:COG1957 187 MVGLdVThQALLT--PEDLARL-AALGTPLGRFLADLLDFYLDFY--RERYGLDGCPLHDPLAVAYL------LDPelfT 255

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 15239586 818 MRAEHIKVIAEGDESRdGKILIDKL----RGKQIKILERVD 854
Cdd:COG1957 256 TRPAPVDVETDGELTR-GQTVVDWRgvtgRPPNARVALDVD 295
nuc_hydro cd00455
nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in ...
 46-398 1.01e-21

nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal proteins similar to the inosine-uridine preferring nucleoside hydrolase from Crithidia fasciculata, the xanthosine-inosine-uridine-adenosine-preferring nucleoside hydrolase RihC from Salmonella enterica serovar Typhimurium, the purine-specific inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax and, pyrimidine-specific uridine-cytidine preferring nucleoside hydrolases such as URH1 from Saccharomyces cerevisiae, RihA and RihB from Escherichia coli. Nucleoside hydrolases are of interest as a target for antiprotozoan drugs as, no nucleoside hydrolase activity or genes encoding these enzymes have been detected in humans and, parasitic protozoans lack de novo purine synthesis relying on nucleoside hydrolase to scavenge purine and/or pyrimidines from the environment.


Pssm-ID: 238257 [Multi-domain]  Cd Length: 295  Bit Score: 96.63  E-value: 1.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  46 FAILYLLKLNksEFDLVGITLSA-NawTNAGHAVNQVYDLLHMMDRDDIPVGVGGEggisddgtihsdvggyFPIIEqgm 124
Cdd:cd00455  13 FALMYALLHP--EIELVGIVATYgN--VTLEQATQNAAYLLELLGRLDIPVYAGAT----------------RPLTG--- 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 125 tttGECRYRQAIPKGLGGLLDIDSNYGFRKqflpqgnrrytplqqPTAQKVIVDKISEGP--TTVILLGSHTNFALFLMS 202
Cdd:cd00455  70 ---EIPAAYPEIHGEGGLGLPIPPIIEADD---------------PEAVQLLIDLIRKYPdeITIVALGPLTNLAMAFIL 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 203 NPHLKHNIQHIYIMGGGVrsqnptgccpanstvaecqprqcGNRGNLFtdytsnPYSEFNIFADPFAAYQVFHSGVPVTL 282
Cdd:cd00455 132 DPDIKDRVKEIVIMGGAF-----------------------LVPGNVT------PVAEANFYGDPEAANIVFNSAKNLTI 182

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 283 VPLDATNTIPInqkffetfENNYQRTYEAQYVFLSLKIARdtwFDDEFYKSYF--------MWDSFTAGVAVsimrnsan 354
Cdd:cd00455 183 VPLDVTNQAVL--------TPPMVERIFEQGTSIGLLIKP---MIDYYYKAYQkpgiegspIHDPLAVAYLL-------- 243

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 15239586 355 knnkngENDFAEMEYMNITVVTSNKPYGRSdgsnpFFDNRRTPK 398
Cdd:cd00455 244 ------NPSMFDYSKVPVDVDTDGLTRGQT-----IADFRENPG 276
PRK10768 PRK10768
ribonucleoside hydrolase RihC; Provisional
 181-303 5.26e-19

ribonucleoside hydrolase RihC; Provisional


Pssm-ID: 182713 [Multi-domain]  Cd Length: 304  Bit Score: 88.81  E-value: 5.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  181 SEGPTTVILLGSHTNFALFLMSNPHLKHNIQHIYIMGGGVrsqnptgccpanstvaecqprqcgNRGNLftdytsNPYSE 260
Cdd:PRK10768 114 APEPVTLVAIGPLTNIALLLSTYPEVKPYIKRIVLMGGSA------------------------GRGNV------TPNAE 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 15239586  261 FNIFADPFAAYQVFHSGVPVTLVPLDATNTIPINQKFFETFEN 303
Cdd:PRK10768 164 FNIAVDPEAAAIVFRSGIPIVMCGLDVTNQALLTPDYLATLPE 206
rihA PRK10443
ribonucleoside hydrolase 1; Provisional
 47-288 1.52e-18

ribonucleoside hydrolase 1; Provisional


Pssm-ID: 182465 [Multi-domain]  Cd Length: 311  Bit Score: 87.42  E-value: 1.52e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   47 AILYLLKLNKSEFDLVGITLSANAWTnAGHAVNQVYDLLHMMDRDDIPVGVGGEGGISDDGTIHSDVGGyfpiiEQGMTT 126
Cdd:PRK10443  16 AIALVLALASPELDVKAVTTSAGNQT-PEKTLRNALRMLTLLNRTDIPVAGGAVKPLMRELIIADNVHG-----ESGLDG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  127 TgecryrqAIPKglgglldidsnygfrKQFLPQGNrrytplqqpTAQKVIVDKISEGPTTVILL--GSHTNFALFLMSNP 204
Cdd:PRK10443  90 P-------ALPE---------------PTFAPQNC---------TAVELMAKTLRESAEPVTLVstGPQTNVALLLASHP 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  205 HLKHNIQHIYIMGGGVRSQNPTgccpanstvaecqprqcgnrgnlftdytsnPYSEFNIFADPFAAYQVFHSGVPVTLVP 284
Cdd:PRK10443 139 ELHSKIARIVIMGGAMGLGNWT------------------------------PAAEFNIYVDPEAAEIVFQSGIPIVMAG 188


                 ....
gi 15239586  285 LDAT 288
Cdd:PRK10443 189 LDVT 192
nuc_hydro cd00455
nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in ...
 511-750 9.83e-17

nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal proteins similar to the inosine-uridine preferring nucleoside hydrolase from Crithidia fasciculata, the xanthosine-inosine-uridine-adenosine-preferring nucleoside hydrolase RihC from Salmonella enterica serovar Typhimurium, the purine-specific inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax and, pyrimidine-specific uridine-cytidine preferring nucleoside hydrolases such as URH1 from Saccharomyces cerevisiae, RihA and RihB from Escherichia coli. Nucleoside hydrolases are of interest as a target for antiprotozoan drugs as, no nucleoside hydrolase activity or genes encoding these enzymes have been detected in humans and, parasitic protozoans lack de novo purine synthesis relying on nucleoside hydrolase to scavenge purine and/or pyrimidines from the environment.


Pssm-ID: 238257 [Multi-domain]  Cd Length: 295  Bit Score: 81.61  E-value: 9.83e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 511 VVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIvspTGWANA----ATIDVVYdLLHMMGRDDIPVGLGDMLALNQSDPIF 586
Cdd:cd00455   1 VILDTDPGIDDAFALMYALLHP--EIELVGIV---ATYGNVtleqATQNAAY-LLELLGRLDIPVYAGATRPLTGEIPAA 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 587 PPVGGCKYVKAIPrgcggfldsdtlyglardlprSPRRYTAENsvthgaprdtdrpelrqPLAIEVWQNLTKSGNGvsKI 666
Cdd:cd00455  75 YPEIHGEGGLGLP---------------------IPPIIEADD-----------------PEAVQLLIDLIRKYPD--EI 114

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 667 TVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHinreksdkgniFTIPSNAY--AEFNMFLDPLAAKTVLESALNITLV 744
Cdd:cd00455 115 TIVALGPLTNLAMAFILDPDIKDRVKEIVIMGGA-----------FLVPGNVTpvAEANFYGDPEAANIVFNSAKNLTIV 183


                ....*..
gi 15239586 745 PL-ATQH 750
Cdd:cd00455 184 PLdVTNQ 190
nuc_hydro_CeIAG cd02649
nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring ...
 509-745 1.49e-13

nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal proteins similar to the purine-preferring nucleoside hydrolase (IAG-NH) from C. elegans and the salivary purine nucleosidase from Aedes aegypti. C. elegans IAG-NH exhibits a high affinity for the substrate analogue p-nitrophenylriboside (p-NPR).


Pssm-ID: 239115 [Multi-domain]  Cd Length: 306  Bit Score: 72.29  E-value: 1.49e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 509 KPVVFDMDMSAGDFLSLFYLLKVPvdKIDLKAI-IVsptgWANAATIDVVYD---LLHMMGRDDIPVGLGdmlalnQSDP 584
Cdd:cd02649   1 RKLIIDTDCGGDDAWALLMALASP--NVEVLAItCV----HGNTNVEQVVKNalrVLEACGRRDIPVYRG------ASKP 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 585 IFPPVGGCKYVkaipRGCGGFLDSDtlyglardLPRSPRRYTAENsvTHGAprdtdrpelrqpLAIevwQNLTKSGNGVs 664
Cdd:cd02649  69 LLGPGPTAAYF----HGKDGFGDVG--------FPEPKDELELQK--EHAV------------DAI---IRLVREYPGE- 118

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 665 kITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGhiNREKsdKGNIftipsNAYAEFNMFLDPLAAKTVLESA-LNITL 743
Cdd:cd02649 119 -ITLVALGPLTNLALAYRLDPSLPQKIKRLYIMGG--NREG--VGNT-----TPAAEFNFHVDPEAAHIVLNSFgCPITI 188


                ..
gi 15239586 744 VP 745
Cdd:cd02649 189 VP 190
nuc_hydro_CeIAG cd02649
nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring ...
 46-325 2.59e-13

nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal proteins similar to the purine-preferring nucleoside hydrolase (IAG-NH) from C. elegans and the salivary purine nucleosidase from Aedes aegypti. C. elegans IAG-NH exhibits a high affinity for the substrate analogue p-nitrophenylriboside (p-NPR).


Pssm-ID: 239115 [Multi-domain]  Cd Length: 306  Bit Score: 71.52  E-value: 2.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  46 FAILYLLKLNKseFDLVGITLSA-NawTNAGHAVNQVYDLLHMMDRDDIPVGVGGEGgisddgtihsdvggyfPIIEQGM 124
Cdd:cd02649  15 WALLMALASPN--VEVLAITCVHgN--TNVEQVVKNALRVLEACGRRDIPVYRGASK----------------PLLGPGP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 125 TTT---GEcryrqaipKGLGglldiDSNYGFRKQFLPqgnrrytpLQQPTAQKVIVDKISEGP--TTVILLGSHTNFALF 199
Cdd:cd02649  75 TAAyfhGK--------DGFG-----DVGFPEPKDELE--------LQKEHAVDAIIRLVREYPgeITLVALGPLTNLALA 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 200 LMSNPHLKHNIQHIYIMGGgvrsqNPTGccpanstvaecqprqcgnRGNlftdytSNPYSEFNIFADPFAAYQVFHS-GV 278
Cdd:cd02649 134 YRLDPSLPQKIKRLYIMGG-----NREG------------------VGN------TTPAAEFNFHVDPEAAHIVLNSfGC 184

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 15239586 279 PVTLVPLDAT-NTIPINQKFFE--TFENNYQRTYEA----QYVFLSLKIARDTW 325
Cdd:cd02649 185 PITIVPWETTlLAFPLDWEFEDkwANRLEKALFAESlnrrEYAFASEGLGGDGW 238
nuc_hydro_CaPnhB cd02650
NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes ...
 46-289 1.75e-12

NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.


Pssm-ID: 239116 [Multi-domain]  Cd Length: 304  Bit Score: 69.23  E-value: 1.75e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  46 FAILYLLKlnKSEFDLVGITLS-ANAWTNAGhAVNQVYdLLHMMDRDDIPVGVGGEGGISDDGT-----IHSDvggyfpi 119
Cdd:cd02650  14 MALAYALA--HPDVDLIGVTTVyGNVTIETA-TRNALA-LLELFGRPDVPVAEGAAKPLTRPPFriatfVHGD------- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 120 ieqgmtttgecryrqaipKGLGGLldidsnygfrkqFLPQGNRRytPLQQPTAQkVIVDKISEGP--TTVILLGSHTNFA 197
Cdd:cd02650  83 ------------------NGLGDV------------ELPAPPRQ--PEDESAAD-FLIELANEYPgeLTLVAVGPLTNLA 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 198 LFLMSNPHLKHNIQHIYIMGGGVRSqnptgccpanstvaecqprqcgnRGNLftdytsNPYSEFNIFADPFAAYQVFHSG 277
Cdd:cd02650 130 LALARDPDFAKLVKQVVVMGGAFTV-----------------------PGNV------TPAAEANIHGDPEAADIVFTAG 180

                       250
                ....*....|..
gi 15239586 278 VPVTLVPLDATN 289
Cdd:cd02650 181 ADLTMVGLDVTT 192
nuc_hydro_IU_UC_XIUA cd02651
nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, ...
 638-778 4.72e-12

nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains proteins similar to nucleoside hydrolases which hydrolyze both pyrimidine and purine ribonucleosides: the inosine-uridine preferring nucleoside hydrolase from Crithidia fasciculata, the inosine-uridine-xanthosine preferring nucleoside hydrolase RihC from Escherichia coli and the xanthosine-inosine-uridine-adenosine-preferring nucleoside hydrolase RihC from Salmonella enterica serovar Typhimurium. This group also contains proteins similar to the pyrimidine-specific uridine-cytidine preferring nucleoside hydrolases URH1 from Saccharomyces cerevisiae, E. coli RihA and E. coli RihB. E. coli RihA is equally efficient with uridine and cytidine, E. coli RihB prefers cytidine over uridine. S. cerevisiae URH1 prefers uridine over cytidine.


Pssm-ID: 239117 [Multi-domain]  Cd Length: 302  Bit Score: 67.96  E-value: 4.72e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 638 DTDRPELRQPlAIEVWQNLTKSGNGvsKITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINReksdkGNIftipsN 717
Cdd:cd02651  91 PPPRRPEDIH-AVDAIIDTLRASPE--PITLVATGPLTNIALLLRKYPELAERIKEIVLMGGALGR-----GNI-----T 157

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15239586 718 AYAEFNMFLDPLAAKTVLESALNITLVPLATQHKLSSFQTMLDRLYSSTKtPEARFVKRLL 778
Cdd:cd02651 158 PAAEFNIFVDPEAAKIVFNSGIPITMVPLDVTHKALATPEVIERIRALGN-PVGKMLAELL 217
PLN02717 PLN02717
uridine nucleosidase
 46-288 1.98e-11

uridine nucleosidase


Pssm-ID: 178319 [Multi-domain]  Cd Length: 316  Bit Score: 66.17  E-value: 1.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586   46 FAILylLKLNKSEFDLVGIT-LSANAWT-----NAGHavnqvydLLHMMDRDDIPVGvggeggisdDGTIHSDVGGYFPI 119
Cdd:PLN02717  15 MAIL--MALRSPEVEVIGLTtIFGNVTTklatrNALH-------LLEMAGRPDVPVA---------EGSHEPLKGGTKPR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  120 IeqgmtttgecryrQAIPKGLGGLLDIdsnygfrkqFLPQgnrrytPLQQP---TAQKVIVDKISEGP--TTVILLGSHT 194
Cdd:PLN02717  77 I-------------ADFVHGSDGLGNT---------NLPP------PKGKKiekSAAEFLVEKVSEYPgeVTVVALGPLT 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  195 NFALFLMSNPHLKHNIQHIYIMGGGVRSQnptgccpanstvaecqprqcgnrGNLftdytsNPYSEFNIFADPFAAYQVF 274
Cdd:PLN02717 129 NLALAIKLDPSFAKKVGQIVVLGGAFFVN-----------------------GNV------NPAAEANIFGDPEAADIVF 179

                        250
                 ....*....|....
gi 15239586  275 HSGVPVTLVPLDAT 288
Cdd:PLN02717 180 TSGADITVVGINVT 193
nuc_hydro_1 cd02648
NH_1: A subgroup of nucleoside hydrolases. This group contains fungal proteins similar to ...
 51-299 7.81e-11

NH_1: A subgroup of nucleoside hydrolases. This group contains fungal proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.


Pssm-ID: 239114 [Multi-domain]  Cd Length: 367  Bit Score: 64.91  E-value: 7.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  51 LLKLNKS-EFDLVGITLS-ANawTNAGHAVNQVYDLLHMMDRDDI-PVGVGGEGGisddGTIHSDVGgyfPIIEQGMTTT 127
Cdd:cd02648  19 LLALSSPeEVDVALISLTfGN--TTLDHALRNVLRLFHVLERERAwRATPGVRYR----AFSADAEK---PIVASGSDQP 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 128 -GECRYRQAI---PKGLGGLLDIDSNYGFRKQFLPQGNRRYTPLQQPTAQkVIVDKISEGP---TTVILLGSHTNFALFL 200
Cdd:cd02648  90 lEGERLTASYfhgRDGLSGVHWLHPDFTPVETWIPEIVAPLTPSDKPAYD-VILDILREEPdhtVTIAALGPLTNLAAAA 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 201 MSNPHLKHNIQHIYIMGGGVRsqnptgcCPANSTvaecqprqcgnrgnlftdytsnPYSEFNIFADPFAAYQVF------ 274
Cdd:cd02648 169 RKDPETFAKVGEVVVMGGAID-------VPGNTS----------------------PVAEFNCFADPYAAAVVIdeppst 219

                       250       260       270
                ....*....|....*....|....*....|.
gi 15239586 275 ----HSGVPVTLVPLDAT--NTIPINQKFFE 299
Cdd:cd02648 220 apeaRRKLPLQVFPLDITtgHTLPYSSLFAT 250
rihB PRK09955
ribosylpyrimidine nucleosidase;
172-289 1.14e-09

ribosylpyrimidine nucleosidase;


Pssm-ID: 182166 [Multi-domain]  Cd Length: 313  Bit Score: 60.73  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  172 AQKVIVDKI--SEGPTTVILLGSHTNFALFLMSNPHLKHNIQHIYIMGGGVRSQNptgccpanstvaecqprqcgnrgnl 249
Cdd:PRK09955 104 AVKYIIDTLmaSDGDITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYGTGN------------------------- 158

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 15239586  250 FTdytsnPYSEFNIFADPFAAYQVFHSGVPVTLVPLDATN 289
Cdd:PRK09955 159 FT-----PSAEFNIFADPEAARVVFTSGVPLVMMGLDLTN 193
rihA PRK10443
ribonucleoside hydrolase 1; Provisional
 509-751 5.20e-09

ribonucleoside hydrolase 1; Provisional


Pssm-ID: 182465 [Multi-domain]  Cd Length: 311  Bit Score: 58.53  E-value: 5.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  509 KPVVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIVSPTGWANAATIDVVYDLLHMMGRDDIPVGLGdmlalnqsdpifpp 588
Cdd:PRK10443   3 LPIILDCDPGHDDAIALVLALASP--ELDVKAVTTSAGNQTPEKTLRNALRMLTLLNRTDIPVAGG-------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  589 vggckyvKAIPrgcggfldsdtlygLARDLprsprrYTAENsvTHGAPrDTDRPELRQP-------LAIEVW-QNLTKSG 660
Cdd:PRK10443  67 -------AVKP--------------LMREL------IIADN--VHGES-GLDGPALPEPtfapqncTAVELMaKTLRESA 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  661 ngvSKITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINreksdKGNifTIPSnayAEFNMFLDPLAAKTVLESALN 740
Cdd:PRK10443 117 ---EPVTLVSTGPQTNVALLLASHPELHSKIARIVIMGGAMG-----LGN--WTPA---AEFNIYVDPEAAEIVFQSGIP 183

                        250
                 ....*....|.
gi 15239586  741 ITLVPLATQHK 751
Cdd:PRK10443 184 IVMAGLDVTHK 194
nuc_hydro_3 cd02653
NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial ...
 510-750 1.55e-08

NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.


Pssm-ID: 239119 [Multi-domain]  Cd Length: 320  Bit Score: 57.39  E-value: 1.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 510 PVVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIVSPtgwANAATIDVVYD---LLHMMGRDDIPVGLGDMLALNQSDPIF 586
Cdd:cd02653   1 KVIIDCDPGIDDALALLYLLASP--DLDVVGITTTA---GNVPVEQVAANalgVLELLGRTDIPVYLGADKPLAGPLTTA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 587 PPVGGckyvkaiPRGCGgfldsdtlYGlarDLPRSPRRYTAENSVThgaprdtdrpelrqplaieVWQNLTKSGNgvsKI 666
Cdd:cd02653  76 QDTHG-------PDGLG--------YA---ELPASTRTLSDESAAQ-------------------AWVDLARAHP---DL 115

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 667 TVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINREksdkGNifTIPSnayAEFNMFLDPLAAKTVLE----SALNIT 742
Cdd:cd02653 116 IGLATGPLTNLALALREEPELPRLLRRLVIMGGAFNSR----GN--TSPV---AEWNYWVDPEAAKEVLAafggHPVRPT 186


                ....*....
gi 15239586 743 LVPL-ATQH 750
Cdd:cd02653 187 ICGLdVTRA 195
nuc_hydro_CaPnhB cd02650
NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes ...
 511-778 3.93e-08

NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.


Pssm-ID: 239116 [Multi-domain]  Cd Length: 304  Bit Score: 55.75  E-value: 3.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 511 VVFDMDMSAGDFLSLFYLLKVPvdKIDLKAIIvspTGWANA----ATIDVVYdLLHMMGRDDIPVGLGdmlalnqsdpif 586
Cdd:cd02650   2 LILDTDPGIDDAMALAYALAHP--DVDLIGVT---TVYGNVtietATRNALA-LLELFGRPDVPVAEG------------ 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 587 ppvggckyvKAIPrgcggfldsdtlygLARDLPRSPRRYTAENSVTH-GAPRDTDRPELRQplAIEVWQNLTKSGNGvsK 665
Cdd:cd02650  64 ---------AAKP--------------LTRPPFRIATFVHGDNGLGDvELPAPPRQPEDES--AADFLIELANEYPG--E 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 666 ITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGhinreksdkgnIFTIPSNA--YAEFNMFLDPLAAKTVLESALNITL 743
Cdd:cd02650 117 LTLVAVGPLTNLALALARDPDFAKLVKQVVVMGG-----------AFTVPGNVtpAAEANIHGDPEAADIVFTAGADLTM 185

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 15239586 744 VPLATQHklssfQTMLDRLY----SSTKTPEARFVKRLL 778
Cdd:cd02650 186 VGLDVTT-----QTLLTREDldelRDSGGKAGQFLADML 219
PRK10768 PRK10768
ribonucleoside hydrolase RihC; Provisional
 645-746 1.14e-07

ribonucleoside hydrolase RihC; Provisional


Pssm-ID: 182713 [Multi-domain]  Cd Length: 304  Bit Score: 54.53  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  645 RQPL---AIEVWQN-LTKSgngVSKITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINReksdkGNIftipsNAYA 720
Cdd:PRK10768  96 RKPLsipAVEAMRDaLMNA---PEPVTLVAIGPLTNIALLLSTYPEVKPYIKRIVLMGGSAGR-----GNV-----TPNA 162

                         90       100
                 ....*....|....*....|....*.
gi 15239586  721 EFNMFLDPLAAKTVLESALNITLVPL 746
Cdd:PRK10768 163 EFNIAVDPEAAAIVFRSGIPIVMCGL 188
PTZ00313 PTZ00313
inosine-adenosine-guanosine-nucleoside hydrolase; Provisional
 507-736 9.10e-07

inosine-adenosine-guanosine-nucleoside hydrolase; Provisional


Pssm-ID: 140334 [Multi-domain]  Cd Length: 326  Bit Score: 51.79  E-value: 9.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  507 PGKPVVFDMDMSAGDFLSLFYLLKVPvDKIDLKAIIVSPTGWANAATIDVVYDLLHMMGRddipvglgdmlalNQSDPIF 586
Cdd:PTZ00313   1 MPKPVILDHDGNHDDLVALALLLGNP-EKVKVIGCICTDADCFVDDAFNVTGKLMCMMHA-------------REATPLF 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  587 P-PVGGCKYVKAIP---RGCGGFLDsdtlyglarDLPrsprrytAENSVTHGAPRDTDRPELRQPLAIEVWQNLTKSGNg 662
Cdd:PTZ00313  67 PiGKSSFKGVNPFPsewRWSAKNMD---------DLP-------CLNIPEHVAIWEKLKPENEALVGEELLADLVMSSP- 129

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15239586  663 vSKITVLTNGPLTNLA-KIISSDKKSSSLIKEVYIVGGHINReksdKGNIFTIPSNAYAEFNMFLDPLAAKTVLE 736
Cdd:PTZ00313 130 -EKVTICVTGPLSNVAwCIEKYGEEFTKKVEECVIMGGAVDV----GGNVFLPGTDGSAEWNIYWDPPAAKTVLM 199
PLN02717 PLN02717
uridine nucleosidase
 665-798 6.85e-06

uridine nucleosidase


Pssm-ID: 178319 [Multi-domain]  Cd Length: 316  Bit Score: 48.84  E-value: 6.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  665 KITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINReksdKGNIftipsNAYAEFNMFLDPLAAKTVLESALNITLV 744
Cdd:PLN02717 118 EVTVVALGPLTNLALAIKLDPSFAKKVGQIVVLGGAFFV----NGNV-----NPAAEANIFGDPEAADIVFTSGADITVV 188

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15239586  745 PL--ATQHKLSSFQtmLDRLYSStKTPEARFVKRLlvrLQALHQKHRRYTHID-MFL 798
Cdd:PLN02717 189 GInvTTQVVLTDAD--LEELRDS-KGKYAQFLCDI---CKFYRDWHRKSYGIDgIYL 239
nuc_hydro_1 cd02648
NH_1: A subgroup of nucleoside hydrolases. This group contains fungal proteins similar to ...
 510-800 1.45e-05

NH_1: A subgroup of nucleoside hydrolases. This group contains fungal proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.


Pssm-ID: 239114 [Multi-domain]  Cd Length: 367  Bit Score: 48.34  E-value: 1.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 510 PVVFDMDMSAGDFLSLFYLLKVPvDKIDLKAIIVS------PTGWANAATIdvvYDLL--HMMGRDDIPVGLGDMLALNQ 581
Cdd:cd02648   3 PIIIDTDPGVDDVLAILLALSSP-EEVDVALISLTfgnttlDHALRNVLRL---FHVLerERAWRATPGVRYRAFSADAE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 582 SdPIFP-----PVGGCKYVKAIprgcggFLDSDTLYGLARDLPR-SPRRYTAENSVTHGAPRDTdrpelrqpLAIEVWQN 655
Cdd:cd02648  79 K-PIVAsgsdqPLEGERLTASY------FHGRDGLSGVHWLHPDfTPVETWIPEIVAPLTPSDK--------PAYDVILD 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 656 LTKSGNGVSkITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINReksdKGNIFTIpsnayAEFNMFLDPLAAKTVL 735
Cdd:cd02648 144 ILREEPDHT-VTIAALGPLTNLAAAARKDPETFAKVGEVVVMGGAIDV----PGNTSPV-----AEFNCFADPYAAAVVI 213

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 736 ESA----------LNITLVPL--ATQHKLSS----FQTMLDRLYSSTKTPEARFvkrLLVRLQALHQKHRRYTHIDMFLG 799
Cdd:cd02648 214 DEPpstapearrkLPLQVFPLdiTTGHTLPYsslfATYVTPRDAPERGSPLARW---LEHVFISTFLTHPRAFTPEEFLP 290


                .
gi 15239586 800 E 800
Cdd:cd02648 291 D 291
nuc_hydro_CjNH cd02654
nuc_hydro_CjNH. Nucleoside hydrolases similar to Campylobacter jejuni nucleoside hydrolase. ...
 666-776 1.48e-05

nuc_hydro_CjNH. Nucleoside hydrolases similar to Campylobacter jejuni nucleoside hydrolase. This group contains eukaryotic and bacterial proteins similar to C. jejuni nucleoside hydrolase. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. C. jejuni nucleoside hydrolase is inactive against natural nucleosides or against common nucleoside analogues.


Pssm-ID: 239120 [Multi-domain]  Cd Length: 318  Bit Score: 47.93  E-value: 1.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586 666 ITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINREKSdkgnifTIPSNAYAEFNMFLDPLAAKTVLES-------A 738
Cdd:cd02654 131 VSIVAAGPLTNLALALRIDPDFAPLAKELVIMGGYLDDIGE------FVNRHYASDFNLIMDPEAASIVLTApwksitiP 204

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15239586 739 LNITLVPLATQHKLSSFQTMLDRLYSSTKTPEARFVKR 776
Cdd:cd02654 205 GNVTNRTCLTPEQIKADDPLRDFIRETLDLPIDYAKEF 242
PTZ00313 PTZ00313
inosine-adenosine-guanosine-nucleoside hydrolase; Provisional
 246-380 2.34e-05

inosine-adenosine-guanosine-nucleoside hydrolase; Provisional


Pssm-ID: 140334 [Multi-domain]  Cd Length: 326  Bit Score: 47.55  E-value: 2.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  246 RGNLFTDYTSNPySEFNIFADPFAAYQVFH-SGVPVTLVPLDATNTIPINQKFFETFennyqrtyEAQYVFLSLKIARDT 324
Cdd:PTZ00313 171 GGNVFLPGTDGS-AEWNIYWDPPAAKTVLMcPHIRKVLFSLDSTNSVPVTSEVVKKF--------GAQNKYLLSQFVGST 241

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15239586  325 WFDDEFYK------SYFMWDSFTAGVAVsimrnsanknnkngENDFAEMEYMNITVVTSNKP 380
Cdd:PTZ00313 242 WAMCTHHEllrpgdGYYAWDVLTAAYVI--------------ERNLAELEPVPLEVVVEKAK 289
rihB PRK09955
ribosylpyrimidine nucleosidase;
666-762 1.64e-03

ribosylpyrimidine nucleosidase;


Pssm-ID: 182166 [Multi-domain]  Cd Length: 313  Bit Score: 41.47  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239586  666 ITVLTNGPLTNLAKIISSDKKSSSLIKEVYIVGGHINreksdKGNiFTiPSnayAEFNMFLDPLAAKTVLESALNITLVP 745
Cdd:PRK09955 119 ITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYG-----TGN-FT-PS---AEFNIFADPEAARVVFTSGVPLVMMG 188

                         90
                 ....*....|....*..
gi 15239586  746 LATQHKLSSFQTMLDRL 762
Cdd:PRK09955 189 LDLTNQTVCTPDVIARM 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH