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Conserved domains on  [gi|15242326|ref|NP_197059|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD repeat WDR12/YTM1 family ribosome biogenesis protein( domain architecture ID 10548159)

WD repeat WDR12/YTM1 family ribosome biogenesis protein is required for maturation of ribosomal RNAs and the formation of the ribosome

CATH:  2.130.10.10
Gene Ontology:  GO:0042254|GO:0005515
PubMed:  10322433|18448671|17353269|18925368|8090199|21468892|29026209|30069656
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-426 1.44e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.03  E-value: 1.44e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 109 HDDWVSAVN-GSSPRFILTGCYDGLGRVWSSA-GSCSHILEGHSGAISSVALVNSNDaetvTVATASKDRTLRLFkfdpa 186
Cdd:cd00200   8 HTGGVTCVAfSPDGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADGT----YLASGSSDKTIRLW----- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 187 eSVDSTTKVRaykILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWNTNEstsegesvsvkkrkgnnqaeesqseGEAVT 266
Cdd:cd00200  79 -DLETGECVR---TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-------------------------GKCLT 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 267 SLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWDVETGKdSLNLFCG--KALNTVDVGGESSALIAaGGSDPILRVWDPR 343
Cdd:cd00200 130 TLRGHTDWVNSVAFsPDGTFVASSSQDGTIKLWDLRTGK-CVATLTGhtGEVNSVAFSPDGEKLLS-SSSDGTIKLWDLS 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 344 kpgTSAPVFQFSSHSSWISACKWHKSSWFhLLSASYDGKIMLWDLRTAWPLSVIDTHNDKVLSADWWK-GESVVSGGADS 422
Cdd:cd00200 208 ---TGKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPdGKRLASGSADG 283


                ....
gi 15242326 423 NLRI 426
Cdd:cd00200 284 TIRI 287
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 12-79 2.16e-20

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


:

Pssm-ID: 462380  Cd Length: 66  Bit Score: 84.50  E-value: 2.16e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15242326    12 LHVKFVTKlDSPFKVPVNSVAIPSNVTRLGLSSIVNSIIESENpEWKTEPFDFLIDGELIRMSLEEFL 79
Cdd:pfam08154   1 VQVRFVTK-EGELAVPGTPLDVPVSLTRYQLSELVNSLLKNEE-LEKPVPFDFLINGEFLRTSLEEHL 66
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-426 1.44e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.03  E-value: 1.44e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 109 HDDWVSAVN-GSSPRFILTGCYDGLGRVWSSA-GSCSHILEGHSGAISSVALVNSNDaetvTVATASKDRTLRLFkfdpa 186
Cdd:cd00200   8 HTGGVTCVAfSPDGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADGT----YLASGSSDKTIRLW----- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 187 eSVDSTTKVRaykILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWNTNEstsegesvsvkkrkgnnqaeesqseGEAVT 266
Cdd:cd00200  79 -DLETGECVR---TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-------------------------GKCLT 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 267 SLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWDVETGKdSLNLFCG--KALNTVDVGGESSALIAaGGSDPILRVWDPR 343
Cdd:cd00200 130 TLRGHTDWVNSVAFsPDGTFVASSSQDGTIKLWDLRTGK-CVATLTGhtGEVNSVAFSPDGEKLLS-SSSDGTIKLWDLS 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 344 kpgTSAPVFQFSSHSSWISACKWHKSSWFhLLSASYDGKIMLWDLRTAWPLSVIDTHNDKVLSADWWK-GESVVSGGADS 422
Cdd:cd00200 208 ---TGKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPdGKRLASGSADG 283


                ....
gi 15242326 423 NLRI 426
Cdd:cd00200 284 TIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
96-426 4.54e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 139.66  E-value: 4.54e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326  96 RAVTPRKEEEPSLHDDWVSAVNgSSP--RFILTGCYDGLGRVWSSA-GSCSHILEGHSGAISSVALvnSNDAETVtvATA 172
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVA-FSPdgKTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVTSVAF--SPDGKLL--ASG 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 173 SKDRTLRLFkfdpaeSVDSTTKVRaykILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWNTNEstsegesvsvkkrkgn 252
Cdd:COG2319 181 SDDGTVRLW------DLATGKLLR---TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT---------------- 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 253 nqaeesqseGEAVTSLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWDVETGKDSLNL-FCGKALNTVDVGGESSaLIAA 330
Cdd:COG2319 236 ---------GKLLRTLTGHSGSVRSVAFsPDGRLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGK-LLAS 305

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 331 GGSDPILRVWDPRkpgTSAPVFQFSSHSSWISACKWHKSSWFhLLSASYDGKIMLWDLRTAWPLSVIDTHNDKVLSADWW 410
Cdd:COG2319 306 GSDDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                       330
                ....*....|....*..
gi 15242326 411 K-GESVVSGGADSNLRI 426
Cdd:COG2319 382 PdGRTLASGSADGTVRL 398
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 12-79 2.16e-20

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 84.50  E-value: 2.16e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15242326    12 LHVKFVTKlDSPFKVPVNSVAIPSNVTRLGLSSIVNSIIESENpEWKTEPFDFLIDGELIRMSLEEFL 79
Cdd:pfam08154   1 VQVRFVTK-EGELAVPGTPLDVPVSLTRYQLSELVNSLLKNEE-LEKPVPFDFLINGEFLRTSLEEHL 66
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 347-387 3.30e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.30e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15242326    347 TSAPVFQFSSHSSWISACKWHKSSWFhLLSASYDGKIMLWD 387
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
199-233 2.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15242326   199 KILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWN 233
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 201-401 1.84e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326  201 LRGHKASVQSVSAQKS-GNMVCSSSWDCTINLWntnESTSEGESVsvkkrkgnNQAEESQsegeavTSLVGHTQCVSSVV 279
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVW---EIPHNDESV--------KEIKDPQ------CILKGHKKKISIID 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326  280 WPEHD--VIYSSSWDHSVRRWDVETGKDSLNLFCGKALNTV--DVGGEssaLIAAGGSDPILRVWDPRKPGTSApvfQFS 355
Cdd:PTZ00420 133 WNPMNyyIMCSSGFDSFVNIWDIENEKRAFQINMPKKLSSLkwNIKGN---LLSGTCVGKHMHIIDPRKQEIAS---SFH 206

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 15242326  356 SHsswiSACKWHKSSWF--------HLLSASYDGKIM----LWDLR-TAWPLSVIDTHN 401
Cdd:PTZ00420 207 IH----DGGKNTKNIWIdglggddnYILSTGFSKNNMremkLWDLKnTTSALVTMSIDN 261
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-426 1.44e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.03  E-value: 1.44e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 109 HDDWVSAVN-GSSPRFILTGCYDGLGRVWSSA-GSCSHILEGHSGAISSVALVNSNDaetvTVATASKDRTLRLFkfdpa 186
Cdd:cd00200   8 HTGGVTCVAfSPDGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADGT----YLASGSSDKTIRLW----- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 187 eSVDSTTKVRaykILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWNTNEstsegesvsvkkrkgnnqaeesqseGEAVT 266
Cdd:cd00200  79 -DLETGECVR---TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-------------------------GKCLT 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 267 SLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWDVETGKdSLNLFCG--KALNTVDVGGESSALIAaGGSDPILRVWDPR 343
Cdd:cd00200 130 TLRGHTDWVNSVAFsPDGTFVASSSQDGTIKLWDLRTGK-CVATLTGhtGEVNSVAFSPDGEKLLS-SSSDGTIKLWDLS 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 344 kpgTSAPVFQFSSHSSWISACKWHKSSWFhLLSASYDGKIMLWDLRTAWPLSVIDTHNDKVLSADWWK-GESVVSGGADS 422
Cdd:cd00200 208 ---TGKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPdGKRLASGSADG 283


                ....
gi 15242326 423 NLRI 426
Cdd:cd00200 284 TIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
96-426 4.54e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 139.66  E-value: 4.54e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326  96 RAVTPRKEEEPSLHDDWVSAVNgSSP--RFILTGCYDGLGRVWSSA-GSCSHILEGHSGAISSVALvnSNDAETVtvATA 172
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVA-FSPdgKTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVTSVAF--SPDGKLL--ASG 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 173 SKDRTLRLFkfdpaeSVDSTTKVRaykILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWNTNEstsegesvsvkkrkgn 252
Cdd:COG2319 181 SDDGTVRLW------DLATGKLLR---TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT---------------- 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 253 nqaeesqseGEAVTSLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWDVETGKDSLNL-FCGKALNTVDVGGESSaLIAA 330
Cdd:COG2319 236 ---------GKLLRTLTGHSGSVRSVAFsPDGRLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGK-LLAS 305

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 331 GGSDPILRVWDPRkpgTSAPVFQFSSHSSWISACKWHKSSWFhLLSASYDGKIMLWDLRTAWPLSVIDTHNDKVLSADWW 410
Cdd:COG2319 306 GSDDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                       330
                ....*....|....*..
gi 15242326 411 K-GESVVSGGADSNLRI 426
Cdd:COG2319 382 PdGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
79-426 2.14e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 2.14e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326  79 LLAKGISAERTLEIEYIRAVTPRKEEEPSLHDDWVSAVNGSS-PRFILTGCYDGLGRVWS-SAGSCSHILEGHSGAISSV 156
Cdd:COG2319  47 DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPdGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSV 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 157 ALvnSNDAETVtvATASKDRTLRLFKFDPAESVdsttkvrayKILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWNTne 236
Cdd:COG2319 127 AF--SPDGKTL--ASGSADGTVRLWDLATGKLL---------RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL-- 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 237 stsegesvsvkkrkgnnqaeesqSEGEAVTSLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWDVETGKdslnlfCGKAL 315
Cdd:COG2319 192 -----------------------ATGKLLRTLTGHTGAVRSVAFsPDGKLLASGSADGTVRLWDLATGK------LLRTL 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 316 NTVDVGGESSA------LIAAGGSDPILRVWDPRkpgTSAPVFQFSSHSSWISACKWHKSSWfHLLSASYDGKIMLWDLR 389
Cdd:COG2319 243 TGHSGSVRSVAfspdgrLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLA 318

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 15242326 390 TAWPLSVIDTHNDKVLSADWW-KGESVVSGGADSNLRI 426
Cdd:COG2319 319 TGKLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRL 356
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 142-426 3.17e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 3.17e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 142 CSHILEGHSGAISSVALVNSNDaetvTVATASKDRTLRLFKFDPAESVDSttkvraykiLRGHKASVQSVSAQKSGNMVC 221
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGK----LLATGSGDGTIKVWDLETGELLRT---------LKGHTGPVRDVAASADGTYLA 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 222 SSSWDCTINLWNTNEstsegesvsvkkrkgnnqaeesqseGEAVTSLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWDV 300
Cdd:cd00200  68 SGSSDKTIRLWDLET-------------------------GECVRTLTGHTSYVSSVAFsPDGRILSSSSRDKTIKVWDV 122

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 301 ETGKDSLNLFC-GKALNTVDVGGeSSALIAAGGSDPILRVWDPRkpgTSAPVFQFSSHSSWISACKWHKSSwFHLLSASY 379
Cdd:cd00200 123 ETGKCLTTLRGhTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLR---TGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSS 197

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 15242326 380 DGKIMLWDLRTAWPLSVIDTHNDKVLSADW-WKGESVVSGGADSNLRI 426
Cdd:cd00200 198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFsPDGYLLASGSEDGTIRV 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-387 4.43e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 4.43e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 109 HDDWVSAVNGSSP-RFILTGCYDGLGRVWS-SAGSCSHILEGHSGAISSVALVNSNDaetvTVATASKDRTLRLFKFDPA 186
Cdd:cd00200  50 HTGPVRDVAASADgTYLASGSSDKTIRLWDlETGECVRTLTGHTSYVSSVAFSPDGR----ILSSSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 187 ESVdsttkvrayKILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWNTNestsegesvsvkkrkgnnqaeesqsEGEAVT 266
Cdd:cd00200 126 KCL---------TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-------------------------TGKCVA 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 267 SLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWDVETGKdSLNLFCG--KALNTVDVGGeSSALIAAGGSDPILRVWDPR 343
Cdd:cd00200 172 TLTGHTGEVNSVAFsPDGEKLLSSSSDGTIKLWDLSTGK-CLGTLRGheNGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 15242326 344 KPgtsAPVFQFSSHSSWISACKWHKSSwFHLLSASYDGKIMLWD 387
Cdd:cd00200 250 TG---ECVQTLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
109-390 1.40e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 1.40e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 109 HDDWVSAVNGSSP-RFILTGCYDGLGRVWSSA-GSCSHILEGHSGAISSVALvnSNDAETVtvATASKDRTLRLFkfdpa 186
Cdd:COG2319 161 HSGAVTSVAFSPDgKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAF--SPDGKLL--ASGSADGTVRLW----- 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 187 eSVDSTTKVRaykILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWNTNEstsegesvsvkkrkgnnqaeesqseGEAVT 266
Cdd:COG2319 232 -DLATGKLLR---TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-------------------------GELLR 282

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 267 SLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWDVETGKdSLNLFCGKALNTVDVG-GESSALIAAGGSDPILRVWDPRk 344
Cdd:COG2319 283 TLTGHSGGVNSVAFsPDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLA- 360

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 15242326 345 pgTSAPVFQFSSHSSWISACKWHKSSwFHLLSASYDGKIMLWDLRT 390
Cdd:COG2319 361 --TGELLRTLTGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
84-426 6.45e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 6.45e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326  84 ISAERTLEIEYIRAVTPRKEEEPSLHDDWVSAVNGSSPRFILTGCYDGLGRVWSSAGSCSHILEGHSGAISSVALvnsnD 163
Cdd:COG2319  12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF----S 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 164 AETVTVATASKDRTLRLFKFDPAESVdsttkvrayKILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWNTnestseges 243
Cdd:COG2319  88 PDGRLLASASADGTVRLWDLATGLLL---------RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--------- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 244 vsvkkrkgnnqaeesqSEGEAVTSLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWDVETGKdslnlfCGKALNTVDVGG 322
Cdd:COG2319 150 ----------------ATGKLLRTLTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGK------LLRTLTGHTGAV 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326 323 ESSA------LIAAGGSDPILRVWDPRkpgTSAPVFQFSSHSSWISACKWHKSSwFHLLSASYDGKIMLWDLRTAWPLSV 396
Cdd:COG2319 208 RSVAfspdgkLLASGSADGTVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSADGTVRLWDLATGELLRT 283

                       330       340       350
                ....*....|....*....|....*....|.
gi 15242326 397 IDTHNDKVLSADW-WKGESVVSGGADSNLRI 426
Cdd:COG2319 284 LTGHSGGVNSVAFsPDGKLLASGSDDGTVRL 314
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 12-79 2.16e-20

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 84.50  E-value: 2.16e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15242326    12 LHVKFVTKlDSPFKVPVNSVAIPSNVTRLGLSSIVNSIIESENpEWKTEPFDFLIDGELIRMSLEEFL 79
Cdd:pfam08154   1 VQVRFVTK-EGELAVPGTPLDVPVSLTRYQLSELVNSLLKNEE-LEKPVPFDFLINGEFLRTSLEEHL 66
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 347-387 3.30e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.30e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15242326    347 TSAPVFQFSSHSSWISACKWHKSSWFhLLSASYDGKIMLWD 387
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
199-233 2.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15242326   199 KILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWN 233
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-233 6.63e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 6.63e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 15242326    199 KILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWN 233
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
350-387 1.12e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 15242326   350 PVFQFSSHSSWISACKWHKSSwFHLLSASYDGKIMLWD 387
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 262-299 1.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 15242326    262 GEAVTSLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWD 299
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFsPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
262-299 1.21e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15242326   262 GEAVTSLVGHTQCVSSVVW-PEHDVIYSSSWDHSVRRWD 299
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFsPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 201-401 1.84e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326  201 LRGHKASVQSVSAQKS-GNMVCSSSWDCTINLWntnESTSEGESVsvkkrkgnNQAEESQsegeavTSLVGHTQCVSSVV 279
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVW---EIPHNDESV--------KEIKDPQ------CILKGHKKKISIID 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242326  280 WPEHD--VIYSSSWDHSVRRWDVETGKDSLNLFCGKALNTV--DVGGEssaLIAAGGSDPILRVWDPRKPGTSApvfQFS 355
Cdd:PTZ00420 133 WNPMNyyIMCSSGFDSFVNIWDIENEKRAFQINMPKKLSSLkwNIKGN---LLSGTCVGKHMHIIDPRKQEIAS---SFH 206

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 15242326  356 SHsswiSACKWHKSSWF--------HLLSASYDGKIM----LWDLR-TAWPLSVIDTHN 401
Cdd:PTZ00420 207 IH----DGGKNTKNIWIdglggddnYILSTGFSKNNMremkLWDLKnTTSALVTMSIDN 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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