NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15240758|ref|NP_196900|]
View 

histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 360-595 1.34e-133

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


:

Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 390.23  E-value: 1.34e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 360 SGFTYIKSLIIEPNVIIPKSSTGCNCRGSCTD-SKKCACAKLNGGnfPYVDLNDGRLIESRDVVFECGPHCGCGPKCVNR 438
Cdd:cd10545   1 SGFTYTVKLIIPPGVSLPVPSTGCDCKNRCTDgASDCACVKKNGG--EIPYNFNGRLIRAKPAIYECGPLCKCPPSCYNR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 439 TSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTIS-DNEYIFEIDCQQTMQGLGGRQRRlrdvA 517
Cdd:cd10545  79 VTQKGLRYRLEVFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSgNDDYLFDIDNRQTNRGWDGGQRL----D 154

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15240758 518 VPMNNGVSQSSEDENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYGY 595
Cdd:cd10545 155 VGMSDGERSSAEDEESSEFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHNDLRLPRVMLFAADNIPPLQELTYDYGY 232
SAD_SRA pfam02182
SAD/SRA domain; The domain goes by several names including SAD, SRA and YDG. It adopts a beta ...
 147-303 6.79e-69

SAD/SRA domain; The domain goes by several names including SAD, SRA and YDG. It adopts a beta barrel, modified PUA-like, fold that is widely present in eukaryotic chromatin proteins and in bacteria. Versions of this domain are known to bind hemi-methylated CpG dinucleotides and also other 5mC containing dinucleotides. The domain binds DNA by flipping out the methylated cytosine base from the DNA double helix.The conserved tyrosine and aspartate residues and a glycine rich patch are critical for recognition of the flipped out base. Mammalian UHRF1 that contains this domain plays an important role in maintenance of methylation at CpG dinucleotides by recruiting DNMT1 to hemimethylated sites associated with replication forks. The SAD/SRA domain has been combined with other domains involved in the ubiquitin pathway on multiple occasions and such proteins link recognition of DNA methylation to chromatin-protein ubiquitination. The domain is also found in species that lack DNA methylation, such as certain apicomplexans, suggestive of other DNA-binding modes or functions. A highly derived and distinct version of the domain is also found in fungi where it is fused to AlkB-type 2OGFeDO domains. In bacteria, the domain is usually fused or associated with restriction endonucleases, many of which target methylated or hemi-methylated DNA.


:

Pssm-ID: 460476  Cd Length: 146  Bit Score: 220.11  E-value: 6.79e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758   147 IIGDLPGIDVGHRFFSRAEMCAVGFHNHWLNGIDYMSMEYekeysnyklplAVSIVMSGQYEDDLDNADTVTYTGQGGHN 226
Cdd:pfam02182   1 RFGHVPGVEVGDIFSSRAELCVVGLHRPTQAGIDGMKSEG-----------AYSIVLSGGYEDDEDNGDVLIYTGSGGRD 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15240758   227 LTgNKRQIKDQLLERGNLALKHCCEYNVPVRVTRGHNCKSSYTKRVYTYDGLYKVEKFWAQKGVSGFTVYKYRLKRL 303
Cdd:pfam02182  70 NT-KKKQSADQKLERGNLALANSCETGNPVRVIRGSKRDSYPPKKGYRYDGLYKVEKYWEEKGKSGFLVFKFKLRRL 145
 
Name Accession Description Interval E-value
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 360-595 1.34e-133

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 390.23  E-value: 1.34e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 360 SGFTYIKSLIIEPNVIIPKSSTGCNCRGSCTD-SKKCACAKLNGGnfPYVDLNDGRLIESRDVVFECGPHCGCGPKCVNR 438
Cdd:cd10545   1 SGFTYTVKLIIPPGVSLPVPSTGCDCKNRCTDgASDCACVKKNGG--EIPYNFNGRLIRAKPAIYECGPLCKCPPSCYNR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 439 TSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTIS-DNEYIFEIDCQQTMQGLGGRQRRlrdvA 517
Cdd:cd10545  79 VTQKGLRYRLEVFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSgNDDYLFDIDNRQTNRGWDGGQRL----D 154

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15240758 518 VPMNNGVSQSSEDENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYGY 595
Cdd:cd10545 155 VGMSDGERSSAEDEESSEFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHNDLRLPRVMLFAADNIPPLQELTYDYGY 232
SAD_SRA pfam02182
SAD/SRA domain; The domain goes by several names including SAD, SRA and YDG. It adopts a beta ...
 147-303 6.79e-69

SAD/SRA domain; The domain goes by several names including SAD, SRA and YDG. It adopts a beta barrel, modified PUA-like, fold that is widely present in eukaryotic chromatin proteins and in bacteria. Versions of this domain are known to bind hemi-methylated CpG dinucleotides and also other 5mC containing dinucleotides. The domain binds DNA by flipping out the methylated cytosine base from the DNA double helix.The conserved tyrosine and aspartate residues and a glycine rich patch are critical for recognition of the flipped out base. Mammalian UHRF1 that contains this domain plays an important role in maintenance of methylation at CpG dinucleotides by recruiting DNMT1 to hemimethylated sites associated with replication forks. The SAD/SRA domain has been combined with other domains involved in the ubiquitin pathway on multiple occasions and such proteins link recognition of DNA methylation to chromatin-protein ubiquitination. The domain is also found in species that lack DNA methylation, such as certain apicomplexans, suggestive of other DNA-binding modes or functions. A highly derived and distinct version of the domain is also found in fungi where it is fused to AlkB-type 2OGFeDO domains. In bacteria, the domain is usually fused or associated with restriction endonucleases, many of which target methylated or hemi-methylated DNA.


Pssm-ID: 460476  Cd Length: 146  Bit Score: 220.11  E-value: 6.79e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758   147 IIGDLPGIDVGHRFFSRAEMCAVGFHNHWLNGIDYMSMEYekeysnyklplAVSIVMSGQYEDDLDNADTVTYTGQGGHN 226
Cdd:pfam02182   1 RFGHVPGVEVGDIFSSRAELCVVGLHRPTQAGIDGMKSEG-----------AYSIVLSGGYEDDEDNGDVLIYTGSGGRD 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15240758   227 LTgNKRQIKDQLLERGNLALKHCCEYNVPVRVTRGHNCKSSYTKRVYTYDGLYKVEKFWAQKGVSGFTVYKYRLKRL 303
Cdd:pfam02182  70 NT-KKKQSADQKLERGNLALANSCETGNPVRVIRGSKRDSYPPKKGYRYDGLYKVEKYWEEKGKSGFLVFKFKLRRL 145
SRA smart00466
SET and RING finger associated domain; Domain of unknown function in SET domain containing ...
 144-306 8.13e-56

SET and RING finger associated domain; Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533.


Pssm-ID: 197742  Cd Length: 155  Bit Score: 186.03  E-value: 8.13e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758    144 PRKIIGDLPGIDVGHRFFSRAEMCAVGFHNHWLNGIDYMSMEYEKeysnyklPLAVSIVMSGQYEDDLDNADTVTYTGQG 223
Cdd:smart00466   1 MKRIFGPVPGVEVGDIFFYRVELCLVGLHRPTQAGIDGLESDEGE-------PGATSVVSSGGYEDDTDDGDVLIYTGQG 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758    224 GHNLTGnkRQIKDQLLERGNLALKHCCEYNVPVRVTRGHNCKSSYT-KRVYTYDGLYKVEKFWAQKGVSGFTVYKYRLKR 302
Cdd:smart00466  74 GRDMTH--GQPEDQKLERGNLALEASCRKGIPVRVVRGMKGYSKYApGKGYIYDGLYRIVDYWREVGKSGFLVFKFKLVR 151


                   ....
gi 15240758    303 LEGQ 306
Cdd:smart00466 152 IPGQ 155
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 446-599 1.23e-30

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 116.28  E-value: 1.23e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758    446 FNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTIS--------DNEYIFEIDCqqtmqglggrqrrlrdva 517
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPkaydtdgaKAFYLFDIDS------------------ 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758    518 vpmnngvsqssedenapEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYGYAL 597
Cdd:smart00317  63 -----------------DLCIDARRKGNLARFINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSDY 121


                   ..
gi 15240758    598 DS 599
Cdd:smart00317 122 AN 123
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 336-438 3.38e-23

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 94.41  E-value: 3.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758   336 ISGGLEFKGIPATNRVDDSPvsPTSGFTYIKSLIIEPNVIIPKSStGCNCrGSCtDSKKCACAKLNGGN--FPYVDlnDG 413
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDEP--PPPDFTYITSYIYPKEFLLIIPQ-GCDC-GDC-SSEKCSCAQLNGGEfrFPYDK--DG 73

                          90       100
                  ....*....|....*....|....*.
gi 15240758   414 RLIE-SRDVVFECGPHCGCGPKCVNR 438
Cdd:pfam05033  74 LLVPeSKPPIYECNPLCGCPPSCPNR 99
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
443-622 2.28e-18

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 81.55  E-value: 2.28e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 443 RLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTISDNE-----YIFEIDCQQTmqglggrqrrlrdva 517
Cdd:COG2940   3 MLHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKeplhtYLFELDDDGV--------------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 518 vpmnngvsqssedenapefcIDAGSTGNFARFINHSCEPNlfvqCVLsshqDIRLARVVLFAADNISPMQELTYDYGYAL 597
Cdd:COG2940  68 --------------------IDGALGGNPARFINHSCDPN----CEA----DEEDGRIFIVALRDIAAGEELTYDYGLDY 119

                       170       180
                ....*....|....*....|....*
gi 15240758 598 DSvhgpdgkvKQLACYCGalNCRKR 622
Cdd:COG2940 120 DE--------EEYPCRCP--NCRGT 134
 
Name Accession Description Interval E-value
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 360-595 1.34e-133

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 390.23  E-value: 1.34e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 360 SGFTYIKSLIIEPNVIIPKSSTGCNCRGSCTD-SKKCACAKLNGGnfPYVDLNDGRLIESRDVVFECGPHCGCGPKCVNR 438
Cdd:cd10545   1 SGFTYTVKLIIPPGVSLPVPSTGCDCKNRCTDgASDCACVKKNGG--EIPYNFNGRLIRAKPAIYECGPLCKCPPSCYNR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 439 TSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTIS-DNEYIFEIDCQQTMQGLGGRQRRlrdvA 517
Cdd:cd10545  79 VTQKGLRYRLEVFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSgNDDYLFDIDNRQTNRGWDGGQRL----D 154

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15240758 518 VPMNNGVSQSSEDENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYGY 595
Cdd:cd10545 155 VGMSDGERSSAEDEESSEFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHNDLRLPRVMLFAADNIPPLQELTYDYGY 232
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 360-594 1.35e-93

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 286.96  E-value: 1.35e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 360 SGFTYIKSLIIEPNVII---PKSSTGCNCRGSCTDsKKCACAKLNGGNFPYVDLNDGRLIESRDVVFECGPHCGCGPKCV 436
Cdd:cd10538   1 PSFTYIKDNIVGKNVQPfsnIIDSVGCKCKDDCLD-SKCACAAESDGIFAYTKNGLLRLNNSPPPIFECNSKCSCDDDCK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 437 NRTSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTI------SDNEYIFEIDCQQTMqglggrq 510
Cdd:cd10538  80 NRVVQRGLQARLQVFRTSKKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRgkiydkSGGSYLFDLDEFSDS------- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 511 rrlrdvavpmnngvsqsseDENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELT 590
Cdd:cd10538 153 -------------------DGDGEELCVDATFCGNVSRFINHSCDPNLFPFNVVIDHDDLRYPRIALFATRDILPGEELT 213


                ....
gi 15240758 591 YDYG 594
Cdd:cd10538 214 FDYG 217
SAD_SRA pfam02182
SAD/SRA domain; The domain goes by several names including SAD, SRA and YDG. It adopts a beta ...
 147-303 6.79e-69

SAD/SRA domain; The domain goes by several names including SAD, SRA and YDG. It adopts a beta barrel, modified PUA-like, fold that is widely present in eukaryotic chromatin proteins and in bacteria. Versions of this domain are known to bind hemi-methylated CpG dinucleotides and also other 5mC containing dinucleotides. The domain binds DNA by flipping out the methylated cytosine base from the DNA double helix.The conserved tyrosine and aspartate residues and a glycine rich patch are critical for recognition of the flipped out base. Mammalian UHRF1 that contains this domain plays an important role in maintenance of methylation at CpG dinucleotides by recruiting DNMT1 to hemimethylated sites associated with replication forks. The SAD/SRA domain has been combined with other domains involved in the ubiquitin pathway on multiple occasions and such proteins link recognition of DNA methylation to chromatin-protein ubiquitination. The domain is also found in species that lack DNA methylation, such as certain apicomplexans, suggestive of other DNA-binding modes or functions. A highly derived and distinct version of the domain is also found in fungi where it is fused to AlkB-type 2OGFeDO domains. In bacteria, the domain is usually fused or associated with restriction endonucleases, many of which target methylated or hemi-methylated DNA.


Pssm-ID: 460476  Cd Length: 146  Bit Score: 220.11  E-value: 6.79e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758   147 IIGDLPGIDVGHRFFSRAEMCAVGFHNHWLNGIDYMSMEYekeysnyklplAVSIVMSGQYEDDLDNADTVTYTGQGGHN 226
Cdd:pfam02182   1 RFGHVPGVEVGDIFSSRAELCVVGLHRPTQAGIDGMKSEG-----------AYSIVLSGGYEDDEDNGDVLIYTGSGGRD 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15240758   227 LTgNKRQIKDQLLERGNLALKHCCEYNVPVRVTRGHNCKSSYTKRVYTYDGLYKVEKFWAQKGVSGFTVYKYRLKRL 303
Cdd:pfam02182  70 NT-KKKQSADQKLERGNLALANSCETGNPVRVIRGSKRDSYPPKKGYRYDGLYKVEKYWEEKGKSGFLVFKFKLRRL 145
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 334-624 9.47e-62

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 206.76  E-value: 9.47e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 334 EDISGGLEFKGIPATNRVDDSPVSPtsgFTYIKSLIIEPNVIIPKSS---TGCNCRGSCTDSKKCACAKL---------N 401
Cdd:cd10517   7 CDISYGKEGVPIPCVNEIDNSSPPY---VEYSKERIPGKGVNINLDPdflVGCDCTDGCRDKSKCACQQLtieataatpG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 402 GGNFPYVDLNDGRLIES-RDVVFECGPHCGCGPKCVNRTSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVR 480
Cdd:cd10517  84 GQINPSAGYQYRRLMEKlPTGVYECNSRCKCDKRCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQIL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 481 RTADVD---TISDNEYIFEIDCQQTMQGLggrqrrlrdvavpmnngvsQSSEDENAPEFC--IDAGSTGNFARFINHSCE 555
Cdd:cd10517 164 TEDEANeegLQYGDEYFAELDYIEVVEKL-------------------KEGYESDVEEHCyiIDAKSEGNLGRYLNHSCS 224

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240758 556 PNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYGYALDSVHGpdgkvKQLACYCGALNCRKRLY 624
Cdd:cd10517 225 PNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDYNYEVGSVPG-----KVLYCYCGSSNCRGRLL 288
SRA smart00466
SET and RING finger associated domain; Domain of unknown function in SET domain containing ...
 144-306 8.13e-56

SET and RING finger associated domain; Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533.


Pssm-ID: 197742  Cd Length: 155  Bit Score: 186.03  E-value: 8.13e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758    144 PRKIIGDLPGIDVGHRFFSRAEMCAVGFHNHWLNGIDYMSMEYEKeysnyklPLAVSIVMSGQYEDDLDNADTVTYTGQG 223
Cdd:smart00466   1 MKRIFGPVPGVEVGDIFFYRVELCLVGLHRPTQAGIDGLESDEGE-------PGATSVVSSGGYEDDTDDGDVLIYTGQG 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758    224 GHNLTGnkRQIKDQLLERGNLALKHCCEYNVPVRVTRGHNCKSSYT-KRVYTYDGLYKVEKFWAQKGVSGFTVYKYRLKR 302
Cdd:smart00466  74 GRDMTH--GQPEDQKLERGNLALEASCRKGIPVRVVRGMKGYSKYApGKGYIYDGLYRIVDYWREVGKSGFLVFKFKLVR 151


                   ....
gi 15240758    303 LEGQ 306
Cdd:smart00466 152 IPGQ 155
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 360-623 1.19e-53

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 183.65  E-value: 1.19e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 360 SGFTYIKSLIIEPNVIIPKSS-TGCNCRGSCTDSKKCACAKLNGGNFPYVDlnDGRL-IESRDVVFECGPHCGCGPKCVN 437
Cdd:cd10542   1 PNFQYINDYIPGDGVKIPEDFlVGCECTEDCHNNNPTCCPAESGVKFAYDK--QGRLrLPPGTPIYECNSRCKCGPDCPN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 438 RTSQKRLRFNLEVFR-SAKKGWAVRSWEYIPAGSPVCEYIGVV-------RRTADVDTISDNeYIFEIDcqqtmqglggr 509
Cdd:cd10542  79 RVVQRGRKVPLCIFRtSNGRGWGVKTLEDIKKGTFVMEYVGEIitseeaeRRGKIYDANGRT-YLFDLD----------- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 510 qrrlrdvavpmnngvsqssEDENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQEL 589
Cdd:cd10542 147 -------------------YNDDDCEYTVDAAYYGNISHFINHSCDPNLAVYAVWINHLDPRLPRIAFFAKRDIKAGEEL 207

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 15240758 590 TYDYGYALD----SVHGPDGKVKQLACYCGALNCRKRL 623
Cdd:cd10542 208 TFDYLMTGTggssESTIPKPKDVRVPCLCGSKNCRKYL 245
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 362-620 2.81e-48

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 168.67  E-value: 2.81e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 362 FTYIKSLIIEPNVIIPKSST---GCNCRGSCtDSKKCACAKLNGGNfpYVDlNDGRLIES-----RDVVFECGPHCGCGP 433
Cdd:cd10543   3 FLYVTENCETSPLNIDRNITslqTCSCRDDC-SSDNCVCGRLSVRC--WYD-KEGRLLPDfnkldPPLIFECNRACSCWR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 434 KCVNRTSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTISDNEYIFEIDCQqtmqglggrqrrl 513
Cdd:cd10543  79 NCRNRVVQNGIRYRLQLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEADSREDDSYLFDLDNK------------- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 514 rdvavpmnngvsqssedeNAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDY 593
Cdd:cd10543 146 ------------------DGETYCIDARRYGNISRFINHLCEPNLIPVRVFVEHQDLRFPRIAFFASRDIKAGEELGFDY 207

                       250       260
                ....*....|....*....|....*..
gi 15240758 594 GYALDSVhgpdgKVKQLACYCGALNCR 620
Cdd:cd10543 208 GEKFWRI-----KGKYFTCRCGSPKCK 229
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 360-623 1.69e-42

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 153.61  E-value: 1.69e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 360 SGFTYIKSLIIEPNVIIPKSST---GCNCRGSCTDSKKCACAKLNGGNFpyvdlNDGRLIESRDV-----VFECGPHCGC 431
Cdd:cd10544   1 PDFQYTPENVPGPGADTDPNEItfpGCDCKTSSCEPETCSCLRKYGPNY-----DDDGCLLDFDGkysgpVFECNSMCKC 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 432 GPKCVNRTSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVV-------RRTADvDTISDNEYIFeidcqqtmq 504
Cdd:cd10544  76 SESCQNRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVigfeearRRTKS-QTKGDMNYII--------- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 505 glggrqrrlrdvavpmnnGVSQSSEDENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVlsshqdiRLARVV----LFAA 580
Cdd:cd10544 146 ------------------VLREHLSSGKVLETFVDPTYIGNIGRFLNHSCEPNLFMVPV-------RVDSMVpklaLFAA 200

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 15240758 581 DNISPMQELTYDYG-----YALDSVHGPDGKVKQL-ACYCGALNCRKRL 623
Cdd:cd10544 201 RDIVAGEELSFDYSgefsnSVESVTLARQDESKSRkPCLCGAENCRGFL 249
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 383-620 5.87e-38

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 140.45  E-value: 5.87e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 383 CNCRGSCTdSKKCACAKL--------NGGNFPYVDLNDGRLIesrdvvFECGPHCGCGPKCVNRTSQKRLRFNLEVFRSA 454
Cdd:cd10535  27 CVCIDDCS-SSNCMCGQLsmrcwydkDGRLLPEFNMAEPPLI------FECNHACSCWRNCRNRVVQNGLRARLQLYRTR 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 455 KKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTISDNEYIFEIDcqqtmqglggrqrrlrdvavpmnngvsqsseDENAP 534
Cdd:cd10535 100 DMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLD-------------------------------NKDGE 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 535 EFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYGYALDSVHGpdgkvKQLACYC 614
Cdd:cd10535 149 VYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKG-----KLFSCRC 223


                ....*.
gi 15240758 615 GALNCR 620
Cdd:cd10535 224 GSPKCR 229
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 383-620 1.10e-37

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 139.77  E-value: 1.10e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 383 CNCRGSCTdSKKCACAKLNGGNfpYVDlNDGRLIESRD-----VVFECGPHCGCGPKCVNRTSQKRLRFNLEVFRSAKKG 457
Cdd:cd10533  27 CTCVDDCS-SSNCLCGQLSIRC--WYD-KDGRLLQEFNkieppLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMG 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 458 WAVRSWEYIPAGSPVCEYIGVVRRTADVDTISDNEYIFEIDcqqtmqglggrqrrlrdvavpmnngvsqsseDENAPEFC 537
Cdd:cd10533 103 WGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLD-------------------------------NKDGEVYC 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 538 IDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYGYALdsvhgPDGKVKQLACYCGAL 617
Cdd:cd10533 152 IDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRF-----WDIKSKYFTCQCGSE 226


                ...
gi 15240758 618 NCR 620
Cdd:cd10533 227 KCK 229
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 366-623 5.65e-36

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 134.98  E-value: 5.65e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 366 KSLIIEPNVIIPKSSTGCNCRGSCTDSKKCACAKLNGGN-----FPYVDLNDG----RLIESRDV-VFECGPHCGCGPK- 434
Cdd:cd10541   1 KPFYYIPDISYGKFLVGCDCTDGCRDKSKCACHQLTIQAtactpGGQDNPTAGyqykRLEECLPTgVYECNKLCKCDPNm 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 435 CVNRTSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVD---TISDNEYIFEIDcqqtmqglggrqr 511
Cdd:cd10541  81 CQNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKILTDDFADkegLEMGDEYFANLD------------- 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 512 RLRDVAvpmnngvsqssedenapeFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTY 591
Cdd:cd10541 148 HIEESC------------------YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIKAGTELTW 209

                       250       260       270
                ....*....|....*....|....*....|..
gi 15240758 592 DYGYALDSVHGpdgkvKQLACYCGALNCRKRL 623
Cdd:cd10541 210 DYNYEVGSVEG-----KELLCCCGSNECRGRL 236
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 369-624 1.72e-35

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 134.62  E-value: 1.72e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 369 IIEPNviiPKSSTGCNC--RGSC--TDSKKCACAK-LNGGNFPYVDlnDGRLIESRD-VVFECGPHCGCGPKCVNRTSQK 442
Cdd:cd20073  15 IEPPD---PLFISGCSCskLGGCdlNNPGSCQCLEdSNEKSFAYDE--YGRVRANTGsIIYECNENCDCGINCPNRVVQR 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 443 RLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADV---DTISDNE---YIFEIDCqqtmqglggrqrrlrdv 516
Cdd:cd20073  90 GRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAeirGKKYDNVgvtYLFDLDL----------------- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 517 avpmnngvsqsSEDENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYGYA 596
Cdd:cd20073 153 -----------FEDQVDEYYTVDAQYCGDVTRFINHSCDPNLAIYSVLRDKSDSKIYDLAFFAIKDIPALEELTFDYSGR 221

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 15240758 597 LD----------SVHGPDGKVKQLACYCGALNCRKRLY 624
Cdd:cd20073 222 NNfdqlgfignrSNSKYINLKNKRPCYCGSANCRGWLF 259
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 383-623 4.94e-34

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 130.72  E-value: 4.94e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 383 CNCRGSCTDSKKCACAKLNGGNFPYVDLNDG---------RLIESRDV-VFECGPHCGCG-PKCVNRTSQKRLRFNLEVF 451
Cdd:cd10523  34 CDCTDGCIDILKCACLQLTARAFSKSESSPSkggrgykykRLQEPIPSgLYECNVSCKCNrMLCQNRVVQHGLQVRLQVF 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 452 RSAKKGWAVRSWEYIPAGSPVCEYIGVV-RRTADVDT--ISDNEYIFEIDCQQTMQGLGGRQRRLRDvavpmnngvsqss 528
Cdd:cd10523 114 KTEKKGWGVRCLDDIDKGTFVCIYAGRVlSRARSPTEplPPKLELPSENEVEVVTSWLILSKKRKLR------------- 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 529 edENApeFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYGYALDSVhgPDgkvK 608
Cdd:cd10523 181 --ENV--CFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWDYSYDAGTS--PE---Q 251

                       250
                ....*....|....*
gi 15240758 609 QLACYCGALNCRKRL 623
Cdd:cd10523 252 EIPCLCGVNKCQKKI 266
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 360-623 8.65e-31

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 121.66  E-value: 8.65e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 360 SGFTYIKSLIIEPNVIIPKSS--TGCNCR--GSCTDSKkCAC-------AKLNGGNFPYV--------DLNDGRLIESRD 420
Cdd:cd19473   1 PDFRFIEKSILGEGVELADEEfrSGCECTddEDCMYSG-CLClqdvdpdDDRDPGKKKNAyhssgakkGCLRGHMLNSRL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 421 VVFECGPHCGCGPKCVNRTSQKRLRFNLEVFR-SAKKGWAVRSWEYIPAGSPVCEYIGVV--------RRTADVDTISDN 491
Cdd:cd19473  80 PIYECHEGCACSDDCPNRVVERGRKVPLQIFRtSDGRGWGVRSTVDIKRGQFVDCYVGEIitpeeaqrRRDAATIAQRKD 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 492 EYIFEIDcqqtmqglggrqrRLRDVAvpmnngvSQSSEDENAPeFCID----AGSTgnfaRFINHSCEPNLFVQCVLSSH 567
Cdd:cd19473 160 VYLFALD-------------KFSDPD-------SLDPRLRGDP-YEIDgefmSGPT----RFINHSCDPNLRIFARVGDH 214

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15240758 568 QDIRLARVVLFAADNISPMQELTYDYgyaLDSVHGPD------GKVKQLA-CYCGALNCRKRL 623
Cdd:cd19473 215 ADKHIHDLAFFAIKDIPRGTELTFDY---VDGVTGLDddagdeEKEKEMTkCLCGSPKCRGYL 274
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 446-599 1.23e-30

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 116.28  E-value: 1.23e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758    446 FNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTIS--------DNEYIFEIDCqqtmqglggrqrrlrdva 517
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPkaydtdgaKAFYLFDIDS------------------ 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758    518 vpmnngvsqssedenapEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYGYAL 597
Cdd:smart00317  63 -----------------DLCIDARRKGNLARFINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSDY 121


                   ..
gi 15240758    598 DS 599
Cdd:smart00317 122 AN 123
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 360-623 1.88e-30

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 119.61  E-value: 1.88e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 360 SGFTYIKSLIIEPNV-IIPKSSTGCncrgSCTD--SKKCaCAKLNGGNFPYvDLNDGRLIESRDVVFECGPHCGCGPKCV 436
Cdd:cd10532   1 IDFYYINEYKPAPGInLDNEATVGC----DCSDcfFGKC-CPAEAGVLFAY-NEHGQLKIPPGTPIYECNSRCKCGPDCP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 437 NRTSQKRLRFNLEVFRSAK-KGWAVRSWEYIPAGSPVCEYIGVVRRTADVDtisdneyifeidcqqtmqglggRQRRLRD 515
Cdd:cd10532  75 NRVVQKGTQYSLCIFRTSNgRGWGVKTLQKIKKNSFVMEYVGEVITSEEAE----------------------RRGQFYD 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 516 vavpmNNGVSQSSE-DENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDY- 593
Cdd:cd10532 133 -----SKGITYLFDlDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYq 207

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 15240758 594 --GY---ALDSV-HGPDGKVKQLACYCGALNCRKRL 623
Cdd:cd10532 208 mkGSgdlSSDSIdNSPAKKRVRTVCKCGAVTCRGYL 243
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 362-624 1.47e-29

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 117.69  E-value: 1.47e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 362 FTYIKSLIIEPNVIIPKSSTGCNCRGSCTDSKKCACAKLNGGNFPYvdlNDGRLIESRD--VVFECGPHCGCGPKCVNRT 439
Cdd:cd10525   3 FVYINEYKVGEGVTLNQVAVGCECQDCLSQPVGGCCPGASKHRFAY---NEQGQVKVRPglPIYECNSRCRCGPDCPNRV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 440 SQKRLRFNLEVFRSAK-KGWAVRSWEYIPAGSPVCEYIGVVRRTADVD---TISDNE---YIFEIDcqqtmqglggrqrR 512
Cdd:cd10525  80 VQKGIQYDLCIFRTDNgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAErrgQIYDRQgatYLFDLD-------------Y 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 513 LRDVavpmnngvsqssedenapeFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYD 592
Cdd:cd10525 147 VEDV-------------------YTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFD 207

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 15240758 593 YGYALDSVH----------------GPDGKVKQLACYCGALNCRKRLY 624
Cdd:cd10525 208 YNMQVDPVDaestkmdsnfglaglpGSPKKRVRIECKCGVRSCRKYLF 255
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 447-621 5.91e-25

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 100.83  E-value: 5.91e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 447 NLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVrrtadvdtISDNEYifeidcqqtmqglggRQRrlrdvavpmNNGVSQ 526
Cdd:cd19174   1 GLERFRTEDKGWGVRTKEPIKAGQFIIEYVGEV--------VSEQEF---------------RRR---------MIEQYH 48

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 527 SSEDENAPEFC----IDAGSTGNFARFINHSCEPNLFVQCVLSSHQdirlARVVLFAADNISPMQELTYDYGYALDSVHg 602
Cdd:cd19174  49 NHSHHYCLNLDsgmvIDGYRMGNEARFVNHSCDPNCEMQKWSVNGV----YRIGLFALKDIPAGEELTYDYNFHSFNVE- 123

                       170
                ....*....|....*....
gi 15240758 603 pdgkvKQLACYCGALNCRK 621
Cdd:cd19174 124 -----KQQPCKCGSPNCRG 137
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 441-620 2.08e-23

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 96.51  E-value: 2.08e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 441 QKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRT--ADV------DTISDNEYIFEIDcqqtmqglggrqrr 512
Cdd:cd10518   9 RSRLKERLRVGKSGIHGWGLFAKRPIAAGEMVIEYVGEVIRPivADKrekrydEEGGGGTYMFRID-------------- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 513 lrdvavpmnngvsqssedenaPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYD 592
Cdd:cd10518  75 ---------------------EDLVIDATKKGNIARFINHSCDPNCYAKIITVDGEK----HIVIFAKRDIAPGEELTYD 129

                       170       180
                ....*....|....*....|....*...
gi 15240758 593 YGYALDSvhgpdgkVKQLACYCGALNCR 620
Cdd:cd10518 130 YKFPIED-------EEKIPCLCGAPNCR 150
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 336-438 3.38e-23

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 94.41  E-value: 3.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758   336 ISGGLEFKGIPATNRVDDSPvsPTSGFTYIKSLIIEPNVIIPKSStGCNCrGSCtDSKKCACAKLNGGN--FPYVDlnDG 413
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDEP--PPPDFTYITSYIYPKEFLLIIPQ-GCDC-GDC-SSEKCSCAQLNGGEfrFPYDK--DG 73

                          90       100
                  ....*....|....*....|....*.
gi 15240758   414 RLIE-SRDVVFECGPHCGCGPKCVNR 438
Cdd:pfam05033  74 LLVPeSKPPIYECNPLCGCPPSCPNR 99
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 333-430 4.98e-22

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 90.94  E-value: 4.98e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758    333 CEDISGGLEFKGIPATNRVDDSPvsPTSGFTYIKSLIIEPNVIIPKSST---GCNCRGSCTDSKKCACAKLNGGNFPYvD 409
Cdd:smart00468   1 CLDISNGKENVPVPLVNEVDEDP--PPPDFEYISEYIYGQGVPIDRSPSplvGCSCSGDCSSSNKCECARKNGGEFAY-E 77

                           90       100
                   ....*....|....*....|.
gi 15240758    410 LNDGRLIESRDVVFECGPHCG 430
Cdd:smart00468  78 LNGGLRLKRKPLIYECNSRCS 98
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 447-621 5.88e-22

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 92.26  E-value: 5.88e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 447 NLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVrrtadvdtISDNEYifeidcqqtmqglggrQRRLRDVAvpmNNGVS- 525
Cdd:cd19172   3 KVEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEV--------LDEKEF----------------KRRMKEYA---REGNRh 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 526 ------QSSEdenapefCIDAGSTGNFARFINHSCEPNLFVQ--CVLsshqdiRLARVVLFAADNISPMQELTYDYGYal 597
Cdd:cd19172  56 yyfmalKSDE-------IIDATKKGNLSRFINHSCEPNCETQkwTVN------GELRVGFFAKRDIPAGEELTFDYQF-- 120

                       170       180
                ....*....|....*....|....
gi 15240758 598 dSVHGPDGKvkqlACYCGALNCRK 621
Cdd:cd19172 121 -ERYGKEAQ----KCYCGSPNCRG 139
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 448-623 5.67e-21

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 89.40  E-value: 5.67e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 448 LEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVrrtadvdtISDNEyifeidCQQTMQGLGGRqrrlrdvaVPMNNGVSQS 527
Cdd:cd19175   2 MKLVKTEKCGWGLVADEDINAGEFIIEYVGEV--------IDDKT------CEERLWDMKHK--------GEKNFYMCEI 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 528 SEDenapeFCIDAGSTGNFARFINHSCEPNlfvqCVLSSHQDIRLARVVLFAADNISPMQELTYDYGYaldSVHGPDGKv 607
Cdd:cd19175  60 DKD-----MVIDATFKGNLSRFINHSCDPN----CELQKWQVDGETRIGVFAIRDIKKGEELTYDYQF---VQFGADQD- 126

                       170
                ....*....|....*.
gi 15240758 608 kqlaCYCGALNCRKRL 623
Cdd:cd19175 127 ----CHCGSKNCRGKL 138
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 447-620 1.06e-20

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 88.47  E-value: 1.06e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 447 NLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVV------RRTADVDTISD--NEYIFEIDcqqtmqglggrqrrlRDVAv 518
Cdd:cd10531   1 KLELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVidkkefKERLDEYEELGksNFYILSLS---------------DDVV- 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 519 pmnngvsqssedenapefcIDAGSTGNFARFINHSCEPNLFVQCVLSSHQdirlARVVLFAADNISPMQELTYDYGYALD 598
Cdd:cd10531  65 -------------------IDATRKGNLSRFINHSCEPNCETQKWIVNGE----YRIGIFALRDIPAGEELTFDYNFVNY 121

                       170       180
                ....*....|....*....|..
gi 15240758 599 SVHGPDgkvkqlaCYCGALNCR 620
Cdd:cd10531 122 NEAKQV-------CLCGAQNCR 136
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 447-619 3.08e-20

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 87.37  E-value: 3.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 447 NLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGvvrrtadvdtisdnEYIFEIDCQqtmqglggrqRRLRDvavpmnngvSQ 526
Cdd:cd19173   3 PTEPFKTGDRGWGLRTKRDIKKGDFVIEYVG--------------ELIDEEECR----------RRLKK---------AH 49

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 527 SSEDEN------APEFCIDAGSTGNFARFINHSCEPNLFVQ--CVLSSHqdirlaRVVLFAADNISPMQELTYDYGyaLD 598
Cdd:cd19173  50 ENNITNfymltlDKDRIIDAGPKGNLSRFMNHSCQPNCETQkwTVNGDT------RVGLFAVRDIPAGEELTFNYN--LD 121

                       170       180
                ....*....|....*....|.
gi 15240758 599 SVHGpdgkvKQLACYCGALNC 619
Cdd:cd19173 122 CLGN-----EKKVCRCGAPNC 137
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 457-594 3.36e-19

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 83.34  E-value: 3.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758   457 GWAVRSWEYIPAGSPVCEYIGVVRrtadvdtISDNEYIFEIDCQQTMQGLGGRQRRLRDVavpmnngvsqssedENAPEF 536
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLL-------ITKEEADKRELLYYDKLELRLWGPYLFTL--------------DEDSEY 59

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758   537 CIDAGST--GNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYG 594
Cdd:pfam00856  60 CIDARALyyGNWARFINHSCDPNCEVRVVYVNGGP----RIVIFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
443-622 2.28e-18

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 81.55  E-value: 2.28e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 443 RLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTISDNE-----YIFEIDCQQTmqglggrqrrlrdva 517
Cdd:COG2940   3 MLHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKeplhtYLFELDDDGV--------------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 518 vpmnngvsqssedenapefcIDAGSTGNFARFINHSCEPNlfvqCVLsshqDIRLARVVLFAADNISPMQELTYDYGYAL 597
Cdd:COG2940  68 --------------------IDGALGGNPARFINHSCDPN----CEA----DEEDGRIFIVALRDIAAGEELTYDYGLDY 119

                       170       180
                ....*....|....*....|....*
gi 15240758 598 DSvhgpdgkvKQLACYCGalNCRKR 622
Cdd:COG2940 120 DE--------EEYPCRCP--NCRGT 134
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 442-620 1.71e-17

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 79.69  E-value: 1.71e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 442 KRLRFNlevfRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTadvdTISDNeyifeidcqqtmqglggRQRRLRDVavpmn 521
Cdd:cd19169  13 KQLKFA----KSRIHDWGLFALEPIAADEMVIEYVGQVIRQ----SVADE-----------------REKRYEAI----- 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 522 nGVSQSSEDENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYGYALDsvh 601
Cdd:cd19169  63 -GIGSSYLFRVDDDTIIDATKCGNLARFINHSCNPNCYAKIITVESQK----KIVIYSKRPIAVNEEITYDYKFPIE--- 134

                       170
                ....*....|....*....
gi 15240758 602 gpDGKVkqlACYCGALNCR 620
Cdd:cd19169 135 --DEKI---PCLCGAPQCR 148
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 438-623 7.89e-17

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 77.82  E-value: 7.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 438 RTSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTisdNEYIFEidcqqtMQGLGGRQRRLRDVA 517
Cdd:cd19170   6 RHLRKTAKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGEVIRSVLTDK---REKYYE------SKGIGCYMFRIDDDE 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 518 VpmnngvsqssedenapefcIDAGSTGNFARFINHSCEPNLFVQCVlssHQDIRlARVVLFAADNISPMQELTYDYGYAL 597
Cdd:cd19170  77 V-------------------VDATMHGNAARFINHSCEPNCYSRVV---NIDGK-KHIVIFALRRILRGEELTYDYKFPI 133

                       170       180
                ....*....|....*....|....*.
gi 15240758 598 DSVhgpdgkvkQLACYCGALNCRKRL 623
Cdd:cd19170 134 EDV--------KIPCTCGSKKCRKYL 151
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 438-620 5.83e-15

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 72.46  E-value: 5.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 438 RTSQKRLRFNlevfRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRtadvDTISDNeyifeidcqqtmqglggRQRRLrdva 517
Cdd:cd20072   9 KKRKKQLKFA----RSAIHNWGLYAMENISAKDMVIEYVGEVIR----QQVADE-----------------REKRY---- 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 518 vpMNNGVSQS---SEDENApefCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYG 594
Cdd:cd20072  60 --LRQGIGSSylfRIDDDT---VVDATKKGNIARFINHCCDPNCTAKIIKVEGEK----RIVIYAKRDIAAGEELTYDYK 130

                       170       180
                ....*....|....*....|....*.
gi 15240758 595 YALDSVHGPdgkvkqlaCYCGALNCR 620
Cdd:cd20072 131 FPREEDKIP--------CLCGAPNCR 148
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 534-621 1.75e-14

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 71.31  E-value: 1.75e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 534 PEFCIDAGSTGNFARFINHSCEPNlfvqCVLSSHQDIRLARVVLFAADNISPMQELTYDYGYALdsvhgpDGKVKQLACY 613
Cdd:cd19171  74 NDWVIDATMTGGPARYINHSCNPN----CVAEVVTFDKEKKIIIISNRRIAKGEELTYDYKFDF------EDDQHKIPCL 143


                ....*...
gi 15240758 614 CGALNCRK 621
Cdd:cd19171 144 CGAPNCRK 151
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 438-623 8.95e-14

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 69.28  E-value: 8.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 438 RTSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTisdNEYIFEidcqqtMQGLGGRQRRLRDVA 517
Cdd:cd19206   6 RHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYSGNVIRSILTDK---REKYYD------SKGIGCYMFRIDDSE 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 518 VpmnngvsqssedenapefcIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYGYAL 597
Cdd:cd19206  77 V-------------------VDATMHGNAARFINHSCEPNCYSRVINIDGQK----HIVIFAMRKIYRGEELTYDYKFPI 133

                       170       180
                ....*....|....*....|....*.
gi 15240758 598 DSVHgpdgkvKQLACYCGALNCRKRL 623
Cdd:cd19206 134 EDAS------NKLPCNCGAKKCRKFL 153
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 449-619 1.53e-13

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 68.03  E-value: 1.53e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 449 EVFRSAKKGWAVRSWEYIPAGSPVCEYIGvvrrtadvdtisdnEYIFEIDCQQtmqglggRQRRLRDvavpmnNGVSQSS 528
Cdd:cd19212   5 EIIKTERRGWGLRTKRSIKKGEFVNEYVG--------------ELIDEEECRL-------RIKRAHE------NSVTNFY 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 529 EDENAPEFCIDAGSTGNFARFINHSCEPNLFVQcVLSSHQDIrlaRVVLFAADNISPMQELTYDYGyaLDSVHgpDGKVK 608
Cdd:cd19212  58 MLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQ-KWTVNGDV---RVGLFALCDIPAGMELTFNYN--LDCLG--NGRTE 129

                       170
                ....*....|.
gi 15240758 609 qlaCYCGALNC 619
Cdd:cd19212 130 ---CHCGADNC 137
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 441-623 2.00e-13

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 68.16  E-value: 2.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 441 QKRLRFnlevFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTisdneyifeidcqqtmqglggRQRRLRDvavpm 520
Cdd:cd19205  13 KKKLKF----CKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADM---------------------REKRYED----- 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 521 nNGVSQSSEDENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYGYALDSv 600
Cdd:cd19205  63 -EGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQK----KIVIYSKQHINVNEEITYDYKFPIED- 136

                       170       180
                ....*....|....*....|...
gi 15240758 601 hgpdgkvKQLACYCGALNCRKRL 623
Cdd:cd19205 137 -------VKIPCLCGSENCRGTL 152
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 441-623 9.17e-13

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 66.20  E-value: 9.17e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 441 QKRLRFNlevfRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTisdneyifeidcqqtmqglggRQRRLrdvavpM 520
Cdd:cd19204  13 KKKLRFG----RSRIHEWGLFAMEPIAADEMVIEYVGQNIRQVVADM---------------------REKRY------V 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 521 NNGVSQSSEDENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYGYALDSv 600
Cdd:cd19204  62 QEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQK----KIVIYSKQPIGVNEEITYDYKFPIED- 136

                       170       180
                ....*....|....*....|...
gi 15240758 601 hgpdgkvKQLACYCGALNCRKRL 623
Cdd:cd19204 137 -------NKIPCLCGTENCRGTL 152
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 448-619 1.56e-12

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 65.33  E-value: 1.56e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 448 LEVFRSAKKGWAVRSWEYIPAGSPVCEYIGvvrrtadvdtisdnEYIFEIDCQQTMqglggRQRRLRDVAvpmNNGVSQS 527
Cdd:cd19210   4 VEIFRTLGRGWGLRCKTDIKKGEFVNEYVG--------------ELIDEEECRARI-----RYAQEHDIT---NFYMLTL 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 528 SEDEnapefCIDAGSTGNFARFINHSCEPNLFVQ--CVLSShqdirlARVVLFAADNISPMQELTYDYGyaLDSVHgpDG 605
Cdd:cd19210  62 DKDR-----IIDAGPKGNYARFMNHCCQPNCETQkwTVNGD------TRVGLFALCDIKAGTELTFNYN--LECLG--NG 126

                       170
                ....*....|....
gi 15240758 606 KVkqlACYCGALNC 619
Cdd:cd19210 127 KT---VCKCGAPNC 137
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 450-623 2.53e-12

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 65.04  E-value: 2.53e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 450 VFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTisdNEYIFEidcqqtMQGLGGRQRRLRDVAVpmnngvsqsse 529
Cdd:cd19207  18 VYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDK---REKFYD------SKGIGCYMFRIDDFDV----------- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 530 denapefcIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYGYALDSVHgpdgkvKQ 609
Cdd:cd19207  78 --------VDATMHGNAARFINHSCEPNCYSRVIHVEGQK----HIVIFALRKIYRGEELTYDYKFPIEDAS------NK 139

                       170
                ....*....|....
gi 15240758 610 LACYCGALNCRKRL 623
Cdd:cd19207 140 LPCNCGAKRCRRFL 153
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 449-619 8.69e-12

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 63.09  E-value: 8.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 449 EVFRSAKKGWAVRSWEYIPAGSPVCEYIGvvrrtadvdtisdnEYIFEIDCQqtmqglgGRQRRLRDvavpmnNGVSQSS 528
Cdd:cd19211   5 KIIKTEGKGWGLIAKRDIKKGEFVNEYVG--------------ELIDEEECM-------ARIKHAHE------NDITHFY 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 529 EDENAPEFCIDAGSTGNFARFINHSCEPNLFVQcVLSSHQDirlARVVLFAADNISPMQELTYDYGyaLDSVhgpdGKVK 608
Cdd:cd19211  58 MLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQ-KWTVNGD---TRVGLFAVCDIPAGTELTFNYN--LDCL----GNEK 127

                       170
                ....*....|.
gi 15240758 609 QLaCYCGALNC 619
Cdd:cd19211 128 TV-CRCGAPNC 137
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 535-621 3.54e-11

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 61.64  E-value: 3.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 535 EFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYGYAL-DSVHgpdgkvkQLACY 613
Cdd:cd19209  77 EHVIDATLTGGPARYINHSCAPNCVAEVVTFDKED----KIIIISSRRIPKGEELTYDYQFDFeDDQH-------KIPCH 145


                ....*...
gi 15240758 614 CGALNCRK 621
Cdd:cd19209 146 CGAWNCRK 153
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 532-595 3.85e-11

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 60.82  E-value: 3.85e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15240758 532 NAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSShqdiRLARVVLFAADNISPMQELTYDYGY 595
Cdd:cd10522  59 NGDILVIDAGKKGNLTRFINHSDQPNLELIVRTLK----GEQHIGFVAIRDIKPGEELFISYGP 118
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 546-594 1.00e-10

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 57.65  E-value: 1.00e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15240758 546 FARFINHSCEPNlfvqCVLSSHQDIRLARVVLFAADNISPMQELTYDYG 594
Cdd:cd08161  28 LARFINHSCEPN----CEFEEVYVGGKPRVFIVALRDIKAGEELTVDYG 72
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 466-595 1.34e-10

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 59.21  E-value: 1.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 466 IPAGSPVCEYIGVVRRTADVDTISDNE-----YIFEIDCQqtmqglggrqrrlrdvavpmnngvsqssedeNAPEFCIDA 540
Cdd:cd10529  25 ISPGEPILEYKGEVSLRSEFKEDNGFFkrpspFVFFYDGF-------------------------------EGLPLCVDA 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15240758 541 GSTGNFARFINHSCEPNLFVQCVLSSHQDIRLArvvLFAADNISPMQELTYDYGY 595
Cdd:cd10529  74 RKYGNEARFIRRSCRPNAELRHVVVSNGELRLF---IFALKDIRKGTEITIPFDY 125
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 438-621 2.15e-10

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 59.64  E-value: 2.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 438 RTSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTAdvdtisdneyifeidcqqtmqgLGGRQRRLRDva 517
Cdd:cd19208   7 RKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNE----------------------VANRKEKLYE-- 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 518 vPMNNGVSQSSEDEnapEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYGYAL 597
Cdd:cd19208  63 -SQNRGVYMFRIDN---DHVIDATLTGGPARYINHSCAPNCVAEVVTFEKGH----KIIISSSRRIQKGEELCYDYKFDF 134

                       170       180
                ....*....|....*....|....*
gi 15240758 598 -DSVHgpdgkvkQLACYCGALNCRK 621
Cdd:cd19208 135 eDDQH-------KIPCHCGAVNCRK 152
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 535-595 2.59e-10

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 58.02  E-value: 2.59e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15240758 535 EFCIDAGSTGNFARFINHSCEPNLF--VQCVLSSHqdirlaRVVLFAADNISPMQELTYDYGY 595
Cdd:cd10519  61 QFVVDATRKGNKIRFANHSSNPNCYakVMMVNGDH------RIGIFAKRDIEAGEELFFDYGY 117
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 466-601 1.67e-07

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 51.63  E-value: 1.67e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 466 IPAGSPVCEYIGVVRRTADVDTISDNEYifeidcqqtmQGLGGRQRRLrdVAVPMNngvsqssedenapEFCIDAGSTGN 545
Cdd:cd19183  22 IPAGDPIQELLGEIGLQSEYIADPENQY----------QILGAPKPHV--FFHPQS-------------PLYIDTRRSGS 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15240758 546 FARFINHSCEPNLFVQCVLSshQDIRLARVVLFAADNISPMQELTYDYGYalDSVH 601
Cdd:cd19183  77 VARFIRRSCRPNAELVTVAS--DSGSVLKFVLYASRDISPGEEITIGWDW--DNPH 128
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 536-594 7.05e-07

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 48.73  E-value: 7.05e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15240758 536 FCIDA-GSTGNFARFINHSC-EPNLF-VQCVLSSHqdirlARVVLFAADNISPMQELTYDYG 594
Cdd:cd10528  83 YCVDAtKESGRLGRLINHSKkKPNLKtKLLVIDGV-----PHLILVAKRDIKPGEELLYDYG 139
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 535-595 1.21e-05

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 44.90  E-value: 1.21e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15240758 535 EFCIDAGSTGNFARFINHSCEPNLF--VQCVLSSHqdirlaRVVLFAADNISPMQELTYDYGY 595
Cdd:cd19218  64 DFVVDATRKGNKIRFANHSVNPNCYakVMMVNGDH------RIGIFAKRAIQTGEELFFDYRY 120
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 532-619 3.05e-05

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 44.61  E-value: 3.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240758 532 NAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHqdirLARVVLFAADNISPMQELT--YDYGYAldsvhGPDGKVkQ 609
Cdd:cd19181  67 NGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADG----MIHLCIYAVAAIAKDAEVTiaFDYEYS-----NCNYKV-D 136

                        90
                ....*....|
gi 15240758 610 LACYCGALNC 619
Cdd:cd19181 137 CACHKGNRNC 146
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 535-596 1.33e-04

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 42.36  E-value: 1.33e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15240758 535 EFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDirlaRVVLFAADNISPMQELTYDYGYA 596
Cdd:cd19217  66 DFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDH----RIGIFAKRAIQQGEELFFDYRYS 123
SET_KMT2E cd19182
SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...
 535-594 2.04e-04

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.


Pssm-ID: 380959  Cd Length: 129  Bit Score: 41.42  E-value: 2.04e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15240758 535 EFCIDAGSTGNFARFINHSCEPNLFVQCVLsshQDIRLaRVVLFAADNISPMQELT----YDYG 594
Cdd:cd19182  70 EMCVDARTFGNEARFIRRSCTPNAEVRHVI---EDGTI-HLYIYSIRSIPKGTEITiafdFDYG 129
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 532-601 9.75e-04

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 39.28  E-value: 9.75e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15240758 532 NAPEFCIDAGSTGN----FARFINHSCEPNLFVQCVLSShqdirlaRVVLFAADNISPMQELTYDYGYALDSVH 601
Cdd:cd20071  37 NSFSLTDGLNEIGVglfpLASLLNHSCDPNAVVVFDGNG-------TLRVRALRDIKAGEELTISYIDPLLPRT 103
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 547-594 3.17e-03

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 38.42  E-value: 3.17e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 15240758 547 ARFINHSCEPNlfvqCVLSShqdIRLARVVLFAADNISPMQELTYDYG 594
Cdd:cd10524  77 AAFINHDCRPN----CKFVP---TGKSTACVKVLRDIEPGEEITVYYG 117
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 538-594 4.80e-03

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 37.55  E-value: 4.80e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15240758 538 IDAGSTGNFARFINHSCEP----NLFVQCVLSSHQdirlARVVLFAADNISPMQELTYDYG 594
Cdd:cd19168  65 VDAAIYGNLSRYINHATDKvktgNCMPKIMYVNHE----WRIKFTAIKDIKIGEELFFNYG 121
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 549-595 5.33e-03

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 38.82  E-value: 5.33e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 15240758 549 FINHSCEPNLFVQCVLSShqdirlarVVLFAADNISPMQELTYDYGY 595
Cdd:cd10536 153 LLNHSCDPNTIRSFYGNT--------IVVRATRPIKKGEEITICYGP 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH