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Conserved domains on  [gi|30683535|ref|NP_196685|]
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transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11456769)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-230 3.88e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.07  E-value: 3.88e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  12 SFSPALDYLALSTGDGRIKIWDTVKGQVQTEFadiasteetniytkvgKGH----LSVDYTcmkwlslekkkkrkLGTSV 87
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTL----------------TGHsgsvRSVAFS--------------PDGRL 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  88 LVLGTGGGDVLALDVASGQLKWRISDcHPGGVNAVSSSAKASCIYSGGADGMVCQIDPHSGNLIRKFKASTKTVSSLCVS 167
Cdd:COG2319 261 LASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 339

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30683535 168 PDGKILVTASTQ--LKTFNCSDLKKIQKFTGHPGVVRCVAFTEDGKYVLSSAvGERYIAVWKTDG 230
Cdd:COG2319 340 PDGKTLASGSDDgtVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS-ADGTVRLWDLAT 403
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 465-557 1.39e-06

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 47.16  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535   465 PPKKLKSAVLSMEPSTAFKTLEALAAMWQTRACGGRHLLPWIYSIMVNHSHYIMSQePKNQQLLNTLVKITKSRGTALQQ 544
Cdd:pfam04003  14 PPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSN-PDLRPVLRSLQKLLRRRLKELKD 92

                          90
                  ....*....|....
gi 30683535   545 LLQLS-GRLQLVTA 557
Cdd:pfam04003  93 LLGLNlGALDYLLS 106
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-230 3.88e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.07  E-value: 3.88e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  12 SFSPALDYLALSTGDGRIKIWDTVKGQVQTEFadiasteetniytkvgKGH----LSVDYTcmkwlslekkkkrkLGTSV 87
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTL----------------TGHsgsvRSVAFS--------------PDGRL 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  88 LVLGTGGGDVLALDVASGQLKWRISDcHPGGVNAVSSSAKASCIYSGGADGMVCQIDPHSGNLIRKFKASTKTVSSLCVS 167
Cdd:COG2319 261 LASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 339

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30683535 168 PDGKILVTASTQ--LKTFNCSDLKKIQKFTGHPGVVRCVAFTEDGKYVLSSAvGERYIAVWKTDG 230
Cdd:COG2319 340 PDGKTLASGSDDgtVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS-ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-274 2.02e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 2.02e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  13 FSPALDYLALSTGDGRIKIWDTVKGQVQTEFadiasteetniytkvgKGHLSVDYTCMKWLSLEKkkkrklgtsvLVLGT 92
Cdd:cd00200  17 FSPDGKLLATGSGDGTIKVWDLETGELLRTL----------------KGHTGPVRDVAASADGTY----------LASGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  93 GGGDVLALDVASGQLKWRISdCHPGGVNAVSSSAKASCIYSGGADGMVCQIDPHSGNLIRKFKASTKTVSSLCVSPDGKI 172
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLT-GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535 173 LVTAS--TQLKTFNCSDLKKIQKFTGHPGVVRCVAFTEDGKYVLSSAvGERYIAVWKTDgAKKQSASCVlALEHPPVFVD 250
Cdd:cd00200 150 VASSSqdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS-SDGTIKLWDLS-TGKCLGTLR-GHENGVNSVA 226

                       250       260
                ....*....|....*....|....
gi 30683535 251 swgeTNEKGLYVLAISEIGVCYFW 274
Cdd:cd00200 227 ----FSPDGYLLASGSEDGTIRVW 246
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 465-557 1.39e-06

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 47.16  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535   465 PPKKLKSAVLSMEPSTAFKTLEALAAMWQTRACGGRHLLPWIYSIMVNHSHYIMSQePKNQQLLNTLVKITKSRGTALQQ 544
Cdd:pfam04003  14 PPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSN-PDLRPVLRSLQKLLRRRLKELKD 92

                          90
                  ....*....|....
gi 30683535   545 LLQLS-GRLQLVTA 557
Cdd:pfam04003  93 LLGLNlGALDYLLS 106
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 147-177 1.65e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.65e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 30683535    147 SGNLIRKFKASTKTVSSLCVSPDGKILVTAS 177
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS 31
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 87-179 1.98e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 40.08  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535    87 VLVLGTGGGDVLALDVASGQLKWRISDCHPGGVNAVSSSA--------KASCIYSGGADGMVCQIDPHSGNLIrkfkaST 158
Cdd:pfam13360 120 TVVAGFSSGKLVALDPATGKVRWEAPLAAPRGTNELERLVditgtpvvAGGRVFASAYQGRLVAFDAATGRRL-----WT 194

                          90       100
                  ....*....|....*....|..
gi 30683535   159 KTVSS-LCVSPDGKILVTASTQ 179
Cdd:pfam13360 195 REISGpNGPILDGDLLYVVSDD 216
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-230 3.88e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.07  E-value: 3.88e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  12 SFSPALDYLALSTGDGRIKIWDTVKGQVQTEFadiasteetniytkvgKGH----LSVDYTcmkwlslekkkkrkLGTSV 87
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTL----------------TGHsgsvRSVAFS--------------PDGRL 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  88 LVLGTGGGDVLALDVASGQLKWRISDcHPGGVNAVSSSAKASCIYSGGADGMVCQIDPHSGNLIRKFKASTKTVSSLCVS 167
Cdd:COG2319 261 LASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 339

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30683535 168 PDGKILVTASTQ--LKTFNCSDLKKIQKFTGHPGVVRCVAFTEDGKYVLSSAvGERYIAVWKTDG 230
Cdd:COG2319 340 PDGKTLASGSDDgtVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS-ADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
12-232 5.58e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 5.58e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  12 SFSPALDYLALSTGDGRIKIWDTVKGQVQTEFadiasteetniytkvgKGH----LSVDYtcmkwlSLEKKkkrklgtsV 87
Cdd:COG2319 169 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTL----------------TGHtgavRSVAF------SPDGK--------L 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  88 LVLGTGGGDVLALDVASGQLKWRISDcHPGGVNAVSSSAKASCIYSGGADGMVCQIDPHSGNLIRKFKASTKTVSSLCVS 167
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30683535 168 PDGKILVTAS--TQLKTFNCSDLKKIQKFTGHPGVVRCVAFTEDGKYVLSSAvGERYIAVWKTDGAK 232
Cdd:COG2319 298 PDGKLLASGSddGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS-DDGTVRLWDLATGE 363
WD40 COG2319
WD40 repeat [General function prediction only];
12-251 1.57e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 1.57e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  12 SFSPALDYLALSTGDGRIKIWDTVKGQVQTEFadiasteetniytkvgKGHLSVdytcmkwlslekkkkrklGTSV---- 87
Cdd:COG2319  85 AFSPDGRLLASASADGTVRLWDLATGLLLRTL----------------TGHTGA------------------VRSVafsp 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  88 ----LVLGTGGGDVLALDVASGQLKWRISDcHPGGVNAVSSSAKASCIYSGGADGMVCQIDPHSGNLIRKFKASTKTVSS 163
Cdd:COG2319 131 dgktLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535 164 LCVSPDGKILVTAST--QLKTFNCSDLKKIQKFTGHPGVVRCVAFTEDGKYVLsSAVGERYIAVWKTDGAKkqsasCVLA 241
Cdd:COG2319 210 VAFSPDGKLLASGSAdgTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTVRLWDLATGE-----LLRT 283

                       250
                ....*....|
gi 30683535 242 LEHPPVFVDS 251
Cdd:COG2319 284 LTGHSGGVNS 293
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-274 2.02e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 2.02e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  13 FSPALDYLALSTGDGRIKIWDTVKGQVQTEFadiasteetniytkvgKGHLSVDYTCMKWLSLEKkkkrklgtsvLVLGT 92
Cdd:cd00200  17 FSPDGKLLATGSGDGTIKVWDLETGELLRTL----------------KGHTGPVRDVAASADGTY----------LASGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  93 GGGDVLALDVASGQLKWRISdCHPGGVNAVSSSAKASCIYSGGADGMVCQIDPHSGNLIRKFKASTKTVSSLCVSPDGKI 172
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLT-GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535 173 LVTAS--TQLKTFNCSDLKKIQKFTGHPGVVRCVAFTEDGKYVLSSAvGERYIAVWKTDgAKKQSASCVlALEHPPVFVD 250
Cdd:cd00200 150 VASSSqdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS-SDGTIKLWDLS-TGKCLGTLR-GHENGVNSVA 226

                       250       260
                ....*....|....*....|....
gi 30683535 251 swgeTNEKGLYVLAISEIGVCYFW 274
Cdd:cd00200 227 ----FSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-227 1.92e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 1.92e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  12 SFSPALDYLALSTGDGRIKIWDTVKGQVQTEFadiasteetniytkvgKGHLSvDYTCMKWLSLEKkkkrklgtsvlVLG 91
Cdd:cd00200 100 AFSPDGRILSSSSRDKTIKVWDVETGKCLTTL----------------RGHTD-WVNSVAFSPDGT-----------FVA 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  92 TGGGD--VLALDVASGQLKWRISDcHPGGVNAVSSSAKASCIYSGGADGMVCQIDPHSGNLIRKFKASTKTVSSLCVSPD 169
Cdd:cd00200 152 SSSQDgtIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30683535 170 GKILVTASTQlKTFNCSDLKK---IQKFTGHPGVVRCVAFTEDGKYVLSSAVGERyIAVWK 227
Cdd:cd00200 231 GYLLASGSED-GTIRVWDLRTgecVQTLSGHTNSVTSLAWSPDGKRLASGSADGT-IRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-232 5.79e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 5.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  56 TKVGKGHLSVdYTCMKWLSLEKKkkrklgtsvlvLGTGGGD--VLALDVASGQLKWRISDcHPGGVNAVSSSAKASCIYS 133
Cdd:cd00200   2 RRTLKGHTGG-VTCVAFSPDGKL-----------LATGSGDgtIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLAS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535 134 GGADGMVCQIDPHSGNLIRKFKASTKTVSSLCVSPDGKILVTASTQ--LKTFNCSDLKKIQKFTGHPGVVRCVAFTEDGK 211
Cdd:cd00200  69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDktIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT 148

                       170       180
                ....*....|....*....|.
gi 30683535 212 YVlSSAVGERYIAVWKTDGAK 232
Cdd:cd00200 149 FV-ASSSQDGTIKLWDLRTGK 168
WD40 COG2319
WD40 repeat [General function prediction only];
86-251 2.16e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 2.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  86 SVLVLGTGGGDVLALDVASGQLKWRISDcHPGGVNAVSSSAKASCIYSGGADGMVCQIDPHSGNLIRKFKASTKTVSSLC 165
Cdd:COG2319  49 ARLAAGAGDLTLLLLDAAAGALLATLLG-HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535 166 VSPDGKILVTAST--QLKTFNCSDLKKIQKFTGHPGVVRCVAFTEDGKYvLSSAVGERYIAVWKTDGAKkqsasCVLALE 243
Cdd:COG2319 128 FSPDGKTLASGSAdgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGK-----LLRTLT 201


                ....*...
gi 30683535 244 HPPVFVDS 251
Cdd:COG2319 202 GHTGAVRS 209
WD40 COG2319
WD40 repeat [General function prediction only];
88-251 4.08e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 4.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  88 LVLGTGGGDVLALDVASGQLKWRISDCHPGGVNAVSSSAKASCIYSGGADGMVCQIDPHSGNLIRKFKASTKTVSSLCVS 167
Cdd:COG2319   8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535 168 PDGKILVTAST--QLKTFNCSDLKKIQKFTGHPGVVRCVAFTEDGKYVLSSAvGERYIAVWKTDGAKkqsasCVLALEHP 245
Cdd:COG2319  88 PDGRLLASASAdgTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGS-ADGTVRLWDLATGK-----LLRTLTGH 161


                ....*.
gi 30683535 246 PVFVDS 251
Cdd:COG2319 162 SGAVTS 167
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-233 5.35e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 5.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535 150 LIRKFKASTKTVSSLCVSPDGKILVTAST--QLKTFNCSDLKKIQKFTGHPGVVRCVAFTEDGKYVLSSAvGERYIAVWK 227
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGdgTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGS-SDKTIRLWD 79


                ....*.
gi 30683535 228 TDGAKK 233
Cdd:cd00200  80 LETGEC 85
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 465-557 1.39e-06

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 47.16  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535   465 PPKKLKSAVLSMEPSTAFKTLEALAAMWQTRACGGRHLLPWIYSIMVNHSHYIMSQePKNQQLLNTLVKITKSRGTALQQ 544
Cdd:pfam04003  14 PPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSN-PDLRPVLRSLQKLLRRRLKELKD 92

                          90
                  ....*....|....
gi 30683535   545 LLQLS-GRLQLVTA 557
Cdd:pfam04003  93 LLGLNlGALDYLLS 106
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
23-178 4.77e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 4.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  23 STGDGRIKIWDTVKGQVQTEFadiasteetniytKVGKG--HLSVDYTcmkwlslekkkkrklGTSVLVLGTGGGDVLAL 100
Cdd:COG3391  86 NSGSGRVSVIDLATGKVVATI-------------PVGGGprGLAVDPD---------------GGRLYVADSGNGRVSVI 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535 101 DVASGQLKWRISDC-HPGGVnAVSSSAK---ASCIYSGGADGMVCQIDPHSGNLIRKFKAStKTVSSLCVSPDGKILVTA 176
Cdd:COG3391 138 DTATGKVVATIPVGaGPHGI-AVDPDGKrlyVANSGSNTVSVIVSVIDTATGKVVATIPVG-GGPVGVAVSPDGRRLYVA 215


                ..
gi 30683535 177 ST 178
Cdd:COG3391 216 NR 217
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 147-177 1.65e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.65e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 30683535    147 SGNLIRKFKASTKTVSSLCVSPDGKILVTAS 177
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS 31
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 87-179 1.98e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 40.08  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535    87 VLVLGTGGGDVLALDVASGQLKWRISDCHPGGVNAVSSSA--------KASCIYSGGADGMVCQIDPHSGNLIrkfkaST 158
Cdd:pfam13360 120 TVVAGFSSGKLVALDPATGKVRWEAPLAAPRGTNELERLVditgtpvvAGGRVFASAYQGRLVAFDAATGRRL-----WT 194

                          90       100
                  ....*....|....*....|..
gi 30683535   159 KTVSS-LCVSPDGKILVTASTQ 179
Cdd:pfam13360 195 REISGpNGPILDGDLLYVVSDD 216
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
79-253 6.59e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 39.12  E-value: 6.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535  79 KKRKLGTSVLVLGTGGGD-----VLALDVASGQLKWRISDCHPGGVNAVSSSAKASCIYSG--GADGMVC--QIDPHSGN 149
Cdd:COG2706   2 KRLLLSTFVYVGTYTSGEsegiyVFRLDTATGELTLLGLVAALGNPSFLALSPDGRFLYAVneVDDGGVSafRIDPADGT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30683535 150 LIRKFKAST--KTVSSLCVSPDGKILVTAS--------------------TQLKTFNCSDLKKIQKFTGHPgvvRCVAFT 207
Cdd:COG2706  82 LTLLNTVSSggASPCHLSVDPDGRFLFVANygggsvsvfpidadgslgepVQVIQHEGSGPNPERQEGPHA---HSVVFD 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 30683535 208 EDGKYVLSSAVGERYIAVWKTDGAKKqsascvlALEHPPVFVDSWG 253
Cdd:COG2706 159 PDGRFLYVPDLGTDRIYVYRLDPATG-------KLPEPPEVSLPPG 197
WD40 pfam00400
WD domain, G-beta repeat;
189-226 6.84e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 6.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 30683535   189 KKIQKFTGHPGVVRCVAFTEDGKYVLSSAVgERYIAVW 226
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSD-DGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 187-227 8.99e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 8.99e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 30683535    187 DLKKIQKFTGHPGVVRCVAFTEDGKYVLSSAvGERYIAVWK 227
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS-DDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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