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Conserved domains on  [gi|15239955|ref|NP_196238|]
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Uncharacterized protein family (UPF0497) [Arabidopsis thaliana]

Protein Classification

MARVEL/CASP family protein( domain architecture ID 2507)

MARVEL (MAL and related proteins for vesicle trafficking and membrane link)/CASP (Casparian strip membrane protein) family protein similar to Arabidopsis thaliana CASP-like protein 1B2

Gene Ontology:  GO:0016020
PubMed:  21593871

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MARVEL super family cl04571
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 63-199 1.04e-27

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


The actual alignment was detected with superfamily member TIGR01569:

Pssm-ID: 383772  Cd Length: 154  Bit Score: 102.09  E-value: 1.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239955    63 MGTSDETLPFFTQFLQFEASYDDLPTFQFFVVAIAIVAGYLVLSLPFSVVTIVRPLAVAPRLLLLVLDTAALALDTAAAS 142
Cdd:TIGR01569  18 MGTNRETKVVFVQLITFKAKFSDLPAFVYFVVANAIACGYSLLSLVVSIFGLLKRRVFFKLIALFFLDLVMLALLSSGTS 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15239955   143 AAAAIVYLAHNGNTNTNWLPICQQFGDFCQKTSGAVVSAFASVTFLAILVVISGVSL 199
Cdd:TIGR01569  98 AAAAVAYVGKLGNKEAGWLKICGVFGKFCDRIAGSLALSLFAVILLVLLSILSAISL 154
 
Name Accession Description Interval E-value
A_tha_TIGR01569 TIGR01569
plant integral membrane protein TIGR01569; This model describes a region of ~160 residues ...
 63-199 1.04e-27

plant integral membrane protein TIGR01569; This model describes a region of ~160 residues found exclusively in plant proteins, generally as the near complete length of the protein. At least 24 different members are found in Arabidopsis thaliana. Members have four predicted transmembrane regions, the last of which is preceded by an invariant CXXXXX[FY]C motif. The family is not functionally characterized.


Pssm-ID: 273695  Cd Length: 154  Bit Score: 102.09  E-value: 1.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239955    63 MGTSDETLPFFTQFLQFEASYDDLPTFQFFVVAIAIVAGYLVLSLPFSVVTIVRPLAVAPRLLLLVLDTAALALDTAAAS 142
Cdd:TIGR01569  18 MGTNRETKVVFVQLITFKAKFSDLPAFVYFVVANAIACGYSLLSLVVSIFGLLKRRVFFKLIALFFLDLVMLALLSSGTS 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15239955   143 AAAAIVYLAHNGNTNTNWLPICQQFGDFCQKTSGAVVSAFASVTFLAILVVISGVSL 199
Cdd:TIGR01569  98 AAAAVAYVGKLGNKEAGWLKICGVFGKFCDRIAGSLALSLFAVILLVLLSILSAISL 154
CASP_dom pfam04535
Casparian strip membrane protein domain; This domain is found mainly in plant proteins known ...
 63-187 7.32e-26

Casparian strip membrane protein domain; This domain is found mainly in plant proteins known as Casparian strip membrane proteins (CASPs) and CASP-like proteins (CASPLs). CASPs are four-membrane-span proteins that mediate the deposition of Casparian strips in the endodermis by recruiting the lignin polymerization machinery. Interestingly, the CASP first extracellular loop was found conserved in euphyllophytes but absent in plants lacking Casparian strips.


Pssm-ID: 367980  Cd Length: 150  Bit Score: 97.39  E-value: 7.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239955    63 MGTSDETLPFFtqFLQFEASYDDLPTFQFFVVAIAIVAGYLVLSLPFSVVTIVR--PLAVAPRLLLLVLDTAALALDTAA 140
Cdd:pfam04535  26 MGTNKQTKSFF--FIQFKAKFSDYPAFRYLVVANAIAAGYSLLQLVLSVYSLSRkrLRSAALAWLLFILDQVMAYLLLSA 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 15239955   141 ASAAAAIVYLAHNGNTNTNWLPICQQFGDFCQKTSGAVVSAFASVTF 187
Cdd:pfam04535 104 ASAAAAIVYLARNGNSHAQWLKICNQFGRFCNRVAASVALSFLAFLL 150
 
Name Accession Description Interval E-value
A_tha_TIGR01569 TIGR01569
plant integral membrane protein TIGR01569; This model describes a region of ~160 residues ...
 63-199 1.04e-27

plant integral membrane protein TIGR01569; This model describes a region of ~160 residues found exclusively in plant proteins, generally as the near complete length of the protein. At least 24 different members are found in Arabidopsis thaliana. Members have four predicted transmembrane regions, the last of which is preceded by an invariant CXXXXX[FY]C motif. The family is not functionally characterized.


Pssm-ID: 273695  Cd Length: 154  Bit Score: 102.09  E-value: 1.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239955    63 MGTSDETLPFFTQFLQFEASYDDLPTFQFFVVAIAIVAGYLVLSLPFSVVTIVRPLAVAPRLLLLVLDTAALALDTAAAS 142
Cdd:TIGR01569  18 MGTNRETKVVFVQLITFKAKFSDLPAFVYFVVANAIACGYSLLSLVVSIFGLLKRRVFFKLIALFFLDLVMLALLSSGTS 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15239955   143 AAAAIVYLAHNGNTNTNWLPICQQFGDFCQKTSGAVVSAFASVTFLAILVVISGVSL 199
Cdd:TIGR01569  98 AAAAVAYVGKLGNKEAGWLKICGVFGKFCDRIAGSLALSLFAVILLVLLSILSAISL 154
CASP_dom pfam04535
Casparian strip membrane protein domain; This domain is found mainly in plant proteins known ...
 63-187 7.32e-26

Casparian strip membrane protein domain; This domain is found mainly in plant proteins known as Casparian strip membrane proteins (CASPs) and CASP-like proteins (CASPLs). CASPs are four-membrane-span proteins that mediate the deposition of Casparian strips in the endodermis by recruiting the lignin polymerization machinery. Interestingly, the CASP first extracellular loop was found conserved in euphyllophytes but absent in plants lacking Casparian strips.


Pssm-ID: 367980  Cd Length: 150  Bit Score: 97.39  E-value: 7.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239955    63 MGTSDETLPFFtqFLQFEASYDDLPTFQFFVVAIAIVAGYLVLSLPFSVVTIVR--PLAVAPRLLLLVLDTAALALDTAA 140
Cdd:pfam04535  26 MGTNKQTKSFF--FIQFKAKFSDYPAFRYLVVANAIAAGYSLLQLVLSVYSLSRkrLRSAALAWLLFILDQVMAYLLLSA 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 15239955   141 ASAAAAIVYLAHNGNTNTNWLPICQQFGDFCQKTSGAVVSAFASVTF 187
Cdd:pfam04535 104 ASAAAAIVYLARNGNSHAQWLKICNQFGRFCNRVAASVALSFLAFLL 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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