NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15238246|ref|NP_196084|]
View 

AGAMOUS-like 99 [Arabidopsis thaliana]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 12901090)

MADS (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor)-box domain-containing protein functions as a transcription factor and may be involved in various important aspects of development and differentiation; such as serum response factor that binds to the serum response element (SRE), and controls expression of genes that regulate the cytoskeleton during development, morphogenesis and cell migration

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 5-81 1.25e-22

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


:

Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 89.63  E-value: 1.25e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238246   5 KRKISIELIEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIIATPVSSKSNVSFYT---FGHSSVDNVVAAFLTNQRP 81
Cdd:cd00266   2 RKKIKIKRIENKKKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSsevEGVISRFEVLSALERKKKA 81
ARG80 super family cl34888
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 5-162 7.46e-06

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


The actual alignment was detected with superfamily member COG5068:

Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 47.32  E-value: 7.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238246   5 KRKISIELIEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIiaTPVSSKSNVsfYTFGHSSVDNVVAAFLTNQRPREG 84
Cdd:COG5068  83 GRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLL--LVISENGLV--HTFTTPKLESVVKSLEGKSLIQSP 158

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15238246  85 LGLDYwwEDERLSKSEDLEELRDAMDSmSKMLKDLKDLQNQRDCEEDVKKKGVLHGTHQKQtfnPESCSVNFDGFNKN 162
Cdd:COG5068 159 CSNAP--SDSSEEPSSSASFSVDPNDN-NPMGSFQHNGSPQTNFIPLQNPQTQQYQQHSSR---KDHPTVPHSNTNNG 230
 
Name Accession Description Interval E-value
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 5-81 1.25e-22

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 89.63  E-value: 1.25e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238246   5 KRKISIELIEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIIATPVSSKSNVSFYT---FGHSSVDNVVAAFLTNQRP 81
Cdd:cd00266   2 RKKIKIKRIENKKKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSsevEGVISRFEVLSALERKKKA 81
MADS smart00432
MADS domain;
5-66 2.72e-14

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 66.43  E-value: 2.72e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238246      5 KRKISIELIEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIIatpVSSKSNvSFYTFGHS 66
Cdd:smart00432   2 RRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALI---VFSPTG-KLYEFASP 59
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
13-63 5.76e-10

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 53.97  E-value: 5.76e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15238246    13 IEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIIatpVSSKSNvSFYTF 63
Cdd:pfam00319   2 IENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVI---VFSPTG-KLYTF 48
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 5-162 7.46e-06

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 47.32  E-value: 7.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238246   5 KRKISIELIEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIiaTPVSSKSNVsfYTFGHSSVDNVVAAFLTNQRPREG 84
Cdd:COG5068  83 GRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLL--LVISENGLV--HTFTTPKLESVVKSLEGKSLIQSP 158

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15238246  85 LGLDYwwEDERLSKSEDLEELRDAMDSmSKMLKDLKDLQNQRDCEEDVKKKGVLHGTHQKQtfnPESCSVNFDGFNKN 162
Cdd:COG5068 159 CSNAP--SDSSEEPSSSASFSVDPNDN-NPMGSFQHNGSPQTNFIPLQNPQTQQYQQHSSR---KDHPTVPHSNTNNG 230
 
Name Accession Description Interval E-value
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 5-81 1.25e-22

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 89.63  E-value: 1.25e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238246   5 KRKISIELIEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIIATPVSSKSNVSFYT---FGHSSVDNVVAAFLTNQRP 81
Cdd:cd00266   2 RKKIKIKRIENKKKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSsevEGVISRFEVLSALERKKKA 81
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 5-66 4.72e-19

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 79.48  E-value: 4.72e-19
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238246   5 KRKISIELIEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIIATPVSSKSnvsfYTFGHS 66
Cdd:cd00120   2 RGKIEIKRIENKTSRQVTFSKRRNGLFKKASELSVLCDAEVAVIVFSPSGKL----YEFWSS 59
MADS smart00432
MADS domain;
5-66 2.72e-14

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 66.43  E-value: 2.72e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238246      5 KRKISIELIEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIIatpVSSKSNvSFYTFGHS 66
Cdd:smart00432   2 RRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALI---VFSPTG-KLYEFASP 59
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
13-63 5.76e-10

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 53.97  E-value: 5.76e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15238246    13 IEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIIatpVSSKSNvSFYTF 63
Cdd:pfam00319   2 IENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVI---VFSPTG-KLYTF 48
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 5-162 7.46e-06

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 47.32  E-value: 7.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238246   5 KRKISIELIEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIiaTPVSSKSNVsfYTFGHSSVDNVVAAFLTNQRPREG 84
Cdd:COG5068  83 GRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLL--LVISENGLV--HTFTTPKLESVVKSLEGKSLIQSP 158

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15238246  85 LGLDYwwEDERLSKSEDLEELRDAMDSmSKMLKDLKDLQNQRDCEEDVKKKGVLHGTHQKQtfnPESCSVNFDGFNKN 162
Cdd:COG5068 159 CSNAP--SDSSEEPSSSASFSVDPNDN-NPMGSFQHNGSPQTNFIPLQNPQTQQYQQHSSR---KDHPTVPHSNTNNG 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH