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Conserved domains on  [gi|334187409|ref|NP_196003|]
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CDK inhibitor P21 binding protein [Arabidopsis thaliana]

Protein Classification

BCIP domain-containing protein( domain architecture ID 10620558)

BCIP domain-containing protein similar to Saccharomyces cerevisiae protein BCP1 and Homo sapiens BRCA2 and CDKN1A-interacting protein (BCCIP)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BCCIP pfam13862
BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. ...
 75-207 1.50e-32

BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. In fungi, BCP1 is involved in nuclear export, actin cytoskeleton organization and vesicular transport. Its homolog in human and mouse, BCCIP, may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A/p21 and may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2.


:

Pssm-ID: 464002  Cd Length: 199  Bit Score: 118.45  E-value: 1.50e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187409   75 GFVDLILNQTALGTVVKVADDEDEAlFALITALNLARYKENKCFRELKEFLLKVCSE-KNVASDLELLL--EKKAKDVGL 151
Cdd:pfam13862  38 ELADLILSQPTVGSVIKVDGEESDP-YGFLSVLNLKKHKDKPCIKQLKEYLLSKAKKhKESLKKLQKLLssSSKDKKVGL 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 334187409  152 LVSQRVMNLPLQLLPPLYDGLFDEVSWATEDEPteelrgSFRFKSYILIAKIYKVS 207
Cdd:pfam13862 117 LISERLINMPPQLVPPLYKMLLEEIEWALEDKE------PYNFTHYLIISKVYKEV 166
 
Name Accession Description Interval E-value
BCCIP pfam13862
BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. ...
 75-207 1.50e-32

BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. In fungi, BCP1 is involved in nuclear export, actin cytoskeleton organization and vesicular transport. Its homolog in human and mouse, BCCIP, may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A/p21 and may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2.


Pssm-ID: 464002  Cd Length: 199  Bit Score: 118.45  E-value: 1.50e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187409   75 GFVDLILNQTALGTVVKVADDEDEAlFALITALNLARYKENKCFRELKEFLLKVCSE-KNVASDLELLL--EKKAKDVGL 151
Cdd:pfam13862  38 ELADLILSQPTVGSVIKVDGEESDP-YGFLSVLNLKKHKDKPCIKQLKEYLLSKAKKhKESLKKLQKLLssSSKDKKVGL 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 334187409  152 LVSQRVMNLPLQLLPPLYDGLFDEVSWATEDEPteelrgSFRFKSYILIAKIYKVS 207
Cdd:pfam13862 117 LISERLINMPPQLVPPLYKMLLEEIEWALEDKE------PYNFTHYLIISKVYKEV 166
 
Name Accession Description Interval E-value
BCCIP pfam13862
BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. ...
 75-207 1.50e-32

BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. In fungi, BCP1 is involved in nuclear export, actin cytoskeleton organization and vesicular transport. Its homolog in human and mouse, BCCIP, may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A/p21 and may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2.


Pssm-ID: 464002  Cd Length: 199  Bit Score: 118.45  E-value: 1.50e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187409   75 GFVDLILNQTALGTVVKVADDEDEAlFALITALNLARYKENKCFRELKEFLLKVCSE-KNVASDLELLL--EKKAKDVGL 151
Cdd:pfam13862  38 ELADLILSQPTVGSVIKVDGEESDP-YGFLSVLNLKKHKDKPCIKQLKEYLLSKAKKhKESLKKLQKLLssSSKDKKVGL 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 334187409  152 LVSQRVMNLPLQLLPPLYDGLFDEVSWATEDEPteelrgSFRFKSYILIAKIYKVS 207
Cdd:pfam13862 117 LISERLINMPPQLVPPLYKMLLEEIEWALEDKE------PYNFTHYLIISKVYKEV 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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