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Conserved domains on  [gi|15241094|ref|NP_195814|]
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eukaryotic translation initiation factor 2B family protein / eIF-2B family protein [Arabidopsis thaliana]

Protein Classification

eukaryotic translation initiation factor eIF-2-beta/eIF-5 family protein( domain architecture ID 10652752)

eukaryotic translation initiation factor eIF-2-beta/eIF-5 family protein similar to eukaryotic translation initiation factor 2 subunit 2 (eIF-2-beta), a component of eIF-2 that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

Gene Ontology:  GO:0003743|GO:0006413
SCOP:  4000606

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
97-202 7.06e-45

domain present in translation initiation factor eIF2B and eIF5;


:

Pssm-ID: 214764  Cd Length: 110  Bit Score: 145.85  E-value: 7.06e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094     97 RPRTVMMPPQLLAEGT-ITVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKQQRLEIKGLVSSKDFQAVFRKYIDAF 175
Cdd:smart00653   1 FYRFKMPPPQVLREGKgKTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGKGRLIVNGRFTPKKLQDLLRRYIKEY 80
                           90       100
                   ....*....|....*....|....*..
gi 15241094    176 VICVCCKSPDTALAEEgNGLFNLRCET 202
Cdd:smart00653  81 VLCPECGSPDTELIKE-NRLFFLKCEA 106
 
Name Accession Description Interval E-value
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
97-202 7.06e-45

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 145.85  E-value: 7.06e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094     97 RPRTVMMPPQLLAEGT-ITVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKQQRLEIKGLVSSKDFQAVFRKYIDAF 175
Cdd:smart00653   1 FYRFKMPPPQVLREGKgKTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGKGRLIVNGRFTPKKLQDLLRRYIKEY 80
                           90       100
                   ....*....|....*....|....*..
gi 15241094    176 VICVCCKSPDTALAEEgNGLFNLRCET 202
Cdd:smart00653  81 VLCPECGSPDTELIKE-NRLFFLKCEA 106
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
92-201 4.72e-30

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 107.98  E-value: 4.72e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094    92 EVSTERPRTVMMPPQLLAEGTI-TVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKQQRLEIKGLVSSKDFQAVFRK 170
Cdd:pfam01873   1 DVTDSFYRYKMPPPQVKREGKGkTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSIDENGRLIINGKFSAKQIEDLLDK 80
                          90       100       110
                  ....*....|....*....|....*....|.
gi 15241094   171 YIDAFVICVCCKSPDTALAEEgNGLFNLRCE 201
Cdd:pfam01873  81 YIEEYVLCPECGSPDTELIKE-NRLLFLKCE 110
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
72-201 5.43e-25

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 95.27  E-value: 5.43e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094  72 DYGYKELLsmvfDRLREEDVEVSTERPRTVMMPPQLLAEGTITVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKQq 151
Cdd:COG1601   1 DMDYEELL----DRAYEKLPEKVGSGERFEVPEPEVRIEGNRTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIEGG- 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15241094 152 RLEIKGLVSSKDFQAVFRKYIDAFVICVCCKSPDTALAEEGnGLFNLRCE 201
Cdd:COG1601  76 RAILQGKFSPEDINALIDRYVKEYVICPECGSPDTRLVKEG-RVLMLKCE 124
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
72-201 2.88e-22

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 88.43  E-value: 2.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094   72 DYGYKELLsmvfDRLREEDVEVSTERPRTVMMPPQLLAEGTITVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKqQ 151
Cdd:PRK03988   4 YYDYEELL----DRAYEKLPEKVFKESRFEVPKPDVRIEGNRTIIRNFKEIADRLNRDPKHVAKFLLKELGTAGNIEG-G 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 15241094  152 RLEIKGLVSSKDFQAVFRKYIDAFVICVCCKSPDTALAEEGNGLFnLRCE 201
Cdd:PRK03988  79 RLILQGKFSPRVINEKIDRYVKEYVICPECGSPDTKLIKEGRIWV-LKCE 127
aIF-2beta TIGR00311
translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high ...
75-201 1.39e-13

translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high enough to select only archaeal members. The suggested cutoff is set to include most eukaryotic members but largely exclude the related eIF-5. [Protein synthesis, Translation factors]


Pssm-ID: 129411  Cd Length: 133  Bit Score: 65.26  E-value: 1.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094    75 YKELLSMVFDRLREEDVEVST-ERPRTvmmppQLLAEGTITVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKQqRL 153
Cdd:TIGR00311   2 YEELLERAFEQLPDKVFVRERfEIPRV-----SIQIEGNRTIIKNFREIAKALNRDEDHLYKYLLKELGTAGNLEGG-RL 75
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 15241094   154 EIKGLVSSKDFQAVFRKYIDAFVICVCCKSPDTALAEEGNGLFnLRCE 201
Cdd:TIGR00311  76 ILQGKFTESLLQKRIDDYVRLYVICRECNSPDTEIIKEGRVLL-LKCL 122
 
Name Accession Description Interval E-value
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
97-202 7.06e-45

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 145.85  E-value: 7.06e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094     97 RPRTVMMPPQLLAEGT-ITVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKQQRLEIKGLVSSKDFQAVFRKYIDAF 175
Cdd:smart00653   1 FYRFKMPPPQVLREGKgKTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGKGRLIVNGRFTPKKLQDLLRRYIKEY 80
                           90       100
                   ....*....|....*....|....*..
gi 15241094    176 VICVCCKSPDTALAEEgNGLFNLRCET 202
Cdd:smart00653  81 VLCPECGSPDTELIKE-NRLFFLKCEA 106
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
92-201 4.72e-30

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 107.98  E-value: 4.72e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094    92 EVSTERPRTVMMPPQLLAEGTI-TVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKQQRLEIKGLVSSKDFQAVFRK 170
Cdd:pfam01873   1 DVTDSFYRYKMPPPQVKREGKGkTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSIDENGRLIINGKFSAKQIEDLLDK 80
                          90       100       110
                  ....*....|....*....|....*....|.
gi 15241094   171 YIDAFVICVCCKSPDTALAEEgNGLFNLRCE 201
Cdd:pfam01873  81 YIEEYVLCPECGSPDTELIKE-NRLLFLKCE 110
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
72-201 5.43e-25

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 95.27  E-value: 5.43e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094  72 DYGYKELLsmvfDRLREEDVEVSTERPRTVMMPPQLLAEGTITVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKQq 151
Cdd:COG1601   1 DMDYEELL----DRAYEKLPEKVGSGERFEVPEPEVRIEGNRTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIEGG- 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15241094 152 RLEIKGLVSSKDFQAVFRKYIDAFVICVCCKSPDTALAEEGnGLFNLRCE 201
Cdd:COG1601  76 RAILQGKFSPEDINALIDRYVKEYVICPECGSPDTRLVKEG-RVLMLKCE 124
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
72-201 2.88e-22

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 88.43  E-value: 2.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094   72 DYGYKELLsmvfDRLREEDVEVSTERPRTVMMPPQLLAEGTITVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKqQ 151
Cdd:PRK03988   4 YYDYEELL----DRAYEKLPEKVFKESRFEVPKPDVRIEGNRTIIRNFKEIADRLNRDPKHVAKFLLKELGTAGNIEG-G 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 15241094  152 RLEIKGLVSSKDFQAVFRKYIDAFVICVCCKSPDTALAEEGNGLFnLRCE 201
Cdd:PRK03988  79 RLILQGKFSPRVINEKIDRYVKEYVICPECGSPDTKLIKEGRIWV-LKCE 127
PRK12336 PRK12336
translation initiation factor IF-2 subunit beta; Provisional
73-201 9.55e-21

translation initiation factor IF-2 subunit beta; Provisional


Pssm-ID: 183451 [Multi-domain]  Cd Length: 201  Bit Score: 86.15  E-value: 9.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094   73 YGYKELLsmvfDRLREEDVEVSTERPRTVMMPPQLLAEGTITVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNkQQR 152
Cdd:PRK12336   1 MDYESLL----DRAMEVLPEPTKSGERFSIPEPKIFIEGKTTILTNFGEIADALNRDPDHLMKFLQRELGTAGKIE-GGR 75
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 15241094  153 LEIKGLVSSKDFQAVFRKYIDAFVICVCCKSPDTALAEEGnGLFNLRCE 201
Cdd:PRK12336  76 AVFNGKFTEEDIQAAIDAYVDEYVICSECGLPDTRLVKED-RVLMLRCD 123
aIF-2beta TIGR00311
translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high ...
75-201 1.39e-13

translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high enough to select only archaeal members. The suggested cutoff is set to include most eukaryotic members but largely exclude the related eIF-5. [Protein synthesis, Translation factors]


Pssm-ID: 129411  Cd Length: 133  Bit Score: 65.26  E-value: 1.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241094    75 YKELLSMVFDRLREEDVEVST-ERPRTvmmppQLLAEGTITVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKQqRL 153
Cdd:TIGR00311   2 YEELLERAFEQLPDKVFVRERfEIPRV-----SIQIEGNRTIIKNFREIAKALNRDEDHLYKYLLKELGTAGNLEGG-RL 75
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 15241094   154 EIKGLVSSKDFQAVFRKYIDAFVICVCCKSPDTALAEEGNGLFnLRCE 201
Cdd:TIGR00311  76 ILQGKFTESLLQKRIDDYVRLYVICRECNSPDTEIIKEGRVLL-LKCL 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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