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Conserved domains on  [gi|15235138|ref|NP_195665|]
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Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/kelch-repeat protein( domain architecture ID 17778853)

F-box/kelch-repeat protein may be a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.120.10.80
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  10603472|31898225|11178263|31442578|24959344|10581972
SCOP:  4001927|3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 25-67 3.20e-17

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438923  Cd Length: 45  Bit Score: 74.53  E-value: 3.20e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15235138  25 PSLPDDLVVSCLARVSRLYYPTLSLVSKSFRSLIASPDLYKTR 67
Cdd:cd22152   3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
140-333 3.85e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.03  E-value: 3.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138 140 SGLVAVGSNIYNIGGPIDKAHSSIVS----VLDCQSHTWHEGPGMRVERRYPAANVVEGKIYVTGGCKDcSNSSNWMEVF 215
Cdd:COG3055  64 AAAVAQDGKLYVFGGFTGANPSSTPLndvyVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDD-GGNVAWVEVY 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138 216 DPRTQTWESVSS-PGAEIGgcsiHKSAVV-EGEILIANshGLIYKPKEGRWERMKwDMDIGWVWYSYCVVENVLYY--YY 291
Cdd:COG3055 143 DPATGTWTQLAPlPTPRDH----LAAAVLpDGKILVIG--GRNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVfgGE 215

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 15235138 292 KGVFK---WYDTMARLWRdlkgVKG-LPrFARCGGKMADYGGKMAV 333
Cdd:COG3055 216 SGFSDeveAYDPATNTWT----ALGeLP-TPRHGHAAVLTDGKVYV 256
 
Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 25-67 3.20e-17

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 74.53  E-value: 3.20e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15235138  25 PSLPDDLVVSCLARVSRLYYPTLSLVSKSFRSLIASPDLYKTR 67
Cdd:cd22152   3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
140-333 3.85e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.03  E-value: 3.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138 140 SGLVAVGSNIYNIGGPIDKAHSSIVS----VLDCQSHTWHEGPGMRVERRYPAANVVEGKIYVTGGCKDcSNSSNWMEVF 215
Cdd:COG3055  64 AAAVAQDGKLYVFGGFTGANPSSTPLndvyVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDD-GGNVAWVEVY 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138 216 DPRTQTWESVSS-PGAEIGgcsiHKSAVV-EGEILIANshGLIYKPKEGRWERMKwDMDIGWVWYSYCVVENVLYY--YY 291
Cdd:COG3055 143 DPATGTWTQLAPlPTPRDH----LAAAVLpDGKILVIG--GRNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVfgGE 215

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 15235138 292 KGVFK---WYDTMARLWRdlkgVKG-LPrFARCGGKMADYGGKMAV 333
Cdd:COG3055 216 SGFSDeveAYDPATNTWT----ALGeLP-TPRHGHAAVLTDGKVYV 256
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 184-229 2.18e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.92  E-value: 2.18e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15235138   184 RRYPAANVVEGKIYVTGGCKDcSNSSNWMEVFDPRTQTWESVSSPG 229
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPSMP 46
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 26-66 1.21e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 47.53  E-value: 1.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15235138    26 SLPDDLVVSCLARVSRLYYPTLSLVSKSFRSLIASPDLYKT 66
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
PHA03098 PHA03098
kelch-like protein; Provisional
 141-288 3.41e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 52.08  E-value: 3.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138  141 GLVAVGSNIYNIGGPIDKAHSSIVSVLDCQSHTWHEGPGMRVERRYPAANVVEGKIYVTGGCKDCSNSSNWMEVFDPRTQ 220
Cdd:PHA03098 337 GVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTN 416

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15235138  221 TWESVS-SPGAEIGGCSIH---KSAVVEGEILIANSHG----LIYKPKEGRWeRMKWDMDIGWVWYSYCVVENVLY 288
Cdd:PHA03098 417 KWSKGSpLPISHYGGCAIYhdgKIYVIGGISYIDNIKVynivESYNPVTNKW-TELSSLNFPRINASLCIFNNKIY 491
FBOX smart00256
A Receptor for Ubiquitination Targets;
27-67 1.12e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.04  E-value: 1.12e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15235138     27 LPDDLVVSCLARVSRLYYPTLSLVSKSFRSLIASPDLYKTR 67
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
Kelch smart00612
Kelch domain;
195-227 1.41e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.38  E-value: 1.41e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15235138    195 KIYVTGGCkDCSNSSNWMEVFDPRTQTWESVSS 227
Cdd:smart00612   1 KIYVVGGF-DGGQRLKSVEVYDPETNKWTPLPS 32
 
Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 25-67 3.20e-17

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 74.53  E-value: 3.20e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15235138  25 PSLPDDLVVSCLARVSRLYYPTLSLVSKSFRSLIASPDLYKTR 67
Cdd:cd22152   3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
140-333 3.85e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.03  E-value: 3.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138 140 SGLVAVGSNIYNIGGPIDKAHSSIVS----VLDCQSHTWHEGPGMRVERRYPAANVVEGKIYVTGGCKDcSNSSNWMEVF 215
Cdd:COG3055  64 AAAVAQDGKLYVFGGFTGANPSSTPLndvyVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDD-GGNVAWVEVY 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138 216 DPRTQTWESVSS-PGAEIGgcsiHKSAVV-EGEILIANshGLIYKPKEGRWERMKwDMDIGWVWYSYCVVENVLYY--YY 291
Cdd:COG3055 143 DPATGTWTQLAPlPTPRDH----LAAAVLpDGKILVIG--GRNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVfgGE 215

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 15235138 292 KGVFK---WYDTMARLWRdlkgVKG-LPrFARCGGKMADYGGKMAV 333
Cdd:COG3055 216 SGFSDeveAYDPATNTWT----ALGeLP-TPRHGHAAVLTDGKVYV 256
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
143-267 8.55e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.10  E-value: 8.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138 143 VAVGSNIYNIGGPIDKAHSSIVSVLDCQSHTWHEGPGMRVERR-YPAANVVEGKIYVTGGCKDCSNSSNWM---EVFDPR 218
Cdd:COG3055  19 ALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTGANPSSTPLndvYVYDPA 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15235138 219 TQTWESVSSPGAEIGGcsiHKSAVVEGEILIANSHG--------LIYKPKEGRWERM 267
Cdd:COG3055  99 TNTWTKLAPMPTPRGG---ATALLLDGKIYVVGGWDdggnvawvEVYDPATGTWTQL 152
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
173-267 8.21e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 59.01  E-value: 8.21e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138 173 TWHEGPGMRVERRYPAANVVEGKIYVTGGcKDCSNSSNWMEVFDPRTQTWESVSS-PGAEIGGcsiHKSAVVEGEILIAN 251
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGG-LSGGSASNSFEVYDPATNTWSELAPlPGPPRHH---AAAVAQDGKLYVFG 77

                        90       100
                ....*....|....*....|....*...
gi 15235138 252 ------------SHGLIYKPKEGRWERM 267
Cdd:COG3055  78 gftganpsstplNDVYVYDPATNTWTKL 105
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 184-229 2.18e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.92  E-value: 2.18e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15235138   184 RRYPAANVVEGKIYVTGGCKDcSNSSNWMEVFDPRTQTWESVSSPG 229
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPSMP 46
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
126-251 1.05e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.85  E-value: 1.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138 126 LAAIPVlhsrPAYWSGLVAVGSNIYNIGGPIDKAHSSIVSVLDCQSHTWHEGPGMRVERRYP-AANVVEGKIYVTGGCKD 204
Cdd:COG3055 105 LAPMPT----PRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGKILVIGGRNG 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138 205 CSNSSNW----------------------------------MEVFDPRTQTWESVSS-PGAEIGgcsiHKSAVVEGEILI 249
Cdd:COG3055 181 SGFSNTWttlaplptaraghaaavlggkilvfggesgfsdeVEAYDPATNTWTALGElPTPRHG----HAAVLTDGKVYV 256


                ..
gi 15235138 250 AN 251
Cdd:COG3055 257 IG 258
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 26-66 1.21e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 47.53  E-value: 1.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15235138    26 SLPDDLVVSCLARVSRLYYPTLSLVSKSFRSLIASPDLYKT 66
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
PHA03098 PHA03098
kelch-like protein; Provisional
 141-288 3.41e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 52.08  E-value: 3.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138  141 GLVAVGSNIYNIGGPIDKAHSSIVSVLDCQSHTWHEGPGMRVERRYPAANVVEGKIYVTGGCKDCSNSSNWMEVFDPRTQ 220
Cdd:PHA03098 337 GVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTN 416

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15235138  221 TWESVS-SPGAEIGGCSIH---KSAVVEGEILIANSHG----LIYKPKEGRWeRMKWDMDIGWVWYSYCVVENVLY 288
Cdd:PHA03098 417 KWSKGSpLPISHYGGCAIYhdgKIYVIGGISYIDNIKVynivESYNPVTNKW-TELSSLNFPRINASLCIFNNKIY 491
FBOX smart00256
A Receptor for Ubiquitination Targets;
27-67 1.12e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.04  E-value: 1.12e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15235138     27 LPDDLVVSCLARVSRLYYPTLSLVSKSFRSLIASPDLYKTR 67
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
Kelch_6 pfam13964
Kelch motif;
184-228 3.95e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.78  E-value: 3.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15235138   184 RRYPAANVVEGKIYVTGGCKDCSNSSNWMEVFDPRTQTWESVSSP 228
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPL 46
PHA03098 PHA03098
kelch-like protein; Provisional
 148-237 2.24e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.22  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138  148 NIYNIGGP--IDKAHS-SIVSVLDCQSHTWHEGPGMRVERRYPAANVVEGKIYVTGGCKDCSNSSNwMEVFDPRTQTWES 224
Cdd:PHA03098 439 KIYVIGGIsyIDNIKVyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINE-IEVYDDKTNTWTL 517

                         90
                 ....*....|...
gi 15235138  225 VSSPGAEIGGCSI 237
Cdd:PHA03098 518 FCKFPKVIGSLEK 530
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
 26-67 3.13e-04

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 37.98  E-value: 3.13e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15235138  26 SLPDDLVVSCLARVSRLYYPTLSLVSKSFRSlIASPDLYKTR 67
Cdd:cd22143   4 SLPDEILSIIFSHLPQSDLYNLLFVNKHFYS-LALPELWRSI 44
Kelch smart00612
Kelch domain;
195-227 1.41e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.38  E-value: 1.41e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15235138    195 KIYVTGGCkDCSNSSNWMEVFDPRTQTWESVSS 227
Cdd:smart00612   1 KIYVVGGF-DGGQRLKSVEVYDPETNKWTPLPS 32
PHA03098 PHA03098
kelch-like protein; Provisional
 137-223 1.74e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 40.52  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138  137 AYWSGLVAVGSNIYNIGGPIDKAHS--SIVSVlDCQSHTWHEGPGMRVERRYPAANVVEGKIYVTGGCKDcSNSSNWMEV 214
Cdd:PHA03098 285 VYCFGSVVLNNVIYFIGGMNKNNLSvnSVVSY-DTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYN-SISLNTVES 362


                 ....*....
gi 15235138  215 FDPRTQTWE 223
Cdd:PHA03098 363 WKPGESKWR 371
PLN02153 PLN02153
epithiospecifier protein
 178-249 3.94e-03

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 38.81  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235138  178 PGMRVERRYPAA-NVVEGKIYVT---------GGCKDcsNSSNWMEVFDPRTQTWESVSSPGAEIGGCSIHKSAVVEGEI 247
Cdd:PLN02153 177 PGENFEKRGGAGfAVVQGKIWVVygfatsilpGGKSD--YESNAVQFFDPASGKWTEVETTGAKPSARSVFAHAVVGKYI 254


                 ..
gi 15235138  248 LI 249
Cdd:PLN02153 255 II 256
Kelch_4 pfam13418
Galactose oxidase, central domain;
194-228 5.49e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.51  E-value: 5.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15235138   194 GKIYVTGGCKDCSNSSNWMEVFDPRTQTWESVSSP 228
Cdd:pfam13418  13 DTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSL 47
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
133-201 5.63e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 38.21  E-value: 5.63e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15235138 133 HSRPAYWSGLVAVGSNIYNIGGpiDKAHSSIVSVLDCQSHTWHEGPGMRVERRYPAANVVEGKIYVTGG 201
Cdd:COG3055 193 LPTARAGHAAAVLGGKILVFGG--ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 25-62 8.11e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 33.97  E-value: 8.11e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15235138  25 PSLPDDLVVSCLARVSRLYYPTLSLVSKSFRSLIASPD 62
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPS 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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