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Conserved domains on  [gi|22329204|ref|NP_195330|]
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basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

Protein Classification

basic helix-loop-helix domain-containing protein( domain architecture ID 14413597)

basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor

CATH:  4.10.280.10
Gene Ontology:  GO:0003677|GO:0046983
PubMed:  20219281|15186484|1755826|8018712|19942615|12679534
SCOP:  4000913

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bHLH_AtILR3_like cd11446
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine ...
 31-105 3.43e-32

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine resistant 3 (ILR3) and similar proteins; ILR3, also termed AtbHLH105, or EN 133, is a bHLH transcription factor that plays a role in resistance to amide-linked indole-3-acetic acid (IAA) conjugates such as IAA-Leu and IAA-Phe. It may regulate gene expression in response to metal homeostasis changes.


:

Pssm-ID: 381452 [Multi-domain]  Cd Length: 76  Bit Score: 113.20  E-value: 3.43e-32
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22329204  31 KAEREKLRRDKLKEQFLELGNALDPNR-PKSDKASVLTDTIQMLKDVMNQVDRLKAEYETLSQESRELIQEKSELR 105
Cdd:cd11446   1 KACREKLRRDKLNERFMELSNVLEPGRpPKTDKATILGDAIRMLKQLRGEVQKLKEENSSLQEESKELKAEKNELR 76
 
Name Accession Description Interval E-value
bHLH_AtILR3_like cd11446
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine ...
 31-105 3.43e-32

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine resistant 3 (ILR3) and similar proteins; ILR3, also termed AtbHLH105, or EN 133, is a bHLH transcription factor that plays a role in resistance to amide-linked indole-3-acetic acid (IAA) conjugates such as IAA-Leu and IAA-Phe. It may regulate gene expression in response to metal homeostasis changes.


Pssm-ID: 381452 [Multi-domain]  Cd Length: 76  Bit Score: 113.20  E-value: 3.43e-32
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22329204  31 KAEREKLRRDKLKEQFLELGNALDPNR-PKSDKASVLTDTIQMLKDVMNQVDRLKAEYETLSQESRELIQEKSELR 105
Cdd:cd11446   1 KACREKLRRDKLNERFMELSNVLEPGRpPKTDKATILGDAIRMLKQLRGEVQKLKEENSSLQEESKELKAEKNELR 76
HLH smart00353
helix loop helix domain;
33-81 1.55e-05

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 41.44  E-value: 1.55e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 22329204     33 EREKLRRDKLKEQFLELGNALDPNRP--KSDKASVLTDTIQMLKDVMNQVD 81
Cdd:smart00353   2 ARERRRRRKINEAFDELRSLLPTLPKnkKLSKAEILRLAIEYIKSLQEELQ 52
HLH pfam00010
Helix-loop-helix DNA-binding domain;
31-75 5.42e-04

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 37.05  E-value: 5.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 22329204    31 KAEREKLRRDKLKEQFLELGNAL--DPNRPKSDKASVLTDTIQMLKD 75
Cdd:pfam00010   5 HNERERRRRDRINDAFDELRELLptLPPDKKLSKAEILRLAIEYIKH 51
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 59-129 2.12e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.04  E-value: 2.12e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22329204  59 KSDKASVLTDTIQMLKDVMNQVDRLKAEYETLSQESRELIQEKSELREEKATLKSDIEILNAQYQHRIKTM 129
Cdd:COG3883  18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREEL 88
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 28-118 3.12e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 38.76  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329204   28 CSQKAEREKLRrdKLKEQFLELGNALDPNRPKSDKASVLTDTIQMLK--DVMNQVDRLKAEYETLSQESRELIQEKSELR 105
Cdd:PRK05771  36 LKEELSNERLR--KLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSvkSLEELIKDVEEELEKIEKEIKELEEEISELE 113

                         90
                 ....*....|...
gi 22329204  106 EEKATLKSDIEIL 118
Cdd:PRK05771 114 NEIKELEQEIERL 126
 
Name Accession Description Interval E-value
bHLH_AtILR3_like cd11446
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine ...
 31-105 3.43e-32

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine resistant 3 (ILR3) and similar proteins; ILR3, also termed AtbHLH105, or EN 133, is a bHLH transcription factor that plays a role in resistance to amide-linked indole-3-acetic acid (IAA) conjugates such as IAA-Leu and IAA-Phe. It may regulate gene expression in response to metal homeostasis changes.


Pssm-ID: 381452 [Multi-domain]  Cd Length: 76  Bit Score: 113.20  E-value: 3.43e-32
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22329204  31 KAEREKLRRDKLKEQFLELGNALDPNR-PKSDKASVLTDTIQMLKDVMNQVDRLKAEYETLSQESRELIQEKSELR 105
Cdd:cd11446   1 KACREKLRRDKLNERFMELSNVLEPGRpPKTDKATILGDAIRMLKQLRGEVQKLKEENSSLQEESKELKAEKNELR 76
bHLH_AtMYC1_like cd18918
basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; ...
 35-89 2.90e-06

basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; MYC1, also termed AtbHLH12, or EN 58, acts as a transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2.


Pssm-ID: 381488 [Multi-domain]  Cd Length: 70  Bit Score: 43.86  E-value: 2.90e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22329204  35 EKLRRDKLKEQFLELGNaLDPNRPKSDKASVLTDTIQMLKDVMNQVDRLKAEYET 89
Cdd:cd18918   5 ERERREKLNEKFSDLRN-LIPNPTKNDRASILSDAIKYINELQRTVEELKSLVEK 58
bHLH_AtAIG1_like cd11455
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar ...
 21-89 4.20e-06

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar proteins; AIG1, also termed AtbHLH32, or EN 54, or protein target of MOOPTEROS 5, is a transcription factor required for MONOPTEROS-dependent root initiation in embryo.


Pssm-ID: 381461  Cd Length: 80  Bit Score: 43.82  E-value: 4.20e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22329204  21 EVKKEAVCSQKAEREKLRRDKLKEQFLELGNALdPNRPKSDKASVLTDTIQMLKDVMNQVDRLKAEYET 89
Cdd:cd11455   1 EDKALAASKSHSEAERRRRERINSHLATLRTLL-PNLSKTDKASLLAEVVQHVKELKRQAAEITTPPDV 68
bHLH_AtTT8_like cd11451
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 ...
 35-95 7.77e-06

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 (TT8) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as TT8, EGL1, and GL3. TT8, also termed AtbHLH42, or EN 32, is involved in the control of flavonoid pigmentation and plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). EGL1, also termed AtbHLH2, or EN 30, or AtMYC146, or protein enhancer of GLABRA 3, is involved in epidermal cell fate specification and regulates negatively stomata formation but promotes trichome formation. GL3, also termed AtbHLH1, or AtMYC6, or protein shapeshifter, or EN 31, is involved in epidermal cell fate specification. It regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication.


Pssm-ID: 381457  Cd Length: 75  Bit Score: 42.79  E-value: 7.77e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22329204  35 EKLRRDKLKEQFLELGNaLDPNRPKSDKASVLTDTIQMLKDVMNQVDRLKAEYETLSQESR 95
Cdd:cd11451  10 ERRRREKLNERFITLRS-MVPFVTKMDKVSILGDAIEYLKQLQRRVEELESRRKSSDTETR 69
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
 34-83 1.07e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 41.78  E-value: 1.07e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 22329204  34 REKLRRDKLKEQFLELGNaLDPNRPKSDKASVLTDTIQMLKDVMNQVDRL 83
Cdd:cd11393   4 AERKRREKINERIRALRS-LVPNGGKTDKASILDEAIEYIKFLQEQVKVL 52
HLH smart00353
helix loop helix domain;
33-81 1.55e-05

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 41.44  E-value: 1.55e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 22329204     33 EREKLRRDKLKEQFLELGNALDPNRP--KSDKASVLTDTIQMLKDVMNQVD 81
Cdd:smart00353   2 ARERRRRRKINEAFDELRSLLPTLPKnkKLSKAEILRLAIEYIKSLQEELQ 52
bHLH_AtNAI1_like cd11452
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein NAI1 and similar ...
 35-101 3.80e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein NAI1 and similar proteins; NAI1, also termed AtbHLH20, or EN 27, is a bHLH transcription activator that regulates the expression of at least NAI2, PYK10 and PBP1. It is required for and mediates the formation of endoplasmic reticulum bodies (ER bodies). It plays a role in the symbiotic interactions with the endophytes of the Sebacinaceae fungus family, such as Piriformospora indica and Sebacina.


Pssm-ID: 381458 [Multi-domain]  Cd Length: 75  Bit Score: 40.91  E-value: 3.80e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22329204  35 EKLRRDKLKEQFLELgNALDPNRPKSDKASVLTDTIQMLKDVMNQVDRLKAEYETLSQESRELIQEK 101
Cdd:cd11452  10 ERKRREKLSQRFIAL-SALVPGLKKMDKASVLGDAIKHIKQLQERVKELEEEKKEKRLMSVVIVKKS 75
bHLH_AtAIB_like cd11449
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE ...
 33-100 4.44e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE bHLH-TYPE (AIB) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as AIB and MYC proteins (MYC2, MYC3 and MYC4). AIB, also termed AtbHLH17, or EN 35, is a transcription activator that regulates positively abscisic acid (ABA) response. MYC2, also termed protein jasmonate insensitive 1, or R-homologous Arabidopsis protein 1 (RAP-1), or AtbHLH6, or EN 38, or Z-box binding factor 1 protein, is a transcriptional activator involved in abscisic acid (ABA), jasmonic acid (JA), and light signaling pathways. MYC3, also termed protein altered tryptophan regulation 2, or AtbHLH5, or transcription factor ATR2, or EN 36, is a transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. MYC4, also termed AtbHLH4, or EN 37, is a transcription factor involved in jasmonic acid (JA) gene regulation. MYC2, together with MYC3 and MYC4, controls additively subsets of JA-dependent responses.


Pssm-ID: 381455 [Multi-domain]  Cd Length: 78  Bit Score: 40.84  E-value: 4.44e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22329204  33 EREKLRRDKLKEQFLELgNALDPNRPKSDKASVLTDTIQMLKDVMNQVDRLKAEYETLSQESRELIQE 100
Cdd:cd11449  11 EAERQRREKLNQRFYAL-RAVVPNVSKMDKASLLGDAISYINELKSKVQDMETEKKEMKRQESEKKTE 77
bHLH_AtFIT_like cd11450
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana Fe-deficiency induced ...
 29-97 1.91e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana Fe-deficiency induced transcription factor 1 (FIT) and similar proteins; The family includes bHLH transcription factors from Arabidopsis thaliana, such as FIT and DYT1. FIT, also termed FER-like iron deficiency-induced transcription factor, or FER-like regulator of iron uptake, or AtbHLH29, or EN 43, is a bHLH transcription factor that is required for the iron deficiency response in plant. It regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. DYT1, also termed AtbHLH22, or protein dysfunctional tapetum 1, or EN 49, is a bHLH transcription factor involved in the control of tapetum development. It is required for male fertility and pollen differentiation, especially during callose deposition.


Pssm-ID: 381456 [Multi-domain]  Cd Length: 76  Bit Score: 39.04  E-value: 1.91e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22329204  29 SQKAEREKLRRDKLKEQFLELgNALDPNRPKSDKASVLTDTIQMLKDVMNQVDRLKAEYETLSQESREL 97
Cdd:cd11450   5 SKNLVSERNRRQKLNQRLFAL-RSVVPNITKMDKASIIKDAISYIQELQYQEKKLEAEIRELESRPPST 72
HLH pfam00010
Helix-loop-helix DNA-binding domain;
31-75 5.42e-04

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 37.05  E-value: 5.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 22329204    31 KAEREKLRRDKLKEQFLELGNAL--DPNRPKSDKASVLTDTIQMLKD 75
Cdd:pfam00010   5 HNERERRRRDRINDAFDELRELLptLPPDKKLSKAEILRLAIEYIKH 51
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 35-75 6.47e-04

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 36.73  E-value: 6.47e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 22329204  35 EKLRRDKLKEQFLELGNALD--PNRPKSDKASVLTDTIQMLKD 75
Cdd:cd00083   1 ERRRRDKINDAFEELKRLLPelPDSKKLSKASILQKAVEYIRE 43
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 59-129 2.12e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.04  E-value: 2.12e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22329204  59 KSDKASVLTDTIQMLKDVMNQVDRLKAEYETLSQESRELIQEKSELREEKATLKSDIEILNAQYQHRIKTM 129
Cdd:COG3883  18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREEL 88
ZapB pfam06005
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ...
 61-118 2.32e-03

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.


Pssm-ID: 428718 [Multi-domain]  Cd Length: 71  Bit Score: 35.70  E-value: 2.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 22329204    61 DKASVLTDTIQMLKdvmNQVDRLKAEYETLSQESRELIQEKSELREEKATLKSDIEIL 118
Cdd:pfam06005  11 TKIQAAVDTIALLQ---MENEELKEENEELKEEANELEEENQQLKQERNQWQERIRGL 65
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 28-118 3.12e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 38.76  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329204   28 CSQKAEREKLRrdKLKEQFLELGNALDPNRPKSDKASVLTDTIQMLK--DVMNQVDRLKAEYETLSQESRELIQEKSELR 105
Cdd:PRK05771  36 LKEELSNERLR--KLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSvkSLEELIKDVEEELEKIEKEIKELEEEISELE 113

                         90
                 ....*....|...
gi 22329204  106 EEKATLKSDIEIL 118
Cdd:PRK05771 114 NEIKELEQEIERL 126
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 73-123 4.77e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 38.14  E-value: 4.77e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 22329204  73 LKDVMNQVDRLKAEYETLSQESRELIQEK-SELREEKATLKSDIEILNAQYQ 123
Cdd:COG0542 413 LDELERRLEQLEIEKEALKKEQDEASFERlAELRDELAELEEELEALKARWE 464
bHLH_AtPIF_like cd11445
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting ...
 35-80 4.87e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting factors (PIFs) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as PIFs, ALC, PIL1, SPATULA, and UNE10. PIFs (PIF1, PIF3, PIF4, PIF5, PIF6 and PIF7) have been shown to control light-regulated gene expression. They directly bind to the photoactivated phytochromes and are degraded in response to light signals. ALC, also termed AtbHLH73, or protein ALCATRAZ, or EN 98, is required for the dehiscence of fruit, especially for the separation of the valve cells from the replum. It promotes the differentiation of a strip of labile non-lignified cells sandwiched between layers of lignified cells. PIL1, also termed AtbHLH124, or protein phytochrome interacting factor 3-like 1, or EN 110, is involved in responses to transient and long-term shade. It is required for the light-mediated inhibition of hypocotyl elongation and necessary for rapid light-induced expression of the photomorphogenesis- and circadian-related gene APRR9. PIL1 seems to play a role in multiple PHYB responses, such as flowering transition and petiole elongation. SPATULA, also termed AtbHLH24, or EN 99, plays a role in floral organogenesis. It promotes the growth of carpel margins and of pollen tract tissues derived from them. UNE10, also termed AtbHLH16, or protein UNFERTILIZED EMBRYO SAC 10, or EN 99, is required during the fertilization of ovules by pollen.


Pssm-ID: 381451  Cd Length: 64  Bit Score: 34.66  E-value: 4.87e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 22329204  35 EKLRRDKLKEQFLELGNaLDPNRPKSDKASVLTDTIQMLKDVMNQV 80
Cdd:cd11445  10 ERRRRDRINEKMKALQE-LIPNCNKTDKASMLDEAIEYLKSLQLQV 54
bHLH_AtAMS_like cd11443
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein aborted microspores ...
 29-98 5.86e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein aborted microspores (AMS) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as AMS, ICE1 and SCREAM2. AMS, also termed AtbHLH21, or EN 48, plays a crucial role in tapetum development and it is required for male fertility and pollen differentiation. ICE1, also termed inducer of CBF expression 1, or AtbHLH116, or EN 45, or SCREAM, acts as a transcriptional activator that regulates the cold-induced transcription of CBF/DREB1 genes. It binds specifically to the MYC recognition sites (5'-CANNTG-3') found in the CBF3/DREB1A promoter. SCREAM2, also termed AtbHLH33, or EN 44, mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA.


Pssm-ID: 381449 [Multi-domain]  Cd Length: 72  Bit Score: 34.66  E-value: 5.86e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329204  29 SQKAEREKLRRDKLKEQFLELgNALDPNRPKSDKASVLTDTIQMLKDVMNQVDRLKAEYETLSQESRELI 98
Cdd:cd11443   1 SKNLMAERRRRKKLNDRLYML-RSVVPKITKMDRASILGDAIDYVKELLQEINELQDELEGLPESESGET 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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