|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
96-478 |
6.77e-143 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 418.40 E-value: 6.77e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 96 IKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIilalqeEIMMPIAAGEgPI 175
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLL------QRLDPSRPRA-PQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 176 ALVICPSRELAKQTYDVVEQFVASLvedgypRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACR 255
Cdd:COG0513 74 ALILAPTRELALQVAEELRKLAKYL------GLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 256 LLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVNVGRAGAANLDVIQEVEYVKQEA 335
Cdd:COG0513 148 TLVLDEADRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 336 KIVYLLECLQKTTPP-VLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDF 414
Cdd:COG0513 228 KLELLRRLLRDEDPErAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDI 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15234166 415 PDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFINKNQseitLLDLKHLLQEAKQRIPPV 478
Cdd:COG0513 308 DDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDE----RRLLRAIEKLIGQKIEEE 367
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
108-313 |
4.78e-132 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 382.46 E-value: 4.78e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEIMMPIAAGEGPIALVICPSRELAK 187
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPFIKGEGPYGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 188 QTYDVVEQFVASLVEDGYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVD 267
Cdd:cd17951 81 QTHEVIEYYCKALQEGGYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMID 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15234166 268 LGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVN 313
Cdd:cd17951 161 MGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTVN 206
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
68-482 |
2.55e-128 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 385.67 E-value: 2.55e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 68 VRKMSTKQMDLIRKQWHIT-VNGEDIPPPIKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSG 146
Cdd:PTZ00110 100 VSALSSKEVDEIRKEKEITiIAGENVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSG 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 147 KTLVFVLPMIILALQEEIMMPiaaGEGPIALVICPSRELAKQTYDVVEQFVASLvedgypRLRSLLCIGGVDMRSQLDVV 226
Cdd:PTZ00110 180 KTLAFLLPAIVHINAQPLLRY---GDGPIVLVLAPTRELAEQIREQCNKFGASS------KIRNTVAYGGVPKRGQIYAL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 227 KKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSaL 306
Cdd:PTZ00110 251 RRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARD-L 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 307 VK--PVTVNVGRAG-AANLDVIQEVEYVKQEAKIVYLLECLQK---TTPPVLIFCENKADVDDIHEYLLLKGVEAVAIHG 380
Cdd:PTZ00110 330 CKeePVHVNVGSLDlTACHNIKQEVFVVEEHEKRGKLKMLLQRimrDGDKILIFVETKKGADFLTKELRLDGWPALCIHG 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 381 GKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFINKNQSEIT 460
Cdd:PTZ00110 410 DKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPDKYRLA 489
|
410 420
....*....|....*....|..
gi 15234166 461 lLDLKHLLQEAKQRIPPVLAEL 482
Cdd:PTZ00110 490 -RDLVKVLREAKQPVPPELEKL 510
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
99-453 |
2.05e-86 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 274.76 E-value: 2.05e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 99 FMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMiilaLQeeimmPIAAGE-GPIAL 177
Cdd:PRK11776 6 FSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGL----LQ-----KLDVKRfRVQAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 178 VICPSRELAKQtydvveqfVASlvedgypRLRSL-----------LCiGGVDMRSQLDVVKKGVHIVVATPGRLKDILAK 246
Cdd:PRK11776 77 VLCPTRELADQ--------VAK-------EIRRLarfipnikvltLC-GGVPMGPQIDSLEHGAHIIVGTPGRILDHLRK 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 247 KKMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVNVgrAGAANLDVIQ 326
Cdd:PRK11776 141 GTLDLDALNTLVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKV--ESTHDLPAIE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 327 EVEY-VKQEAKIVYLLECLQKTTP-PVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVA 404
Cdd:PRK11776 219 QRFYeVSPDERLPALQRLLLHHQPeSCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVA 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 15234166 405 TDVASKGLDFPDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFIN 453
Cdd:PRK11776 299 TDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVA 347
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
108-476 |
4.23e-84 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 268.60 E-value: 4.23e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEimmPIAAGEGPI-ALVICPSRELA 186
Cdd:PRK10590 12 ILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQ---PHAKGRRPVrALILTPTRELA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 187 KQTYDVVEQFVAslvedgYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLV 266
Cdd:PRK10590 89 AQIGENVRDYSK------YLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRML 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 267 DLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVNVGRAGAANLDVIQEVEYVKQEAKIVYLLECLQK 346
Cdd:PRK10590 163 DMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRKRELLSQMIGK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 347 TT-PPVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDM 425
Cdd:PRK10590 243 GNwQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYEL 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15234166 426 PGEIENYVHRIGRTGRCGKTGIATTFINKNQSEItLLDLKHLLqeaKQRIP 476
Cdd:PRK10590 323 PNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKL-LRDIEKLL---KKEIP 369
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
108-312 |
1.56e-79 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 247.74 E-value: 1.56e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPmIILALQEEimmPIAAGEGPIALVICPSRELAK 187
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLP-ILEKLLPE---PKKKGRGPQALVLAPTRELAM 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 188 QTYDVVEQFVaslvedGYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVD 267
Cdd:cd00268 77 QIAEVARKLG------KGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLD 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15234166 268 LGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd00268 151 MGFEEDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
71-480 |
3.57e-79 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 257.41 E-value: 3.57e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 71 MSTKQMDLIRKQWHITVNGEDIPPPIKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLV 150
Cdd:PLN00206 95 LSSSQAELLRRKLEIHVKGEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTAS 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 151 FVLPMIILALQEEIMMPiAAGEGPIALVICPSRELAKQtydVVEQfvASLVEDGYPrLRSLLCIGGVDMRSQLDVVKKGV 230
Cdd:PLN00206 175 FLVPIISRCCTIRSGHP-SEQRNPLAMVLTPTRELCVQ---VEDQ--AKVLGKGLP-FKTALVVGGDAMPQQLYRIQQGV 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 231 HIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHFkSQRQTLLFSATMPAKIQIFATSALVKPV 310
Cdd:PLN00206 248 ELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQAL-SQPQVLLFSATVSPEVEKFASSLAKDII 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 311 TVNVGRAGAANLDVIQEVEYV---KQEAKIVYLLECLQKTTPPVLIFCENKADVDDIHEYL-LLKGVEAVAIHGGKDQED 386
Cdd:PLN00206 327 LISIGNPNRPNKAVKQLAIWVetkQKKQKLFDILKSKQHFKPPAVVFVSSRLGADLLANAItVVTGLKALSIHGEKSMKE 406
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 387 RDYAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFINkNQSEITLLDLKH 466
Cdd:PLN00206 407 RREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVN-EEDRNLFPELVA 485
|
410
....*....|....
gi 15234166 467 LLQEAKQRIPPVLA 480
Cdd:PLN00206 486 LLKSSGAAIPRELA 499
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
97-452 |
4.54e-72 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 236.38 E-value: 4.54e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 97 KNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPmiilALQEEIMMPIAAGEGPIA 176
Cdd:PRK11192 1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLP----ALQHLLDFPRRKSGPPRI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 177 LVICPSRELAKQTYDVVEQFVAslvedgYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRL 256
Cdd:PRK11192 77 LILTPTRELAMQVADQARELAK------HTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVET 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 257 LTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAK-IQIFATSALVKPVTVNVG-----RAgaanldVIQEVEY 330
Cdd:PRK11192 151 LILDEADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEGDaVQDFAERLLNDPVEVEAEpsrreRK------KIHQWYY 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 331 V--KQEAKIVYLLECL-QKTTPPVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDV 407
Cdd:PRK11192 225 RadDLEHKTALLCHLLkQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDV 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15234166 408 ASKGLDFPDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFI 452
Cdd:PRK11192 305 AARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLV 349
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
98-493 |
1.56e-69 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 233.69 E-value: 1.56e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 98 NFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEeimmPIAAG---EGP 174
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSR----PALADrkpEDP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 175 IALVICPSRELAKQTYDVVEQFVASLvedgypRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKM-SLDA 253
Cdd:PRK04537 86 RALILAPTRELAIQIHKDAVKFGADL------GLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVvSLHA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 254 CRLLTLDEADRLVDLGFEDDIRHVFDHF--KSQRQTLLFSATMPAKIQIFATSALVKPVTVNVGRAGAANLDVIQEVEYV 331
Cdd:PRK04537 160 CEICVLDEADRMFDLGFIKDIRFLLRRMpeRGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 332 KQEAKIVYLLECLQKTT-PPVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASK 410
Cdd:PRK04537 240 ADEEKQTLLLGLLSRSEgARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAAR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 411 GLDFPDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFINKNQSeITLLDLKHLLQeakQRIP--PVLAELNGPMEE 488
Cdd:PRK04537 320 GLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYA-MSLPDIEAYIE---QKIPvePVTAELLTPLPR 395
|
....*
gi 15234166 489 TETIA 493
Cdd:PRK04537 396 PPRVP 400
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
99-457 |
1.23e-66 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 223.25 E-value: 1.23e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 99 FMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEIMMPIAAGEgPIALV 178
Cdd:PRK01297 89 FHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKERYMGE-PRALI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 179 ICPSRELAKQtydvVEQFVASLVEdgYPRLRSLLCIGGVDMRSQLDVVK-KGVHIVVATPGRLKDILAKKKMSLDACRLL 257
Cdd:PRK01297 168 IAPTRELVVQ----IAKDAAALTK--YTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVM 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 258 TLDEADRLVDLGFEDDIRHV--FDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVNVGRAGAANLDVIQEVEYVKQEA 335
Cdd:PRK01297 242 VLDEADRMLDMGFIPQVRQIirQTPRKEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVAGSD 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 336 KIVYLLECL-QKTTPPVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDF 414
Cdd:PRK01297 322 KYKLLYNLVtQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHI 401
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 15234166 415 PDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFINKNQS 457
Cdd:PRK01297 402 DGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDA 444
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
86-312 |
1.94e-66 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 214.55 E-value: 1.94e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 86 TVNGEDIPPPIKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMI--ILAlqee 163
Cdd:cd17953 1 KVRGKDCPKPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFrhIKD---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 164 iMMPIAAGEGPIALVICPSRELAKQTYDVVEQFVASLvedgypRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDI 243
Cdd:cd17953 77 -QRPVKPGEGPIGLIMAPTRELALQIYVECKKFSKAL------GLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDI 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15234166 244 LA---KKKMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd17953 150 LTannGRVTNLRRVTYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
97-451 |
2.59e-66 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 221.00 E-value: 2.59e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 97 KNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEeimmPIAAGE---G 173
Cdd:PRK04837 8 QKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSH----PAPEDRkvnQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 174 PIALVICPSRELAKQTYDVVEQFVASlvedgyPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDA 253
Cdd:PRK04837 84 PRALIMAPTRELAVQIHADAEPLAQA------TGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 254 CRLLTLDEADRLVDLGFEDDIRHVFDHF--KSQRQTLLFSATMPAKIQIFATSALVKPVTVNVGRAGAANLDVIQEVEYV 331
Cdd:PRK04837 158 IQVVVLDEADRMFDLGFIKDIRWLFRRMppANQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFYP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 332 KQEAKIVYLLECLQKTTPP-VLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASK 410
Cdd:PRK04837 238 SNEEKMRLLQTLIEEEWPDrAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAAR 317
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15234166 411 GLDFPDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTF 451
Cdd:PRK04837 318 GLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
99-318 |
4.52e-63 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 205.80 E-value: 4.52e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 99 FMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEIMMPIAAGEG--PIA 176
Cdd:cd17967 2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRGRRKayPSA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 177 LVICPSRELAKQTYDVVEQFVASLVedgyprLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRL 256
Cdd:cd17967 82 LILAPTRELAIQIYEEARKFSYRSG------VRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKF 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15234166 257 LTLDEADRLVDLGFEDDIRHVFDHF----KSQRQTLLFSATMPAKIQIFATSALVKPVTVNVGRAG 318
Cdd:cd17967 156 LVLDEADRMLDMGFEPQIRKIVEHPdmppKGERQTLMFSATFPREIQRLAADFLKNYIFLTVGRVG 221
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
99-478 |
9.42e-63 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 216.64 E-value: 9.42e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 99 FMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIilalqEEIMMPIAAgegPIALV 178
Cdd:PRK11634 8 FADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLL-----HNLDPELKA---PQILV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 179 ICPSRELAKQtydvveqfVASLVEDGYPRLRSLLCI---GGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACR 255
Cdd:PRK11634 80 LAPTRELAVQ--------VAEAMTDFSKHMRGVNVValyGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 256 LLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVNVGRAGAANLDVIQEVEYV---- 331
Cdd:PRK11634 152 GLVLDEADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVwgmr 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 332 KQEAkIVYLLEClqKTTPPVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKG 411
Cdd:PRK11634 232 KNEA-LVRFLEA--EDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARG 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15234166 412 LDFPDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFINKNQSEItlldLKHLLQEAKQRIPPV 478
Cdd:PRK11634 309 LDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRL----LRNIERTMKLTIPEV 371
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
74-315 |
1.74e-62 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 204.86 E-value: 1.74e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 74 KQMDLIRKQWHITVNGEDIPPPIKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVL 153
Cdd:cd18049 1 QEVEQYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 154 PMIILALQEEIMmpiAAGEGPIALVICPSRELAKQTYDVVEQFVASLvedgypRLRSLLCIGGVDMRSQLDVVKKGVHIV 233
Cdd:cd18049 81 PAIVHINHQPFL---ERGDGPICLVLAPTRELAQQVQQVAAEYGRAC------RLKSTCIYGGAPKGPQIRDLERGVEIC 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 234 VATPGRLKDILAKKKMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVN 313
Cdd:cd18049 152 IATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHIN 231
|
..
gi 15234166 314 VG 315
Cdd:cd18049 232 IG 233
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
72-452 |
9.23e-62 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 208.53 E-value: 9.23e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 72 STKQMDLIRKQWHITVNGEDIpppIKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVF 151
Cdd:PTZ00424 6 QKNQSEQVASTGTIESNYDEI---VDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 152 VlpmiILALQEeIMMPIAAGEgpiALVICPSRELAKQTYDVVeqfvasLVEDGYPRLRSLLCIGGVDMRSQLDVVKKGVH 231
Cdd:PTZ00424 83 V----IAALQL-IDYDLNACQ---ALILAPTRELAQQIQKVV------LALGDYLKVRCHACVGGTVVRDDINKLKAGVH 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 232 IVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVT 311
Cdd:PTZ00424 149 MVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKR 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 312 VNVgRAGAANLDVIQEVeYV---KQEAKIVYLLECLQK-TTPPVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDR 387
Cdd:PTZ00424 229 ILV-KKDELTLEGIRQF-YVaveKEEWKFDTLCDLYETlTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDR 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15234166 388 DYAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFI 452
Cdd:PTZ00424 307 DLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFV 371
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
108-313 |
1.32e-61 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 201.06 E-value: 1.32e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEimmPIAAGEGPIALVICPSRELAK 187
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQP---PLERGDGPIVLVLAPTRELAQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 188 QTYDVVEQFVASLvedgypRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVD 267
Cdd:cd17966 78 QIQQEANKFGGSS------RLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15234166 268 LGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVN 313
Cdd:cd17966 152 MGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQVN 197
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
108-312 |
1.69e-61 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 200.72 E-value: 1.69e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMII-LALQEEImmpiAAGEGPIALVICPSRELA 186
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVhIMDQREL----EKGEGPIAVIVAPTRELA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 187 KQTYDVVEQFVAslvedgYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLV 266
Cdd:cd17952 77 QQIYLEAKKFGK------AYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMF 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15234166 267 DLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd17952 151 DMGFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
68-315 |
2.92e-61 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 202.93 E-value: 2.92e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 68 VRKMSTKQMDLIRKQWHITVNGEDIPPPIKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGK 147
Cdd:cd18050 33 VARMTQYDVEELRRKKEITIRGVGCPKPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGK 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 148 TLVFVLPMIILALQEEIMmpiAAGEGPIALVICPSRELAKQTYDVVEQFVASlvedgyPRLRSLLCIGGVDMRSQLDVVK 227
Cdd:cd18050 113 TLAYLLPAIVHINHQPYL---ERGDGPICLVLAPTRELAQQVQQVADDYGKS------SRLKSTCIYGGAPKGPQIRDLE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 228 KGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALV 307
Cdd:cd18050 184 RGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLR 263
|
....*...
gi 15234166 308 KPVTVNVG 315
Cdd:cd18050 264 DYVQINIG 271
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
87-318 |
3.06e-58 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 194.80 E-value: 3.06e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 87 VNGEDIPPPIKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEIMM 166
Cdd:cd18052 33 VTGRNPPPAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 167 PIAAG-EGPIALVICPSRELAKQTYDVVEQFVASLVedgyprLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILA 245
Cdd:cd18052 113 SSFSEvQEPQALIVAPTRELANQIFLEARKFSYGTC------IRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIG 186
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15234166 246 KKKMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHF----KSQRQTLLFSATMPAKIQIFATSAL-VKPVTVNVGRAG 318
Cdd:cd18052 187 RGKISLSKLKYLILDEADRMLDMGFGPEIRKLVSEPgmpsKEDRQTLMFSATFPEEIQRLAAEFLkEDYLFLTVGRVG 264
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
108-312 |
1.02e-56 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 189.07 E-value: 1.02e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEIMMPIAAGEGPIALVICPSRELAK 187
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 188 QTYDVVEQFVAslvedgYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVD 267
Cdd:cd17945 81 QIEEETQKFAK------PLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMID 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15234166 268 LGFEDDIRHVFDHF--------------------KSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd17945 155 MGFEPQVTKILDAMpvsnkkpdteeaeklaasgkHRYRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
324-452 |
7.83e-55 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 180.78 E-value: 7.83e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 324 VIQEVEYVKQEAKIVYLLECLQKTTPP--VLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDV 401
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPgkAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 15234166 402 LVATDVASKGLDFPDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFI 452
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
89-319 |
1.51e-54 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 184.47 E-value: 1.51e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 89 GEDIPPPIKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEIMMPI 168
Cdd:cd18051 13 GENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQGPGESL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 169 AAGEG--------PIALVICPSRELAKQTYDVVEQFVaslvedgY-PRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGR 239
Cdd:cd18051 93 PSESGyygrrkqyPLALVLAPTRELASQIYDEARKFA-------YrSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 240 LKDILAKKKMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHF----KSQRQTLLFSATMPAKIQIFATSALVKPVTVNVG 315
Cdd:cd18051 166 LVDMLERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDtmppTGERQTLMFSATFPKEIQMLARDFLDNYIFLAVG 245
|
....
gi 15234166 316 RAGA 319
Cdd:cd18051 246 RVGS 249
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
108-312 |
1.63e-52 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 177.06 E-value: 1.63e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIilalqEEIMMPIAAGEGPIALVICPSRELAK 187
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPIL-----ERLLYRPKKKAATRVLVLVPTRELAM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 188 QTYDVVEQFVAslvedgYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAK-KKMSLDACRLLTLDEADRLV 266
Cdd:cd17947 76 QCFSVLQQLAQ------FTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNsPSFDLDSIEILVLDEADRML 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15234166 267 DLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd17947 150 EEGFADELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
98-313 |
1.25e-51 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 175.19 E-value: 1.25e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 98 NFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIilalqeEIMMPIAAGEGPIAL 177
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMI------EKLKAHSPTVGARAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 178 VICPSRELAKQTYDVVEQFVAslvedgYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLL 257
Cdd:cd17959 76 ILSPTRELALQTLKVTKELGK------FTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYV 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 15234166 258 TLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVN 313
Cdd:cd17959 150 VFDEADRLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLIR 205
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
99-310 |
1.61e-51 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 174.72 E-value: 1.61e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 99 FMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPmIILALQEEimmpiaaGEGPIALV 178
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALP-ILQRLSED-------PYGIFALV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 179 ICPSRELAKQtydVVEQFVASlvedGYP-RLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDIL---AKKKMSLDAC 254
Cdd:cd17955 73 LTPTRELAYQ---IAEQFRAL----GAPlGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLrssDDTTKVLSRV 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 15234166 255 RLLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPV 310
Cdd:cd17955 146 KFLVLDEADRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
99-312 |
4.98e-51 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 173.66 E-value: 4.98e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 99 FMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMiilaLQEEIMMPiaagEGPIALV 178
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPI----LQALLENP----QRFFALV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 179 ICPSRELAKQtydVVEQFVA--SLVEdgyprLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKK-MSLDACR 255
Cdd:cd17954 74 LAPTRELAQQ---ISEQFEAlgSSIG-----LKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKgFSLKSLK 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 15234166 256 LLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd17954 146 FLVMDEADRLLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
121-301 |
9.93e-50 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 168.57 E-value: 9.93e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 121 TPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEimmpiaagEGPIALVICPSRELAKQTYDVVEQFVASL 200
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLD--------NGPQALVLAPTRELAEQIYEELKKLGKGL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 201 vedgypRLRSLLCIGGVDMRSQLDVVKkGVHIVVATPGRLKDILAKKKmSLDACRLLTLDEADRLVDLGFEDDIRHVFDH 280
Cdd:pfam00270 73 ------GLKVASLLGGDSRKEQLEKLK-GPDILVGTPGRLLDLLQERK-LLKNLKLLVLDEAHRLLDMGFGPDLEEILRR 144
|
170 180
....*....|....*....|.
gi 15234166 281 FKSQRQTLLFSATMPAKIQIF 301
Cdd:pfam00270 145 LPKKRQILLLSATLPRNLEDL 165
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
108-313 |
9.00e-48 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 164.67 E-value: 9.00e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPM--IILALQEEIMMPiaageGPIALVICPSREL 185
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVleILLKRKANLKKG-----QVGALIISPTREL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 186 AKQTYDVVEQFVaslvEDGYPRLRSLLCIGGVDMRSQL-DVVKKGVHIVVATPGRLKDIL--AKKKMSLDACRLLTLDEA 262
Cdd:cd17960 76 ATQIYEVLQSFL----EHHLPKLKCQLLIGGTNVEEDVkKFKRNGPNILVGTPGRLEELLsrKADKVKVKSLEVLVLDEA 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 15234166 263 DRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVN 313
Cdd:cd17960 152 DRLLDLGFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRVV 202
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
106-306 |
4.18e-47 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 163.14 E-value: 4.18e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 106 SPLLRMLKDKGIMHPTPIQVQGLPVVLS-GRDMIGIAFTGSGKTLVFVLPmiilALQEEIMMPIAAGEGPI-ALVICPSR 183
Cdd:cd17964 3 PSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLP----AIQSLLNTKPAGRRSGVsALIISPTR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 184 ELAKQTYDVVEQfvaslVEDGYPRLRSLLCIGGVDMRSQL-DVVKKGVHIVVATPGRLKDILAKKKM--SLDACRLLTLD 260
Cdd:cd17964 79 ELALQIAAEAKK-----LLQGLRKLRVQSAVGGTSRRAELnRLRRGRPDILVATPGRLIDHLENPGVakAFTDLDYLVLD 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 15234166 261 EADRLVDLGFEDDI----RHVFDHFKSQRQTLLFSATMPAKIQIFATSAL 306
Cdd:cd17964 154 EADRLLDMGFRPDLeqilRHLPEKNADPRQTLLFSATVPDEVQQIARLTL 203
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
112-325 |
2.22e-45 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 158.42 E-value: 2.22e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 112 LKDKGIMHPTPIQVQGLPVVLSG-RDMIGIAFTGSGKTLVFVLPMIILALQeeimmpiaaGEGPIALVICPSRELAKQTY 190
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKR---------GKGGRVLVLVPTRELAEQWA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 191 DVVEQFVaslvedGYPRLRSLLCIGGVDMRSQLDVVKKGV-HIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVDLG 269
Cdd:smart00487 72 EELKKLG------PSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGG 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 15234166 270 FEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVNVGRAGAANLDVI 325
Cdd:smart00487 146 FGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
99-313 |
3.65e-45 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 157.84 E-value: 3.65e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 99 FMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIilalqEEIMMPIAAGEgpiALV 178
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPIL-----EKIDPKKDVIQ---ALI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 179 ICPSRELAKQTYDVVEQFVAslvedgYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLT 258
Cdd:cd17940 73 LVPTRELALQTSQVCKELGK------HMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLV 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 15234166 259 LDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVN 313
Cdd:cd17940 147 LDEADKLLSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEIN 201
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
108-312 |
6.20e-45 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 156.94 E-value: 6.20e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEimmpiaagEGPIALVICPSRELAK 187
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEH--------RNPSALILTPTRELAV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 188 QTYDVveqfvASLVEDGYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVD 267
Cdd:cd17962 73 QIEDQ-----AKELMKGLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLK 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15234166 268 LGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd17962 148 MGFQQQVLDILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
99-294 |
5.11e-44 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 154.79 E-value: 5.11e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 99 FMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIilalqeEIMMpiaagegpiALV 178
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVL------QIVV---------ALI 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 179 ICPSRELAKQTYDVVEQFvASLVEDgyPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLT 258
Cdd:cd17938 66 LEPSRELAEQTYNCIENF-KKYLDN--PKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFV 142
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15234166 259 LDEADRLVDLGFEDDIRHVFDHF-----KSQR-QTLLFSATM 294
Cdd:cd17938 143 LDEADRLLSQGNLETINRIYNRIpkitsDGKRlQVIVCSATL 184
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
108-312 |
5.99e-44 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 154.54 E-value: 5.99e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEImmPIAAGEGPIALVICPSRELAK 187
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPI--PREQRNGPGVLVLTPTRELAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 188 QTYDVVEQFvaslvedGYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVD 267
Cdd:cd17958 79 QIEAECSKY-------SYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15234166 268 LGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd17958 152 MGFEPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
108-315 |
2.28e-43 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 152.74 E-value: 2.28e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMI--ILALQEEimmpiaagEGPIALVICPSREL 185
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILqkLGKPRKK--------KGLRALILAPTREL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 186 AKQTYDVVEQFVaslveDGYPrLRS-LLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADR 264
Cdd:cd17957 73 ASQIYRELLKLS-----KGTG-LRIvLLSKSLEAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADK 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 15234166 265 LVDLGFEDDIRHVFDHFKSQR-QTLLFSATMPAKIQIFATSALVKPVTVNVG 315
Cdd:cd17957 147 LFEPGFREQTDEILAACTNPNlQRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
109-313 |
4.13e-43 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 152.13 E-value: 4.13e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 109 LRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEIMMPIAAGegpiALVICPSRELAKQ 188
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPRNGTG----VIIISPTRELALQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 189 TYDVVEQFVAslvedgYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSL-DACRLLTLDEADRLVD 267
Cdd:cd17942 78 IYGVAKELLK------YHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLyKNLQCLIIDEADRILE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 15234166 268 LGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALV-KPVTVN 313
Cdd:cd17942 152 IGFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKkKPLYVG 198
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
108-312 |
7.00e-43 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 151.97 E-value: 7.00e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDK-GIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMI--ILALQEeimmPIAAGEGPIALVICPSRE 184
Cdd:cd17949 1 LVSHLKSKmGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIqrLLSLEP----RVDRSDGTLALVLVPTRE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 185 LAKQTYDVVEQFVASlvedgYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKD-ILAKKKMSLDACRLLTLDEAD 263
Cdd:cd17949 77 LALQIYEVLEKLLKP-----FHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDhLKNTQSFDVSNLRWLVLDEAD 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15234166 264 RLVDLGFEDDIRHVFDHF-------------KSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd17949 152 RLLDMGFEKDITKILELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
109-314 |
1.04e-41 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 148.59 E-value: 1.04e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 109 LRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPmiilALQEEIMMPIAAGEGPIALVICPSRELAKQ 188
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVP----LLEKLYRERWTPEDGLGALIISPTRELAMQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 189 TYDVVEQ------FVASLVedgyprlrsllcIGGVDMRSQLDVVKkGVHIVVATPGRLKDILAKK-KMSLDACRLLTLDE 261
Cdd:cd17941 78 IFEVLRKvgkyhsFSAGLI------------IGGKDVKEEKERIN-RMNILVCTPGRLLQHMDETpGFDTSNLQMLVLDE 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 15234166 262 ADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVNV 314
Cdd:cd17941 145 ADRILDMGFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
108-295 |
2.58e-38 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 138.94 E-value: 2.58e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIilalqeeiMMPIAAGEGPIALVICPSRELAK 187
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIAL--------ESLDLERRHPQVLILAPTREIAV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 188 QTYDVVEQFVASLvedgyPRLRSLLCIGGVDMrsQLDVVK-KGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLV 266
Cdd:cd17943 73 QIHDVFKKIGKKL-----EGLKCEVFIGGTPV--KEDKKKlKGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLM 145
|
170 180
....*....|....*....|....*....
gi 15234166 267 DLGFEDDIRHVFDHFKSQRQTLLFSATMP 295
Cdd:cd17943 146 EGSFQKDVNWIFSSLPKNKQVIAFSATYP 174
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
108-294 |
2.98e-38 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 140.45 E-value: 2.98e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPV-VLSGRDMIGIAFTGSGKTLVFVLPMI--ILALQEEIMMPIAAGeGPIALVICPSRE 184
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAaIRDGKDVIGAAETGSGKTLAFGIPILerLLSQKSSNGVGGKQK-PLRALILTPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 185 LAKQtydVVEQFVASLvedGYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKM---SLDACRLLTLDE 261
Cdd:cd17946 80 LAVQ---VKDHLKAIA---KYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEhlaNLKSLRFLVLDE 153
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 15234166 262 ADRLVDLGFEDDIRHVFDHFKS-------QRQTLLFSATM 294
Cdd:cd17946 154 ADRMLEKGHFAELEKILELLNKdragkkrKRQTFVFSATL 193
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
108-312 |
9.29e-37 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 135.40 E-value: 9.29e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEIMmpIAAGEGPIALVICPSRELAK 187
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAE--SGEEQGTRALILVPTRELAQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 188 QTYDVVEQFVASLvedgYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKK-KMSLDACRLLTLDEADRLV 266
Cdd:cd17961 83 QVSKVLEQLTAYC----RKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGsLLLLSTLKYLVIDEADLVL 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15234166 267 DLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd17961 159 SYGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAIL 204
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
101-310 |
1.71e-35 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 131.68 E-value: 1.71e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 101 DMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVlpmiILALQEEIMMPIAagegPIALVIC 180
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFS----IGALQRIDTTVRE----TQALVLA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 181 PSRELAKQTYDVVE---QFVASlvedgyprlRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLL 257
Cdd:cd17939 73 PTRELAQQIQKVVKalgDYMGV---------KVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMF 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 15234166 258 TLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPV 310
Cdd:cd17939 144 VLDEADEMLSRGFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPV 196
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
105-312 |
4.29e-35 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 130.39 E-value: 4.29e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 105 PSPLLRMLKDKGIMHPTPIQVQGLPVVLSG--RDMIGIAFTGSGKTLVFVLPM---IILALQEeimmpiaagegPIALVI 179
Cdd:cd17963 2 KPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMlsrVDPTLKS-----------PQALCL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 180 CPSRELAKQTYDVVEQFVAslvedgYPRLRSLLCIGGVDMRSQLDVVKkgvHIVVATPGRLKDILAKKKMSLDACRLLTL 259
Cdd:cd17963 71 APTRELARQIGEVVEKMGK------FTGVKVALAVPGNDVPRGKKITA---QIVIGTPGTVLDWLKKRQLDLKKIKILVL 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 15234166 260 DEADRLVDL-GFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd17963 142 DEADVMLDTqGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
335-443 |
6.78e-34 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 124.25 E-value: 6.78e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 335 AKIVYLLECLQKTTPP-VLIFCENKADVDdIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLD 413
Cdd:pfam00271 1 EKLEALLELLKKERGGkVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100 110
....*....|....*....|....*....|
gi 15234166 414 FPDIQHVINYDMPGEIENYVHRIGRTGRCG 443
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
108-295 |
8.84e-34 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 127.87 E-value: 8.84e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMI--ILALQEEIMMPIAAgegPIALVICPSREL 185
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIqrLLRYKLLAEGPFNA---PRGLVITPSREL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 186 AKQTYDVVEQFVASLvedGYpRLRSLLciGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRL 265
Cdd:cd17948 78 AEQIGSVAQSLTEGL---GL-KVKVIT--GGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTL 151
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 15234166 266 VDLGFEDDIRHVFDHFKSQR-------------QTLLFSATMP 295
Cdd:cd17948 152 LDDSFNEKLSHFLRRFPLASrrsentdgldpgtQLVLVSATMP 194
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
99-312 |
3.95e-33 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 125.25 E-value: 3.95e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 99 FMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVlpmiILALQEeIMMPIAAgegPIALV 178
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFS----ISILQQ-IDTSLKA---TQALV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 179 ICPSRELAKQtydvVEQFVASLVEdgYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLT 258
Cdd:cd18046 73 LAPTRELAQQ----IQKVVMALGD--YMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFV 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 15234166 259 LDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd18046 147 LDEADEMLSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
109-295 |
7.92e-31 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 118.80 E-value: 7.92e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 109 LRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIiLALQEEiMMPIAAGEGPIALVICPSRELAKQ 188
Cdd:cd17944 2 IKLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLI-EKLQED-QQPRKRGRAPKVLVLAPTRELANQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 189 tydvveqfVASLVEDGYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVDL 268
Cdd:cd17944 80 --------VTKDFKDITRKLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDM 151
|
170 180 190
....*....|....*....|....*....|..
gi 15234166 269 GFEDDIRHVFD-HFKSQR----QTLLFSATMP 295
Cdd:cd17944 152 GFAEQVEEILSvSYKKDSednpQTLLFSATCP 183
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
362-443 |
7.15e-29 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 109.22 E-value: 7.15e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 362 DDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDMPGEIENYVHRIGRTGR 441
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 15234166 442 CG 443
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
99-298 |
8.68e-29 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 113.21 E-value: 8.68e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 99 FMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPmiilALQEeimmpIAAGEGPI-AL 177
Cdd:cd17950 4 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLS----TLQQ-----LEPVDGQVsVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 178 VICPSRELAKQTYDVVEQFVASLvedgyPRLRSLLCIGGVDMRSQLDVVKKGV-HIVVATPGRLKDILAKKKMSLDACRL 256
Cdd:cd17950 75 VICHTRELAFQISNEYERFSKYM-----PNVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKH 149
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 15234166 257 LTLDEADRLV-DLGFEDDIRHVFDHFKSQRQTLLFSATMPAKI 298
Cdd:cd17950 150 FVLDECDKMLeQLDMRRDVQEIFRATPHDKQVMMFSATLSKEI 192
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
99-312 |
3.09e-28 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 111.79 E-value: 3.09e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 99 FMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVF---VLPMIILALQEeimmpiaagegPI 175
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFsisVLQCLDIQVRE-----------TQ 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 176 ALVICPSRELAKQTYDVVeqfvasLVEDGYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACR 255
Cdd:cd18045 70 ALILSPTRELAVQIQKVL------LALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIK 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 15234166 256 LLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTV 312
Cdd:cd18045 144 MLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
108-299 |
2.47e-25 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 104.25 E-value: 2.47e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVVLSG---------RDMIGIAFTGSGKTLVFVLPmIILALQEEImmpiaageGPI--A 176
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLP-IVQALSKRV--------VPRlrA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 177 LVICPSRELAKQTYDVVEQFVASLVedgyprLRSLLCIGGVD-----MRSQLDVVKKG---VHIVVATPGRLKD-ILAKK 247
Cdd:cd17956 72 LIVVPTKELVQQVYKVFESLCKGTG------LKVVSLSGQKSfkkeqKLLLVDTSGRYlsrVDILVATPGRLVDhLNSTP 145
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15234166 248 KMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHFK--------------------SQRQTLLFSATM---PAKIQ 299
Cdd:cd17956 146 GFTLKHLRFLVIDEADRLLNQSFQDWLETVMKALGrptapdlgsfgdanllersvRPLQKLLFSATLtrdPEKLS 220
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
143-421 |
1.16e-21 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 98.56 E-value: 1.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 143 TGSGKTLVFVlpMIILALQEeimmpiaageGPIALVICPSRELAKQTYDVVEQFVASLVEDGYPRlrsllciggvdmrsq 222
Cdd:COG1061 109 TGTGKTVLAL--ALAAELLR----------GKRVLVLVPRRELLEQWAEELRRFLGDPLAGGGKK--------------- 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 223 ldvvKKGVHIVVATPGRLKDILAKKKMSlDACRLLTLDEADRLVDLGFeddiRHVFDHFKSQRqTLLFSAT------MPA 296
Cdd:COG1061 162 ----DSDAPITVATYQSLARRAHLDELG-DRFGLVIIDEAHHAGAPSY----RRILEAFPAAY-RLGLTATpfrsdgREI 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 297 KIQIFA-----------------TSALVKPVTVNVGRAGAANLDVIQEVEYV---KQEAKIVYLLECLQKT--TPPVLIF 354
Cdd:COG1061 232 LLFLFDgivyeyslkeaiedgylAPPEYYGIRVDLTDERAEYDALSERLREAlaaDAERKDKILRELLREHpdDRKTLVF 311
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15234166 355 CENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFPDIQHVI 421
Cdd:COG1061 312 CSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAI 378
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
131-451 |
1.53e-16 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 82.11 E-value: 1.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 131 VLSGRDMIGIAFTGSGKTLVFVLPMIILalqeeimmpiaagEGPiALVICP--SreLAK-QtydvveqfVASLVEDGYP- 206
Cdd:COG0514 29 VLAGRDALVVMPTGGGKSLCYQLPALLL-------------PGL-TLVVSPliA--LMKdQ--------VDALRAAGIRa 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 207 -RLRSLLciGGVDMRSQLDVVKKG-VHIVVATPGRLK-----DILAKKKMSLdacrlLTLDEA--------D------RL 265
Cdd:COG0514 85 aFLNSSL--SAEERREVLRALRAGeLKLLYVAPERLLnprflELLRRLKISL-----FAIDEAhcisqwghDfrpdyrRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 266 VDLgfeddiRHVFDHfksqRQTLLFSATMPAKIQ--IFATSALVKPVTVnvgRAGAA--NLDViqEVEYVKQEAKIVYLL 341
Cdd:COG0514 158 GEL------RERLPN----VPVLALTATATPRVRadIAEQLGLEDPRVF---VGSFDrpNLRL--EVVPKPPDDKLAQLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 342 ECLQKTTP-PVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATdVA-SKGLDFPDIQH 419
Cdd:COG0514 223 DFLKEHPGgSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-IAfGMGIDKPDVRF 301
|
330 340 350
....*....|....*....|....*....|..
gi 15234166 420 VINYDMPGEIENYVHRIGRTGRCGKTGIATTF 451
Cdd:COG0514 302 VIHYDLPKSIEAYYQEIGRAGRDGLPAEALLL 333
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
352-451 |
1.53e-16 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 76.09 E-value: 1.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 352 LIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDMPGEIEN 431
Cdd:cd18794 34 IIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMES 113
|
90 100
....*....|....*....|
gi 15234166 432 YVHRIGRTGRCGKTGIATTF 451
Cdd:cd18794 114 YYQESGRAGRDGLPSECILF 133
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
96-309 |
8.55e-16 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 76.60 E-value: 8.55e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 96 IKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSG--RDMIGIAFTGSGKTLVFVLPMIILALQEEIMmpiaageg 173
Cdd:cd18048 17 VKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLY-------- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 174 PIALVICPSRELAKQTYDVVEQ---FVASlVEDGYPrLRSLLCIGGVDMRSQldvvkkgvhIVVATPGRLKDILAKKKM- 249
Cdd:cd18048 89 PQCLCLSPTFELALQTGKVVEEmgkFCVG-IQVIYA-IRGNRPGKGTDIEAQ---------IVIGTPGTVLDWCFKLRLi 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15234166 250 SLDACRLLTLDEADRLVDL-GFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKP 309
Cdd:cd18048 158 DVTNISVFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDP 218
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
108-295 |
1.33e-15 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 76.65 E-value: 1.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLPVvLSGRDMIGI-----------------AFTGSGKTLVFVLPMIILALQEEIMMPIAA 170
Cdd:cd17965 19 LKGSNKTDEEIKPSPIQTLAIKK-LLKTLMRKVtkqtsneepklevfllaAETGSGKTLAYLAPLLDYLKRQEQEPFEEA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 171 GEG---------PIALVICPSRELAKQTYDVVEQF--VASLvedgypRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGR 239
Cdd:cd17965 98 EEEyesakdtgrPRSVILVPTHELVEQVYSVLKKLshTVKL------GIKTFSSGFGPSYQRLQLAFKGRIDILVTTPGK 171
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 15234166 240 LKDiLAKKKMS-LDACRLLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMP 295
Cdd:cd17965 172 LAS-LAKSRPKiLSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIP 227
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
97-309 |
1.12e-11 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 64.36 E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 97 KNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSG--RDMIGIAFTGSGKTLVFVLPMIilalqeEIMMPiaAGEGP 174
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAML------SQVEP--ANKYP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 175 IALVICPSRELAKQTYDVVEQfvaslVEDGYPRLRSLLCIGGVDMRSQLDVVKKgvhIVVATPGRLKDILAKKKM-SLDA 253
Cdd:cd18047 73 QCLCLSPTYELALQTGKVIEQ-----MGKFYPELKLAYAVRGNKLERGQKISEQ---IVIGTPGTVLDWCSKLKFiDPKK 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 15234166 254 CRLLTLDEADRLVDL-GFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKP 309
Cdd:cd18047 145 IKVFVLDEADVMIATqGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
336-441 |
1.13e-11 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 67.45 E-value: 1.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 336 KIVYLLECLQKT--TPP---VLIFCENKADVDDIHEYLLLKGVEAVAIHG--GKDQED------RDYAISLFKAGKKDVL 402
Cdd:COG1111 336 KLSKLREILKEQlgTNPdsrIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGqaSKEGDKgltqkeQIEILERFRAGEFNVL 415
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 15234166 403 VATDVASKGLDFPDIQHVINYD-MPGEIEnYVHRIGRTGR 441
Cdd:COG1111 416 VATSVAEEGLDIPEVDLVIFYEpVPSEIR-SIQRKGRTGR 454
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
143-293 |
1.82e-11 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 62.04 E-value: 1.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 143 TGSGKTLVFVLPMIILALQEeimmpiaageGPIALVICPSRELAKQTYDVVEQFVASLVEDGYprlrsllCIGGVDMRSQ 222
Cdd:cd00046 10 TGSGKTLAALLAALLLLLKK----------GKKVLVLVPTKALALQTAERLRELFGPGIRVAV-------LVGGSSAEER 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15234166 223 LDVVKKGVHIVVATPGRL-KDILAKKKMSLDACRLLTLDEADRLVDLGFE---DDIRHVFDHFKsQRQTLLFSAT 293
Cdd:cd00046 73 EKNKLGDADIIIATPDMLlNLLLREDRLFLKDLKLIIVDEAHALLIDSRGaliLDLAVRKAGLK-NAQVILLSAT 146
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
105-448 |
2.03e-10 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 63.32 E-value: 2.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 105 PSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPmiilALQEeimmpIAAGEGPIALVICPSRE 184
Cdd:COG1205 42 PPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLP----VLEA-----LLEDPGATALYLYPTKA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 185 LAK-QtydvvEQFVASLVEDGYPRLRSLLCIGGVDM--RSQldvVKKGVHIVVATPgrlkDIL------AKKKMS--LDA 253
Cdd:COG1205 113 LARdQ-----LRRLRELAEALGLGVRVATYDGDTPPeeRRW---IREHPDIVLTNP----DMLhygllpHHTRWArfFRN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 254 CRLLTLDEA---------------DRLvdlgfeddiRHVFDHFKSQRQTLLFSATM--PAKiqiFAtSALV-KPVTVnVG 315
Cdd:COG1205 181 LRYVVIDEAhtyrgvfgshvanvlRRL---------RRICRHYGSDPQFILASATIgnPAE---HA-ERLTgRPVTV-VD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 316 RAGAA---------NLDVIQEVEYVKQEAKIVYLL-ECLQ---KTtppvLIFCENKADVDDIHEYL---LLKGVEAVAI- 378
Cdd:COG1205 247 EDGSPrgertfvlwNPPLVDDGIRRSALAEAARLLaDLVReglRT----LVFTRSRRGAELLARYArraLREPDLADRVa 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15234166 379 --HGGKDQEDRDYAISLFKAGKKDVLVAT-------DVAskGLDFpdiqhVINYDMPGEIENYVHRIGRTGRCGKTGIA 448
Cdd:COG1205 323 ayRAGYLPEERREIERGLRSGELLGVVSTnalelgiDIG--GLDA-----VVLAGYPGTRASFWQQAGRAGRRGQDSLV 394
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
382-438 |
2.92e-10 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 58.37 E-value: 2.92e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 15234166 382 KDQEDrdyAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDMPGEIENYVHRIGR 438
Cdd:cd18802 77 RKQKE---TLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR 130
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
329-475 |
4.26e-10 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 62.55 E-value: 4.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 329 EYVKQEAKIVYLLECLQKTTP---PVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGK--KDVLV 403
Cdd:COG0553 527 ELSGRSAKLEALLELLEELLAegeKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPeaPVFLI 606
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 404 ATDVASKGLDFPDIQHVINYDMP----------GEIenyvHRIGRTGRCgktgIATTFINKNQSEITLLDlkhlLQEAKQ 473
Cdd:COG0553 607 SLKAGGEGLNLTAADHVIHYDLWwnpaveeqaiDRA----HRIGQTRDV----QVYKLVAEGTIEEKILE----LLEEKR 674
|
..
gi 15234166 474 RI 475
Cdd:COG0553 675 AL 676
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
335-437 |
5.97e-10 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 57.49 E-value: 5.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 335 AKIVYLLECLQKTTPP---VLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKD--VLVATDVAS 409
Cdd:cd18793 11 GKLEALLELLEELREPgekVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIrvFLLSTKAGG 90
|
90 100 110
....*....|....*....|....*....|....
gi 15234166 410 KGLDFPDIQHVINYDM---PGEIE---NYVHRIG 437
Cdd:cd18793 91 VGLNLTAANRVILYDPwwnPAVEEqaiDRAHRIG 124
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
352-443 |
9.23e-10 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 61.27 E-value: 9.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 352 LIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDMPGEIEN 431
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIES 319
|
90
....*....|..
gi 15234166 432 YVHRIGRTGRCG 443
Cdd:PRK11057 320 YYQETGRAGRDG 331
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
143-262 |
1.85e-08 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 54.58 E-value: 1.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 143 TGSGKTLVFVlpMIILALQEEIMMPiaAGEGPIALVICPSRELAKQTYDVVEQFVASLVEDgyprLRSLLcigGVDM--R 220
Cdd:cd18034 25 TGSGKTLIAV--MLIKEMGELNRKE--KNPKKRAVFLVPTVPLVAQQAEAIRSHTDLKVGE----YSGEM---GVDKwtK 93
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 15234166 221 SQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEA 262
Cdd:cd18034 94 ERWKEELEKYDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
350-452 |
3.63e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.40 E-value: 3.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 350 PVLIFCENKADVDDIHEYLLlkgveavaihggkdqedrdyaislfkagkkdVLVATDVASKGLDFPDIQHVINYDMPGEI 429
Cdd:cd18785 5 KIIVFTNSIEHAEEIASSLE-------------------------------ILVATNVLGEGIDVPSLDTVIFFDPPSSA 53
|
90 100
....*....|....*....|....
gi 15234166 430 ENYVHRIGRTGRCGKT-GIATTFI 452
Cdd:cd18785 54 ASYIQRVGRAGRGGKDeGEVILFV 77
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
351-441 |
4.09e-08 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 56.04 E-value: 4.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 351 VLIFCENKADVDDIHEYLLLKGVEAVAIHGgkdQEDRDY-----------AISLFKAGKKDVLVATDVASKGLDFPDIQH 419
Cdd:PRK13766 368 IIVFTQYRDTAEKIVDLLEKEGIKAVRFVG---QASKDGdkgmsqkeqieILDKFRAGEFNVLVSTSVAEEGLDIPSVDL 444
|
90 100
....*....|....*....|...
gi 15234166 420 VINYD-MPGEIENyVHRIGRTGR 441
Cdd:PRK13766 445 VIFYEpVPSEIRS-IQRKGRTGR 466
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
351-441 |
1.91e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 50.43 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 351 VLIFCENKADVDDIHEYLL--LKGVEAVAIHG--------GKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFPDIQHV 420
Cdd:cd18801 33 VIIFSEFRDSAEEIVNFLSkiRPGIRATRFIGqasgksskGMSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLI 112
|
90 100
....*....|....*....|..
gi 15234166 421 INYD-MPGEIENyVHRIGRTGR 441
Cdd:cd18801 113 ICYDaSPSPIRM-IQRMGRTGR 133
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
143-293 |
2.47e-07 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 50.00 E-value: 2.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 143 TGSGKTLVfvlpmiILALQEEIMmpiaagEGPIaLVICPSRELAKQTYDVVEQFVASlvedgyprlRSLLCIGGVDMRSQ 222
Cdd:cd17926 27 TGSGKTLT------ALALIAYLK------ELRT-LIVVPTDALLDQWKERFEDFLGD---------SSIGLIGGGKKKDF 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15234166 223 LDVVkkgvhIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVDLGFeddiRHVFDHFKSQRQtLLFSAT 293
Cdd:cd17926 85 DDAN-----VVVATYQSLSNLAEEEKDLFDQFGLLIVDEAHHLPAKTF----SEILKELNAKYR-LGLTAT 145
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
121-262 |
6.15e-07 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 49.95 E-value: 6.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 121 TPIQVQGL-PVVLSGRDMIGIAFTGSGKTLVFVLpMIILALqeeimmpiaAGEGPIALVICPSRELAKQTY-DVVEQFVA 198
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLIAEL-AILRAL---------ATSGGKAVYIAPTRALVNQKEaDLRERFGP 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15234166 199 SLVEDGyprlrslLCIGGVDMRSQLDvvkKGVHIVVATPGRLkDILAKK--KMSLDACRLLTLDEA 262
Cdd:cd17921 73 LGKNVG-------LLTGDPSVNKLLL---AEADILVATPEKL-DLLLRNggERLIQDVRLVVVDEA 127
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
108-444 |
1.64e-06 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 50.66 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 108 LLRMLKDKGIMHPTPIQVQGLP-VVLSGRDMIGIAFTGSGKTLVfvlpmIILALQEEIMmpiaagEGPIALVICPSRELA 186
Cdd:COG1204 11 VIEFLKERGIEELYPPQAEALEaGLLEGKNLVVSAPTASGKTLI-----AELAILKALL------NGGKALYIVPLRALA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 187 KQtydVVEQFVASLVEDGYprlRSLLCIGGVDMRSQLdvvKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEA---- 262
Cdd:COG1204 80 SE---KYREFKRDFEELGI---KVGVSTGDYDSDDEW---LGRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAhlid 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 263 --DRLVDLgfED---DIRHVfdhfKSQRQTLLFSATMPAkIQIFAT---SALVK----PVTVNVGRAGAANLDViQEVEY 330
Cdd:COG1204 151 deSRGPTL--EVllaRLRRL----NPEAQIVALSATIGN-AEEIAEwldAELVKsdwrPVPLNEGVLYDGVLRF-DDGSR 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 331 VKQEAKIVYLLECLQKTTpPVLIFCENKADV---------------------------DDIHEY------------LLLK 371
Cdd:COG1204 223 RSKDPTLALALDLLEEGG-QVLVFVSSRRDAeslakkladelkrrltpeereeleelaEELLEVseethtnekladCLEK 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 372 GveaVAIH-GGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFP-------DIQHVINYDMP-GEIENYvhrIGRTGRC 442
Cdd:COG1204 302 G---VAFHhAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLParrviirDTKRGGMVPIPvLEFKQM---AGRAGRP 375
|
..
gi 15234166 443 GK 444
Cdd:COG1204 376 GY 377
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
143-293 |
3.01e-06 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 47.28 E-value: 3.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 143 TGSGKTLVFVLpmIILALQEeimmpiaAGEGPIALVICPSRELAKQTYDVVEQFV---ASLVEDGYPRLRsllciggvdm 219
Cdd:pfam04851 32 TGSGKTLTAAK--LIARLFK-------KGPIKKVLFLVPRKDLLEQALEEFKKFLpnyVEIGEIISGDKK---------- 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15234166 220 rsqlDVVKKGVHIVVATPGRLK--DILAKKKMSLDACRLLTLDEADRLVDLGFeddiRHVFDHFKSQRQtLLFSAT 293
Cdd:pfam04851 93 ----DESVDDNKIVVTTIQSLYkaLELASLELLPDFFDVIIIDEAHRSGASSY----RNILEYFKPAFL-LGLTAT 159
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
352-444 |
4.87e-06 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 49.51 E-value: 4.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 352 LIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDMPGEIEN 431
Cdd:PLN03137 684 IIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEG 763
|
90
....*....|...
gi 15234166 432 YVHRIGRTGRCGK 444
Cdd:PLN03137 764 YHQECGRAGRDGQ 776
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
373-441 |
3.93e-05 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 43.79 E-value: 3.93e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 373 VEAVAIHGGK-DQEDRDYAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDMPGEIENYVHRIGRTGR 441
Cdd:cd18796 68 PDFIALHHGSlSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGH 137
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
123-237 |
4.34e-04 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 41.57 E-value: 4.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 123 IQVQGLPVVL-SGRDMIGIAFTGSGKTLVFVLPMIILaLQEEIMMPIAAgegPIALVICPSRELAKQTYDvveQFVASLV 201
Cdd:cd18023 5 IQSEVFPDLLySDKNFVVSAPTGSGKTVLFELAILRL-LKERNPLPWGN---RKVVYIAPIKALCSEKYD---DWKEKFG 77
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90 100 110
....*....|....*....|....*....|....*.
gi 15234166 202 EDGyprLRSLLCIGGVDMRSQLDVvkKGVHIVVATP 237
Cdd:cd18023 78 PLG---LSCAELTGDTEMDDTFEI--QDADIILTTP 108
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| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
352-417 |
7.92e-04 |
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C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 39.46 E-value: 7.92e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15234166 352 LIFCENKADVDDIHEYLLLKGVEAVAIHGG-KDQEDRDYAISLFKAGKK--DVLVATDVASKGLDFPDI 417
Cdd:cd18799 10 LIFCVSIEHAEFMAEAFNEAGIDAVALNSDySDRERGDEALILLFFGELkpPILVTVDLLTTGVDIPEV 78
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| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
119-157 |
1.96e-03 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 41.24 E-value: 1.96e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 15234166 119 HPTPIQVQGLPVVLSGRDMIGIAFTGSGKTL-VFvLPMII 157
Cdd:COG1201 24 APTPPQREAWPAIAAGESTLLIAPTGSGKTLaAF-LPALD 62
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|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
124-266 |
2.52e-03 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 39.03 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234166 124 QVQGLPVVLSGRDMIgIAFTGSGKTLVFVLpmiilalqeeIMMPIAAGEGPIALVICPSRELAKQTYDVVEQFVASlved 203
Cdd:cd18035 7 QVLIAAVALNGNTLI-VLPTGLGKTIIAIL----------VAADRLTKKGGKVLILAPSRPLVEQHAENLKRVLNI---- 71
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15234166 204 gyprlrSLLCI---GGVDMRSQLDVVKKGvHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLV 266
Cdd:cd18035 72 ------PDKITsltGEVKPEERAERWDAS-KIIVATPQVIENDLLAGRITLDDVSLLIFDEAHHAV 130
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| RecG |
COG1200 |
RecG-like helicase [Replication, recombination and repair]; |
359-407 |
5.94e-03 |
|
RecG-like helicase [Replication, recombination and repair];
Pssm-ID: 440813 [Multi-domain] Cd Length: 684 Bit Score: 39.26 E-value: 5.94e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 15234166 359 ADVDDIHEYL--LLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDV 407
Cdd:COG1200 488 QAAEETYEELreAFPGLRVGLLHGRMKPAEKDAVMAAFKAGEIDVLVATTV 538
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|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
351-416 |
6.56e-03 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 37.61 E-value: 6.56e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15234166 351 VLIFCENKADVDDIHEYLLLKgveavAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFPD 416
Cdd:cd18789 52 IIVFTDNVEALYRYAKRLLKP-----FITGETPQSEREEILQNFREGEYNTLVVSKVGDEGIDLPE 112
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| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
360-415 |
6.95e-03 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 37.32 E-value: 6.95e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 15234166 360 DVDDIHEYL--LLKGVEAVA-IHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFP 415
Cdd:cd18811 46 AAVAMYEYLkeRFRPELNVGlLHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVP 104
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