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Conserved domains on  [gi|15234125|ref|NP_195052|]
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Transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
149-421 9.98e-57

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.43  E-value: 9.98e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 149 DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVGSLAW--NNH 226
Cdd:COG2319 141 DGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFspDGK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 227 ILTTGGMDGLIINNDVRiRSPIVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRsvassnSTTQWLHRLEEHTSA 306
Cdd:COG2319 218 LLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG 290

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 307 VKALAWCPfQANLLATggGGGDRTIKFWNTHTGACLNSVD-TGSQVCSLLWSKNERELLSshGFTQNQLTLWKYPSMVKM 385
Cdd:COG2319 291 VNSVAFSP-DGKLLAS--GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELL 365

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 15234125 386 AELTGHTSRVLYMAQSPDGCTVASAAGDETLRFWNV 421
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
149-421 9.98e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.43  E-value: 9.98e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 149 DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVGSLAW--NNH 226
Cdd:COG2319 141 DGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFspDGK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 227 ILTTGGMDGLIINNDVRiRSPIVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRsvassnSTTQWLHRLEEHTSA 306
Cdd:COG2319 218 LLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG 290

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 307 VKALAWCPfQANLLATggGGGDRTIKFWNTHTGACLNSVD-TGSQVCSLLWSKNERELLSshGFTQNQLTLWKYPSMVKM 385
Cdd:COG2319 291 VNSVAFSP-DGKLLAS--GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELL 365

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 15234125 386 AELTGHTSRVLYMAQSPDGCTVASAAGDETLRFWNV 421
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-420 1.56e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.11  E-value: 1.56e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 149 DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKGgHQSRVGSLAW--NNH 226
Cdd:cd00200  30 DGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG-HTSYVSSVAFspDGR 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 227 ILTTGGMDGLIINNDVRIRSPIVeTYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDrsvASSNSTtqwLHRLEEHTSA 306
Cdd:cd00200 107 ILSSSSRDKTIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD---LRTGKC---VATLTGHTGE 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 307 VKALAWCPFQANLLAtggGGGDRTIKFWNTHTGACLNSVDT-GSQVCSLLWSKNeRELLSShGFTQNQLTLWKYPSMVKM 385
Cdd:cd00200 180 VNSVAFSPDGEKLLS---SSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD-GYLLAS-GSEDGTIRVWDLRTGECV 254

                       250       260       270
                ....*....|....*....|....*....|....*
gi 15234125 386 AELTGHTSRVLYMAQSPDGCTVASAAGDETLRFWN 420
Cdd:cd00200 255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 237-421 4.15e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 4.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125  237 IINNDVRIRSPIVETyrGHTQEVCGLKW-SGSGQQLASGGNDNVVHIWDrsVASSNSTTQwlhrLEEHTSAVKALAWCPF 315
Cdd:PLN00181 515 IIKDGRDIHYPVVEL--ASRSKLSGICWnSYIKSQVASSNFEGVVQVWD--VARSQLVTE----MKEHEKRVWSIDYSSA 586

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125  316 QANLLATGGGGGdrTIKFWNTHTGACLNSVDTGSQVCSLLW-SKNERELL---SSHGFTQNQLTLWKYPsmvkMAELTGH 391
Cdd:PLN00181 587 DPTLLASGSDDG--SVKLWSINQGVSIGTIKTKANICCVQFpSESGRSLAfgsADHKVYYYDLRNPKLP----LCTMIGH 660

                        170       180       190
                 ....*....|....*....|....*....|
gi 15234125  392 TSRVLYMaQSPDGCTVASAAGDETLRFWNV 421
Cdd:PLN00181 661 SKTVSYV-RFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 249-284 4.16e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.16e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15234125    249 VETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD 284
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
249-284 1.36e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.36e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15234125   249 VETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD 284
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
149-421 9.98e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.43  E-value: 9.98e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 149 DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVGSLAW--NNH 226
Cdd:COG2319 141 DGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFspDGK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 227 ILTTGGMDGLIINNDVRiRSPIVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRsvassnSTTQWLHRLEEHTSA 306
Cdd:COG2319 218 LLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG 290

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 307 VKALAWCPfQANLLATggGGGDRTIKFWNTHTGACLNSVD-TGSQVCSLLWSKNERELLSshGFTQNQLTLWKYPSMVKM 385
Cdd:COG2319 291 VNSVAFSP-DGKLLAS--GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELL 365

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 15234125 386 AELTGHTSRVLYMAQSPDGCTVASAAGDETLRFWNV 421
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
143-421 1.30e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 184.34  E-value: 1.30e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 143 VLAIALDHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVGSLA 222
Cdd:COG2319  93 LASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-GHSGAVTSVA 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 223 W--NNHILTTGGMDGLiinndVRIRSP----IVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRsvassnSTTQW 296
Cdd:COG2319 170 FspDGKLLASGSDDGT-----VRLWDLatgkLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL------ATGKL 238

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 297 LHRLEEHTSAVKALAWCPfQANLLATggGGGDRTIKFWNTHTGACLNSVDT-GSQVCSLLWSKNERELLSshGFTQNQLT 375
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSP-DGRLLAS--GSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVR 313

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 15234125 376 LWKYPSMVKMAELTGHTSRVLYMAQSPDGCTVASAAGDETLRFWNV 421
Cdd:COG2319 314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-420 1.56e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.11  E-value: 1.56e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 149 DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKGgHQSRVGSLAW--NNH 226
Cdd:cd00200  30 DGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG-HTSYVSSVAFspDGR 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 227 ILTTGGMDGLIINNDVRIRSPIVeTYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDrsvASSNSTtqwLHRLEEHTSA 306
Cdd:cd00200 107 ILSSSSRDKTIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD---LRTGKC---VATLTGHTGE 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 307 VKALAWCPFQANLLAtggGGGDRTIKFWNTHTGACLNSVDT-GSQVCSLLWSKNeRELLSShGFTQNQLTLWKYPSMVKM 385
Cdd:cd00200 180 VNSVAFSPDGEKLLS---SSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD-GYLLAS-GSEDGTIRVWDLRTGECV 254

                       250       260       270
                ....*....|....*....|....*....|....*
gi 15234125 386 AELTGHTSRVLYMAQSPDGCTVASAAGDETLRFWN 420
Cdd:cd00200 255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
135-421 6.33e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 6.33e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 135 LLDWGSANVLAIALDHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGH 214
Cdd:COG2319  43 AASPDGARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GH 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 215 QSRVGSLAW--NNHILTTGGMDGliinnDVRIRSP----IVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRsva 288
Cdd:COG2319 120 TGAVRSVAFspDGKTLASGSADG-----TVRLWDLatgkLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--- 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 289 ssnSTTQWLHRLEEHTSAVKALAWCPfQANLLATggGGGDRTIKFWNTHTGACLNSVDT-GSQVCSLLWSKNERELLSSH 367
Cdd:COG2319 192 ---ATGKLLRTLTGHTGAVRSVAFSP-DGKLLAS--GSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGS 265

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 15234125 368 GftQNQLTLWKYPSMVKMAELTGHTSRVLYMAQSPDGCTVASAAGDETLRFWNV 421
Cdd:COG2319 266 A--DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
142-338 2.38e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 2.38e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 142 NVLAIA-LDHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLkGGHQSRVGS 220
Cdd:COG2319 217 KLLASGsADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL-TGHSGGVNS 293

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 221 LAW--NNHILTTGGMDGliinnDVRIRSP----IVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRSvassnsTT 294
Cdd:COG2319 294 VAFspDGKLLASGSDDG-----TVRLWDLatgkLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA------TG 362

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 15234125 295 QWLHRLEEHTSAVKALAWCPfQANLLATGGGggDRTIKFWNTHT 338
Cdd:COG2319 363 ELLRTLTGHTGAVTSVAFSP-DGRTLASGSA--DGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 167-421 7.23e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 7.23e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 167 TIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKGgHQSRVGSLAW--NNHILTTGGMDGLI----INN 240
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAAsaDGTYLASGSSDKTIrlwdLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 241 DVRIRspiveTYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDrsvassNSTTQWLHRLEEHTSAVKALAWCPFQaNLL 320
Cdd:cd00200  83 GECVR-----TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD------VETGKCLTTLRGHTDWVNSVAFSPDG-TFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 321 AtgGGGGDRTIKFWNTHTGAClnsvdtgsqvcsllwsknerellsshgftqnqltlwkypsmvkMAELTGHTSRVLYMAQ 400
Cdd:cd00200 151 A--SSSQDGTIKLWDLRTGKC-------------------------------------------VATLTGHTGEVNSVAF 185

                       250       260
                ....*....|....*....|.
gi 15234125 401 SPDGCTVASAAGDETLRFWNV 421
Cdd:cd00200 186 SPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
133-286 5.35e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 5.35e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 133 LNLLDWGSANVLAIAL------------DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWD 200
Cdd:COG2319 239 LRTLTGHSGSVRSVAFspdgrllasgsaDGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 201 SASNRQLRTLKGgHQSRVGSLAW--NNHILTTGGMDGLiinndVRIRSP----IVETYRGHTQEVCGLKWSGSGQQLASG 274
Cdd:COG2319 317 LATGKLLRTLTG-HTGAVRSVAFspDGKTLASGSDDGT-----VRLWDLatgeLLRTLTGHTGAVTSVAFSPDGRTLASG 390

                       170
                ....*....|..
gi 15234125 275 GNDNVVHIWDRS 286
Cdd:COG2319 391 SADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
181-421 7.74e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 7.74e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 181 APDGRHVAVGLNNSEVQLWDSASNRQLRTLKGGHQSRVGSLAWNNHILTTGGMDGLIINNDVRIRSPIVETYRGHTQEVC 260
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 261 GLKWSGSGQQLASGGNDNVVHIWDRsvassnSTTQWLHRLEEHTSAVKALAWCPfQANLLATggGGGDRTIKFWNTHTGA 340
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDL------ATGLLLRTLTGHTGAVRSVAFSP-DGKTLAS--GSADGTVRLWDLATGK 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 341 CLNSVDTGSQ-VCSLLWSKNERELLSshGFTQNQLTLWKYPSMVKMAELTGHTSRVLYMAQSPDGCTVASAAGDETLRFW 419
Cdd:COG2319 154 LLRTLTGHSGaVTSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231


                ..
gi 15234125 420 NV 421
Cdd:COG2319 232 DL 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-284 1.43e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 1.43e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 143 VLAIALDHTVYLWDASTGSTSElvTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVGSLA 222
Cdd:cd00200 150 VASSSQDGTIKLWDLRTGKCVA--TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHENGVNSVA 226

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15234125 223 W--NNHILTTGGMDGLIINNDVRIRSPiVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD 284
Cdd:cd00200 227 FspDGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-237 2.99e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 2.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125 140 SANVLAIALDHTVYLWDASTGSTseLVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVG 219
Cdd:cd00200 189 GEKLLSSSSDGTIKLWDLSTGKC--LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVT 265

                        90       100
                ....*....|....*....|
gi 15234125 220 SLAWNNH--ILTTGGMDGLI 237
Cdd:cd00200 266 SLAWSPDgkRLASGSADGTI 285
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 237-421 4.15e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 4.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125  237 IINNDVRIRSPIVETyrGHTQEVCGLKW-SGSGQQLASGGNDNVVHIWDrsVASSNSTTQwlhrLEEHTSAVKALAWCPF 315
Cdd:PLN00181 515 IIKDGRDIHYPVVEL--ASRSKLSGICWnSYIKSQVASSNFEGVVQVWD--VARSQLVTE----MKEHEKRVWSIDYSSA 586

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125  316 QANLLATGGGGGdrTIKFWNTHTGACLNSVDTGSQVCSLLW-SKNERELL---SSHGFTQNQLTLWKYPsmvkMAELTGH 391
Cdd:PLN00181 587 DPTLLASGSDDG--SVKLWSINQGVSIGTIKTKANICCVQFpSESGRSLAfgsADHKVYYYDLRNPKLP----LCTMIGH 660

                        170       180       190
                 ....*....|....*....|....*....|
gi 15234125  392 TSRVLYMaQSPDGCTVASAAGDETLRFWNV 421
Cdd:PLN00181 661 SKTVSYV-RFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 249-284 4.16e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.16e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15234125    249 VETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD 284
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
249-284 1.36e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.36e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15234125   249 VETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD 284
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 133-367 5.16e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 5.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125  133 LNLLDWGS---ANVLAIALDHTVYLWDASTgstSELVT-IDEEKGPVTSINWAP-DGRHVAVGLNNSEVQLWDSASNRQL 207
Cdd:PLN00181 535 LSGICWNSyikSQVASSNFEGVVQVWDVAR---SQLVTeMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSI 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125  208 RTLKGghQSRVGSLAW---NNHILTTGGMDGLIINNDVRIRSPIVETYRGHTQEVCGLKWSGSgQQLASGGNDNVVHIWD 284
Cdd:PLN00181 612 GTIKT--KANICCVQFpseSGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLWD 688

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125  285 RSVASSNSTTQWLHRLEEHTSaVKALAWCPFQANLLATGGGGGD------------RTIKFWNTHTGACLnSVDTGSQ-V 351
Cdd:PLN00181 689 LSMSISGINETPLHSFMGHTN-VKNFVGLSVSDGYIATGSETNEvfvyhkafpmpvLSYKFKTIDPVSGL-EVDDASQfI 766

                        250
                 ....*....|....*.
gi 15234125  352 CSLLWSKNERELLSSH 367
Cdd:PLN00181 767 SSVCWRGQSSTLVAAN 782
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 381-420 6.27e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.27e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15234125    381 SMVKMAELTGHTSRVLYMAQSPDGCTVASAAGDETLRFWN 420
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 297-335 1.18e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.18e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 15234125    297 LHRLEEHTSAVKALAWCPfQANLLATggGGGDRTIKFWN 335
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSP-DGKYLAS--GSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
386-420 2.73e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15234125   386 AELTGHTSRVLYMAQSPDGCTVASAAGDETLRFWN 420
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 169-224 3.80e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 3.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15234125   169 DEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVGSLAWN 224
Cdd:pfam12894  35 DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFS-AGSDLITCLGWG 89
PTZ00421 PTZ00421
coronin; Provisional
 213-354 1.13e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234125  213 GHQSRVGSLAWN---NHILTTGGMDGLIINNDVRiRSPIVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD-RS-- 286
Cdd:PTZ00421 123 GHTKKVGIVSFHpsaMNVLASAGADMVVNVWDVE-RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDpRDgt 201

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15234125  287 -VASSNSttqwlhrleeHTSAVKALA-WCPfQANLLATGG--GGGDRTIKFWNTHTGACLNSVDTGSQVCSL 354
Cdd:PTZ00421 202 iVSSVEA----------HASAKSQRClWAK-RKDLIITLGcsKSQQRQIMLWDTRKMASPYSTVDLDQSSAL 262
WD40 pfam00400
WD domain, G-beta repeat;
297-335 1.89e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15234125   297 LHRLEEHTSAVKALAWCPFQaNLLATggGGGDRTIKFWN 335
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDG-KLLAS--GSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 296-359 2.66e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 2.66e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15234125   296 WLHRL----------EEHTSAVKALAWCPfQANLLATGGGGGdrTIKFWNTHTGACLNSVDTGS-QVCSLLWSKN 359
Cdd:pfam12894  20 LLHRLnwqrvwtlspDKEDLEVTSLAWRP-DGKLLAVGYSDG--TVRLLDAENGKIVHHFSAGSdLITCLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 161-200 6.28e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 6.28e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15234125    161 STSELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWD 200
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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