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Conserved domains on  [gi|334187101|ref|NP_195008|]
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Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
37-166 2.11e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.94  E-value: 2.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101   37 GLLKLQAKDYDKARELLESILKdpiitnskvetIANDNHLhhlrflALKNLATVFLELGssHYENALNCYLQAIDLDAKD 116
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALE-----------LDPDDAE------ALYNLGLAYLRLG--RYEEALADYEQALELDPDD 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 334187101  117 SVLWNHLGTLSCSMGLLSISRWAFEQGLLCSPNNWNCMEKLLEVLIAVGD 166
Cdd:COG0457    76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
37-166 2.11e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.94  E-value: 2.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101   37 GLLKLQAKDYDKARELLESILKdpiitnskvetIANDNHLhhlrflALKNLATVFLELGssHYENALNCYLQAIDLDAKD 116
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALE-----------LDPDDAE------ALYNLGLAYLRLG--RYEEALADYEQALELDPDD 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 334187101  117 SVLWNHLGTLSCSMGLLSISRWAFEQGLLCSPNNWNCMEKLLEVLIAVGD 166
Cdd:COG0457    76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125
TPR_12 pfam13424
Tetratricopeptide repeat;
37-115 5.85e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 40.06  E-value: 5.85e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334187101    37 GLLKLQAKDYDKARELLESILkdpiitnSKVETIANDNHLHHLRflALKNLATVFLELGssHYENALNCYLQAIDLDAK 115
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKAL-------EIARRLLGPDHPLTAT--TLLNLGRLYLELG--RYEEALELLERALALAEK 77
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
37-166 2.11e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.94  E-value: 2.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101   37 GLLKLQAKDYDKARELLESILKdpiitnskvetIANDNHLhhlrflALKNLATVFLELGssHYENALNCYLQAIDLDAKD 116
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALE-----------LDPDDAE------ALYNLGLAYLRLG--RYEEALADYEQALELDPDD 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 334187101  117 SVLWNHLGTLSCSMGLLSISRWAFEQGLLCSPNNWNCMEKLLEVLIAVGD 166
Cdd:COG0457    76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 19-189 1.35e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.46  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101   19 LAPSKEAQEFHLSQTYHdgllklQAKDYDKARELLESILKdpiitnskvetIANDNHLHHLrflalkNLATVFLELGssH 98
Cdd:COG3914   107 LNPDNAEALFNLGNLLL------ALGRLEEALAALRRALA-----------LNPDFAEAYL------NLGEALRRLG--R 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101   99 YENALNCYLQAIDLDAKDSVLWNHLGTLSCSMGLLSISRWAFEQGLLCSPNN----------------WNCMEKLLEVLI 162
Cdd:COG3914   162 LEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNadahsnllfalrqacdWEVYDRFEELLA 241

                         170       180
                  ....*....|....*....|....*..
gi 334187101  163 AVGDEVSclSVANLILRHWPSHSRALH 189
Cdd:COG3914   242 ALARGPS--ELSPFALLYLPDDDPAEL 266
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 5-148 4.66e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.42  E-value: 4.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101    5 AAINDTESTEKWEPLAPSKEAQEFHLSQTYHDGLLKLQAKDYDKARELLESILKdpiitnskvetIANDNhlhhlrFLAL 84
Cdd:COG5010    29 AALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ-----------LDPNN------PELY 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334187101   85 KNLATVFLELGssHYENALNCYLQAIDLDAKDSVLWNHLGTLSCSMGLLSISRWAFEQGLLCSP 148
Cdd:COG5010    92 YNLALLYSRSG--DKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
37-144 6.08e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.62  E-value: 6.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101   37 GLLKLQAKDYDKARELLESILKdpiitnskvetIANDNHLhhlrflALKNLATVFLELGssHYENALNCYLQAIDLDAKD 116
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALE-----------LDPDDAE------ALYNLGLALLELG--RYDEAIEAYERALELDPDD 143

                          90       100
                  ....*....|....*....|....*...
gi 334187101  117 SVLWNHLGTLSCSMGLLSISRWAFEQGL 144
Cdd:COG0457   144 ADALYNLGIALEKLGRYEEALELLEKLE 171
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 30-184 7.77e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 7.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101   30 LSQTYHDGLLKLQAKDYDKARELLESILKdpiitnskvetiANDNHLHhlrflALKNLATVFLELGssHYENALNCYLQA 109
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALE------------LDPDNPE-----AFALLGEILLQLG--DLDEAIVLLHEA 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334187101  110 IDLDAKDSVLWNHLGTLSCSMGLLSISRWAFEQGLLCSPNNWNCMEKLLEVLIAVGDEVSCLSVANLILRHWPSH 184
Cdd:COG4783    65 LELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 34-189 2.77e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 2.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101   34 YHDGLLKLQAKDYDKARELLESILK-DPiitnskvETIAndnhlhhlrflALKNLATVFLELGssHYENALNCYLQAIDL 112
Cdd:COG2956    12 YFKGLNYLLNGQPDKAIDLLEEALElDP-------ETVE-----------AHLALGNLYRRRG--EYDRAIRIHQKLLER 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334187101  113 DAKDSVLWNHLGTLSCSMGLLSISRWAFEQGLLCSPNNWNCMEKLLEVLIAVGDEVSCLSVANLILRHWPSHSRALH 189
Cdd:COG2956    72 DPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYC 148
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 32-166 1.04e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.57  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101   32 QTYHDGLLKLQAKDYDKARELLESILKDPIITNSKVETIANDNHLHHLRFLALKNLATVFLELGSSHYENALNCYLQAID 111
Cdd:COG5010     3 ALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 334187101  112 LDAKDSVLWNHLGTLSCSMGLLSISRWAFEQGLLCSPNNWNCMEKLLEVLIAVGD 166
Cdd:COG5010    83 LDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQ 137
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
90-166 3.98e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.31  E-value: 3.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334187101   90 VFLELGssHYENALNCYLQAIDLDAKDSVLWNHLGTLSCSMGLLSISRwAFEQGLLCSPNNWNCMEKLLEVLIAVGD 166
Cdd:COG3063     1 LYLKLG--DLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGD 74
TPR_12 pfam13424
Tetratricopeptide repeat;
37-115 5.85e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 40.06  E-value: 5.85e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334187101    37 GLLKLQAKDYDKARELLESILkdpiitnSKVETIANDNHLHHLRflALKNLATVFLELGssHYENALNCYLQAIDLDAK 115
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKAL-------EIARRLLGPDHPLTAT--TLLNLGRLYLELG--RYEEALELLERALALAEK 77
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
41-151 1.40e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.77  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101   41 LQAKDYDKARELLESILKdpiitnskvetiandnhLHHLRFLALKNLATVFLELGssHYENALNcYLQAIDLDAKDSVLW 120
Cdd:COG3063     3 LKLGDLEEAEEYYEKALE-----------------LDPDNADALNNLGLLLLEQG--RYDEAIA-LEKALKLDPNNAEAL 62

                          90       100       110
                  ....*....|....*....|....*....|.
gi 334187101  121 NHLGTLSCSMGLLSISRWAFEQGLLCSPNNW 151
Cdd:COG3063    63 LNLAELLLELGDYDEALAYLERALELDPSAL 93
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 37-126 6.97e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.48  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187101   37 GLLKLQAKDYDKARELLESILKdpiitnskvetiANDNHLHhlrflALKNLATVFLELGssHYENALNCYLQAIDLDAKD 116
Cdd:COG2956   151 AELYLEQGDYDEAIEALEKALK------------LDPDCAR-----ALLLLAELYLEQG--DYEEAIAALERALEQDPDY 211

                          90
                  ....*....|
gi 334187101  117 SVLWNHLGTL 126
Cdd:COG2956   212 LPALPRLAEL 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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