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Conserved domains on  [gi|186514864|ref|NP_194754|]
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P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

ATP-binding protein( domain architecture ID 16031656)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain may function as an ATPase, similar to Arabidopsis thaliana BCS1-like protein

CATH:  3.40.50.300
EC:  3.6.1.-
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  15037234|18466635|16689629
SCOP:  4003976

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 223-391 5.23e-69

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 217.99  E-value: 5.23e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 223 IMEDLREFANGQGFYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQNNSELRKLLMKTSSK-SIIV 301
Cdd:cd19510    1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 302 IEDIDCSISLTKRGKNKKKNGSYeydpgltngsgleepGSSVTLSGLLNFTDGLWSccGSEKIFVFTTNHIEKLDSALMR 381
Cdd:cd19510   81 LEDIDAAFESREHNKKNPSAYGG---------------LSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERLDPALIR 143

                        170
                 ....*....|
gi 186514864 382 SGRMDMHVHM 391
Cdd:cd19510  144 PGRVDMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 26-127 6.69e-31

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


:

Pssm-ID: 464152  Cd Length: 95  Bit Score: 114.96  E-value: 6.69e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864   26 FPPELRLAFLHFLTRIRHVFSSHIYFDITEIDGVNTNELYNAVQLYLSSSvtvndavSSSNNNTRLSLTRVPNSSSVTFG 105
Cdd:pfam14363   1 LPPELRDYLSSKLARLFSRFSPYLTIVIDEFDGFSRNELYDAAQTYLSTK-------ISPSSARRLKASKSPKSKSLVLS 73

                          90       100
                  ....*....|....*....|..
gi 186514864  106 LSNNDRITDVFNGVTILWEHVV 127
Cdd:pfam14363  74 LDDNEEVTDVFEGVKLWWTLVV 95
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 223-391 5.23e-69

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 217.99  E-value: 5.23e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 223 IMEDLREFANGQGFYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQNNSELRKLLMKTSSK-SIIV 301
Cdd:cd19510    1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 302 IEDIDCSISLTKRGKNKKKNGSYeydpgltngsgleepGSSVTLSGLLNFTDGLWSccGSEKIFVFTTNHIEKLDSALMR 381
Cdd:cd19510   81 LEDIDAAFESREHNKKNPSAYGG---------------LSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERLDPALIR 143

                        170
                 ....*....|
gi 186514864 382 SGRMDMHVHM 391
Cdd:cd19510  144 PGRVDMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 26-127 6.69e-31

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


Pssm-ID: 464152  Cd Length: 95  Bit Score: 114.96  E-value: 6.69e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864   26 FPPELRLAFLHFLTRIRHVFSSHIYFDITEIDGVNTNELYNAVQLYLSSSvtvndavSSSNNNTRLSLTRVPNSSSVTFG 105
Cdd:pfam14363   1 LPPELRDYLSSKLARLFSRFSPYLTIVIDEFDGFSRNELYDAAQTYLSTK-------ISPSSARRLKASKSPKSKSLVLS 73

                          90       100
                  ....*....|....*....|..
gi 186514864  106 LSNNDRITDVFNGVTILWEHVV 127
Cdd:pfam14363  74 LDDNEEVTDVFEGVKLWWTLVV 95
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 248-392 1.34e-17

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 79.17  E-value: 1.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864  248 YLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQNN------SELRKLLM--KTSSKSIIVIEDIDcSIsltkrgknkk 319
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKyvgeseKRLRELFEaaKKLAPCVIFIDEID-AL---------- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186514864  320 kngsyeydpgLTNGSGLEEPGSSVTLSGLLNFTDGLwSCCGSEKIFVFTTNHIEKLDSALMrsGRMDMHVHMG 392
Cdd:pfam00004  70 ----------AGSRGSGGDSESRRVVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 196-456 1.00e-16

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 81.21  E-value: 1.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 196 SHPWDSVRFKHPS-TFDTLAMDPEKKKRIMEDL-REFANGQgFYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDI 273
Cdd:COG1222   62 TPRGTAVPAESPDvTFDDIGGLDEQIEEIREAVeLPLKNPE-LFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPF 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 274 YDLELTEVQN----NSE--LRKL--LMKTSSKSIIVIEDIDcSIsltkrgknkkkngsyeydpGLTNGSGLEEPGSSVTL 345
Cdd:COG1222  141 IRVRGSELVSkyigEGArnVREVfeLAREKAPSIIFIDEID-AI-------------------AARRTDDGTSGEVQRTV 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 346 SGLLNFTDGLWSccgSEKIFVF-TTNHIEKLDSALMRSGRMDMHVHMGFCKFPALKILLKNYLR----LEEEDMDSVVLK 420
Cdd:COG1222  201 NQLLAELDGFES---RGDVLIIaATNRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKIHLRdmplADDVDLDKLAKL 277

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 186514864 421 emeecveEAEITPADVSEVL-------IRNR------SDAEKAVREIVS 456
Cdd:COG1222  278 -------TEGFSGADLKAIVteagmfaIREGrdtvtmEDLEKAIEKVKK 319
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
208-419 4.35e-09

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 58.89  E-value: 4.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 208 STFDTLAMDPEKKKRIMEdLREFANGQGFYQKTGRAWKRGYLLYGPPGTGKSSL---IAAMANYLGYDIYDLELTEV--- 281
Cdd:PRK10733 149 TTFADVAGCDEAKEEVAE-LVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLakaIAGEAKVPFFTISGSDFVEMfvg 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 282 QNNSELRKLL--MKTSSKSIIVIEDIDCsisltkrgknkkknGSYEYDPGLTNGSGLEEPgssvTLSGLLNFTDGLWscc 359
Cdd:PRK10733 228 VGASRVRDMFeqAKKAAPCIIFIDEIDA--------------VGRQRGAGLGGGHDEREQ----TLNQMLVEMDGFE--- 286

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186514864 360 GSEKIFVF-TTNHIEKLDSALMRSGRMDMHVHMGFCKFPALKILLKNYLRLE--EEDMDSVVL 419
Cdd:PRK10733 287 GNEGIIVIaATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVplAPDIDAAII 349
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 205-415 9.51e-09

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 57.99  E-value: 9.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864  205 KHPSTFDTLAMDPEKkkrimedlrefangqgfyqktgrawkrGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEV--- 281
Cdd:TIGR01243 199 KHPELFEHLGIEPPK---------------------------GVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEImsk 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864  282 ---QNNSELRKLLMKT--SSKSIIVIEDIDcSISltkrgknkkkngsyeydPGLTNGSGLEEpgsSVTLSGLLNFTDGLW 356
Cdd:TIGR01243 252 yygESEERLREIFKEAeeNAPSIIFIDEID-AIA-----------------PKREEVTGEVE---KRVVAQLLTLMDGLK 310

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186514864  357 sccGSEKIFVF-TTNHIEKLDSALMRSGRMDMHVHMGFCKFPA----LKILLKNYLRLEEEDMD 415
Cdd:TIGR01243 311 ---GRGRVIVIgATNRPDALDPALRRPGRFDREIVIRVPDKRArkeiLKVHTRNMPLAEDVDLD 371
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 245-392 6.36e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 6.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864   245 KRGYLLYGPPGTGKSSLIAAMANYLGYDiydleltevqnnselrkllmktsSKSIIViedIDCSISLTKRGKNKKKNGSY 324
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPP-----------------------GGGVIY---IDGEDILEEVLDQLLLIIVG 55

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864   325 EYDPGLTNGSGLE-----------------EPGS--SVTLSGLLNFTDGLWSCCGSEK----IFVFTTNHIEKLDSALMR 381
Cdd:smart00382  56 GKKASGSGELRLRlalalarklkpdvlildEITSllDAEQEALLLLLEELRLLLLLKSeknlTVILTTNDEKDLGPALLR 135

                          170
                   ....*....|.
gi 186514864   382 SgRMDMHVHMG 392
Cdd:smart00382 136 R-RFDRRIVLL 145
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 223-391 5.23e-69

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 217.99  E-value: 5.23e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 223 IMEDLREFANGQGFYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQNNSELRKLLMKTSSK-SIIV 301
Cdd:cd19510    1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 302 IEDIDCSISLTKRGKNKKKNGSYeydpgltngsgleepGSSVTLSGLLNFTDGLWSccGSEKIFVFTTNHIEKLDSALMR 381
Cdd:cd19510   81 LEDIDAAFESREHNKKNPSAYGG---------------LSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERLDPALIR 143

                        170
                 ....*....|
gi 186514864 382 SGRMDMHVHM 391
Cdd:cd19510  144 PGRVDMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 26-127 6.69e-31

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


Pssm-ID: 464152  Cd Length: 95  Bit Score: 114.96  E-value: 6.69e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864   26 FPPELRLAFLHFLTRIRHVFSSHIYFDITEIDGVNTNELYNAVQLYLSSSvtvndavSSSNNNTRLSLTRVPNSSSVTFG 105
Cdd:pfam14363   1 LPPELRDYLSSKLARLFSRFSPYLTIVIDEFDGFSRNELYDAAQTYLSTK-------ISPSSARRLKASKSPKSKSLVLS 73

                          90       100
                  ....*....|....*....|..
gi 186514864  106 LSNNDRITDVFNGVTILWEHVV 127
Cdd:pfam14363  74 LDDNEEVTDVFEGVKLWWTLVV 95
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 220-390 1.30e-22

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 94.27  E-value: 1.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 220 KKRIMEDLREFANgQGFYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQNNS------ELRKL--L 291
Cdd:cd19481    2 KASLREAVEAPRR-GSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYvgesekNLRKIfeR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 292 MKTSSKSIIVIEDIDcSIsltkrgknkkkngsyeydpGLTNGSGLEEPGSSVTLSGLLNFTDGLWSCcgsEKIFVF-TTN 370
Cdd:cd19481   81 ARRLAPCILFIDEID-AI-------------------GRKRDSSGESGELRRVLNQLLTELDGVNSR---SKVLVIaATN 137

                        170       180
                 ....*....|....*....|
gi 186514864 371 HIEKLDSALMRSGRMDMHVH 390
Cdd:cd19481  138 RPDLLDPALLRPGRFDEVIE 157
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 248-392 1.34e-17

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 79.17  E-value: 1.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864  248 YLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQNN------SELRKLLM--KTSSKSIIVIEDIDcSIsltkrgknkk 319
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKyvgeseKRLRELFEaaKKLAPCVIFIDEID-AL---------- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186514864  320 kngsyeydpgLTNGSGLEEPGSSVTLSGLLNFTDGLwSCCGSEKIFVFTTNHIEKLDSALMrsGRMDMHVHMG 392
Cdd:pfam00004  70 ----------AGSRGSGGDSESRRVVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 196-456 1.00e-16

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 81.21  E-value: 1.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 196 SHPWDSVRFKHPS-TFDTLAMDPEKKKRIMEDL-REFANGQgFYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDI 273
Cdd:COG1222   62 TPRGTAVPAESPDvTFDDIGGLDEQIEEIREAVeLPLKNPE-LFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPF 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 274 YDLELTEVQN----NSE--LRKL--LMKTSSKSIIVIEDIDcSIsltkrgknkkkngsyeydpGLTNGSGLEEPGSSVTL 345
Cdd:COG1222  141 IRVRGSELVSkyigEGArnVREVfeLAREKAPSIIFIDEID-AI-------------------AARRTDDGTSGEVQRTV 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 346 SGLLNFTDGLWSccgSEKIFVF-TTNHIEKLDSALMRSGRMDMHVHMGFCKFPALKILLKNYLR----LEEEDMDSVVLK 420
Cdd:COG1222  201 NQLLAELDGFES---RGDVLIIaATNRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKIHLRdmplADDVDLDKLAKL 277

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 186514864 421 emeecveEAEITPADVSEVL-------IRNR------SDAEKAVREIVS 456
Cdd:COG1222  278 -------TEGFSGADLKAIVteagmfaIREGrdtvtmEDLEKAIEKVKK 319
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 187-456 2.16e-15

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 78.03  E-value: 2.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 187 SRGVSLDARSHPWDSVRFKHPSTFDTLAMDPEKKKRIMEDLREFANGQGFYQKTGRAWKRGYLLYGPPGTGKSSLIAAMA 266
Cdd:COG0464  133 APLVTYEDIGGLEEELLELREAILDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALA 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 267 NYLGYDIYDLELTEVQN----NSE--LRKLL--MKTSSKSIIVIEDIDcsiSLtkrgknkkkngsyeydpgLTNGSGLEE 338
Cdd:COG0464  213 GELGLPLIEVDLSDLVSkyvgETEknLREVFdkARGLAPCVLFIDEAD---AL------------------AGKRGEVGD 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 339 PGSSVTLSGLLNFTDGLwsccGSEKIFVFTTNHIEKLDSALMRsgRMDMHVHMGFCKFPALKILLKNYLR----LEEEDM 414
Cdd:COG0464  272 GVGRRVVNTLLTEMEEL----RSDVVVIAATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEIFRIHLRkrplDEDVDL 345

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 186514864 415 DSVVLKemeecveEAEITPADVSEVLIRNRSDAEKAVREIVS 456
Cdd:COG0464  346 EELAEA-------TEGLSGADIRNVVRRAALQALRLGREPVT 380
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 237-389 3.70e-14

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 70.40  E-value: 3.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 237 YQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQN----NSE--LRKLLMKTSS--KSIIVIEDIDcs 308
Cdd:cd19503   26 FRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSkylgESEknLREIFEEARShaPSIIFIDEID-- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 309 iSLTKRgknkkkngsyeydpgltNGSGLEEPGSSVtLSGLLNFTDGLWSccGSEKIFVFTTNHIEKLDSALMRSGRMDMH 388
Cdd:cd19503  104 -ALAPK-----------------REEDQREVERRV-VAQLLTLMDGMSS--RGKVVVIAATNRPDAIDPALRRPGRFDRE 162


                 .
gi 186514864 389 V 389
Cdd:cd19503  163 V 163
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 209-390 3.71e-12

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 64.56  E-value: 3.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 209 TFDTLAMDPEKKKRIMEdLREFANGQGFYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLG---YDIYDLELTEV---Q 282
Cdd:cd19501    2 TFKDVAGCEEAKEELKE-VVEFLKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGvpfFSISGSDFVEMfvgV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 283 NNSELRKLL--MKTSSKSIIVIEDIDcsisltkrgknkkkngSYEYDPGLTNGSGLEEpgSSVTLSGLLNFTDGLWSccg 360
Cdd:cd19501   81 GASRVRDLFeqAKKNAPCIVFIDEID----------------AVGRKRGAGLGGGHDE--REQTLNQLLVEMDGFES--- 139

                        170       180       190
                 ....*....|....*....|....*....|.
gi 186514864 361 SEKIFVF-TTNHIEKLDSALMRSGRMDMHVH 390
Cdd:cd19501  140 NTGVIVIaATNRPDVLDPALLRPGRFDRQVY 170
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
210-408 3.37e-11

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 63.36  E-value: 3.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 210 FDTLAMDPEKKKRIMEDLREFANGQGfYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEV------QN 283
Cdd:COG1223    1 LDDVVGQEEAKKKLKLIIKELRRREN-LRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLigsylgET 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 284 NSELRKLLMKTSS-KSIIVIEDIDcSISLtkrgknkkkngsyeyDPGLTNGSGlEepgSSVTLSGLLNFTDGLwsccGSE 362
Cdd:COG1223   80 ARNLRKLFDFARRaPCVIFFDEFD-AIAK---------------DRGDQNDVG-E---VKRVVNALLQELDGL----PSG 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 186514864 363 KIFVFTTNHIEKLDSALMRsgRMDMHVHMGFCKFPALKILLKNYLR 408
Cdd:COG1223  136 SVVIAATNHPELLDSALWR--RFDEVIEFPLPDKEERKEILELNLK 179
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 237-392 1.86e-10

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 59.76  E-value: 1.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 237 YQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEV------QNNSELRKLLMKTS--SKSIIVIEDIDcS 308
Cdd:cd19519   26 FKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEImsklagESESNLRKAFEEAEknAPAIIFIDEID-A 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 309 ISltkrgknkkkngsyeydPGLTNGSGLEEpgsSVTLSGLLNFTDGLWSccGSEKIFVFTTNHIEKLDSALMRSGRMDMH 388
Cdd:cd19519  105 IA-----------------PKREKTHGEVE---RRIVSQLLTLMDGLKQ--RAHVIVMAATNRPNSIDPALRRFGRFDRE 162


                 ....
gi 186514864 389 VHMG 392
Cdd:cd19519  163 IDIG 166
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 237-390 1.13e-09

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 57.35  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 237 YQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLgydiyDLELTEVqNNSEL------------RKL--LMKTSSKSIIVI 302
Cdd:cd19502   29 FEELGIEPPKGVLLYGPPGTGKTLLAKAVANHT-----DATFIRV-VGSELvqkyigegarlvRELfeMAREKAPSIIFI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 303 EDIDcSISltkrgknkkkngSYEYDPGltnGSGLEEpgSSVTLSGLLNFTDGLWScCGSEKIfVFTTNHIEKLDSALMRS 382
Cdd:cd19502  103 DEID-AIG------------AKRFDSG---TGGDRE--VQRTMLELLNQLDGFDP-RGNIKV-IMATNRPDILDPALLRP 162


                 ....*...
gi 186514864 383 GRMDMHVH 390
Cdd:cd19502  163 GRFDRKIE 170
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
208-419 4.35e-09

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 58.89  E-value: 4.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 208 STFDTLAMDPEKKKRIMEdLREFANGQGFYQKTGRAWKRGYLLYGPPGTGKSSL---IAAMANYLGYDIYDLELTEV--- 281
Cdd:PRK10733 149 TTFADVAGCDEAKEEVAE-LVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLakaIAGEAKVPFFTISGSDFVEMfvg 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 282 QNNSELRKLL--MKTSSKSIIVIEDIDCsisltkrgknkkknGSYEYDPGLTNGSGLEEPgssvTLSGLLNFTDGLWscc 359
Cdd:PRK10733 228 VGASRVRDMFeqAKKAAPCIIFIDEIDA--------------VGRQRGAGLGGGHDEREQ----TLNQMLVEMDGFE--- 286

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186514864 360 GSEKIFVF-TTNHIEKLDSALMRSGRMDMHVHMGFCKFPALKILLKNYLRLE--EEDMDSVVL 419
Cdd:PRK10733 287 GNEGIIVIaATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVplAPDIDAAII 349
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 220-391 7.55e-09

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 54.81  E-value: 7.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 220 KKRIMEDLREFANGQGFYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEV------QNNSELRKLLMK 293
Cdd:cd19529    2 KQELKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELlskwvgESEKAIREIFRK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 294 T--SSKSIIVIEDIDcsisltkrgknkkkngSYEYDPGLTNGSGLEEPgssvTLSGLLNFTDGLWSCcgSEKIFVFTTNH 371
Cdd:cd19529   82 ArqVAPCVIFFDEID----------------SIAPRRGTTGDSGVTER----VVNQLLTELDGLEEM--NGVVVIAATNR 139

                        170       180
                 ....*....|....*....|
gi 186514864 372 IEKLDSALMRSGRMDMHVHM 391
Cdd:cd19529  140 PDIIDPALLRAGRFDRLIYI 159
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 205-415 9.51e-09

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 57.99  E-value: 9.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864  205 KHPSTFDTLAMDPEKkkrimedlrefangqgfyqktgrawkrGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEV--- 281
Cdd:TIGR01243 199 KHPELFEHLGIEPPK---------------------------GVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEImsk 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864  282 ---QNNSELRKLLMKT--SSKSIIVIEDIDcSISltkrgknkkkngsyeydPGLTNGSGLEEpgsSVTLSGLLNFTDGLW 356
Cdd:TIGR01243 252 yygESEERLREIFKEAeeNAPSIIFIDEID-AIA-----------------PKREEVTGEVE---KRVVAQLLTLMDGLK 310

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186514864  357 sccGSEKIFVF-TTNHIEKLDSALMRSGRMDMHVHMGFCKFPA----LKILLKNYLRLEEEDMD 415
Cdd:TIGR01243 311 ---GRGRVIVIgATNRPDALDPALRRPGRFDREIVIRVPDKRArkeiLKVHTRNMPLAEDVDLD 371
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 246-390 1.60e-08

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 53.83  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 246 RGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQN----NSE--LRKLLMKT--SSKSIIVIEDIDcsiSLTKRGkn 317
Cdd:cd19511   28 KGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSkyvgESEraVREIFQKArqAAPCIIFFDEID---SLAPRR-- 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186514864 318 kkkngsyeydpGLTNGSGLEEPgssvTLSGLLNFTDGLWSccGSEKIFVFTTNHIEKLDSALMRSGRMDMHVH 390
Cdd:cd19511  103 -----------GQSDSSGVTDR----VVSQLLTELDGIES--LKGVVVIAATNRPDMIDPALLRPGRLDKLIY 158
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 236-386 1.87e-08

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 53.95  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 236 FYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTE----VQNNSE--LRKLL--MKTSSKSIIVIEDIDc 307
Cdd:cd19518   25 YFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEivsgVSGESEekIRELFdqAISNAPCIVFIDEID- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 308 SISltkrgknkkkngsyeydPGLTNGSGLEEpgsSVTLSGLLNFTDGL--WSCCGSEKIFVFTTNHIEKLDSALMRSGRM 385
Cdd:cd19518  104 AIT-----------------PKRESAQREME---RRIVSQLLTCMDELnnEKTAGGPVLVIGATNRPDSLDPALRRAGRF 163


                 .
gi 186514864 386 D 386
Cdd:cd19518  164 D 164
ftsH CHL00176
cell division protein; Validated
 246-416 3.87e-08

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 55.83  E-value: 3.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 246 RGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQ------NNSELRKLLMKTSSKS--IIVIEDIDcSIsltkrgkn 317
Cdd:CHL00176 217 KGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVemfvgvGAARVRDLFKKAKENSpcIVFIDEID-AV-------- 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 318 kkkngsyeydpGLTNGSGL----EEpgSSVTLSGLLNFTDGLWSCCGSekIFVFTTNHIEKLDSALMRSGRMDMHVHMGF 393
Cdd:CHL00176 288 -----------GRQRGAGIgggnDE--REQTLNQLLTEMDGFKGNKGV--IVIAATNRVDILDAALLRPGRFDRQITVSL 352

                        170       180
                 ....*....|....*....|...
gi 186514864 394 CKFPALKILLKNYLRLEEEDMDS 416
Cdd:CHL00176 353 PDREGRLDILKVHARNKKLSPDV 375
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 237-391 4.68e-08

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 52.51  E-value: 4.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 237 YQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEV------QNNSELRKLLMKT--SSKSIIVIEDIDcS 308
Cdd:cd19528   19 FLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELltmwfgESEANVRDIFDKAraAAPCVLFFDELD-S 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 309 ISLTKrgknkkkngsyeydpgltNGSGLEEPGSS-VTLSGLLNFTDGLWSccgSEKIFVF-TTNHIEKLDSALMRSGRMD 386
Cdd:cd19528   98 IAKAR------------------GGNIGDAGGAAdRVINQILTEMDGMNT---KKNVFIIgATNRPDIIDPAILRPGRLD 156


                 ....*
gi 186514864 387 MHVHM 391
Cdd:cd19528  157 QLIYI 161
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 245-306 3.40e-07

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 49.84  E-value: 3.40e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186514864 245 KRGYLLYGPPGTGKSSLIAAMANYLGYDIYDL------ELTEV--------QNNSELRKLLMKTSSKSIIVIEDID 306
Cdd:cd00009   19 PKNLLLYGPPGTGKTTLARAIANELFRPGAPFlylnasDLLEGlvvaelfgHFLVRLLFELAEKAKPGVLFIDEID 94
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 241-381 6.17e-07

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 49.27  E-value: 6.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 241 GRAWKRGYLLYGPPGTGKSSLIAAMANYLG---YDIYDLELTE--VQNNSELRKLLMKTSSK---SIIVIEDIDcsislt 312
Cdd:cd19509   28 LRGPPRGILLYGPPGTGKTLLARAVASESGstfFSISASSLVSkwVGESEKIVRALFALARElqpSIIFIDEID------ 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186514864 313 krgknkkkngsyeydpGLTNGSGLEEPGSSVTL-SGLLNFTDGLWScCGSEKIFVF-TTNHIEKLDSALMR 381
Cdd:cd19509  102 ----------------SLLSERGSGEHEASRRVkTEFLVQMDGVLN-KPEDRVLVLgATNRPWELDEAFLR 155
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 237-462 8.66e-07

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 51.83  E-value: 8.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864  237 YQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEV------QNNSELRKLLMKT--SSKSIIVIEDIDcS 308
Cdd:TIGR01243 479 FEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEIlskwvgESEKAIREIFRKArqAAPAIIFFDEID-A 557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864  309 ISLTKRGKNKKKNGSYEYDPGLTNGSGLEEPGSSVTLSGllnftdglwsccgsekifvftTNHIEKLDSALMRSGRMDMH 388
Cdd:TIGR01243 558 IAPARGARFDTSVTDRIVNQLLTEMDGIQELSNVVVIAA---------------------TNRPDILDPALLRPGRFDRL 616

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186514864  389 VHMGF----CKFPALKILLKNYLRLEEEDMDSVVLKEMEEcveeaeiTPADVSEVLirnRSDAEKAVREIV-SVLKERV 462
Cdd:TIGR01243 617 ILVPPpdeeARKEIFKIHTRSMPLAEDVDLEELAEMTEGY-------TGADIEAVC---REAAMAALRESIgSPAKEKL 685
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 237-386 4.67e-06

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 46.71  E-value: 4.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 237 YQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQN----NSEL--RKLLM--KTSSKSIIVIEDIDcs 308
Cdd:cd19530   22 YKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNkyvgESERavRQVFQraRASAPCVIFFDEVD-- 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186514864 309 iSLTkrgknkkkngsyeydpglTNGSGLEEPGSSVTLSGLLNFTDGLWsccGSEKIFVF-TTNHIEKLDSALMRSGRMD 386
Cdd:cd19530  100 -ALV------------------PKRGDGGSWASERVVNQLLTEMDGLE---ERSNVFVIaATNRPDIIDPAMLRPGRLD 156
PRK04195 PRK04195
replication factor C large subunit; Provisional
 207-276 7.49e-06

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 48.38  E-value: 7.49e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 207 PSTFDTLAMDPEKKKRIMEDLREFANGQGfyqktgrawKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDL 276
Cdd:PRK04195  10 PKTLSDVVGNEKAKEQLREWIESWLKGKP---------KKALLLYGPPGVGKTSLAHALANDYGWEVIEL 70
PRK08116 PRK08116
hypothetical protein; Validated
 203-269 3.66e-05

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 45.40  E-value: 3.66e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 203 RFKHpSTFDTLAMDPEKKKRImedlrEFANgqgFYQKTGRAWKR---GYLLYGPPGTGKSSLIAAMANYL 269
Cdd:PRK08116  78 KFRN-STFENFLFDKGSEKAY-----KIAR---KYVKKFEEMKKenvGLLLWGSVGTGKTYLAACIANEL 138
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 235-386 6.49e-05

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 45.14  E-value: 6.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 235 GFYQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTE-VQN--NSELRKL-----LMKTSSKSIIVIEDID 306
Cdd:PTZ00454 169 ELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEfVQKylGEGPRMVrdvfrLARENAPSIIFIDEVD 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 307 cSISltkrgknkkkngSYEYDPglTNGSGLEepgSSVTLSGLLNFTDGLWSCCGSEKIfvFTTNHIEKLDSALMRSGRMD 386
Cdd:PTZ00454 249 -SIA------------TKRFDA--QTGADRE---VQRILLELLNQMDGFDQTTNVKVI--MATNRADTLDPALLRPGRLD 308
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 224-386 8.75e-05

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 43.13  E-value: 8.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 224 MEDLREFAN--GQGF---YQKTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEV------QNNSELRKLL- 291
Cdd:cd19507    5 LDNLKDWLKkrKAAFskqASAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLfgglvgESESRLRQMIq 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 292 -MKTSSKSIIVIEDIDcsisltkrgknkkkngsyeydPGLTNGSGLEEPGSSVTLSGllnfTDGLWSCCGSEKIFVFTT- 369
Cdd:cd19507   85 tAEAIAPCVLWIDEIE---------------------KGFSNADSKGDSGTSSRVLG----TFLTWLQEKKKPVFVVATa 139

                        170
                 ....*....|....*..
gi 186514864 370 NHIEKLDSALMRSGRMD 386
Cdd:cd19507  140 NNVQSLPPELLRKGRFD 156
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
239-301 1.09e-04

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 44.58  E-value: 1.09e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186514864 239 KTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYD----------IYDLEL--TEVqnnselrklLMKTSSKSIIV 301
Cdd:COG1224   58 KEGKMAGKGILIVGPPGTGKTALAVAIARELGEDtpfvaisgseIYSAELkkTEF---------LMQALRKAIGV 123
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 236-351 1.75e-04

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 42.28  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 236 FYQKTGRAWKrGYLLYGPPGTGKSSLIAAMANYLG---YDIYDLELT-EVQNNSE-LRKLLMKTS---SKSIIVIEDID- 306
Cdd:cd19522   25 FFKGIRRPWK-GVLMVGPPGTGKTLLAKAVATECGttfFNVSSSTLTsKYRGESEkLVRLLFEMArfyAPTTIFIDEIDs 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 186514864 307 -CSISLTKRGKNKKKNGSYEY---DPGLTNGSGLEEPGSSVTLSGLLNF 351
Cdd:cd19522  104 iCSRRGTSEEHEASRRVKSELlvqMDGVGGASENDDPSKMVMVLAATNF 152
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 209-269 2.18e-04

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 43.32  E-value: 2.18e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186514864 209 TFDTLAMDPEKKKRIMEDLREFANGqgfYQKTGraWKRGYLLYGPPGTGKSSLIAAMANYL 269
Cdd:PRK08939 125 SLADIDLDDRDRLDALMAALDFLEA---YPPGE--KVKGLYLYGDFGVGKSYLLAAIANEL 180
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 242-306 2.58e-04

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 41.77  E-value: 2.58e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186514864 242 RAWkRGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQNN--SELRKL------LMKTSSKSIIVIEDID 306
Cdd:cd19521   38 KPW-SGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKwmGESEKLvkqlfaMARENKPSIIFIDEVD 109
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 249-274 3.08e-04

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 43.15  E-value: 3.08e-04
                         10        20
                 ....*....|....*....|....*.
gi 186514864 249 LLYGPPGTGKSSLIAAMANYLGYDIY 274
Cdd:PRK13342  40 ILWGPPGTGKTTLARIIAGATDAPFE 65
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 245-386 5.13e-04

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 40.96  E-value: 5.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 245 KRGYLLYGPPGTGKSSLIAAMA-----NYL---GYDIYDLELTEVQNNseLRKLLMKTSSKS--IIVIEDIDcsiSLTKr 314
Cdd:cd19527   26 RSGILLYGPPGTGKTLLAKAIAtecslNFLsvkGPELINMYIGESEAN--VREVFQKARDAKpcVIFFDELD---SLAP- 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186514864 315 gknkkkngsyeydpglTNGSGLEEPG-SSVTLSGLLNFTDGLWSccGSEKIFVF-TTNHIEKLDSALMRSGRMD 386
Cdd:cd19527  100 ----------------SRGNSGDSGGvMDRVVSQLLAELDGMSS--SGQDVFVIgATNRPDLLDPALLRPGRFD 155
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 245-392 6.36e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 6.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864   245 KRGYLLYGPPGTGKSSLIAAMANYLGYDiydleltevqnnselrkllmktsSKSIIViedIDCSISLTKRGKNKKKNGSY 324
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPP-----------------------GGGVIY---IDGEDILEEVLDQLLLIIVG 55

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864   325 EYDPGLTNGSGLE-----------------EPGS--SVTLSGLLNFTDGLWSCCGSEK----IFVFTTNHIEKLDSALMR 381
Cdd:smart00382  56 GKKASGSGELRLRlalalarklkpdvlildEITSllDAEQEALLLLLEELRLLLLLKSeknlTVILTTNDEKDLGPALLR 135

                          170
                   ....*....|.
gi 186514864   382 SgRMDMHVHMG 392
Cdd:smart00382 136 R-RFDRRIVLL 145
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 239-310 1.96e-03

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 40.37  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864  239 KTGRAWKRGYLLYGPPGTGKSSLIAAMANYLGYD----------IYDLEL--TEV--QNnseLRK---LLMKTSSKSI-- 299
Cdd:pfam06068  44 KEGKIAGRAVLIAGPPGTGKTALAIAISKELGEDtpftsisgseVYSLEMkkTEAltQA---FRKaigVRIKEEKEVYeg 120

                          90
                  ....*....|....*
gi 186514864  300 ----IVIEDIDCSIS 310
Cdd:pfam06068 121 evveLEIEEAENPLS 135
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 249-276 3.10e-03

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 40.04  E-value: 3.10e-03
                         10        20
                 ....*....|....*....|....*...
gi 186514864 249 LLYGPPGTGKSSLIAAMANYLGYDIYDL 276
Cdd:COG2256   53 ILWGPPGTGKTTLARLIANATDAEFVAL 80
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 240-381 3.72e-03

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 38.29  E-value: 3.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 240 TG-RAWKRGYLLYGPPGTGKSSLIAAMA---NYLGYDIYDLELTE--VQNNSELRKLLMKTSSK---SIIVIEDIDCSIS 310
Cdd:cd19524   27 TGlRAPARGLLLFGPPGNGKTMLAKAVAaesNATFFNISAASLTSkyVGEGEKLVRALFAVARElqpSIIFIDEVDSLLS 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186514864 311 ltkrgknkkkngsyeydpglTNGSGLEEPGSSVTLSGLLNFtDGLWSCCGSEKIFVFTTNHIEKLDSALMR 381
Cdd:cd19524  107 --------------------ERSEGEHEASRRLKTEFLIEF-DGVQSNGDDRVLVMGATNRPQELDDAVLR 156
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 235-389 4.07e-03

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 38.24  E-value: 4.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 235 GFYQKTGRAWKRGYLLYGPPGTGKSSL---IAAMAN------YLGYDIYDLELTEVQNN--------SELRKLLMKTSSK 297
Cdd:cd19504   25 EIVEQLGCKHVKGILLYGPPGTGKTLMarqIGKMLNarepkiVNGPEILNKYVGESEANirklfadaEEEQRRLGANSGL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186514864 298 SIIVIEDIDcSIsltkrgknkkkngsYEYDPGLTNGSGLeepGSSVtLSGLLNFTDGLWSCcgsEKIFVF-TTNHIEKLD 376
Cdd:cd19504  105 HIIIFDEID-AI--------------CKQRGSMAGSTGV---HDTV-VNQLLSKIDGVEQL---NNILVIgMTNRKDLID 162

                        170
                 ....*....|...
gi 186514864 377 SALMRSGRMDMHV 389
Cdd:cd19504  163 EALLRPGRLEVQM 175
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 239-306 4.09e-03

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 38.17  E-value: 4.09e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186514864 239 KTGRAWK--RGYLLYGPPGTGKSSLIAAMANYLGYDIYDLELTEVQNN--SELRKL---LMKTSSK---SIIVIEDID 306
Cdd:cd19520   27 DNSRLLQppKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKwyGESQKLvaaVFSLASKlqpSIIFIDEID 104
AAA_28 pfam13521
AAA domain;
250-271 4.77e-03

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 38.01  E-value: 4.77e-03
                          10        20
                  ....*....|....*....|..
gi 186514864  250 LYGPPGTGKSSLIAAMANYLGY 271
Cdd:pfam13521   4 ITGGPSTGKTTLAEALAARFGY 25
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
245-270 5.57e-03

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 38.80  E-value: 5.57e-03
                         10        20
                 ....*....|....*....|....*.
gi 186514864 245 KRGYLLYGPPGTGKSSLIAAMANYLG 270
Cdd:COG0470   18 PHALLLHGPPGIGKTTLALALARDLL 43
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 243-269 6.36e-03

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 38.20  E-value: 6.36e-03
                         10        20
                 ....*....|....*....|....*..
gi 186514864 243 AWKRGYLLYGPPGTGKSSLIAAMANYL 269
Cdd:cd19508   50 TWNRLVLLHGPPGTGKTSLCKALAQKL 76
PRK06851 PRK06851
hypothetical protein; Provisional
 243-273 8.14e-03

hypothetical protein; Provisional


Pssm-ID: 235878  Cd Length: 367  Bit Score: 38.41  E-value: 8.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 186514864 243 AWKRGYLLYGPPGTGKSSLIAAMANYL---GYDI 273
Cdd:PRK06851  28 GANRIFILKGGPGTGKSTLMKKIGEEFlekGYDV 61
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 246-267 9.05e-03

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 38.27  E-value: 9.05e-03
                         10        20
                 ....*....|....*....|..
gi 186514864 246 RGYLLYGPPGTGKSSLIAAMAN 267
Cdd:PRK03992 166 KGVLLYGPPGTGKTLLAKAVAH 187
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
245-305 9.80e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 37.84  E-value: 9.80e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186514864 245 KRGYLLYGPPGTGKSSLIAAMANYL---GYDIY-----DL--ELTEVQNNSELRKLLMKTSSKSIIVIEDI 305
Cdd:COG1484   99 GENLILLGPPGTGKTHLAIALGHEAcraGYRVRfttapDLvnELKEARADGRLERLLKRLAKVDLLILDEL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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