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Conserved domains on  [gi|30687603|ref|NP_194476|]
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Cystathionine beta-synthase (CBS) family protein [Arabidopsis thaliana]

Protein Classification

CBS domain-containing protein( domain architecture ID 10456749)

CBS (cystathione beta synthase) domain-containing protein may bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet; similar to Arabidopsis thaliana CBS domain-containing protein CBSX5

CATH:  3.10.580.10
PubMed:  16275737|24161944|21958115
SCOP:  4000247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CBS super family cl33927
CBS domain [Signal transduction mechanisms];
335-388 5.93e-05

CBS domain [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0517:

Pssm-ID: 440283 [Multi-domain]  Cd Length: 128  Bit Score: 42.55  E-value: 5.93e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 30687603 335 SEAIVCNPKSSLMAVMIQAVAHRVNYAWVVEKDGCFVGMVTFVDILKVFRKFLE 388
Cdd:COG0517  75 RPPVTVSPDTSLEEAAELMEEHKIRRLPVVDDDGRLVGIITIKDLLKALLEPLA 128
 
Name Accession Description Interval E-value
CBS COG0517
CBS domain [Signal transduction mechanisms];
335-388 5.93e-05

CBS domain [Signal transduction mechanisms];


Pssm-ID: 440283 [Multi-domain]  Cd Length: 128  Bit Score: 42.55  E-value: 5.93e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 30687603 335 SEAIVCNPKSSLMAVMIQAVAHRVNYAWVVEKDGCFVGMVTFVDILKVFRKFLE 388
Cdd:COG0517  75 RPPVTVSPDTSLEEAAELMEEHKIRRLPVVDDDGRLVGIITIKDLLKALLEPLA 128
CBS pfam00571
CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...
 334-385 4.59e-04

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.


Pssm-ID: 425756 [Multi-domain]  Cd Length: 57  Bit Score: 37.96  E-value: 4.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 30687603   334 KSEAIVCNPKSSLMAVMIQAVAHRVNYAWVVEKDGCFVGMVTFVDILKVFRK 385
Cdd:pfam00571   6 TKDVVTVSPDTTLEEALELMREHGISRLPVVDEDGKLVGIVTLKDLLRALLG 57
 
Name Accession Description Interval E-value
CBS COG0517
CBS domain [Signal transduction mechanisms];
335-388 5.93e-05

CBS domain [Signal transduction mechanisms];


Pssm-ID: 440283 [Multi-domain]  Cd Length: 128  Bit Score: 42.55  E-value: 5.93e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 30687603 335 SEAIVCNPKSSLMAVMIQAVAHRVNYAWVVEKDGCFVGMVTFVDILKVFRKFLE 388
Cdd:COG0517  75 RPPVTVSPDTSLEEAAELMEEHKIRRLPVVDDDGRLVGIITIKDLLKALLEPLA 128
COG3448 COG3448
CBS-domain-containing membrane protein [Signal transduction mechanisms];
335-390 2.80e-04

CBS-domain-containing membrane protein [Signal transduction mechanisms];


Pssm-ID: 442671 [Multi-domain]  Cd Length: 136  Bit Score: 40.62  E-value: 2.80e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 30687603 335 SEAIVCNPKSSLMAVMIQAVAHRVNYAWVVEKDGCFVGMVTFVDILKVFRKFLEND 390
Cdd:COG3448  81 RPVVTVTPDTPLEEAAELMLEHGIHRLPVVDDDGRLVGIVTRTDLLRALARLLEEE 136
CBS pfam00571
CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...
 334-385 4.59e-04

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.


Pssm-ID: 425756 [Multi-domain]  Cd Length: 57  Bit Score: 37.96  E-value: 4.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 30687603   334 KSEAIVCNPKSSLMAVMIQAVAHRVNYAWVVEKDGCFVGMVTFVDILKVFRK 385
Cdd:pfam00571   6 TKDVVTVSPDTTLEEALELMREHGISRLPVVDEDGKLVGIVTLKDLLRALLG 57
COG2524 COG2524
Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];
335-383 2.89e-03

Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];


Pssm-ID: 442013 [Multi-domain]  Cd Length: 206  Bit Score: 38.71  E-value: 2.89e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 30687603 335 SEAIVCNPKSSLMAVMIQAVAHRVNYAWVVEKDGCFVGMVTFVDILKVF 383
Cdd:COG2524 158 RDVVTVSEDDSLEEALRLMLEHGIGRLPVVDDDGKLVGIITRTDILRAL 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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